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Nathan Goodyear

Hospitals' Race to Employ Physicians - The Logic Behind a Money-Losing Proposition | He... - 0 views

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    Hospitals' Race to Employ Physicians
Nathan Goodyear

Deficient Glutathione in the Pathophysiology of Mycotoxin-Related Illness - 0 views

  • Decreased function of the enzymes of glutathione production results in a microenvironment depleted of glutathione on a chronic basis
  • In humans, deficiency of glutathione can lead to chronic conditions [97], including chronic asthma
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    Mycotoxins deplete glutathione production and this depletion of glutathione is a portion go the toxicity/ill effects related to mycotoxins.  This article also points to evidence that glutathione can actually be employed in the treatment of mycotoxin related conditions/illnesses.
Nathan Goodyear

Leg vascular and skeletal muscle mitochondrial adaptations to aerobic high-intensity ex... - 0 views

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    The early post menopause phase is critical for women. This is the phase that requires intensify strategy for exercise. The ER alpha signaling is actually increased and the ability to build muscle is intensified if exercise, particularly resistance training, is employed.
Nathan Goodyear

The Dark Side of Testosterone Deficiency: III. Cardiovascular Disease -- Traish et al. ... - 0 views

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    low testosterone is risk factor for CVD in men.  Of course, normalization of testosterone should be employed and followed in those men that have low T.
Nathan Goodyear

Sex steroids and cardiovascular disease Yeap BB - Asian J Androl - 0 views

  • Levels of SHBG are higher in older men, therefore levels of free T decline more steeply than total T as men's age increases.
  • calculations based on mass action equations may not reflect precisely free T measured using a reference method
  • free T declines more steeply with age than total T in both cross-sectional [35] and longitudinal studies, [36] as does free E2 in comparison to total E2
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  • T may slow development of or progression of atherosclerosis by modulating effects on insulin resistance, inflammation, endothelial function, preclinical atherosclerosis or the vasculature.
  • these cross-sectional and longitudinal studies support a relationship between low circulating T with CIMT and higher E2 with its progression
  • lower levels of T are biomarkers for aortic vascular disease
  • circulating free T was negatively associated with the presence of AAA
  • luteinizing hormone (LH) was positively associated.
  • low levels of total or bioavailable T were associated with aortic atherosclerosis manifested as calcified deposits detected by radiography
  • Men with total or free T in the lowest quartile had increased adjusted ORs for PAD defined as ABI <0.90, as did men with free E2 in the highest quartile of values
  • The apparent association of SHBG with intermittent claudication reflects the correlation of total T with SHBG, while the contribution of E2 to risk of PAD remains unclear
  • men with total T in the lowest quartile of values (<11.7 nmol l−1 ) experienced an increased incidence of stroke or transient ischemic attack
  • lower total T with increased incidence of CVD events
  • cohort studies in mostly older men have supported the association of lower androgen levels with higher mortality
  • lower total or free T levels were associated with mortality in older men, but with discordant results for cause-specific mortality and for associations of E2
  • several large studies identifying lower endogenous levels of total or free T as independent predictors of all-cause or CVD-related deaths in middle-aged and older men
  • T exhibits anti-inflammatory effects, enhances flow-mediated brachial artery reactivity, and reduces arterial stiffness
  • Short-term T therapy had a beneficial effect on exercise-induced myocardial ischemia in middle-aged men with coronary artery disease or chronic stable angina, [95],[96],[97] and reduced angina frequency in older men with diabetes and coronary artery disease
  • T therapy resulted in an increase in treadmill test duration and time to ST segment depression
  • there are interventional studies supporting a protective effect of exogenous T against myocardial ischemia in men with coronary artery disease
  • employ conservative doses
    • Nathan Goodyear
       
      This dosing is 100 fold higher then peak production of a  young man at 20-22.
  • Observational studies indicate that lower levels of endogenous T in older men are associated with the presence of carotid atherosclerosis, aortic and peripheral vascular disease, and incidence of CVD events and mortality
  • Interventional studies have shown beneficial effects of exogenous T on vascular function and on exercise-induced myocardial ischemia in men with coronary artery disease
    • Nathan Goodyear
       
      the therapies employed in these studies were massively overdosed.
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    Nice review of all the sex hormones and their relationship to CVD in men.  
Nathan Goodyear

