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Nathan Goodyear

Chronic Testosterone Replacement Exerts Cardioprotection against Cardiac Ischemia-Reper... - 0 views

www.ncbi.nlm.nih.gov/...PMC4379072

cardiovascular disease cardiovascular disease heart health Testosterone low T low Testosterone hormone hormones

shared by Nathan Goodyear on 04 Jun 15 - No Cached
  • In this study, the cardioprotective effects of testosterone in testosterone-deprived rats heart with I/R injury were demonstrated
  • Prior to I/R injury, testosterone replacement provided cardioprotective effects in testosterone-deprived rats as indicated by (1) improved cardiac functions by markedly preserved %EF and %FS, and (2) attenuated cardiac sympathovagal imbalance by a markedly decreased LF/HF ratio
  • Testosterone replacement exerts cardioprotective effects by improving left ventricular function and cardiac sympathovagal balance impaired by testosterone deprivation in ORX rats
  • ...3 more annotations...
  • During the I/R period, testosterone replacement in ORX rats exerted the beneficial effects as indicated by (1) improved left ventricular pressure; (2) markedly decreased infarct size; (3) reduced fatal cardiac arrhythmias by increased time to 1st VT/VF onset and reduced arrhythmia scores; and (4) attenuated cardiac mitochondrial dysfunction caused by I/R injury by reducing ROS production, cardiac mitochondrial swelling and mitochondria membrane depolarization.
  • Chronic testosterone replacement also ameliorates left ventricular dysfunction, and reduces the infarct size and cardiac arrhythmias impaired by I/R injury under testosterone-deprived conditions
  • The mechanisms responsible for these beneficial effects of testosterone could be due to its ability to attenuate cardiac mitochondrial dysfunction and cardiomyocyte apoptosis
  • Nathan Goodyear on 04 Jun 15
     
    animal study finds that Testosterone therapy is cardioprotective in a preventative mode and with myocardial injury.  Normalization of Testosterone in these animals with low T reduced infant injury size and improved heart function.  
Nathan Goodyear

Testosterone therapy not associated with myocardial infarction, stroke | Endocrinology - 0 views

www.healio.com/...h-myocardial-infarction-stroke

low T Testosterone therapy treatment cardiovascular disease MI stroke men male hormone hormones

shared by Nathan Goodyear on 19 May 14 - No Cached
  • Nathan Goodyear on 19 May 14
     
    Retrospective study finds no increase in new MI and/or stroke in men with Testosterone therapy.  There are some men that Testosterone therapy is cardioprotective and some that are not.
Nathan Goodyear

Reverse T3 as a parameter of myocardial function impairment in heart failure. - 0 views

www.pubfacts.com/...n-impairment-in-heart-failure.

Thyroid hormone hormones reverse T3 rT3 free T3) CHF congestive heart failure CVD

shared by Nathan Goodyear on 24 Nov 14 - No Cached
  • Nathan Goodyear on 24 Nov 14
     
    reverse T3 and the free T3:rT3 can be used to assess prognosis of those with CHF.
Nathan Goodyear

JAMA Network | JAMA | Association of Testosterone Therapy With Mortality, Myocardial In... - 0 views

jama.jamanetwork.com/article.aspx

low T low testosterone mortality MI myocardial infarction stroke men male hormone hormones Testosterone

shared by Nathan Goodyear on 14 Nov 14 - No Cached
  • Nathan Goodyear on 14 Nov 14
     
    Little if any conclusion can be drawn from this study.  There has actually been a call for redaction by experts in the field.
Nathan Goodyear

