Tynor Anklet Comfeel
Anklet comfeel is a next generation product, to provide mild compression, warmth and support to the ankle joint. It is used to allay pain and inflammation, generally associated with old age, arthritis or injury. Knitted on 3 dimensional computer controlled circular looms, it conforms to the complex anatomy of the ankle with exactness.
Closed heel
Anatomic shape
Four way stretch
Uniform compression
Simple pull on application.
Tynor Anklet Comfeel Features
Anatomically shaped and reduced compression on patella
Better compression and grip
Easy knee movement
Perfect conformance to the complex anatomy of the ankle
Improved comfort
Bi-layered, cotton on the inside , a dermophillic interphase
Enhanced comfort
Better sweat absorption
Better patient compliance.
Bilayered, nylon on the outside
Ensures long life
Excellent aesthetics
Color fastness.
Four-way stretchable fabric
Effective compression
Enhanced comfort.
Two layered with interwoven air space
Retains body heat effectively.
Speeds up healing
Allays pain
The typical onset of TS occurs at 6–7 years of age and is characterized by the appearance of simple, recurrent motor tics, followed by the manifestation of phonic tics after several months [12]. In most children, TS symptoms undergo a progressive exacerbation, which reaches its zenith at the beginning of puberty (11–12 years of age), and is then followed by a gradual remission in the majority of patients
30–40% of TS-affected children retain their symptoms in adulthood
Multiple neurotransmitters have been implicated in TS, including dopamine (DA), serotonin, norepinephrine, acetylcholine, glutamate and γ-amino-butyric acid (GABA)
female gender may predict greater tic severity in adulthood
male gender is a major risk factor for TS (with a male:female prevalence ratio estimated at ~4:1)
the typical age of onset coincides with adrenarche (6–7 years old); symptoms increase in severity until the beginning of puberty (12 years old) and then undergo a spontaneous amelioration, which becomes apparent with the end of puberty (at 18–19 years of age)
TS is diagnosed later in females than males
ample evidence supports the involvement of DAergic dysfunctions in TS
a number of clinical observations showed that tics in TS patients could be exacerbated by anabolic androgens
steroidogenic enzymes and androgen receptors may serve as putative therapeutic targets for this disorder
Unlike males, tic severity is typically increased after puberty in females
26% of females were found to experience exacerbation of tics in the estrogenic phase of the menstrual cycle, and this phenomenon was found to be correlated with increased tic severity at menarche
biochemical hallmark of adrenarche is the acquisition of 17,20 lyase activity by cytochrome P450 C17 (CYP17A1)
increased synthesis of dehydroepiandrosterone (DHEA) and androstenedione, which leads to the growth of axillary and pubic hair as well as enhancement in the oiliness of the skin
interesting read on hormones and tourette's.. Proposed that 5 alpha reductase activity is involved in worsening of tics. This makes sense as Testosterone in men with low T is known to increase dopamine and dopaminergic dysfunction is known to play a role in tourette's; the clinical presentation of girls vs boys is very different. The authors of this article propose that 5 alpha reductase activity controls a back door method where by progesterone is converted to androgens.
Tynor Functional Knee Support is specially designed to support knees which are injured or not working properly due to old age. It stabilizes knees during rotational and anteroposterior forces and cures the ligamentous knee injuries. It provides support to the knees by wrapping around them and thus facilitates their compression. It provides flexibility and easy movement of the knee. It is made of soft, durable fabric which can be stretched in four ways.
It mimics the natural knee joint. It can bear the load and shock exerted on it from the external forces leaving the knee totally free from pressure. It contains no buckling or vaso constriction which might hinder comfort. It ensures the proper circulation of blood. It compresses the patellar region and hold it in right position and thus can be used for patellofemoral diseases. It is easy to maintain.
Tynor Functional Knee Support
Functional knee Support is an anterior opening device, which offers the advantage of controlled compression around the knee and a rigid lateral support and immobilization. It allows normal flexion and free movement of the knee joint.
