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spineneuro

A Price You Can Afford: Accessing World-Class Brain Tumor Surgery in India - 0 views

www.briefingwire.com/...s-brain-tumor-surgery-in-india

hospitals for brain tumors India brain tumors brain tumors surgery cost

shared by spineneuro on 09 Apr 24 - No Cached
  • spineneuro on 09 Apr 24
     
    Top hospitals for brain tumors India have earned accreditation from esteemed healthcare monitoring organizations such as NABL, NABH, and JCI, owing to their exceptional infrastructure, cutting-edge clinical facilities, and excellent treatments.
spineneuro

Expert ENT Care in India: Top Specialists You Can Trust - 0 views

www.briefingwire.com/...-top-specialists-you-can-trust

12 best ENT specialists best ENT specialists in India ENT Doctors in India

shared by spineneuro on 24 May 24 - No Cached
  • spineneuro on 24 May 24
     
    The 12 best ENT specialists in India are often associated with top-tier hospitals that cater to international patients. They offer streamlined services, including assistance with travel, accommodation, and language translation, ensuring a hassle-free experience. Despite offering world-class services, the 12 best ENT specialists in India provide treatments at a fraction of the cost compared to many Western countries.
indiacardiacsurg

Innovations in Pacemaker Implantation Procedures in India - 0 views

www.apsense.com/...ation-procedures-in-india.html

Pacemaker Implantation Procedure in India Cost of Pacemaker Implant Surgery India Pacemaker Implantation Cost India Low Cost Pacemaker Implantation Surgery India Top Hospitals for Pacemaker Implantation India

shared by indiacardiacsurg on 01 Apr 25 - No Cached
  • indiacardiacsurg on 01 Apr 25
     
    ✨Top hospitals in India for pacemaker implantation offer world-class cardiac care with advanced technology, expert surgeons & affordable treatment!
Child Therapy

Developing Self Confidence In Children - 1 views

My husband and I were really worried with the indifference that our second child has been showing. We noticed that she did not like to mingle with other kids in the class. Her teacher even told us ...

started by Child Therapy on 29 Nov 12 no follow-up yet
Nathan Goodyear

Treatment of Obesity-Related Complications with Novel Classes of Naturally Occurring PP... - 0 views

www.hindawi.com/...897894

PPAR agonist PPAR agonist

shared by Nathan Goodyear on 17 Jan 13 - No Cached
  • Nathan Goodyear on 17 Jan 13
     
    natural PPAR agonists.  Maybe provide some of the anti-inflammatory improved lipid metabolism without the side effects found in their synthetic counterpart avandia
Nathan Goodyear

Telomerase at the intersection of cancer and aging - 0 views

www.ncbi.nlm.nih.gov/...PMC3896987

telomere telomeres telomerase telomerase activator aging disease cancer

shared by Nathan Goodyear on 18 May 16 - No Cached
  • The anti-aging role of telomerase has been demonstrated to be largely mediated by its canonical role in elongating telomeres, which prevents the accumulation of critically short telomeres and loss of tissue homeostasis
  • Short telomeres, and subsequent DDR activation, could occur both in cancer and aging
  • increased abundance of short telomeres correlates with higher genomic instability and decreased longevity in various organisms, including mice, zebrafish, and yeast
  • ...15 more annotations...
  • mice deficient for telomerase or for telomere binding proteins are characterized by accelerated age-related defects
  • In humans, short telomeres are considered good indicators of an individual’s health status and correlate with both genetic and environmental factors
  • Although recent findings strongly support the idea that short telomeres drive several age-related diseases 38 we cannot exclude the possibility that in some situations short telomeres may be a consequence of the disease itself.
  • the current view is that telomerase deficiency may contribute to the early steps of cancer development by fueling chromosomal instability, while subsequent activation of telomerase may be necessary to allow tumor growth and tumor progression towards more malignant states
  • telomerase activation can be an early event in cancer, it is not necessary for cancer initiation
  • telomerase can stimulate tumor progression by ensuring maintenance of telomeres above a critically short length, thus preventing induction of cellular senescence or apoptosis
  • Almost all human cancers present activation of telomerase as a hallmark, most likely as a mechanism to allow unlimited cell proliferation of tumor cells
  • recent evidence demonstrated that short telomeres alone could lead to genomic instability and cancer
  • Getting rid of telomerase can also be problematic; the lack of telomerase could lead to increased chromosomal instability, which in turn could be at the basis for cancer initiation when tumor suppressor barriers are bypassed
  • telomerase activation is a potential therapeutic strategy for the treatment of age-related diseases
  • telomerase activation in adult or old mice by means of a gene therapy strategy was shown to be sufficient to improve metabolic fitness, neuromuscular capacity, and prevent bone loss, as well as significantly increase both median and maximum longevity, without increased cancer incidence
  • These studies suggest that telomerase expression could be considered a feasible approach to reverse tissue dysfunction and extend healthy lifespan without increasing cancer incidence
  • humans almost completely lose telomerase activity from somatic tissues in the adulthood
  • a change of paradigm seems to be occurring in telomerase biology, with a switch from viewing telomerase as fueling cancer to reversing aging
  • Telomerase expression in a background of high levels of tumor suppressors or in aged organisms seems to prevent its expected pro-cancer activity and yet it still functions as an anti-aging factor
  • Nathan Goodyear on 18 May 16
     
