Skip to main content

Home/ Dr. Goodyear/ Group items tagged brain tumors

Rss Feed Group items tagged

Filter: All | Bookmarks | Topics Simple Middle
Nathan Goodyear

Metabolic management of brain cancer - 0 views

www.sciencedirect.com/...S0005272810006857

brain cancer

shared by Nathan Goodyear on 17 Jun 13 - No Cached
  • Glutamine is a major metabolic fuel for both brain tumor cells and tumor-associated macrophages (TAMs)
  • the malignant phenotype of brain tumor cells that survive radiotherapy is often greater than that of the cells from the original tumor.
  • Conventional chemotherapy has faired little better than radiation therapy for the long-term management of malignant brain cancer
  • ...37 more annotations...
  • most conventional radiation and brain cancer chemotherapies can enhance glioma energy metabolism and invasive properties, which would contribute to tumor recurrence and reduced patient survival [34].
  • We contend that all cancer regardless of tissue or cellular origin is a disease of abnormal energy metabolism
  • complex disease phenotypes can be managed through self-organizing networks that display system wide dynamics involving oxidative and non-oxidative (substrate level) phosphorylation
  • As long as brain tumors are provided a physiological environment conducive for their energy needs they will survive; when this environment is restricted or abruptly changed they will either grow slower, growth arrest, or perish [8] and [19]
  • New information also suggests that ketones are toxic to some human tumor cells and that ketones and ketogenic diets might restrict availability of glutamine to tumor cells [68], [69] and [70].
  • The success in dealing with environmental stress and disease is therefore dependent on the integrated action of all cells in the organism
  • Tumor cells survive in hypoxic environments not because they have inherited genes making them more fit or adaptable than normal cells, but because they have damaged mitochondria and have thus acquired the ability to derive energy largely through substrate level phosphorylation
  • Cancer cells survive and multiply only in physiological environments that provide fuels (mostly glucose and glutamine) subserving their requirement for substrate level phosphorylation
  • Integrity of the inner mitochondrial membrane is necessary for ketone body metabolism since β-hydroxybutyrate dehydrogenase, which catalyzes the first step in the metabolism of β-OHB to acetoacetate, interacts with cardiolipin and other phospholipids in the inner membrane
  • the mitochondria of many gliomas and most tumors for that matter are dysfunctional
  • Cardiolipin is essential for efficient oxidative energy production and mitochondrial function
  • Any genetic or environmental alteration in the content or composition of cardiolipin will compromise energy production through oxidative phosphorylation
  • The Crabtree effect involves the inhibition of respiration by high levels of glucose
  • the Warburg effect involves elevated glycolysis from impaired oxidative phosphorylation
  • the Crabtree effect can be reversible, the Warburg effect is largely irreversible because its origin is with permanently damaged mitochondria
  • The continued production of lactic acid in the presence of oxygen is the metabolic hallmark of most cancers and is referred to as aerobic glycolysis or the Warburg effect
  • We recently described how the retrograde signaling system could induce changes in oncogenes and tumor suppressor genes to facilitate tumor cell survival following mitochondrial damage [48].
  • In addition to glycolysis, glutamine can also increase ATP production under hypoxic conditions through substrate level phosphorylation in the TCA cycle after its metabolism to α-ketoglutarate
  • mitochondrial lipid abnormalities, which alter electron transport activities, can account in large part for the Warburg effect
  • targeting both glucose and glutamine metabolism could be effective for managing most cancers including brain cancer
  • The bulk of experimental evidence indicates that mitochondria are dysfunctional in tumors and incapable of generating sufficient ATP through oxidative phosphorylation
  • Cardiolipin defects in tumor cells are also associated with reduced activities of several enzymes of the mitochondrial electron transport chain making it unlikely that tumor cells with cardiolipin abnormalities can generate adequate energy through oxidative phosphorylation
  • The Crabtree effect involves the inhibition of respiration by high levels of glucose
  • Warburg effect involves elevated glycolysis from impaired oxidative phosphorylation
  • TCA cycle substrate level phosphorylation could therefore become another source of ATP production in tumor cells with impairments in oxidative phosphorylation
  • Caloric restriction, which lowers glucose and elevates ketone bodies [63] and [64], improves mitochondrial respiratory function and glutathione redox state in normal cells
  • DR naturally inhibits glycolysis and tumor growth by lowering circulating glucose levels, while at the same time, enhancing the health and vitality of normal cells and tissues through ketone body metabolism
  • DR is anti-angiogenic
  • DR also reduces angiogenesis in prostate and breast cancer
  • We suggest that apoptosis resistance arises largely from enhanced substrate level phosphorylation of tumor cells and to the genes associated with elevated glycolysis and glutaminolysis, e.g., c-Myc, Hif-1a, etc, which inhibit apoptosis
  • Modern medicine has not looked favorably on diet therapies for managing complex diseases especially when well-established procedures for acceptable clinical practice are available, regardless of how ineffective these procedures might be in managing the disease
  • More than 60 years of clinical research indicates that such approaches are largely ineffective in extending survival or improving quality of life
  • The process is rooted in the well-established scientific principle that tumor cells are largely dependent on substrate level phosphorylation for their survival and growth
  • Glucose and glutamine drive substrate level phosphorylation
  • targeting the glycolytically active tumor cells that produce pro-cachexia molecules, restricted diet therapies can potentially reduce tumor cachexia
  • It is important to recognize, however, that “more is not better” with respect to the ketogenic diet
  • Blood glucose ranges between 3.0 and 3.5 mM (55–65 mg/dl) and β-OHB ranges between 4 and 7 mM should be effective for tumor management
  • Nathan Goodyear on 17 Jun 13
     
