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Nathan Goodyear

Coenzyme Q10 in neurodegenerative diseases. [Curr Med Chem. 2003] - PubMed result - 0 views

www.ncbi.nlm.nih.gov/...12871093

CoQ10 Parkinson's disease

shared by Nathan Goodyear on 07 Feb 11 - No Cached
  • supplemental coenzyme Q(10) can slow the functional decline in these disorders, particularly Parkinson's disease.
  • Nathan Goodyear on 07 Feb 11
     
    CoQ10 may slow some aspects of Parkinson's disease
Nathan Goodyear

Dietary supplementation with eicosapentaenoic and ... [Int J Cancer. 1998] - PubMed result - 0 views

www.ncbi.nlm.nih.gov/...9495237

Omega-3 DHA EPA cancer

shared by Nathan Goodyear on 11 Feb 11 - No Cached
  • t is concluded from the results of the present study that the anti-tumoral effect of EPA is related mainly to its inhibition of cell proliferation, whereas that of DHA corresponds with its induction of apoptosis. The alterations in fatty-acid composition induced by EPA or DHA appear to be factors underlying their differential actions on cell proliferation and apoptosis.
  • Nathan Goodyear on 11 Feb 11
     
    Omega-3, DHA and EPA, work differently in their anti-cancer effects
Nathan Goodyear

EDTA chelation therapy in the treatment of vascula... [J Cardiovasc Nurs. 1996] - PubMe... - 0 views

www.ncbi.nlm.nih.gov/...8820322

chelation edta therapy cardiovascular disease

shared by Nathan Goodyear on 14 Feb 11 - No Cached
  • EDTA chelation therapy in the treatment of vascular disease.
  • Nathan Goodyear on 14 Feb 11
     
    Chelation as therapy for cardiovascular disease
Nathan Goodyear

Mitoenergetic failure in Alzheimer disease - 0 views

ajpcell.physiology.org/...C8.abstract

neuro-toxicity Alzheimer's disease mitochondria

shared by Nathan Goodyear on 03 Mar 11 - No Cached
  • This review summarizes new insights based on the interaction of mitoenergetic failure, glutamate excitotoxicity, and amyloid toxicity in the exacerbation of AD.
  • Nathan Goodyear on 03 Mar 11
     
    discussion on mitochondria, neuro-excitotoxicity, and Alzheimer's Disease
Nathan Goodyear

Journal of Clinical Investigation -- Revisiting leptin's role in obesity and weight loss - 0 views

www.jci.org/36284

leptin obesity weight loss

shared by Nathan Goodyear on 04 Mar 11 - No Cached
  • Revisiting leptin’s role in obesity and weight loss
  • Nathan Goodyear on 04 Mar 11
     
    revisiting leptin and obesity
Nathan Goodyear

Randomized, double blind placebo-controlled trial: effects of myo-inositol on ovarian f... - 0 views

www.mendeley.com/...n-metabolic-factors-women-pcos

myo-inositol weight loss leptin insulin overweight

shared by Nathan Goodyear on 01 Jun 11 - No Cached
  • significant weight loss (and leptin reduction) (P < 0.01) was recorded in the myo-inositol group, whereas the placebo group actually increased weight
  • hese data support a beneficial effect of myo-inositol in women with oligomenorrhea and polycystic ovaries in improving ovarian function.
  • Nathan Goodyear on 01 Jun 11
     
    myo-inositol improves weight loss and leptin resistance through insulin secondary messenger
Nathan Goodyear