Diagnosis and treatment of late-onset hypogonadism: Systematic review and meta-analysis... - 0 views

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    Testosterone therapy is complex in hypogonadism.  Much of the marketing-based medicine of Low T today is in fact doping.  Increasing weight is clearly associated with a declining T level in men.  Testosterone therapy should be approach individually and therapies that use the one size fits all approach never work.  This is the case whether the use of synthetics or natural hormones are employed.  Testosterone has been shown to improve dysglycemia, MetS, reduce fat and increase muscle mass.  
Nathan Goodyear

Metabolic syndrome, circulating RBP4, testosterone, and SHBG predict weight regain at 6... - 0 views

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    Interesting study finds that men with low serum Total Testosterone, elevated RBP4 and low SHBG at baseline predict weight regain.  Thus Testosterone should be used as a biomarker of failure in weight loss and if low, Testosterone therapy should be employed to improved metabolic function.  Other parameters, such as leptin, adiponectin, prolactin, progesterone...were not predictive.
Nathan Goodyear

Intermediate and Longer-Term Outcomes From a Prospective Active-Surveillance Program fo... - 0 views

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    low aggressive prostate cancer followed conservatively results in low mortality rate in study.  The study is significant in that it followed 1,298 men up to 18 years and found reclassification to "lethal" grade prostate cancer to be only 5.9%.  This challenges long held dogma that the first approach to cancer is to cut it out. For those with low aggressive prostate cancer, conservative approaches i.e. observation, can be employed.
Nathan Goodyear

Sex Hormone Levels in Patients with Sudden Cardiac Arrest - Heart Rhythm - 0 views

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    Study looked at hormone levels via serum analysis at the time of sudden cardiac arrest in both men and women.  Low Testosterone and elevated Estrogen levels in  men were associated with increased odds (OR) versus women only had increased odds with elevated Estrogen.   ManBoob nation, my first book, discusses the mechanism behind this for men.  The finding in women really calls into question the Estrogen only model currently employed by physicians for post menopausal women.
Nathan Goodyear

Testosterone in Men with Advanced Li... [J Gastroenterol Hepatol. 2014] - PubMed - NCBI - 0 views

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    published ahead of print.  The authors conclude that the Testosterone therapy in hypogonadal men with cirrhosis requires further study.  They, the authors, state that the risk of Testosterone and hepatocellular carcinoma is overstated.  This risk is associated with oral Testosterone replacement and thus in that light is not overstated.  The majority of treatment strategies today employ none oral routes of administration which would support their statement.
Nathan Goodyear

Nattokinase improves blood flow by inhibiting platelet aggregation and thrombus formation - 0 views

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    nattokinase, an enzyme, inhibits platelets aggregation and inhibits inflammatory-induced vascular thrombosis.  Nattokinase is commonly employed as a part of systemic enzyme therapy.
Nathan Goodyear

Hyperbaric Oxygen Therapy Can Improve Post Concussion Syndrome Years after Mild Traumat... - 0 views

  • The changes in SPECT images after treatment indicate that HBOT led to reactivation of neuronal activity in stunned areas that seemed normal under CT and MRI imaging. While SPECT imaging has a limited spatial resolution (compared, for example, to fMRI), the changes in activity were sufficiently robust to be clearly detected by the SPECT images.
  • HBOT might initiate a cellular and vascular repair mechanism and improve cerebral vascular flow
  • HBOT induces regeneration of axonal white matter [61], [62], [63], [64], has positive effect upon the myelinization and maturation of injured neural fibers [65], and can stimulate axonal growth and increase the ability of neurons to function and communicate with each other
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  • HBOT was found to have a role in initiation and/or facilitation of angiogenesis and cell proliferation processes needed for axonal regeneration [67].
  • The observed reactivation of neuronal activity in the stunned areas found here, along with similar results in post-stroke patients
  • At the cellular level, HBOT can improve cellular metabolism, reduce apoptosis, alleviate oxidative stress and increase levels of neurotrophins and nitric oxide through enhancement of mitochondrial function (in both neurons and glial cells)
  • HBOT may promote the neurogenesis of endogenous neural stem cells
  • With regard to secondary injury mechanisms in mTBI, HBOT can initiate vascular repair mechanism and improve cerebral vascular flow [58], [59], [68], [69], promote blood brain barrier integrity and reduce inflammatory reactions [28] as well as brain edema
  • It might be possible that HBOT enables the metabolic change simply by supplying the missing energy/oxygen needed for those regeneration processes.
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    Hbot therapy, according to study, induces neuroplasticity and improves brain function in post concussion syndrome and those with mTBI.  The important point about this study was that the study was done years after the injury; what if the therapy was employed immediately after...
Nathan Goodyear

