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Nathan Goodyear

Akkermansia muciniphila Adheres to Enterocytes and Strengthens the Integrity of the Epi... - 0 views

aem.asm.org/...3655.full

gut gut bacteria gut flora gut health gut microbiome gut microbiota akkermansia muciniphila

shared by Nathan Goodyear on 11 Jul 17 - No Cached
  • Nathan Goodyear on 11 Jul 17
     
    Akkermansia muciniphila found to increase the integrity of the gut mucosal lining.  Important in gut healing and likely a good biomarker of good/bad gut health and integrity.
Nathan Goodyear

Journal Articles | The Riordan Clinic - 0 views

www.riordanclinic.org/...journal-articles

Riordan Clinic integrative medicine research articles

shared by Nathan Goodyear on 02 Jun 13 - No Cached
  • Nathan Goodyear on 02 Jun 13
     
    Nice review of the research published out of the Riordan Clinic.  This clinic is at the forefront of integrative medicine.
Nathan Goodyear

Metabolic management of brain cancer - 0 views

www.sciencedirect.com/...S0005272810006857

brain cancer

shared by Nathan Goodyear on 17 Jun 13 - No Cached
  • Glutamine is a major metabolic fuel for both brain tumor cells and tumor-associated macrophages (TAMs)
  • the malignant phenotype of brain tumor cells that survive radiotherapy is often greater than that of the cells from the original tumor.
  • Conventional chemotherapy has faired little better than radiation therapy for the long-term management of malignant brain cancer
  • ...37 more annotations...
  • most conventional radiation and brain cancer chemotherapies can enhance glioma energy metabolism and invasive properties, which would contribute to tumor recurrence and reduced patient survival [34].
  • We contend that all cancer regardless of tissue or cellular origin is a disease of abnormal energy metabolism
  • complex disease phenotypes can be managed through self-organizing networks that display system wide dynamics involving oxidative and non-oxidative (substrate level) phosphorylation
  • As long as brain tumors are provided a physiological environment conducive for their energy needs they will survive; when this environment is restricted or abruptly changed they will either grow slower, growth arrest, or perish [8] and [19]
  • New information also suggests that ketones are toxic to some human tumor cells and that ketones and ketogenic diets might restrict availability of glutamine to tumor cells [68], [69] and [70].
  • The success in dealing with environmental stress and disease is therefore dependent on the integrated action of all cells in the organism
  • Tumor cells survive in hypoxic environments not because they have inherited genes making them more fit or adaptable than normal cells, but because they have damaged mitochondria and have thus acquired the ability to derive energy largely through substrate level phosphorylation
  • Cancer cells survive and multiply only in physiological environments that provide fuels (mostly glucose and glutamine) subserving their requirement for substrate level phosphorylation
  • Integrity of the inner mitochondrial membrane is necessary for ketone body metabolism since β-hydroxybutyrate dehydrogenase, which catalyzes the first step in the metabolism of β-OHB to acetoacetate, interacts with cardiolipin and other phospholipids in the inner membrane
  • the mitochondria of many gliomas and most tumors for that matter are dysfunctional
  • Cardiolipin is essential for efficient oxidative energy production and mitochondrial function
  • Any genetic or environmental alteration in the content or composition of cardiolipin will compromise energy production through oxidative phosphorylation
  • The Crabtree effect involves the inhibition of respiration by high levels of glucose
  • the Warburg effect involves elevated glycolysis from impaired oxidative phosphorylation
  • the Crabtree effect can be reversible, the Warburg effect is largely irreversible because its origin is with permanently damaged mitochondria
  • The continued production of lactic acid in the presence of oxygen is the metabolic hallmark of most cancers and is referred to as aerobic glycolysis or the Warburg effect
  • We recently described how the retrograde signaling system could induce changes in oncogenes and tumor suppressor genes to facilitate tumor cell survival following mitochondrial damage [48].
  • In addition to glycolysis, glutamine can also increase ATP production under hypoxic conditions through substrate level phosphorylation in the TCA cycle after its metabolism to α-ketoglutarate
  • mitochondrial lipid abnormalities, which alter electron transport activities, can account in large part for the Warburg effect
  • targeting both glucose and glutamine metabolism could be effective for managing most cancers including brain cancer
  • The bulk of experimental evidence indicates that mitochondria are dysfunctional in tumors and incapable of generating sufficient ATP through oxidative phosphorylation
  • Cardiolipin defects in tumor cells are also associated with reduced activities of several enzymes of the mitochondrial electron transport chain making it unlikely that tumor cells with cardiolipin abnormalities can generate adequate energy through oxidative phosphorylation
  • The Crabtree effect involves the inhibition of respiration by high levels of glucose
  • Warburg effect involves elevated glycolysis from impaired oxidative phosphorylation
  • TCA cycle substrate level phosphorylation could therefore become another source of ATP production in tumor cells with impairments in oxidative phosphorylation
  • Caloric restriction, which lowers glucose and elevates ketone bodies [63] and [64], improves mitochondrial respiratory function and glutathione redox state in normal cells
  • DR naturally inhibits glycolysis and tumor growth by lowering circulating glucose levels, while at the same time, enhancing the health and vitality of normal cells and tissues through ketone body metabolism
  • DR is anti-angiogenic
  • DR also reduces angiogenesis in prostate and breast cancer
  • We suggest that apoptosis resistance arises largely from enhanced substrate level phosphorylation of tumor cells and to the genes associated with elevated glycolysis and glutaminolysis, e.g., c-Myc, Hif-1a, etc, which inhibit apoptosis
  • Modern medicine has not looked favorably on diet therapies for managing complex diseases especially when well-established procedures for acceptable clinical practice are available, regardless of how ineffective these procedures might be in managing the disease
  • More than 60 years of clinical research indicates that such approaches are largely ineffective in extending survival or improving quality of life
  • The process is rooted in the well-established scientific principle that tumor cells are largely dependent on substrate level phosphorylation for their survival and growth
  • Glucose and glutamine drive substrate level phosphorylation
  • targeting the glycolytically active tumor cells that produce pro-cachexia molecules, restricted diet therapies can potentially reduce tumor cachexia
  • It is important to recognize, however, that “more is not better” with respect to the ketogenic diet
  • Blood glucose ranges between 3.0 and 3.5 mM (55–65 mg/dl) and β-OHB ranges between 4 and 7 mM should be effective for tumor management
  • Nathan Goodyear on 17 Jun 13
     