High Exercise Capacity Attenuates the Risk of Early Mortality After a First Myocardial ... - 0 views

www.mayoclinicproceedings.org/...abstract

exercise heart attack myocardial infarction heart health heart disease CVD

shared by Nathan Goodyear on 02 Feb 16 - No Cached
  • Nathan Goodyear on 02 Feb 16
     
    exercise improves survival after heart attack.
Nathan Goodyear

The Effect of an EDTA-based Chelation Regimen on Patients With Diabetes Mellitus and Pr... - 0 views

circoutcomes.ahajournals.org/...CIRCOUTCOMES.113.000663

EDTA chelation diabetes MI myocardial infarction heart attack CVD cardiovascular disease heart disease coronary heart disease CAD coronary artery disease

shared by Nathan Goodyear on 05 Oct 17 - No Cached
  • Nathan Goodyear on 05 Oct 17
     
    Only abstract available here, but EDTA chelation found to reduce risk of death, reinfarction, stroke, hospitalization, angina in individuals with diabetes and prior MI from 38% to 25%.
indiacardiacsurg

Increased Physical Activity after Low Implantable Cardioverter-Defibrillator Price in I... - 0 views

www.freeprnow.com/...r-defibrillator-price-in-india

ICD procedure Implantable cardioverter-defibrillators ICD procedure cost ICD procedure price

shared by indiacardiacsurg on 20 Dec 21 - No Cached
  • indiacardiacsurg on 20 Dec 21
     
    Implantable cardioverter-defibrillators, additionally known as ICDs, are battery-powered gadgets positioned under the skin which could detect peculiar heart rhythms and supply an electric shock to restore a regular heartbeat. ICD procedure cost helps reduce the risk of sudden cardiac death and can be recommended for life-threatening rhythm irregularities due to myocardial infarction, cardiac arrest, or congenital heart disease. India Cardiac Surgery Hospital Helpline Number: +91-9370586696
Nathan Goodyear

JAMA Network | JAMA | Effect of Disodium EDTA Chelation Regimen on Cardiovascular Event... - 0 views

jama.jamanetwork.com/article.aspx

TACT TACT study EDTA chelation cardiovascular events CVD

shared by Nathan Goodyear on 10 Jun 13 - No Cached
  • Nathan Goodyear on 10 Jun 13
     
    This study looked at those with previous MIs.  This study found a reduction in recurrent events in those receiving EDTA chelation versus placebo.  The authors of this study looked at the Hazard ratio, which was reduced in every end point that this study was designed to evaluate.
Nathan Goodyear

Mortality and Other Important Diabetes-Related Outcomes With Insulin vs Other Antihyper... - 0 views

jcem.endojournals.org/...668

type II DM type II diabetes diabetes insulin mortality rate mortality

shared by Nathan Goodyear on 21 Feb 13 - No Cached
  • Nathan Goodyear on 21 Feb 13
     
    not sure if I posted this previously, but new study finds that insulin should be the last thing given to a type II diabetic.  Insulin doubles mortality rate.
Nathan Goodyear

Myocardial infarction is inversely associate... [Int J Epidemiol. 1990] - PubMed - NCBI - 0 views

www.ncbi.nlm.nih.gov/...2262248

CAD CVD vitamin D) 25 OH MI heart attack

shared by Nathan Goodyear on 29 Jun 12 - No Cached
  • Nathan Goodyear on 29 Jun 12
     
    Vitamin D (25 OH) below 34 ng/ml associated with double risk of MI.
Nathan Goodyear

Thyroid Hormone Treatment to Mend a Broken Heart - 0 views

jcem.endojournals.org/...1172.full

free T3 fT3 heart cardiac MI myocardial infarction hypothyroidism hypothyroid CHF congestive heart failure hormone hormones thyroid

shared by Nathan Goodyear on 03 Jul 12 - No Cached
  • Nathan Goodyear on 03 Jul 12
     
    free T3 is critical in the heart healing post MI.  Hypothyroidism and CHF share many hemodynamic and cardiovascular similarities.
Nathan Goodyear

Rebuilding the post-infarcted myocardium by a... [Heart Fail Rev. 2010] - PubMed - NCBI - 0 views

www.ncbi.nlm.nih.gov/...18773293

thyroid MI myocardial infarction heart attack hormone hormones post-MI heart cardiac remodeling

shared by Nathan Goodyear on 03 Jul 12 - No Cached
  • Nathan Goodyear on 03 Jul 12
     
