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Nathan Goodyear

Delayed-Onset Hemolytic Anemia in Patients with Travel-Associated Severe Malaria Treate... - 0 views

wwwnc.cdc.gov/...14-1171_article

artesunate anemia

shared by Nathan Goodyear on 18 Jul 18 - No Cached
  • delayed hemolytic events occur in ≈20% of patients with severe imported malaria, and 60% of these patients require blood transfusion
  • Delayed-onset anemia (herein referred to as postartesunate delayed-onset hemolysis [PADH] pattern of anemia) has been observed to occur 2–3 weeks after initiation of IV artesunate
  • The mechanism of this anemia is hemolytic, as demonstrated by high serum lactate dehydrogenase (LDH) and low plasma haptoglobin levels
  • ...5 more annotations...
  • this side effect is associated with artesunate
  • PADH occurred in 27% of patients in this study, but it was rarely associated with severe anemia and was never fatal
  • median delayed drop in hemoglobin levels was 1.3 g/dL
  • This transfusion rate (<5%) is markedly lower than that previously reported for patients with severe imported malaria and delayed-onset anemia (≈60%)
  • Side effects of artesunate frequently include gastrointestinal disturbances, neutropenia (1.3%), reticulocytopenia (0.6%), and elevated liver enzymes (1.1%)
  • Nathan Goodyear on 18 Jul 18
     
    artesunate
Nathan Goodyear

Efficacy of intranasal administration of artesunate in experimental cerebral malaria | ... - 0 views

malariajournal.biomedcentral.com/...1475-2875-13-501

artesunate malaria dihydroartemisinin

shared by Nathan Goodyear on 22 May 20 - No Cached
  • Nathan Goodyear on 22 May 20
     
    Intranasal artesunate increases dihydroartemisinin across the BBB.
Nathan Goodyear

Penetration of Dihydroartemisinin into Cerebrospinal Fluid after Administration of Intr... - 0 views

www.ncbi.nlm.nih.gov/...PMC148951

dihydroartemisinin artesunate malaria

shared by Nathan Goodyear on 22 May 20 - No Cached
  • Nathan Goodyear on 22 May 20
     
    Artesunate has low lipid solubility and doesn't cross BBB well; but it's high lipid soluble metabolite dihydroartemisinin does.
Nathan Goodyear

Anticancer Effect of AntiMalarial Artemisinin Compounds - 0 views

www.ncbi.nlm.nih.gov/...PMC4389338

artemisinin artesunate malaria cancer

shared by Nathan Goodyear on 25 Apr 20 - No Cached
  • Nathan Goodyear on 25 Apr 20
     
    Good review of artemisinin and its derivatives
Nathan Goodyear

Pharmacokinetics and pharmacodynamics of intravenous artesunate during severe malaria t... - 0 views

www.ncbi.nlm.nih.gov/...PMC3489518

malaira artesunate pharmacokinetics dihydroartimisinin

shared by Nathan Goodyear on 02 May 20 - No Cached
  • Nathan Goodyear on 02 May 20
     
    to be read
Nathan Goodyear

Reversal of multidrug resistance by the anti-malaria drug artesunate in the esophageal ... - 0 views

www.ncbi.nlm.nih.gov/...PMC3813605

esophageal cancer artesunate

shared by Nathan Goodyear on 09 May 20 - No Cached
  • Nathan Goodyear on 09 May 20
     
    artesunate to reverse multi-drug resistance.
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