Prevalence of cardiovascular disease risk factors ... [JAMA. 2009] - PubMed result - 0 views

www.ncbi.nlm.nih.gov/...19470988

cardiovascular prevalence disease NFL players

shared by Nathan Goodyear on 14 May 11 - No Cached
  • NFL players had a lower prevalence of impaired fasting glucose, less reported smoking, a similar prevalence of dyslipidemia, and a higher prevalence of hypertension. Increased size measured by BMI was associated with increased CVD risk factors in this combined population.
  • Nathan Goodyear on 14 May 11
     
    higher disease risk in NFL players
Nathan Goodyear

Triglycerides Induce Leptin Resistance at the Blood-Brain Barrier - 0 views

diabetes.diabetesjournals.org/...1253.full

leptin resistance triglycerides

shared by Nathan Goodyear on 12 Apr 11 - No Cached
  • Obesity is associated with leptin resistance
  • Resistance arises from impaired leptin transport across the blood-brain barrier (BBB)
  • Decreasing triglycerides may potentiate the anorectic effect of leptin by enhancing leptin transport across the BBB.
  • ...2 more annotations...
  • Starvation, like obesity, is accompanied by a decreased BBB transport rate of exogenous leptin
  • hypertriglyceridemia could explain impaired transport of leptin across the BBB in both starvation and obesity
  • Nathan Goodyear on 12 Apr 11
     
    elevated triglycerides and leptin resistance
Nathan Goodyear

The relation between hypomagnesaemia and vascular stiffness in renal transplant recipients - 0 views

ndt.oxfordjournals.org/...ndt.gfq728.abstract

Magnesium arterial disease cardiovascular artery

shared by Nathan Goodyear on 17 Apr 11 - No Cached
  • Serum magnesium is an independent predictor of arterial stiffness in RTR, especially in patients >55 years.
  • Nathan Goodyear on 17 Apr 11
     
    Magnesium deficiency and arterial disease
Nathan Goodyear

Effect of dietary oregano oil and alpha-tocopheryl... [J Anim Physiol Anim Nutr (Berl).... - 0 views

www.ncbi.nlm.nih.gov/...14507415

Oregano essential oil vitamin E

shared by Nathan Goodyear on 15 Apr 11 - No Cached
  • dietary oregano oil exerted a protective action on alpha-tocopherol.
  • Nathan Goodyear on 15 Apr 11
     
    Oregano essential oil aids activity of vitamin E
Nathan Goodyear

Exposure to volatile organic compounds and loss of pulmonary function in the elderly - 0 views

erj.ersjournals.com/...1270.abstract

volatile solvents benzene xylene toluene

shared by Nathan Goodyear on 14 Apr 11 - No Cached
  • is study suggests that exposure to toluene and xylene exert a harmful effect on pulmonary function by exacerbating oxidative stress in elderly people.
  • Nathan Goodyear on 14 Apr 11
     
    volatile solvents and lung damage
Nathan Goodyear

Heavy Metal-induced Immunotoxicity and Its Mechanisms | ResearchGate - 0 views

www.researchgate.net/...unotoxicity_and_Its_Mechanisms

heavy metal immunotoxicity

shared by Nathan Goodyear on 28 Mar 11 - No Cached
  • Heavy Metal-induced Immunotoxicity and Its Mechanisms
  • Nathan Goodyear on 28 Mar 11
     
    Heavy Metal-induced Immunotoxicity and Its Mechanisms
Nathan Goodyear

Effects of endocrine disruptors on obesity. [Int J Androl. 2008] - PubMed result - 0 views

www.ncbi.nlm.nih.gov/...18315718

obesity endocrine disruptors toxins toxicity

shared by Nathan Goodyear on 06 Apr 11 - No Cached
  • Most recently, obesity has been proposed to be yet another adverse health effect of exposure to endocrine disrupting chemicals (EDCs) during critical stages of development. Obesity is quickly becoming a significant human health crisis
  • The emerging idea of an association of EDCs and obesity expands the focus on obesity from intervention and treatment to include prevention and avoidance of these chemical modifiers.
  • Nathan Goodyear on 06 Apr 11
     
    Effects of endocrine disruptors on obesity.
Nathan Goodyear

Depression and risk of sudden cardiac death and co... [J Am Coll Cardiol. 2009] - PubMe... - 0 views

www.ncbi.nlm.nih.gov/...19281925

antidepressants depression risk cardiovascular disease

shared by Nathan Goodyear on 06 Apr 11 - No Cached
  • Although antidepressant use might be a marker of worse depression, its specific association with SCD merits further study.
  • Nathan Goodyear on 06 Apr 11
     
    antidepressants increase sudden cardiac death and are marker for worse depression
Nathan Goodyear