    Telomerase activity and longer telomere length is shown to correlated inversely with many chronic diseases of aging.  In contrast, telomerase activity is found to be involved in carcinogenesis.  Increased carcinogenic potential of telomerase activity has not borne out in studies.  In addition, increased CD8 cell activity as a result of telomerase activation will actually decrease carcinogenic potential via NK activation.
Nathan Goodyear

Vitamin D is associated with testosterone and hypogonadism in Chinese men: Results from... - 0 views

www.ncbi.nlm.nih.gov/...PMC4504177

vitamin d male hormones low T low Testosterone Testosterone

shared by Nathan Goodyear on 09 Jan 17 - No Cached
  • lower 25(OH)D level was significantly associated with lower total T, E2, SHBG, LH and FSH levels after adjusting for age, residence area, economic status and current smoker
  • association between 25(OH)D status and hypogonadism in Chinese men and confirms that this relationship is present in a large population
  • VDR knockout mutant mice showed gonadal insufficiencies
  • ...6 more annotations...
  • High LH and FSH levels in the male mice indicated hypergonadotropic hypogonadism
  • Another mouse study reported a tendency towards low testosterone/LH ratio and Leydig cell hyperplasia in VDR null mice
  • The serum testosterone levels could increase to normal values in vitamin D-deficient rats replete with vitamin D
  • VDR knockout mice had decreased sperm count, reduced sperm motility, and histological abnormality of the testis
  • vitamin D supplementation increases testosterone levels in non-diabetic subjects
  • The data from the European Male Ageing Study [9] indicated that 25(OH)D is positively associated with total T
  • Nathan Goodyear on 09 Jan 17
     
    Study of 713 Chinese men finds a correlation between low vitamin D and low total Testosterone.
Nathan Goodyear

