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Nathan Goodyear

Effects of Ginger for Nausea and Vomiting in Early Pregnancy: A Meta-Analysis - 0 views

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    Meta-analysis of 6 studies finds that ginger is useful therapy for nausea in pregnancy.  But, obviously its use is not confined to just pregnancy.  Therapeutic benefit with avoidance of side effects--novel concept.  Compare this to the class C drugs commonly used for nausea in pregnancy.
Nathan Goodyear

The molecular basis of neurodegeneration in multiple sclerosis - 0 views

  • Inflammation is the most predominant feature during the early (relaping) phases of the disease and declines with aging of the patients and disease duration
  • in the process of oligodendrocyte destruction and demyelination in MS lesions iron is liberated from its intracellular ferritin bound stores into the extracellular space, where it is taken up by microglia and macrophages and again stored together with ferritin. When this happens in MS lesions in an environment, where free radicals are produced by oxidative burst, iron can be liberated from ferritin and transformed into reactive Fe++[114], which reacts with hydrogen peroxide to generate highly reactive hydroxyl radicals [36] and thus amplifies oxidative damage and associated cellular injury
  • anti-inflammatory or immunomodulatory treatments are effective in the relapsing stage, but the benefit is lost when the patients have entered the progressive phase
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  • Inflammation will remain a key target, since the data suggest that microglia activation and oxidative burst is driven by inflammation throughout all stages of the disease.
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    Very nice review of the neurodegenerative process in MS.  
Nathan Goodyear

Hypoxia-inducible Factor 1 Activation by Aerobic Glycolysis Implicates the Warburg Effe... - 0 views

  • HIF-1 activation is highly associated with cancer cell growth and survival, tumor development, tumor angiogenesis, and poor clinical prognosis
  • The adaptation of cancer cells to hypoxia is mediated via hypoxia-inducible Factor 1 (HIF-1),1 a key transcription factor that up-regulates a series of genes involved in glycolytic energy metabolism, angiogenesis, cell survival, and erythropoiesis. Included among these genes are vascular endothelial growth factor (VEGF), erythropoietin (EPO), glucose transporters (GLUT), and several glycolytic enzymes (12, 13).
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    good discussion of HIF-1alpha and cancer
Nathan Goodyear

Male hypogonadism and metabolic syndrome. [Andrologia. 2014] - PubMed - NCBI - 0 views

  • male hypogonadism was an independent risk factor for MS (P < 0.001). We conclude that low testosterone level plays a central role in the development of metabolic syndrome
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    low Testosterone in men was found to be an independent risk factor for metabolic syndrome in men.
Nathan Goodyear

The effects of treatment of subclinical hypothyroi... [Med Arh. 2007] - PubMed result - 0 views

  • These data support an important role of treatment of SH in support metabolic control and insulin sensitivity.
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    Treatment of sub-clinical hypothyroidism required to improve insulin resistance
wheelchairindia9

Karma Vip 515 Wheelchair - 0 views

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    Wheelchair category (standard, transport, power, etc.) could be classified as a reclining wheelchairs, since the product class is built around one key feature: the capability to adjust the backrest and/or footrest into a reclined position. This feature is especially important to users who find it difficult or impossible to sit in a fully upright position, and users who sleep in their chairs frequently. For those that are looking for a more portable chair, however, products from this category may not be a great fit. When compared with a similar, non-reclining chair, a reclining wheelchair tends to weigh more and - unlike other manual models - manual wheelchairs that recline typically aren't foldable. Karma Reclining Wheelchair KM 5000: The karma reclining wheelchair km-5000 Transport Wheelchair is an ultra lightweight folding aluminum reclining wheelchair. With full length padded armrests, an adjustable height head pillow, and more this wheelchair has added comfort for any user. This chair also features swing-away elevating footrests and adjustable length leg supports and footplates. With a weight of 33 Lbs this chair can be transported with ease. Karma Reclining Wheelchair KM 5000 Features: Folding 6061 T-6 Aircraft-grade aluminum frame in black powder coat finish Backrest Reclines 90°~163° and includes anti-tippers Full length padded detachable armrests with side panels Swing-away detachable elevating footrests Adjustable length leg supports & footplates Adjustable-height head pillow 14" Mag wheels with flat free polyurethane tires 7" x 1" Flat free front polyurethane casters Adjustable toggle wheel locks High-grade flame retardant, breathable nylon upholstery Limited lifetime warranty on frames and cross-braces, one year on parts One of only two lightweight recliners available in the USA Also Available in Large Manual Rear Wheel option, (KM- 5000F), please call for more info Frame Color: Silver Karma Reclining Wheelchair KM 5000 Me
Nathan Goodyear