    Dr Seyfriend presents his metabolic approach to the treatment of brain cancer.
Nathan Goodyear

http://orthomolecular.org/library/jom/1992/pdf/1992-v07n01-p005.pdf - 0 views

orthomolecular.org/...1992-v07n01-p005.pdf

vitamin C CVD Pauling Linus Pauling Lp(a) cardiovascular disease hypertension

shared by Nathan Goodyear on 16 Jan 17 - No Cached
  • Nathan Goodyear on 16 Jan 17
     
    This is the unified paper theory of CVD and vitamin C as published by Pauling and Rath.  Vitamin C deficiency results in a decrease in the integrity and stability of the vascular wall.  Chronic deficiency results in in an increase in and accumulation of Lp(a) which leads to atherosclerotic plaques.
Nathan Goodyear

http://www.altmedrev.com/publications/14/1/14.pdf - 0 views

www.altmedrev.com/...14.pdf

stroke hs-CRP homocysteine brain brain health omega-3 krill oil inflammation Testosterone male obesity hormone hormones disease cancer

shared by Nathan Goodyear on 27 Jun 16 - No Cached
  • Nathan Goodyear on 27 Jun 16
     
    nice review, older, of ischemic stroke risk and ways to prevent/heal in a more integrative approach.  Good review of risk associated with hs-CRP and homocysteine as well.
Nathan Goodyear

Mitochondrial oxidative stress and the metabolic syndrome - 0 views

www.cell.com/...S1043-2760(12)00114-2

Mitochondria metabolic syndrome metabolic syndrome

shared by Nathan Goodyear on 26 Aug 13 - No Cached
  • Nathan Goodyear on 26 Aug 13
     
    Growing body of evidence points to mitochondria as an integral component in Metabolic Syndrome.
Nathan Goodyear