Gender and sex hormones in multiple sclerosis pathology and therapy - 0 views

www.ncbi.nlm.nih.gov/...PMC2689399

hormones MS multiple Sclerosis Estriol progesterone

shared by Nathan Goodyear on 11 Jan 17 - No Cached
  • It is now well recognized that the disease manifestation is reduced in pregnant women with relapsing-remitting MS
  • This occurs particularly during the third trimester when levels of estrogens (estradiol and estriol) and progesterone (see Table 2) are elevated up to about 20 times
  • This seems well correlated with a decrease in active white matter lesions detected by MRI
  • ...12 more annotations...
  • This clinical improvement is however followed by temporary rebound exacerbations at post-partum, when the hormone levels decline
  • a shift from Th1 to Th2 immune response, expansion of suppressive regulatory T lymphocytes and decrease in the number of circulating CD16+ natural killer (NK)-cells
  • Th1 lymphocytes secrete proinflammatory cytokines (e.g. IL-2, IFNgamma, lymphotoxin) while Th2 cells secrete anti-inflammatory cytokines (e.g. IL-4, IL-5, IL-10), which favor humoral-mediated responses
  • Th2 cytokines are associated with down-regulation of Th1 cytokines and this Th2 shift is believed to provide protection from allograft rejection during pregnancy as well as from Th1-mediated autoimmune disease
  • it is worth noting that the levels of other hormones with anti-inflammatory activity (1,25-dihydroxy-vitamin D3, norepinephrine, cortisol) also increase by 2 to 4 times during late pregnancy
  • 1,25-dihydroxy vitamin D3 induces regulatory T-cell function important for development of self-tolerance
  • breast-feeding does not alter the relapse rate in women with MS
  • Leptin is a pleiotropic hormone produced primarily by adipocytes but also by T lymphocytes and neurons
  • Several lines of evidence indicate that leptin contributes to EAE/MS pathogenesis, influencing its onset and clinical severity, by acting as a proinflammatory cytokine which promotes regulatory T cell (Treg) anergy and hyporesponsiveness, resulting in increased Th1 (TNFalpha, INFgamma) and reduced Th2 (IL-4) cytokine production
  • circulating leptin levels are increased in relapsing-remitting MS patients (men and women analyzed together) while the CD4+CD25+Treg population decreases
  • As the leptin plasma concentrations are proportional to the amount of fat tissue, obese/overweight individuals produce higher levels of leptin
  • Nielsen et al found that estradiol and progesterone exert neuroprotection against glutamate neurotoxicity, while MPA antagonizes the neuroprotective effect of estradiol and exacerbated neuron death induced by glutamate excitotoxicity
  • Nathan Goodyear on 11 Jan 17
     
    very good review of the differences in MS and hormones between the sexes.
Nathan Goodyear

Effect of Tongkat Ali on stress hormones and psychological mood state in moderately str... - 0 views

www.ncbi.nlm.nih.gov/...PMC3669033

Tongkat Ali long jack cortisol stress testosterone hormone hormones

shared by Nathan Goodyear on 09 Mar 15 - No Cached
  • At the age of 60, testosterone levels are typically only 40-50% of youthful levels and may be lower
  • Eurycoma contains a group of small peptides referred to as “eurypeptides” that are known to have effects in improving energy status and sex drive in studies of rodents
  • The effects of tongkat ali in restoring normal testosterone levels appears to be less due to actually “stimulating” testosterone synthesis, but rather by increasing the release rate of “free” testosterone from its binding hormone, sex-hormone-binding-globulin (SHBG)
  • ...6 more annotations...
  • The current study found that daily supplementation with tongkat ali root extract (200 mg/day) improves stress hormone profile (lower cortisol; higher testosterone) and certain mood state parameters (lower tension, anger, and confusion)
  • tongkat ali supplementation (100 mg/day) improved lean body mass, 1-RM strength, and arm circumference to a significantly greater degree compared to a placebo group.
  • In a recent 12-week trial [46] of Eurycoma longifolia supplementation (300 mg/day), men (30–55 years of age) showed significant improved compared to placebo in the Physical Functioning domain of the SF-36 quality of life survey
  • sexual libido was increased by 11%
  • In men with low testosterone levels (average age 51 years), one month of daily supplementation with tongkat ali extract (200 mg/day) resulted in a significant improvement in serum testosterone levels and quality-of-life parameters
  • rise in cortisol and drop in testosterone is an early signal of “overtraining”
  • Nathan Goodyear on 09 Mar 15
     
    Tongkat Ali, commonly known as long jack, is found to reduce stress and increase Testosterone.  Stress is one of the common causes of low T in men.  It appears that long Jack functions as an adaptogen.
Nathan Goodyear

Circadian variation in salivary testosterone across age classes in Ache Amerindian male... - 0 views

onlinelibrary.wiley.com/...abstract

testosterone secretion diurnal rhythm saliva salivary testing men

shared by Nathan Goodyear on 30 Apr 12 - No Cached
  • Nathan Goodyear on 30 Apr 12
     
    this article looked at normal testosterone rhythm  via saliva.  Normal testosterone peaks in am and is lowest in pm. The normal testosterone rhythm decreases as a man ages.  This is similar results as seen in serum.
Nathan Goodyear

