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Nathan Goodyear

Converging pathways lead to overproduction of IL-17 in the absence of vitamin D signaling - 0 views

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    Low vitamin D levels or the receptors for vitamin D appear to result in an increase in Th17 cells.  An increase in Th17 cells will lead to an imbalance with Treg cells and this imbalance is associated with Lupus and other autoimmune processes.  Vitamin D inhibits Th17 cell activation.
Nathan Goodyear

Systemic lupus erythematosus and hormone repla... [Menopause Int. 2007] - PubMed - NCBI - 0 views

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    Women with SLE enter menopause earlier.  This study comments on the need for hormone testing in women with SLE and appropriate therapy as indicated.  This study recommended against estrogen therapy due to studies revealing increased flares.  The problem with those studies is that they looked at OCPs and synthetic HRT.
Nathan Goodyear

A double-blind, placebo-controlled, clinical trial... [Lupus. 1999] - PubMed result - 0 views

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    DHEA beneficial in mild/moderate SLE
Nathan Goodyear

Dehydroepiandrosterone in systemic lupus erythemat... [Arthritis Rheum. 1995] - PubMed ... - 0 views

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    DHEA aids in SLE treatment for mild/moderat SLE
Nathan Goodyear

Minocycline‐induced lupus: clinical features and response to rechallenge - 0 views

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    we need to think twice before prescribing minocycline for dermatologic conditions
Nathan Goodyear

Inadequate production of progesterone in wome... [Br J Rheumatol. 1992] - PubMed - NCBI - 0 views

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    Low progesterone found to be associated with SLE in women.
Nathan Goodyear

Ovarian function and disease acti... [Clin Exp Rheumatol. 2008 May-Jun] - PubMed - NCBI - 0 views

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    imbalanced sex hormones in women links to SLE. 
Nathan Goodyear

Clinical Utility of Common Serum Rheumatologic Tests - American Family Physician - 0 views

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    older, but good review on autoimmune testing.
Nathan Goodyear

Estriol and Progesterone: A New Role for Sex Hormones - 0 views

  • Pregnancy-associated Th2 shift has been proposed as a mechanism underlying the improvement of Th1-mediated autoimmune diseases (as rheumatoid arthritis, multiple sclerosis (MS), autoimmune thyoriditis, uveitis, and psoriatic arthritis
  • Th2-mediated autoimmune diseases (as systemic lupus erythematosus)
  • During pregnancy PRG serum level increases by a factor of 4, while estrogen estriol (E3) serum concentration increases by a factor of 20
  • ...1 more annotation...
  • In pregnant women at or near term there is a daily production of about 300 μmol (80 mg) of E3 and 1 mmol (300 mg) of PRG
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    Estriol and Progesterone associated, as found with pregnancy, associated with decrease in Th1 autoimmune disease.
Nathan Goodyear

Increased frequency of delayed type hypersensitivity to metals in patients with connect... - 0 views

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    increased delayed type hypersensitivity reactions in individuals with certain autoimmune diseases.
Nathan Goodyear

Modulation of autoimmune rheumatic diseases by oestrogen and progesterone : Nature Revi... - 0 views

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    only abstract available here, but estradiol increases inflammatory pathways in SLE; in contrast, progesterone decreases these pathways.
Nathan Goodyear

ANA Staining Pattern - 0 views

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    ANA staining pattern
Nathan Goodyear

Molecular mechanisms involved in the estrogen-d... [Clin Immunol. 2000] - PubMed - NCBI - 0 views

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    Another abstract only, but this abstract points out that ER signaling is altered in those with SLE.  No discussion as to whether this was ER alpha or beta or both.
Nathan Goodyear

JAMA Network | JAMA Dermatology | Sex Hormones and the Genesis of Autoimmunity - 0 views

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    Hormones and autoimmune disease.  This article specifically touches on SLE.  Good discussion on the biochemical signaling of hormones and their contribution to the increased autoimmunity found in women.
Nathan Goodyear

Autoimmune response following influenza vaccination in... [Lupus. 2012] - PubMed - NCBI - 0 views

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    Flu vaccine shown to induce autoimmune reaction in those with autoimmune inflammatory rheumatic disease and in the healthy as well.
Nathan Goodyear

Autoimmunity following hepatitis B vaccine as part of ... [Lupus. 2012] - PubMed - NCBI - 0 views

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    This study highlights 93 patients with a post Hepatitis B vaccine induced autoimmune reaction.  More and more of these cases are popping up.
Nathan Goodyear

Effects of prasterone on corticosteroid requiremen... [Arthritis Rheum. 2002] - PubMed ... - 0 views

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    DHEA reduces dosage of prednisone compared to placebo
Nathan Goodyear

An open study of dehydroepiandrosterone in systemi... [Arthritis Rheum. 1994] - PubMed ... - 0 views

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    DHEA improves SLE symptom score and reduces Corticosteroid requirments
Nathan Goodyear

Dehydroepiandrosterone treatment of women with mil... [Arthritis Rheum. 2002] - PubMed ... - 0 views

  • CONCLUSION: The overall results confirm that DHEA treatment was well-tolerated, significantly reduced the number of SLE flares, and improved patient's global assessment of disease activity.
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    DHEA reduces SLE flares
star yu

La Diálisis es el Mejor Tratamiento para Curar la Etaopa 5 de SLE - 0 views

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    Alrededor del 60% de los pacientes con SLE (lupus eritematoso sistémico) tiene daño renal. Cuando el SLE causa la inflamación del riñón, que se traduce en la nefritis lúpica que puede conducir a insuficiencia renal, aunque la etapa 5 de insuficiencia renal. La diálisis es una de las más tratamiento para el tratamiento de esta enfermedad, pero no es la mejor.
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