Effects of vitamin D supplementation on intestinal permeability, cathelicidin and disea... - 0 views

ueg.sagepub.com/...294.full

vitamin D Crohn's Crohn's disease

shared by Nathan Goodyear on 17 Jun 15 - No Cached
  • Nathan Goodyear on 17 Jun 15
     
    vitamin D supplementation (2,000 IU) prolongs remission of Crohn's disease.  Of interesting note, the vitamin D group maintained gut integrity and had a decrease in gut permeability.
Willow O'Donnell

We buy your Refurbished LifeCare Hospira PCA 3 Infusion IV Pump - 0 views

www.wishpot.com/item.aspx

WebuyyourIVpumps Webuyyourinfusionpumps

shared by Willow O'Donnell on 11 Sep 14 - No Cached
  • Willow O'Donnell on 11 Sep 14
     
    Refurbished LifeCare Hospira PCA 3 Infusion IV Pump designed specifically to help prevent medication errors that commonly arise in patient-controlled analgesia, the LifeCare PCA pump features an integrated bar code reader and other features to enhance safe delivery.
wheelchairindia9

Save Internet - 0 views

saveinternet.wheelchairindia.com

save the internet billion people net neutality best internet startups

shared by wheelchairindia9 on 15 Apr 15 - No Cached
  • wheelchairindia9 on 15 Apr 15
     
    The Internet has become an integral part of all of our lives. We use it to do our work, connect with people and gain knowledge about various subjects. As our representatives, many of you use it to gather research about the issues faced by your constituents, the challenges faced by different parts of our country, and the expert knowledge needed to legislate for India's future and shape our national decisions. Today, the Internet in our country is facing the danger of losing its neutrality, which is vital to ensure that it grows to reach many more of our fellow Indians - and the people who use it innovate further. In the interest of furthering this cause, we have launched a campaign with fellow Indians who wish to 'Save the Internet'. This letter is addressed to Parliamentarians who have already taken or are considering taking a position on the recent consultation paper released by the TRAI for Internet licensing and net neutrality. We are grateful for the support we have received and the various public statements made by several of you which cut across party lines. Through this letter we wish to point out the intent and purpose of saveinternet.wheelchairindia.com campaign and also the call for a larger network neutrality law in India.
helensvalechiro

Helensvale Chiropractor - 0 views

www.helensvalechiropractor.net.au

Helensvale Chiropractic Centre Chiropractor Massage Cellular Health Analysis Thermography Scan Remedial Sports Deep Tissue Relaxation Detox weight loss

shared by helensvalechiro on 25 Dec 15 - No Cached
  • helensvalechiro on 25 Dec 15
     
    At Helensvale Chiropractor we not only look after chiropractic but we are also a complete integrated wellness centre for weight loss, detox, VLA etc.
wheelchairindia9

Soma SM 150-3 - 0 views

www.wheelchairindia.com/...Soma-SM-150-3

Soma SM 150.3 Soma SM 150.3 Wheelchair SM 150.3 Wheelchair

shared by wheelchairindia9 on 07 Jan 16 - No Cached
  • wheelchairindia9 on 07 Jan 16
     
    Soma SM 150.3: The SM-150.3 is an aluminum alloy standard wheelchair that is economic, solid, and durable. Soma SM 150.3 Wheelchair Features: Elliptical frame The unique and stylish elliptical frame ensures that the chair is both rigid and robust. Integrated seating system For intensive wheelchair users, we provide seating system that can be free from hammock effect. The innovative and durable seating system makes it easy for you to detach seat upholstery for cleaning purpose. Secure non-slip footplate A non-slip and ergonomic footplate provides you with a stable and comfortable base for placing feet. Energy-saving tipping lever The ergonomic design allows caregivers to operate the lever without much effort so the casters can overcome obstacles such as thresholds and curbs. Item Code:WCI-201 MRP: Rs 12000 Our Price:Rs 9950 Net Price:Rs 9751 ( Apply Coupon Code 'MSW2365' Get 2% Discount ) Soma SM 150.3 Wheelchair Measurements: Seat Width(cm):43 Seat Depth(cm):42 Caster Size(inch):7
wheelchairindia9