Fifty- two-Week Treatment With Diet and Exercise Plus Transdermal Testosterone Reverses... - 0 views

onlinelibrary.wiley.com/...full

diet exercise nutrition diabetes metabolic syndrome men male hormone hormones low T low Testosterone

shared by Nathan Goodyear on 04 Mar 15 - No Cached
  • there appears to be a positive correlation between serum testosterone levels and insulin sensitivity in men across the full spectrum of glucose tolerance (Pitteloud et al, 2005), and this relationship is at least partially direct and not fully dependent on (changes in) elements of the MetS
  • supervised D&E alone led to significant improvements in testosterone concentrations, glycemic control, and components of the MetS
  • diet control, exercise, and testosterone supplementation may be beneficial in the management of men with T2D
  • ...7 more annotations...
  • androgen-deprivation therapy in males with prostatic cancer may be associated with an increased risk for T2D, which may be caused by negative effects on insulin sensitivity
  • insulin sensitivity, measured by HOMA, improved in both groups and with a significantly greater degree when testosterone was added to supervised D&E
  • Fasting insulin concentrations, a good representative of insulin sensitivity, did show a significant correlation with changes in circulating androgen levels, an observation in support of Pitteloud et al (2005), who showed a direct relationship between insulin sensitivity and circulating testosterone concentrations using the hyper-insulinemic euglycemic clamp technique
  • 52 weeks of testosterone treatment also significantly improved circulation levels of adiponectin and hsCRP, key serum markers of insulin sensitivity and hepatic steatosis
  • The changes in both adiponectin and hsCRP were significantly correlated with the therapy-induced changes in bioavailable testosterone
  • a negative correlation was found between hsCRP levels and bioavailable testosterone
  • serum PSA concentrations did not differ between the 2 treatment groups, indicating that short-term testosterone administration appears to be acceptably safe
  • Nathan Goodyear on 04 Mar 15
     
    Study of men with metabolic syndrome and type II Diabetes finds that diet and exercise alone improved glucose control and metabolic syndrome components by 31%.  The addition of Testosterone therapy increased this % to 81%.
Nathan Goodyear

Lipoprotein(a) as a cardiovascular risk factor: current status - 0 views

eurheartj.oxfordjournals.org/...2844.full

cardiovascular risk disease lipoprotein a Lp(a) LDL lipoprotein(a) niacin

shared by Nathan Goodyear on 06 Aug 14 - No Cached
  • Lipoprotein(a) is a plasma lipoprotein consisting of a cholesterol-rich LDL particle with one molecule of apolipoprotein B100 and an additional protein, apolipoprotein(a)
  • Elevated Lp(a) levels can potentially increase the risk of CVD (i) via prothrombotic/anti-fibrinolytic effects as apolipoprotein(a) possesses structural homology with plasminogen and plasmin but has no fibrinolytic activity and (ii) via accelerated atherogenesis as a result of intimal deposition of Lp(a) cholesterol, or both
  • evidence suggests that apolipoprotein(a) adducts extracellularly and covalently to apolipoprotein B100-containing lipoproteins, predominantly LDL
  • ...2 more annotations...
  • Lp(a) is relatively refractory to both lifestyle and drug intervention.
  • Other agents reported to decrease Lp(a) to a minor degree (<10%) include aspirin, l-carnitine, ascorbic acid combined with l-lysine, calcium antagonists, angiotensin-converting enzyme inhibitors, androgens, oestrogen, and its replacements (e.g. tibolone), anti-estrogens (e.g. tamoxifen), and thyroxine replacement in hypothyroid subjects
  • Nathan Goodyear on 06 Aug 14
     
    full article on the previously posted abstract on Lp(a).  
Nathan Goodyear

Role of Oxidative Stress and the Microenvironment in Breast Cancer Development and Prog... - 0 views