    Wow, thyroid hormones play a significant role in cardiac remodeling post MI.  Thyroid hormones, "promotes tissue growth and differentiation and favorably remodels cardiac cell while increases cellular survival..."  How many people post-MI are having their thyroid evaluated, let alone correctly evaluated?
Nathan Goodyear

Estradiol Enhances Recovery After Myocardial Infarction by Augmenting Incorporation of ... - 0 views

circ.ahajournals.org/...1605.long

estradiol estrogen EPCs MI CVD endothelial progenitor cells hormone hormones

shared by Nathan Goodyear on 11 Jul 12 - No Cached
  • Nathan Goodyear on 11 Jul 12
     
    Estradiol shown to increase EPC activity post MI in female MI rat model
Nathan Goodyear

Homocysteine Lowering and Cardiovascular Events after Acute Myocardial Infarction - NEJM - 0 views

www.nejm.org/...NEJMoa055227

NORVIT trial homocysteine vitamin B12 B6 folic acid CVD cardiovascular disease MI stroke strokes events

shared by Nathan Goodyear on 25 Jul 12 - No Cached
  • Nathan Goodyear on 25 Jul 12
     
    NORVIT trial showed that vitamin B12, B6, and folic acid reduced homocysteine levels by 27%, however it did not lower MI, stroke,or mortality rate.  ONe variable to consider is the polypharmacy of the study group ie.  they were taking statins, beta blockers, diuretics, coumadin... so was the lack of change in mortality the result of polypharmacy?  And was the polypharmacy blocking the increased CVD risks associated with elevated homocysteine that would have been treatable with vitamin B12, B6, and folic acid.
Nathan Goodyear

Acute Anti-Ischemic Effect of Testosterone in Men With Coronary Artery Disease - 0 views

circ.ahajournals.org/...1666.full

low T low Testosterone CAD CVD testosterone artery dilation heart myocardium myocardial ischemia cardiology men male hormone hormones

shared by Nathan Goodyear on 17 Jul 12 - No Cached
  • Nathan Goodyear on 17 Jul 12
     
    Testosterone shown to have vasodilatory effect in men.  In this small study, the short course of IV testosterone reduced exercise induced heart ischemia.  This was in men with pre-existing CAD.
Nathan Goodyear

Oestradiol levels in diabetic men with and without a... [Q J Med. 1987] - PubMed - NCBI - 0 views

www.ncbi.nlm.nih.gov/...3671665

aromatase Estradiol E2 Testosterone men male Diabetes hormone hormones MI myocardial infarction

shared by Nathan Goodyear on 04 Mar 14 - No Cached
  • Nathan Goodyear on 04 Mar 14
     
    High Estradiol is reproducible finding in men with Diabetes.  Link to MI not able to be determined.
Nathan Goodyear

Testosterone deficiency syndrome and cardiovascular health: An assessment of beliefs, k... - 0 views