Salivary testosterone: a reliable approach to the ... [Clin Endocrinol (Oxf). 2007] - P... - 0 views

  • Our data showed that Sal-T is a reliable marker of testosterone bioavailability. The results support the inclusion of this biomarker as a noninvasive approach in the diagnosis of male androgen deficiency.
  • A cut-off value of Sal-T < or = 0.195 nm showed 100% sensibility and specificity to rule out hypogonadism.
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    Salivary testosterone: a reliable approach to the diagnosis of male hypogonadism.
Nathan Goodyear

Dietary Strategy to Repair Plasma Membrane After Brain Trauma - 0 views

  • concussive brain injury is a major cause of neuropsychological disability in spite of no obvious neuronal death
  • TBI elicits oxidative damage to plasma membrane phospholipids
  • DHA is the most abundant polyunsaturated fatty acid (PUFA) in the brain, where the DHA-containing phospholipids contribute to plasma membrane biogenesis and receptor signaling
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  • curcumin has potent anti-inflammatory and antioxidant activities that can function to reduce oxidative damage and cognitive deficits associated with neurological disorders
  • Curcumin provided in the diet before TBI can reduce oxidative damage and counteract TBI-related cognitive dysfunction
  • Our previous study indicated that n-3 fatty acids supplemented in the diet counteracted learning disability after TBI
  • curcumin contributes to enhance the effects of DHA on TBI by promoting phosphorylation of the BDNF receptor TrkB in the hippocampus
  • previous evidence indicates that curcumin10 and DHA5 counteract TBI-related learning disability by involving BDNF
  • Our findings indicate that curcumin counteracted the TBI-related reduction in n-3 DPA.
  • curcumin may promote the conversion of n-3 DPA to DHA
  • the combination of both nutrients has been reported to produce anti-inflammatory action
  • the enhanced actions of curcumin and DHA in reducing cholesterol levels could be interpreted as preservation of levels of phospholipids in the plasma membrane
  • curcumin and DHA may contribute to reduce inflammation associated with the action of cholesterol in the pathology of TBI.
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    Curcumin and DHA shown to protect against TBI through a reduction in inflammation and maintenance of brain phospholipid membranes.  BDNF is increases also.
Nathan Goodyear

Branched-chain amino acids in liver diseases - 0 views

  • Serum concentrations of BCAAs are decreased, while the concentrations of the aromatic amino acids (AAAs) phenylalanine and tyrosine are increased, in patients with advanced liver diseases, resulting in a low ratio of BCAAs to AAAs, a ratio called the Fischer ratio
  • BCAAs were reported to stimulate the production of hepatocyte growth factor
  • a simplified Fischer ratio, the BCAA to tyrosine ratio (BTR), has been reported useful for predicting serum albumin concentration one year later
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  • BCAA supplementation was shown to delay the progression of CCl4-induced chronic liver injury in a rat model by reducing hepatic apoptosis
  • BCAAs promoted hepatocyte regeneration in a rat model of hepatectomy
  • BCAA supplementation for advanced cirrhotic patients improves nutritional status and quality of life
  • BCAAs activate mTOR and subsequently increase the production of eukaryotic initiation factor 4E-binding protein-1 and ribosomal protein S6 kinase, which upregulate the synthesis of albumin
  • BCAAs were shown to improve homeostasis model assessment scores for insulin resistance (HOMA-IR) and beta cell function (HOMA-%B) in patients with chronic liver disease, indicating that BCAAs can ameliorate insulin resistance
  • Several clinical trials have suggested that BCAA supplementation improves the prognosis of cirrhotic patients
  • A low Fischer ratio has been associated with hepatic encephalopathy
  • Treatment with BCAAs may therefore have a beneficial effect on patients with hepatic encephalopathy mainly by compensating decreased ratio of BCAAs to AAAs, but not by reducing serum ammonia levels
  • Two randomized studies also showed that BCAAs did not clearly prevent HE in patients with advanced cirrhosis, although BCAAs prevented the progression of hepatic failure
  • a systematic review with meta-analyses on the effect of oral BCAAs for the treatment of HE was published[66]. The review has revealed that supplementation of oral BCAAs in cirrhotic patients inhibits the manifestation of HE, especially in patients with overt HE rather than those with minimal HE, but showed no effect on the survival of those patients[66]. Thus, oral administration of BCAAs is the treatment of choice in cirrhotic patients with HE
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    good review of BCAA and liver disease: both mechanisms and therapy.
Nathan Goodyear