    Dr Seyfriend presents his metabolic approach to the treatment of brain cancer.
Nathan Goodyear

Cancer cells metabolically "fertilize" the tumor microenvironment with hydrogen peroxid... - 0 views

www.ncbi.nlm.nih.gov/...PMC3180189

cancer reverse warburg effect warburg effect NF-kapppB HIF-1alpha Cav-1 H2O2

shared by Nathan Goodyear on 12 Nov 14 - No Cached
  • reducing oxidative stress with powerful antioxidants, is an important strategy for cancer prevention, as it would suppress one of the key early initiating steps where DNA damage and tumor-stroma metabolic-coupling begins. This would prevent cancer cells from acting as metabolic “parasites
  • Oxidative stress in cancer-associated fibroblasts triggers autophagy and mitophagy, resulting in compartmentalized cellular catabolism, loss of mitochondrial function, and the onset of aerobic glycolysis, in the tumor stroma. As such, cancer-associated fibroblasts produce high-energy nutrients (such as lactate and ketones) that fuel mitochondrial biogenesis and oxidative metabolism in cancer cells. We have termed this new energy-transfer mechanism the “reverse Warburg effect.
  • Then, oxidative stress, in cancer-associated fibroblasts, triggers the activation of two main transcription factors, NFκB and HIF-1α, leading to the onset of inflammation, autophagy, mitophagy and aerobic glycolysis in the tumor microenvironment
  • ...38 more annotations...
  • oxidative stress and ROS, produced in cancer-associated fibroblasts, has a “bystander effect” on adjacent cancer cells, leading to DNA damage, genomic instability and aneuploidy, which appears to be driving tumor-stroma co-evolution
  • tumor cells produce and secrete hydrogen peroxide, thereby “fertilizing” the tumor microenvironment and driving the “reverse Warburg effect.”
  • This type of stromal metabolism then produces high-energy nutrients (lactate, ketones and glutamine), as well as recycled chemical building blocks (nucleotides, amino acids, fatty acids), to literally “feed” cancer cells
  • loss of stromal caveolin (Cav-1) is sufficient to drive mitochondrial dysfunction with increased glucose uptake in fibroblasts, mimicking the glycolytic phenotype of cancer-associated fibroblasts.
  • oxidative stress initiated in tumor cells is transferred to cancer-associated fibroblasts.
  • Then, cancer-associated fibroblasts show quantitative reductions in mitochondrial activity and compensatory increases in glucose uptake, as well as high ROS production
  • These findings may explain the prognostic value of a loss of stromal Cav-1 as a marker of a “lethal” tumor microenvironment
  • aerobic glycolysis takes place in cancer-associated fibroblasts, rather than in tumor cells, as previously suspected.
  • our results may also explain the “field effect” in cancer biology,5 as hydrogen peroxide secreted by cancer cells, and the propagation of ROS production, from cancer cells to fibroblasts, would create an increasing “mutagenic field” of ROS production, due to the resulting DNA damage
  • Interruption of this process, by addition of catalase (an enzyme that detoxifies hydrogen peroxide) to the tissue culture media, blocks ROS activity in cancer cells and leads to apoptotic cell death in cancer cells
  • In this new paradigm, cancer cells induce oxidative stress in neighboring cancer-associated fibroblasts
  • cancer-associated fibroblasts have the largest increases in glucose uptake
  • cancer cells secrete hydrogen peroxide, which induces ROS production in cancer-associated fibroblasts
  • Then, oxidative stress in cancer-associated fibroblast leads to decreases in functional mitochondrial activity, and a corresponding increase in glucose uptake, to fuel aerobic glycolysis
  • cancer cells show significant increases in mitochondrial activity, and decreases in glucose uptake
  • fibroblasts and cancer cells in co-culture become metabolically coupled, resulting in the development of a “symbiotic” or “parasitic” relationship.
  • cancer-associated fibroblasts undergo aerobic glycolysis (producing lactate), while cancer cells use oxidative mitochondrial metabolism.