Role of dopamine in congestive heart failure: a contemporary appraisal. - PubMed - NCBI - 0 views

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    dopamine has benefit in CHF.  Actually, use to be a therapy employed.
spineneuro

New Apoplexy Model By Dr. Vipul Gupta Artemis Improves Access to Life-Saving Care - 0 views

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    Dr. Vipul Gupta Artemis currently employs minimally invasive strategies to accomplish a wide kind of treatment inclusive of apoplexy treatment through handing over clot-busting medical supplies immediately to the site of the blockage.
spineneuro

Dr. Vipul Gupta's Leadership in Delhi's Neurological Advancements - 0 views

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    Dr. Vipul Gupta possesses expertise in determining whether surgery is the optimal course of treatment. He employs the latest techniques in spinal surgery and microsurgery for conditions like herniated discs, spinal stenosis, and tumors. The best interventional neurologist in Delhi India is committed to integrating innovative technologies into the care and treatment of his patients.
Nathan Goodyear

Anticonvulsant Mechanisms of the Ketogenic Diet - Bough - 2007 - Epilepsia - Wiley Onli... - 0 views

  • The ketogenic diet (KD) is a high-fat, low-protein, low-carbohydrate diet that has been employed as a treatment for medically refractory epilepsy for 86 years
  • The hallmark feature of KD treatment is the production of ketone bodies by the liver
  • almost any diet that produces ketonemia and/or diminished blood glucose levels can induce an anticonvulsant effect.
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    ketogenic diet reduces seizures.  Proposed mechanisms: reduced insulin, reduced ROS, reduces oxidative stress, reduced inflammation, increased GABA/Gluatamate ratio.  In the end, it reduces inflammation and increases mitochondrial efficiency.
teremoso

Best Health and Fitness Exercise in Toronto - 2 views

In case you're fitness fanatic, when you consider with regards to relocating you are most likely to want a fitness friendly community. Because of this increase in popularity of getting a lot even m...

Fitness Equipment Toronto

started by teremoso on 21 May 12 no follow-up yet
Nathan Goodyear

Redefining Metabolic Syndrome in Men (July 2012) Townsend Letter for Doctors & Patients - 0 views

  • Approximately 95% to 98% of testosterone is bound to a carrier protein at any given time, leaving just the remaining 2% to 5% as completely unbound and available for tissues to use
  • most serum laboratories offer a free testosterone level, which is a calculated value based on SHBG levels or determined with equilibrium dialysis
  • the hormone enters the salivary gland by passive diffusion
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  • Testosterone has a known age-related decline, and total levels typically drop by approximately 1.6% per year beginning for most men in their 30s
  • As estrogen levels rise, they prompt the body to produce more SHBG, which in turn has a higher binding affinity for testosterone, and drives the unbound fraction of the testosterone pool down even further
  • When the increase in SHBG is taken into account, the age-related decline in the level of hormone that can be used by the body is closer to 2% to 3% per year.
  • Stinging nettle (Urtica dioica), an herb commonly used for allergies, can also be employed to bind to SHBG, which leaves more testosterone available to tissues
  • Leptin, an adipose-derived peptide hormone that regulates appetite and metabolism, has been shown to directly inhibit testosterone production in animal models
  • tumor necrosis factor alpha (TNF-alpha) and interleukin-1 (IL-1) further inhibit Leydig cell testosterone production
  • Natural aromatase inhibitors include the bioflavonoids chrysin and luteolin
  • Zinc deficiency causes an upregulation of the aromatase enzyme
  • Testosterone reduces lipoprotein lipase (LPL) activity
  • there are several herbs that can work to boost testosterone levels, including longjack (Eurycoma longifolia), horny goat weed (Epimedium grandiflorum), and tribulus (Tribulus terrestris).
  • the majority of the hormone is bound to carrier proteins including sex hormone binding globulin (SHBG) and albumin
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    nice and short review on testosterone and men's  health.
wheelchairindia9