www.ncbi.nlm.nih.gov/...PMC3950899

cancer oxidative stress warburg effect reverse warburg effect ROS

shared by Nathan Goodyear on 11 Nov 14 - No Cached
  • oxidative stress leads to HIF-1α accumulation
  • increased levels of hydrogen peroxide in exhaled breath condensate from patients with localized breast malignancy, associated with increased clinical severity
  • Oxidative stress generated by breast cancer cells activates HIF-1α and NFκB in fibroblasts, leading to autophagy and lysosomal degradation of Cav-1
  • ...18 more annotations...
  • Comparing mitochondrial metabolic activity revealed a difference between stroma and epithelial cells
  • metalloproteinases (MMP) such as MMP-2, MMP-3, and MMP-9 increase extracellular matrix turnover and are themselves activated by oxidative stress
  • Overexpression of NOX4 in normal breast epithelial cells results in cellular senescence, resistance to apoptosis, and tumorigenic transformation, as well as increased aggressiveness of breast cancer cells
  • Lowered expression of Cav-1 not only leads to myofibroblast conversion and inflammation but also seems to impact aerobic glycolysis, leading to secretion of high energy metabolites such as pyruvate and lactate that drive mitochondrial oxidative phosphorylation in cancer cells
  • Reverse Warburg Effect
  • secreted transforming growth factor β (TGFβ), insulin-like growth factor (IGF), platelet-derived growth factor (PDGF), fibroblast growth factor 2, and stromal-derived factor 1 (SDF1) are able to activate fibroblasts and increase cancer cell proliferation
  • oxidative stress has an important role in the initiation and preservation of breast cancer progression
  • cancer preventive role of healthy mitochondria
  • the cancer cells produce hydrogen peroxide and by driving the “Reverse Warburg Effect” initiate oxidative stress in fibroblasts. As a result of this process, fibroblasts exhibited reduced mitochondrial activity, increased glucose uptake, ROS, and metabolite production.
  • Oxidative stress results from an imbalance between unstable reactive species lacking one or more unpaired electrons (superoxide anion, hydrogen peroxide, hydroxyl radical, reactive nitrogen species) and antioxidants
  • cancer cells are able to induce drivers of oxidative stress, autophagy and mitophagy: HIF-1α and NFκB in surrounding stroma fibro-blasts
  • Studies show that loss of Cav-1 in adjacent breast cancer stroma fibroblasts can be prevented by treatment with N-acetyl cysteine, quercetin, or metformin
  • However, diets rich in antioxidants have fallen short in sufficiently preventing cancer
  • obstructing oxidative stress in the tumor microenvironment can lead to mitophagy and promote breast cancer shutdown is a promising discovery for the development of future therapeutic interventions.
  • It is widely held that HIF-1α function is dependent upon its location within the tumor microenvironment. It acts as a tumor promoter in CAFs and as a tumor suppressor in cancer cells
  • It was reported that overexpression of recombinant (SOD2) (Trimmer et al., 2011) or injection of SOD, catalase, or their pegylated counterparts can block recurrence and metastasis in mice
  • hydrogen peroxide is one of the main factors that can push fibroblasts and cancer cells into senescence
  • Recent studies show that in the breast cancer microenvironment, oxidative stress causes mitochondrial dysfunction
  • Nathan Goodyear on 11 Nov 14
     
    Really fascinating article on tumor signaling. The article points to a complex signaling between cancer cells and stromal fibroblasts that results in myofibroblast transformation that increases the microenvironment favorability of cancer. This article points to oxidative stress as the primary driving force.  
Nathan Goodyear