Anterio Open able
Easy application
Controlled compression.
Perfect lateral splinting.
Anatomical design.
Tynor Functional Knee Support Features
Bi axial heavy duty aluminum hinge
Mimics the natural knee joint
Ensures full weight bearing.
Allows free flexion movement
Four way stretchable fabric
Controlled and comfortable compression
No buckling
No vaso constriction
Enhanced comfort
Open patella design
Release patellar pressure
Hold the patella in position
Can be used for Patellofemoral diseases
Wrap design with anterior closing
Easy application and removal on swollen or asymmetric knees
Easy application and removal for weak or geriatric patients.
Allows customized compression
Offers flexibility in sizing
Ergonomic design
Anti tourniquet effect - ensures no constriction to blood flow
Better grip of the product to the bo
Tynor Cervical Orthosis Plastazote
Cervical orthosis plastazote is an advanced collar with scientific design which ensures complete immobilization on one hand and perfect comfort on the other, It is called as a gold standard in cervical immobilization.
Ultimate comfort.
Perfect immobilisation.
Anatomically moulded.
Minimal contact surface.
Hypoallergenic.
Tynor Cervical Orthosis (Philadlphia) Plastazote Features
Pre-formed chin
Provides rest to the chin, ensures comfort, improves immobilization.
Anatomical and balloon design
Offers perfect immobilization, minimal contact of the neck, allows use in burn or trauma patients.
Plastazote
Light weight, better patient compliance.
Non absorbent ensures easy cleaning and maintenance
Hypoallergenic, Ensures no rash or allergy even to old age patients
Eco friendly manufacturing process
Better patient compliance
Tracheotomy opening
Compatible to use of endo tracheal tube, improves air ventilation.
Improves patient comfort and compliance.
Two piece design
Easy application, firm occipital support, option for varying rigidity.
Better immobilization
Tynor Cervical Orthosis (Philadlphia) Plastazote Measurements
Measure distance between edge of sternum and lower jaw with neck in extension position.
Ivermectin can inactivate the protein kinase PAK1 and blocks the PAK1-dependent growth of human ovarian cancer and NF2 tumor cell lines
PAK proteins encoded by the PAK1 gene are critical for cytoskeleton reorganization and nuclear signaling.
PAK-1 kinase is required for the growth of more than 70% of human cancers such as pancreatic, colon, breast and prostate cancers, and neurofibromatosis
PAK1 has also been implicated for maintenance of glucose homeostasis in pancreatic beta cells and skeletal muscle
Ivermectin induces chloride-dependent membrane hyperpolarization and cell death in leukemia cells (Blood, November 4, 2010, vol.115). The paper states Ivermectin synergizes with chemo agents cytarabine and daunorubicin to induce cell death in leukemia cells.
Praziquantel , my other favorite parasite medication for liver flukes, synergistically enhances Paclitaxel (Taxol) efficacy to inhibit cancer cell growth
Niclosamide (trade name Niclocide) is a teniacide in the antihelmintic family that is especially effective against cestodes, which infects humans. Niclosamide has been FDA approved for such indications and has been used in humans for nearly 50 years
We demonstrated for the first time that niclosamide can inhibit Wnt/β-catenin signaling by inducing LRP6 degradation, and that this activity is closely associated with its antiproliferative and apoptosis inducing activity.
Niclosamide, an old anti-parasitic drug, found to inhibit the Wnt/B-catenin pathways so critical to cancer growth. This triggers apoptosis of the cancer cell.