Soma SM 100.3 - 0 views

www.wheelchairindia.com/...Soma-SM-100-3

Lightweight Chairs Independent For Wheelchair User Ultra Lightweight Wheelchair Lightweight Wheelchair Soma SM 100.3 Light Wheelchairs travel wheelchairs

shared by wheelchairindia9 on 07 Jan 16 - No Cached
  • wheelchairindia9 on 07 Jan 16
     
    Soma SM 100.3 The SM-100.3 is an aluminum alloy standard wheelchair that is economic, solid, and durable. Soma SM 100.3 Wheelchair Features: Elliptical frame The unique and stylish elliptical frame ensures that the chair is both rigid and robust. Integrated seating system For intensive wheelchair users, we provide seating system that can be free from hammock effect. The innovative and durable seating system makes it easy for you to detach seat upholstery for cleaning purpose. Secure non-slip footplate A non-slip and ergonomic footplate provides you with a stable and comfortable base for placing feet. Energy-saving tipping lever The ergonomic design allows caregivers to operate the lever without much effort so the casters can overcome obstacles such as thresholds and curbs. Soma SM 100.3 Wheelchair Measurements: Seat Width(cm):43 Seat Depth(cm):42 Caster Size(inch):7 Rear Wheel Size(Inch/QR) 16F/22F
Nathan Goodyear

microRNA Expression in Ethnic Specific Early Stage Breast Cancer: an Integration and Co... - 0 views

www.nature.com/...s41598-017-16978-y

genetics cancer epigenetics breast cancer

shared by Nathan Goodyear on 06 Feb 18 - No Cached
mamdouh_hfz liked it
  • dysregulated miRNA could be involved in tumor cell proliferation and growth as well as cell cycle progression
  • under-expression of miR-497, 376c and 1271 in Lebanese breast cancer tissues
  • The upregulated miR-183 in our samples was predicted to be responsible for the decrease in expression of the BTG1 mRNA whose protein is involved in cell cycle arrest and apoptosis in breast cancer cells18.
  • ...9 more annotations...
  • nother molecule related to cell proliferation that was over-expressed in our data and suggested as a target of downregulated miR-376c is AURKA
  • the over-expression of miR-183 and miR-21 in Lebanese breast cancer tissues is consistent with downregulation of two important tumor suppressor predicted targets: AKAP12 whose protein regulates cellular adhesion dynamics by controlling cytoskeletal architecture, cell migration, and mitogenic signaling20; and LATS2 whose protein causes cell cycle arrest
  • dysregulation in cancer particularly in breast cancer highlights their importance in tumor development
  • mRNA-miRNA integration analysis of early breast cancer revealed a potential role of miRNA in increasing cellular proliferation and progression, and decreasing invasion and migration
  • most of the miRNA dysregulated in Lebanese breast cancer patients are similar to those dysregulated in American patients, differences in miRNA expression exist and could be attributed either to the patients’ age at diagnosis or to ethnic variation in miRNA epigenetic regulation and sequence variation of pre-miRNA
  • the number one cancer killer of women worldwide
  • microRNA (miRNA) are small non-coding 18–25 nucleotide RNA molecules currently being studied as potential diagnostic, prognostic and therapeutic biomarkers for cancer and other diseases
  • Extensive research on these post-transcriptional modulators has proven that they are deregulated in breast cancerous tissues and even in biological fluids from breast cancer patients
  • five candidate miRNAs (miR-10b, miR-148b, miR-221, miR-21, and miR-155)
  • Nathan Goodyear on 06 Feb 18
     
    Epigenetics plays a role, via disregulated miRNA, in increased cell growth, progression, and invasion in Lebanese women with breast cancer.  It is not just genetics that play a role, but epigenetics.
Nathan Goodyear

Medical education in pharmacogenomics-results from a survey on pharmacogenetic knowledg... - 0 views

www.ncbi.nlm.nih.gov/...PMC5599468

genetics pharmacogenetics

shared by Nathan Goodyear on 17 Jan 18 - No Cached
  • Of participants, 84.3% found pharmacogenomics relevant to their current practice
  • More than two-thirds (65.7%) did not order nor recommend a pharmacogenomic test in the past year
  • pharmacogenomic testing was understood mainly for assessment of the variability of genes affecting drug disposition, metabolism and drug transport leading to individual responses to drugs
  • ...4 more annotations...
  • Pre-emptive, prospective, genotyping to make individualised drug therapy feasible is seen to contribute to personalised medicine
  • assumed to improve drug efficacy and safety
  • Potential benefits of pharmacogenomics (PGx) have been defined such as predicting intended response to medication by more accurate dosing, avoiding adverse drug reactions and therefore enhancing drug safety and reducing health care cost
  • survey among Dutch pharmacists revealed 14.7% recent users of PGx diagnostics [27], whereas in our cohort, the percentage was with 34.3% higher.
  • Nathan Goodyear on 17 Jan 18
     