Exercise-Associated Muscle Cramps - 0 views

www.ncbi.nlm.nih.gov/...PMC3445088

EAMC exercise associated muscle cramps athletes muscle cramps

shared by Nathan Goodyear on 27 Jan 15 - No Cached
  • athletes who develop EAMC often ingest similar amounts of fluid during exercise as do their noncramping counterparts
  • Oral fluid ingestion may be ineffective, and intravenous fluid may provide a faster delivery for athletes suffering from acute EAMC
  • It is interesting that stretching the affected muscle almost immediately relieves EAMC
  • ...9 more annotations...
  • Stretching, the primary treatment for acute EAMC
  • National Athletic Trainers’ Association recommends that athletes prone to muscle cramping add 0.3 to 0.7 g/L of salt to their drinks to stave off muscle cramps
  • Others have recommended adding higher amounts of sodium (about 3.0 to 6.0 g/L) to sports drinks based on the frequency of EAMC
  • intravenous infusion of fluids removes this delay, and it has been used to aid athletes who develop acute EAMC
  • maintaining hydration and adequate electrolyte levels is a good prevention strategy for individuals susceptible to EAMC
  • Fluid volumes of 1.8 L per hour have been well tolerated by tennis athletes who are susceptible to EAMC
  • Monitoring an athlete’s body weight is an easy method of ensuring adequate fluid replacement and individualizes each athlete’s fluid needs
  • the National Athletic Trainers’ Association and the American College of Sports Medicine recommend a volume of fluid that allows for less than a 2% body weight reduction
  • Endurance training may also serve as an effective means of preventing EAMC by expanding plasma volume and the extracellular fluid compartment15 and delaying neuromuscular fatigue
  • Nathan Goodyear on 27 Jan 15
     
    Exercise associated muscle cramps or EAMC is not worked out.  The theories include dehydration, mineral/electrolyte deficiencies, and neuromuscular activity.
Nathan Goodyear

Influence of Sex Hormones on Melanoma - 0 views

jco.ascopubs.org/...e94.short

cancer melanoma ER alpha ER-alpha ER beta ER-beta ER estrogen receptor hormones hormone

shared by Nathan Goodyear on 21 Oct 14 - No Cached
  • Men show lower skin levels of ERβ than women, in whom ERβ expression decreases with age and more rapidly after menopause as a result of loss of estradiol-positive feedback
  • lower ERβ (mRNA and protein) levels in thicker, more invasive melanomas
  • melanoma ERβ levels correlated with both the tumor microenvironment and the depth of invasion
  • ...3 more annotations...
  • Recent immunohistochemical analyses of ERβ protein level in melanoma tissues15,16 have shown that ERβ protein expression decreases with increasing Breslow thickness—the most important independent prognostic factor in melanoma.
  • As in breast cancer, we maintain that ERα and ERβ status also has to be determined in melanoma with the aim of identifying those displaying a high ERα/ERβ ratio
  • An ideal hormone therapy in melanoma should selectively block the proliferative ERα protein and promote the antiproliferative action of ERβ
  • Nathan Goodyear on 21 Oct 14
     
    Melanoma is a known estrogen sensitive cancer.  This study finds ER Beta loss correlates with thickness of lesion.  The authors propose ERalpha/ERbeta ratio be assessed.  ERbeta has been shown to decrease proliferation, promotes differentiation, and decrease inflammation in breast studies.  In contrast, ERalpha promotes proliferation, decreases differentiation, and promotes inflammation.  Here, the same effects seem to apply to melanoma. Of interesting note, men have lower skin ERbeta than women and ERbeta declines with age and menopause in women.  Essentially, the loss of the ability to differentiate, decrease proliferation and inflammation  occurs with increase estrogen stimulus--set up for estrogen promoting cancers.
Nathan Goodyear

Anemia as an independent prognostic factor for survival in patients with cancer - Caro ... - 0 views

onlinelibrary.wiley.com/...full

anemia cancer

shared by Nathan Goodyear on 30 Mar 15 - No Cached
  • Anemia is common in cancer patients,1, 20 and it has been associated with lower survival
  • median survival was reduced by 20–43%
  • Nathan Goodyear on 30 Mar 15
     
    anemia is a poor prognostic biomarker in cancer.  But is it simply a biomarker of more advanced disease and thus merely the result of poor health?
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