www.ncbi.nlm.nih.gov/...PMC3929476

low T Testosterone cardiovascular disease physicians men male hormone hormones

shared by Nathan Goodyear on 03 Mar 14 - No Cached
  • The vast majority (88%) did not screen cardiac patients for TDS.
  • Testosterone deficiency has a prevalence of 7% in the general population, rising to 20% in elderly males
  • Males with CAD have lower testosterone levels than those with normal coronary angiograms of the same age,5 suggesting that the prevalence of testosterone deficiency is much higher in the CAD population
  • ...14 more annotations...
  • Men with hypertension, another established risk factor for CAD, have lower testosterone compared to normotensive men
  • Recent meta-analyses showed that testosterone levels are generally lower among patients with metabolic syndrome, regardless of the various definitions of metabolic syndrome that are used
  • Testosterone (total and bioavailable) and sex-hormone binding globulin (SHBG) are inversely associated with the prevalence of metabolic syndrome in men between the ages of 40 and 80, and this association persists across racial and ethnic backgrounds
  • ower levels of testosterone and SHBG predict a higher incidence of metabolic syndrome.
  • Low testosterone levels have been related to increased insulin resistance and cardiovascular mortality,12 even in the absence of overt type 2 diabetes mellitus.
  • testosterone levels (total and bioavailable) in middle-aged men are inversely correlated with insulin resistance
  • The Massachusetts Male Aging Study (MMAS) demonstrated that low levels of testosterone and SHBG are independent risk factors for the development of type 2 diabetes,
  • Andropausal men (age 58 ± 7 years) have a higher maximal carotid artery intima-media thickness
  • There is an inverse linear correlation between body mass index (BMI) and wait-to-hip ratio with testosterone and insulin-like growth factor-1 levels.
  • Testosterone supplementation for 1 year in hypogonadal men has been shown to cause a significant improvement in body weight, BMI, waist size, lipid profile, and C-reactive protein levels
  • TRT for 3 months in hypogonadal men with type 2 diabetes significantly improved fasting insulin sensitivity, fasting blood glucose and glycated hemoglobin.
  • Testosterone replacement can improve angina symptoms and delay the onset of cardiac ischemia, likely through a coronary vasodilator mechanism
  • ADT is associated with an increased risk of cardiovascular events, including myocardial infarction and cardiovascular mortality.
  • ADT significantly increases fat mass, decreases lean body mass,29,30 increases fasting plasma insulin and decreases insulin sensitivity31 and increases serum cholesterol and triglyceride levels
  • Nathan Goodyear on 03 Mar 14
     
    Startling study on the knowledge of Testosterone and cardiovascular disease in general practitioners and cardiologists in Canada.  Eight-eight percent did not screen patients with cardiovascular disease for low Testosterone.  A whopping 67% of physicians did not know that low T was a risk factor for cardiovascular disease, yet 62% believed Testosterone would increase exercise tolerance. The lack of knowledge displayed by physicians today is staggering and is an indictment of the governing bodies.  This was a survey conducted in Canada so there are obvious limitations to the strength/conclusion of this study.
Nathan Goodyear

Anabolic steroids, acute myocardial infarction and polycythemia: A case report and revi... - 0 views

www.ncbi.nlm.nih.gov/...PMC2663437

Testosterone polycythemia side effects complications anabolic steroids

shared by Nathan Goodyear on 29 Oct 13 - No Cached
  • Nathan Goodyear on 29 Oct 13
     
    Case study and review of potential side effects from the "doping" of Testosterone that is occuring today in physicians offices.
Nathan Goodyear

Sex hormone levels in patients with sudden cardiac arrest - Heart Rhythm - 0 views

www.heartrhythmjournal.com/...abstract

hormone hormones Testosterone low T low Testosterone low estradiol men women CVD cardiovascular disease MI myocardial infarction heart attack

shared by Nathan Goodyear on 27 Sep 14 - No Cached
  • Nathan Goodyear on 27 Sep 14
     
    Study finds increased risk of sudden MI in men with low Testosterone and elevated Estradiol.  In converse, increased risk is associated with elevated Estradiol in women.
Nathan Goodyear

Thyroid Hormone and Cardiac Disease: From Basic Concepts to Clinical Application - 0 views

www.ncbi.nlm.nih.gov/...PMC3134399

T3 cardiovascular death disease heart health MI myocardial infarction CHF heart failure thyroid hormone hormones hypothyroid hypothyroidism CVD

shared by Nathan Goodyear on 24 Sep 14 - No Cached
  • Nathan Goodyear on 24 Sep 14
     
    Low T3 post MI is associated with increased CHF, morbidity and mortality.  Article discusses thyroid hormones and cardiac function/remodeling post infarct.  The article also lays the ground work for a new study of T3 in patients post MI to be followed for 6 months.
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