The role of salivary progesterone in studies of in... [Br J Obstet Gynaecol. 1981] - Pu... - 0 views

  • Salivary progesterone profiles derived from daily sampling of 20 infertile patients not only allowed accurate assessment of ovarian dysfunction but also indicated more effectively than conventional techniques the change in hormonal status following ovulation induction therapy with clomiphene citrate or bromocriptine.
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    The role of salivary progesterone in studies of infertile women--1981!
Nathan Goodyear

[Bone and Men's Health. Measurement of salivary te... [Clin Calcium. 2010] - PubMed result - 0 views

  • Testosterone is secreted into saliva. In saliva, testosterone is not bound to proteins. Thus concentration of testosterone in saliva is quite close to the serum free testosterone level. Currently serum free testosterone is measured by a convenient method in Japan, that reflects only 10% of the correct values. However, the correct measurement of serum free testosterone is quite costly. Collection of saliva is not invasive to subjects, and it can be done without paramedicals. Besides it is relatively cheaper. Acquisition of samples in multiple occasions is possible. These advantages of utilizing saliva will introduce the measurements of salivary testosterone in cohort studies or screening of low testosterone levels in the community.
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    Saliva Testing of Testosterone is standard
Nathan Goodyear

Measurement and meaning of salivary cortisol: a fo... [Stress. 2008] - PubMed result - 0 views

  • the review highlights the use of salivary cortisol measurements to provide information about HPA axis dysfunction associated with psycho- and patho-physiological conditions in children. Novel applications for salivary cortisol measurements in future research into HPA axis activity in children are also discussed.
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    Measurement and meaning of salivary cortisol: a focus on health and disease in children.
Nathan Goodyear

'Maternity blues' and hormone levels in saliva. [J Affect Disord. 1984] - PubMed result - 0 views

  • This pilot study has demonstrated the potential value of using a non-invasive technique (obtaining specimens of saliva) in conjunction with determinations of a predictable mood change.
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    salivary progesterone validated in mood evaluations
Nathan Goodyear

Effects of ethyl-eicosapentaenoic acid omega-3 fat... [Menopause. 2009 Mar-Apr] - PubMe... - 0 views

  • Effects of ethyl-eicosapentaenoic acid omega-3 fatty acid supplementation on hot flashes and quality of life among middle-aged women: a double-blind, placebo-controlled, randomized clinical trial.
  • Supplementation with E-EPA omega-3 fatty acid reduced HF frequency and improved the HF score relative to placebo
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    omega-3 aids in hot flash relief
Nathan Goodyear

C-reactive protein, the metabolic syndrome, and pr... [Circulation. 2004] - PubMed result - 0 views

  • Elevated CRP levels are related to insulin resistance and the presence of the MetS, especially in women
  • both CRP and MetS are independent predictors of new CVD events.
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    elevated CRP helps predict metabolic syndrome and cardiovascular disease
Nathan Goodyear

Vitamin D3 Is More Potent Than Vitamin D2 in Human... [J Clin Endocrinol Metab. 2010] -... - 0 views

  • Given its greater potency and lower cost, D3 should be the preferred treatment option when correcting vitamin D deficiency.
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    Vitamin D3 better absorbed than D2: and should be the preferential treatment in vitamin D deficiency
Nathan Goodyear

Oxidative stress and mitochondrial dysfunction in ... [Biochem Mol Biol Int. 1994] - Pu... - 0 views

  • neurodegenerative disorders such as Parkinson's disease mitochondrial dysfunction and oxidative stress may cause or worsen the clinical features.
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    mitochondrial dysfunction contributes, even cause many neurodegenerative disease, such as Parkinson's
Nathan Goodyear

Oxidative damage to mitochondria and aging. [Exp Gerontol. 2001] - PubMed result - 0 views

  • Oxidative damage to mitochondria and aging.
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    mitochondria and aging
Nathan Goodyear

Mitochondrial medicine for aging and neurodegenera... [Neuromolecular Med. 2008] - PubM... - 0 views

  • This article discusses critical issues of mitochondria causing dysfunction in aging and neurodegenerative diseases, and discusses the potential of developing mitochondrial medicine, particularly mitochondrially targeted antioxidants, to treat aging and neurodegenerative diseases.
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    Great review of mitochondrial medicine to treat age-related and neurodegenerative disease
Nathan Goodyear

Coenzyme Q10 in the central nervous system and its... [Mol Aspects Med. 1997] - PubMed ... - 0 views

  • These findings suggest that coenzyme Q10 might be useful in treating neurodegenerative diseases.
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    CoQ10 useful in treating neurodegenerative diseases
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