  • We have previously shown that oxidative stress in cancer-associated fibroblasts drives a loss of stromal Cav-1, due to its destruction via autophagy/lysosomal degradation
  • a loss of stromal Cav-1 is sufficient to induce further oxidative stress, DNA damage and autophagy, essentially mimicking pseudo-hypoxia and driving mitochondrial dysfunction
  • loss of stromal Cav-1 is a powerful biomarker for identifying breast cancer patients with early tumor recurrence, lymph-node metastasis, drug-resistance and poor clinical outcome
  • this type of metabolism (aerobic glycolysis and autophagy in the tumor stroma) is characteristic of a lethal tumor micro-environment, as it fuels anabolic growth in cancer cells, via the production of high-energy nutrients (such as lactate, ketones and glutamine) and other chemical building blocks
  • the upstream tumor-initiating event appears to be the secretion of hydrogen peroxide
  • one such enzymatically-active protein anti-oxidant that may be of therapeutic use is catalase, as it detoxifies hydrogen peroxide to water
  • numerous studies show that “catalase therapy” in pre-clinical animal models is indeed sufficient to almost completely block tumor recurrence and metastasis
  • by eliminating oxidative stress in cancer cells and the tumor microenvironment,55 we may be able to effectively cut off the tumor's fuel supply, by blocking stromal autophagy and aerobic glycolysis
  • breast cancer patients show systemic evidence of increased oxidative stress and a decreased anti-oxidant defense, which increases with aging and tumor progression.68–70 Chemotherapy and radiation therapy then promote further oxidative stress.69 Unfortunately, “sub-lethal” doses of oxidative stress during cancer therapy may contribute to tumor recurrence and metastasis, via the activation of myofibroblasts.
  • a loss of stromal Cav-1 is associated with the increased expression of gene profiles associated with normal aging, oxidative stress, DNA damage, HIF1/hypoxia, NFκB/inflammation, glycolysis and mitochondrial dysfunction
  • cancer-associated fibroblasts show the largest increases in glucose uptake, while cancer cells show corresponding decreases in glucose uptake, under identical co-culture conditions
  • Thus, increased PET glucose avidity may actually be a surrogate marker for a loss of stromal Cav-1 in human tumors, allowing the rapid detection of a lethal tumor microenvironment.
  • it appears that astrocytes are actually the cell type responsible for the glucose avidity.
  • In the brain, astrocytes are glycolytic and undergo aerobic glycolysis. Thus, astrocytes take up and metabolically process glucose to lactate.7
  • Then, lactate is secreted via a mono-carboxylate transporter, namely MCT4. As a consequence, neurons use lactate as their preferred energy substrate
  • both astrocytes and cancer-associated fibroblasts express MCT4 (which extrudes lactate) and MCT4 is upregulated by oxidative stress in stromal fibroblasts.34
  • In accordance with the idea that cancer-associated fibroblasts take up the bulk of glucose, PET glucose avidity is also now routinely used to measure the extent of fibrosis in a number of human diseases, including interstitial pulmonary fibrosis, postsurgical scars, keloids, arthritis and a variety of collagen-vascular diseases.
  • PET glucose avidity and elevated serum inflammatory markers both correlate with poor prognosis in breast cancers.
  • PET signal over-estimates the actual anatomical size of the tumor, consistent with the idea that PET glucose avidity is really measuring fibrosis and inflammation in the tumor microenvironment.
  • human breast and lung cancer patients can be positively identified by examining their exhaled breath for the presence of hydrogen peroxide.
  • tumor cell production of hydrogen peroxide drives NFκB-activation in adjacent normal cells in culture6 and during metastasis,103 directly implicating the use of antioxidants, NFκB-inhibitors and anti-inflammatory agents, in the treatment of aggressive human cancers.
  • Nathan Goodyear on 12 Nov 14
     