ERβ Impedes Prostate Cancer EMT by Destabilizing HIF-1α and Inhibiting VEGF-M... - 0 views

www.sciencedirect.com/...S1535610810000826

prostate cancer 3-beta androstanediol male hormone hormones ER HIF-1alpha VEGF estrogen receptor receptors ER beta ER-beta

shared by Nathan Goodyear on 21 Jan 14 - No Cached
  • Loss of ERβ1 expression also resulted in a significant increase in migration and invasion (Figure 2F), functions characteristic of an EMT
  • we hypothesized that ERβ functions as a “gatekeeper” of the epithelial phenotype
  • breast and prostate are different with respect to ER expression and function
  • Nathan Goodyear on 21 Jan 14
     
    The process of androgen deprivation therapy needs to be re-evaluated.  Why?  First, the CVD side effects associated with the androgen depletion.  Second, the depletion of 3 beta androstanediol that has been shown to bind to ER beta and inhibit growth.  As in this study that finds that ER beta activity slows prostate cancer through destabilizing of HIF-1 alpha and by inhibiting VEGF.
Nathan Goodyear

Estrogen Receptors in Colorectal Cancer: Goalkeepers, Strikers, or Bystanders? - 0 views

cancerpreventionresearch.aacrjournals.org/...897.full

estrogen colon cancer ER beta ER-beta breast

shared by Nathan Goodyear on 19 Nov 13 - No Cached
  • one can conclude that ERβ has an overall antiproliferative effect, thereby inhibiting cancer cell proliferation and antagonizing ERα function in the breast
  • HRT with estrogen alone did not increase the risk of breast cancer in the Women's Health Initiative clinical trials program
  • colorectal normal or cancer epithelium does not coexpress ERα and ERβ
  • ...7 more annotations...
  • ERβ expression resulted in the inhibition of proliferation and G1 phase cell-cycle arrest
  • ERβ expression strongly inhibited cMyc and tumor growth in a xenograft mouse model
  • induced ERβ in CRC cells has an antiproliferative, tumor-suppressive function that is independent of ERα
  • ERs also have the ability to bind many other compounds with an estrogen-like structure, including phytoestrogens and xenoestrogens (or endocrine disruptors)
  • Phytoestrogens are a diverse class of natural compounds with structural similarity to estradiol
  • Barone et al. recently found that two ERβ-selective phytoestrogens effectively counteracted CRC tumorigenesis and surprisingly increased ERβ expression in mice with mutations of the tumor-suppressor gene adenomatous polyposis coli
  • We can conclude that estrogens are important in protecting against CRC initiation and progression, and that the protective effect most likely is mediated by ERβ
  • Nathan Goodyear on 19 Nov 13
     
    ER beta is a new potential mode of therapy in colon cancer.  ER beta stimulation has been shown to inhibit colon cancer cell growth.
Mirage Marketing

Surrogacy in india information-SCI Healthcare - 1 views

surrogacycentreindia.com

in india SCI Healthcare Isis Hospital surrogacy centre Dr Shivani Sachdev Gour

shared by Mirage Marketing on 22 Oct 13 - No Cached
  • Mirage Marketing on 22 Oct 13
     
    SCI Healthcare and Isis Hospital SCI Healthcare and Isis Hospital and Multispecialty Centre are dedicated to assisting infertile couples from around the world become parents. Our sole aim is to provide our clients with world-class medical facilities and expertise at competitive prices, delivered with compassion and care. We exist solely to help infertile couples experience the joy of holding their newborn baby in their arms. http://surrogacycentreindia.com
Nathan Goodyear

Desiccated Thyroid Extract Compared With Levothyroxine in the Treatment of Hypothyroidi... - 0 views

press.endocrine.org/...jc.2012-4107

hypothyroid hypothyroidism thyroid T4 T3 hormones metabolism

shared by Nathan Goodyear on 24 Sep 14 - No Cached
  • Our study has shown DTE therapy caused modest weight loss, and nearly half (48.6%) of the study patients expressed preference for DTE over l-T4
  • our study showed significantly higher TSH in the DTE-treated group, which suggests that the improvement observed in the DTE-treated group is not mediated through the changes in TSH levels
  • Nathan Goodyear on 24 Sep 14
     
