Journal of Clinical Investigation -- Oxidation of tetrahydrobiopterin leads to uncoupli... - 0 views
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Tetrahydrobiopterin is a critical cofactor for the NO synthases
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at hypertension produces a cascade involving production of ROSs from the NADPH oxidase leading to oxidation of tetrahydrobiopterin and uncoupling of endothelial NO synthase (eNOS). This decreases NO production and increases ROS production from eNOS
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Tetrahydrobiopterin oxidation may represent an important abnormality in hypertension
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