Here, we report on niclosamide as an antileukemic agent with two independent antineoplastic mechanisms: NF-κB pathway inactivation and ROS generation
In this report, we validated the inhibitory action of niclosamide against tumor necrosis factor (TNF)–induced NF-κB activation in AML cells and identified its mechanism, together with generation of reactive oxygen species (ROS), as being responsible for induced apoptosis of AML cells
NF-κB plays a critical role in inflammation, antiapoptotic responses, and carcinogenesis
Old anti-parasitic medication, niclosamide, found to have anti-leukemic acitivty through inactivation of NF-kappaB and increase in ROS production in in Vitro and in Vivo study.
vitamin C deficiency is the fourth most prevalent nutrient deficiency reported in the United States
Hypovitaminosis C (defined as a plasma concentration ≤23 µmol/L)
The CHALICE (Canterbury Health, Ageing and Lifecourse) study is a unique New Zealand study comprising a comprehensive database of determinants of health
The CHALICE cohort of 404 individuals aged 50 years had an average vitamin C intake of ~110 mg/day, which should provide adequate plasma concentrations [14]. Despite this, a significant proportion of the participants had inadequate plasma vitamin C status
inadequate plasma vitamin C concentrations (i.e., <50 µmol/L)
adequate plasma levels (i.e., >50 µmol/L)
Higher plasma vitamin C status was associated with lower weight, BMI and waist circumference
plasma vitamin C was negatively associated with blood triglycerides, HbA1c and insulin, and positively associated with HDL levels.
No correlation was found between plasma vitamin C and the two indicators of heart health; blood pressure and cardiovascular risk score.
2.4% of 50-year-olds were deficient in vitamin C (i.e., <11 µmol/L)
hypovitaminosis C (i.e., <23 µmol/L)
A high proportion (63%) of our participants had inadequate plasma vitamin C concentrations (i.e., <50 µmol/L)
The association of low vitamin C with obesity in this study replicates results in the literature [35,40,41,42,43,44], and it is apparent that individuals with higher weight require higher intakes of vitamin C to reach adequate vitamin C status
higher plasma vitamin C status is associated with lower circulating levels of blood triglycerides, insulin and HbA1c
A role for vitamin C in the prevention or management of diabetes and/or metabolic syndrome has been suggested
In this study, we also demonstrate lower levels of mild cognitive impairment in those with high vitamin C status
The odds of mild cognitive impairment were twice as high for those below 23 μmol/L plasma vitamin C concentration.
Vitamin C is present at very high concentrations in the brain
animal models have shown that the brain is the last organ to be depleted of the vitamin during prolonged deficiency
A recent animal study has shown that moderate vitamin C deficiency may play a role in accelerating amyloid plaque accumulation in Alzheimer’s disease
New study: vitamin C levels correlate with cognitive and metabolic health. What is your vitamin C level? Despite the adequate levels of vitamin C intake, a large % of the individuals had inadequate vitamin C levels which points to a demand issue. Higher oxidative stress, chronic inflammation... would drive demand for vitamin C higher. Lower vitamin C levels were associated with more metabolic disease, ie. DM, and more cognitive decline.
Ear wax removal by irrigation replaces the old fashioned technique of ear syringing. Now Ear irrigation is performed by using an electronic ear irrigation machine to remove ear wax. It is an exceptionally safe, effective and comfortable method of ear cleaning.
Endocrine Disrupting Chemicals from 1970 still disrupting hormones today. Three fold increase in DHEA in 3 year old children via saliva and androstenedione in mothers compared to controls.
New Year, New Beginning. We are here at SN Films Performing Arts, Chandannagar (Hooghly) to nurture your dreams. We will shape up your old passions to new hopes.
Admissions open for acting, film making, singing, spoken English and share trading courses. Contact #snfpa at 9051355050 for detail.
As a neurosurgeon, Dr. Paresh Doshi has performed many lifesaving surgeries to remove brain tumors and blood clots. Recently he has performed a unique deep brain stimulation (DBS) surgical treatment using a complicated auto-sensing device (percept computer) for controlling the signs and symptoms of Parkinson's disease of a forty two-years-old patient, a scientist from Ahmedabad.
For Appointment
Email: dr.pareshdoshi@neurospinehospital.com
Phone No.: +91-9325887033
When Firas's back started to ache, the 51-year-old resident of Oman thought it was just a normal part of the aging process for someone as active as he was.
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