Karma 8020 Wheelchair - 0 views

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    This wheelchair of choice for those who desire an extra wide, heavy-duty chair. Bariatric equipment is designed to be used in the care of large and heavy individuals. With childhood obesity levels also rising, the needs of heavier patients and those caring for them, have to be addressed. Wheelchairs that have been constructed for use by the heaviest individuals have built-in strengthening and bracing of the frame, to reduce the possibility of it twisting or buckling in use. The bariatric chairs are available in 20 and 22 inch widths with a red or blue frame. It comes with dual, reinforced steel cross braces for heavy duty support. The seat upholstery is reinforced for long life and comes with a back carry pouch for small items.The 12″ rear wheels are flat free, and the desk length arms are removable and reversible. Features bariatric chairs: Dual, reinforced steel cross braces. Supports individuals. Reinforced steel frame provides added support. Heavy duty, nylon reinforced upholstery with a back carry pouch. Removable, reversible desk length arms. Adjustable leg support. 12″ flat free rear wheels. Using a Karma KM-8020: wheelchairs require more strength to push by the caregiver and by the user, if the chair is self-propelled. In some cases, it may be wise for the caregiver to ask for assistance from another person in order to push the wheelchair safely. Because heavy duty wheelchairs are wider than standard wheelchairs, they require wider doorways and a larger turning radius. They are also heavier to lift into a vehicle and harder to push uphill. Features Can be used as standard self propelled wheelchair or a transport chair all in one. Quick release 24″ wheels can be removed to transition self propelled chair to a transport chair. All aluminum frame. Comes with two sets of aluminum wheel locks: one for use with wheelchair, one for use with transport chair. Fold down back with deluxe back release. Comes standard with swingaway footre
wheelchairindia9

Heavy Duty Wheelchair - 0 views

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    Bariatric wheelchairs (often referred to as extra wide wheelchairs or heavy duty wheelchairs) are strong enough to accommodate almost any user. Just like lighter manual chairs, bariatric wheelchairs are all foldable and feature armrests and swing-away footrests - but they differ quite a bit in their construction. While lightweight wheelchairs often employ materials like aluminum or titanium alloy, a bariatric wheelchair is usually fashioned from steel. Karma 8020 X Heavy Duty Wheelchair: It comes with detachable swing away footrests. The wheel chair has flip-back armrests. It comes with centre of gravity adjustment. The wheel chair has wide profile casters. Seat Size 20'' inch & 22'' inch Total Weight 17 K.G. Heavy duty wheelchairs (often referred to as extra wide wheelchairs or bariatric wheelchairs) are sturdy enough to accommodate almost any user. Just their lighter cousins, manual chairs, heavy duty models all fold and feature arm rests and swing-away footrests - but they differ quite a bit in their construction. Heavy duty wheelchairs require more strength to push by the caregiver and by the user, if the chair is self-propelled. In some cases, it may be wise for the caregiver to ask for assistance from another person in order to push the wheelchair safely. Karma 8520 Heavy Duty Wheelchair: It comes with detachable swing away footrests. The wheel chair has flip-back armrests. It comes with centre of gravity adjustment. The wheel chair has wide profile casters. Seat Size 20'' inch & 22'' inch Total Weight 17 K.G. Features: Dual, reinforced steel cross braces. Supports individuals maximum weight. Reinforced steel frame provides added support. Heavy duty, nylon reinforced upholstery with a back carry pouch. Removable, reversible desk length arms. Adjustable leg support.
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