    Doctors and pharmacists are slow to integrate pharmacogenetics. Good working definition of pharmacogenetics as well.
Nathan Goodyear

The anti-malarial drug artesunate causes cell cycle arrest and apoptosis of triple-nega... - 0 views

www.ncbi.nlm.nih.gov/...30660598

breast cancer cancer artesunate

shared by Nathan Goodyear on 01 Jul 19 - No Cached
  • Nathan Goodyear on 01 Jul 19
     
    ART inhibited breast cancer cell proliferation via a reactive oxygen species (ROS)-dependent G2/M arrest and ROS-independent G1 arrest. ART-treated MDA-MB-468 and SK-BR-3 cells also experienced apoptotic cell death, which was both ROS- and iron-dependent. ART-induced oxidative stress caused the loss of mitochondrial outer membrane integrity and damage to the cellular DNA of MDA-MB-468 and SK-BR-3 cells. Only abstract available...I will post full article once available.
Nathan Goodyear

High-Dose Vitamin C (PDQ®): Integrative, alternative, and complementary thera... - 0 views

www.uwhealth.org/...ncicdr0000742114.html

IV vitamin C cancer vitamin C

shared by Nathan Goodyear on 09 Apr 20 - No Cached
  • Nathan Goodyear on 09 Apr 20
     
    To be read
Nathan Goodyear

NF-κB, an Active Player in Human Cancers | Cancer Immunology Research - 0 views

cancerimmunolres.aacrjournals.org/...823

tumor microenvironment NF-kappaB angiogenesis metastasis

shared by Nathan Goodyear on 10 Jan 21 - No Cached
  • Nathan Goodyear on 10 Jan 21
     
    NF-kappaB plays integral role in carcinogenesis
Nathan Goodyear

Treatment-induced secretion of WNT16B promotes tumor growth and acquired resistance to ... - 0 views

www.ncbi.nlm.nih.gov/...PMC3572004

chemotherapy Wnt cancer

shared by Nathan Goodyear on 16 Sep 20 - No Cached
  • Nathan Goodyear on 16 Sep 20
     
    increased expression of Wnt family member wingless-type MMTV integration site family member 16B (WNT16B) by the tumor microenvironment in response to cytotoxic damage and signals through the canonical Wnt pathway to promote tumor growth and chemotherapy resistance
KELLY147

How to Build an AI Fitness App - 0 views

www.quytech.com/...d-an-ai-fitness-app-like-zenia

#ArtificialIntelligence ##MachineLearning ##BigData ##INDUSTRY

shared by KELLY147 on 24 Feb 21 - No Cached
  • KELLY147 on 24 Feb 21
     
    Artificial intelligence becoming an integral part of various industries, it would be no surprise to see it in the health and fitness sector too. Yes, it is true that AI has revamped the fitness sector to such an extent that none of us had imagined a decade ago. Today, we have AI-powered fitness trainers, AI fitness mirrors, and other AI-enabled equipment that not only provide valuable information but also help in achieving our fitness goals.
indiacardiacsurg

4 Important Thing One Should Know about Top Hospitals for Heart Valve Repair India | He... - 0 views

indiacardiacsurgery.wordpress.com/...s-for-heart-valve-repair-india

heart valve repair in India top hospitals for heart valve repair in India Best Heart Valve Repair Surgeons of India Heart Valve Repair Surgery

shared by indiacardiacsurg on 30 Nov 21 - No Cached
  • indiacardiacsurg on 30 Nov 21
     
    Most of the top hospitals for heart valve repair in India have integrated advanced technology that helps in achieving higher success rates. India Cardiac Surgery Call us at +91-9370586696 or Email us at enquiry@indiacardiacsurgerysite.com
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