    Study finds desiccated thyroid (armour thyroid) was associated with great weight loss, mood improvement than T4 alone.  Desiccated thyroid was preferred by patients in the study.  Conversion rate was 100 mcg T4 to 88 mg desiccated thyroid.
wheelchairindia9

Reclining Commode Wheelchair - 0 views

www.wheelchairindia.com/...Reclining-Wheelchair-609-GC

High Back Reclining Wheelchair For Handicapped foot rests and backrest handbrake-like controls incremental angles safely comfort and health benefits padded arm rests

shared by wheelchairindia9 on 05 May 15 - No Cached
  • wheelchairindia9 on 05 May 15
     
    wheelchair category (standard, transport, power, etc.) could be classified as a reclining wheelchairs, since the product class is built around one key feature: the capability to adjust the backrest and/or footrest into a reclined position. This feature is especially important to users who find it difficult or impossible to sit in a fully upright position, and users who sleep in their chairs frequently. For those that are looking for a more portable chair, however, products from this category may not be a great fit. When compared with a similar, non-reclining chair, a reclining wheelchair tends to weigh more and - unlike other manual models - manual wheelchairs that recline typically aren't foldable. Some people use special wheelchairs to distribute pressure and thus reduce the risk of skin sores. These chairs also increase comfort and sitting tolerance. One type of chair, called "tilt in space," changes a person's orientation while maintaining fixed hip, knee, and ankle angles. The whole seat, in effect, tilts. The other chair option is called a recline system, which basically changes the seat-to-back angle, flattening out the back of the chair and in some cases raising the legs to form a flat surface. Different Types Of Reclining Wheelchairs: Reclining Wheelchair 902 GC Reclining Wheelchair 609 GC Karma Aurora 4 Reclining Wheelchair Karma Reclining Wheelchair KM 5000 Karma VIP 515 Wheelchair Reclining Wheelchair 902 GC: Reclining Wheelchair 902 GC is one of the basic models of a Reclining Wheelchair which helps transfer to bed to wheelchair easily and comes with head and neck support and Calf support for added comfort. Reclining Wheelchair 902 GC Features: The chair boast of movable armrest and elevating footrest. A well padded thigh support helps the user thigh's during reclining. The front and the rear wheels are designed and placed in such a way so as to support the users weight during reclining. The Pneumatic rear wheels help the movement
Nathan Goodyear

PLOS ONE: The Gut Microbiota and Developmental Programming of the Testis in Mice - 0 views

journals.plos.org/...article

hormone hormones Testosterone gut flora gut microbiome gut microbiota

shared by Nathan Goodyear on 30 Apr 15 - No Cached
  • The intra-testicular level of testosterone in GF mice was found to be significantly lower than in SPF and CBUT mice
  • This study establishes a novel role for the commensal gut microbiota in the regulation of testicular development and function
  • Absence of the normal microbiota influences the formation and the integrity of the BTB as well as the intra-testicular levels of testosterone and serum levels of LH and FSH.
  • ...8 more annotations...
  • Nutritional, socioeconomic, lifestyle and environmental factors (among others) are involved in the regulation of normal spermatogenesis.
  • he gut microbiota is one such potential source of environmental factors/products that has developed an intimate symbiotic relationship with host's physiology.
  • Manipulation of the gut microbiotia through dietary modification, pre- and probiotics can therefore be beneficial for the host's reproductive health.
  • In the current study, colonizing GF mice with CBUT resulted in an increased sperm production, suggesting that bacterial products, e.g. of fermentation, directly or indirectly, can affect the testis.
  • the absence of gut microbiota influenced testosterone levels
  • A recent study demonstrated that dietary supplementation of the probiotics Lactobacillus reuteri increased and restored testosterone levels in aging mice
  • bacterial metabolites such as butyrate have been shown to increase the levels of LH [43] and FSH
  • This suggests that butyrate most likely regulates testosterone production at the testicular level by stimulation of gene expression in Leydig cells and with little or no effect at the pituitary- hypothalamic levels.
  • Nathan Goodyear on 30 Apr 15
     
    gut micro biome effects spermatogenesis, Testosterone production, and the brain-testicle-barrier.
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