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A Brief Update on Ubiquinone (Coenzyme Q10)

good review on CoQ10.  The abstract is the only format available on line to the general public.

CoQ10 useful in treating neurodegenerative diseases

CoQ10 shown to be beneficial in treatment of neurodegenerative diseases, Parkinson's, Alzheimer's, ALS, Huntington's, in animal models

CoQ10 shown to shown to slow progression of the neurodegenerative disease: Huntington's disease

Meta-analysis shows that coQ10 "may" improve heart function in those with CHF.

low serum CoQ10 maternal levels associated with low birth weight.

Pilot study and only abstract available here: Low CoQ10 levels found in amniotic sample in preterm delivered pregnancies; not difference was found in serum levels.

only abstract available here, but Coq10 found to decrease incidence of preeclampsia.

Preeclampsia associated with lower CoQ10 levels in women.

Women with preeclampsia have lower CoQ10 levels compared to normal pregnant women.

low CoQ10 associated with spontaneous miscarriage in abstract.  The authors of this paper found CoQ10 levels increased throughout "normal pregnancy".  Only abstract available here.

CoQ10 levels elevated in women with gestational diabetes.  The authors proposed that this was an adaptation to increased oxidative stress.

200 mg CoQ10 found to decrease the risk of preeclampsia in those women at risk.

CoQ10 reduced Th1 inflammatory cytokines in those women with recurrent early pregnancy loss.  CoQ10 specifically, reduced IFN-gamma.

4 year study finds that 200 mg CoQ10 and 200 mg Se reduced NT-proBNP and cardiovascular mortality.  

CoQ10 supplementation of 150 mg in individuals with CAD found to have increased catalase activity, increased SOD activity, an increased MDA levels.  This reduced oxidative stress, TC, and LDL levels.

high dose CoQ10 shown to slow disease progression in Parkinson's disease.  A similar study had shown the same finding in Huntington's disease.  Both are excitotoxic diseases

CoQ10 at 200 mg shown to significantly reduce the rate of pre-eclampsia in pregnant women.

CoQ10 reduced inflammatory cytokines IL-6 and TNF-alpha.  CoQ10 also increased SOD, catalase, and glutathione perioxidase.  The duration of therapy was quite short--12 weeks.  The patients included in the study had pre-existing CAD.

study finds prolonged exposure to estrogen associated with increased colorectal cancer risk in postmenopausal women. So many unanswered questions. What was the ER status of these patients? What was the weight of these patients? One cannot simply compare estrogen exposure to colorectal cancer risk and say aha! What is the environment of the individual(s)?!Thanks visit; blog.hoop.la