    Good description of the communication between cancer cells and fibroblasts.  This theory is termed the "reverse Warburg effect".
spineneuro

Hope in Every Incision: The Promise of Brain Tumor Surgery - 0 views

www.briefingwire.com/...promise-of-brain-tumor-surgery

brain tumor surgery brain tumor surgery survival rate success rate of brain tumor surgery

shared by spineneuro on 04 Jan 24 - No Cached
  • spineneuro on 04 Jan 24
     
    The observed cost of brain tumor surgery is approximately 60% lower than in other developed Western countries. The affordability of brain tumor surgery is significantly lower when compared to developed countries, making India a preferred choice over other Western destinations for brain tumor surgery. The outstanding success rate of brain tumor surgery is attributed to the expertise of top brain tumor surgeons in the country.
spineneuro

Miracles in the Operating Room: Unveiling the Secrets of Successful Brain Tumor Surgery - 0 views

www.briefingwire.com/...successful-brain-tumor-surgery

Brain tumor surgery brain tumor surgery success rate in India Top hospitals for brain tumors

shared by spineneuro on 22 Jun 23 - No Cached
  • spineneuro on 22 Jun 23
     
    Brain tumor surgery is the most effective and it targets the specific place and the cells, consequently, giving it the highest success rate of brain tumor surgery in India. That is true for people undergoing brain tumor surgery in India, even as in most cases, the patients in the preliminary levels of their cancer get effortlessly cured with high brain tumor surgery success rate in India.
Nathan Goodyear

Frontiers | Management of Glioblastoma Multiforme in a Patient Treated With Ketogenic M... - 0 views

www.frontiersin.org/...full

press-pulse therapy hyperbaric ketogenic metabolic therapy cancer ketogenic diet Glioblastoma glioblastoma multiforme HBOT nutrition

shared by Nathan Goodyear on 01 Apr 18 - No Cached
  • The SOC for GBM was modified in this patient to initiate KMT prior to surgical resection, to eliminate steroid medication, and to include HBOT as part of the therapy
  • the greatest therapeutic benefit for patients (near 1.0)
  • The observed reduction in blood glucose in our patient would reduce lactic acid fermentation in the tumor cells, while the elevation of ketone bodies would fuel normal cells thus protecting them from hypoglycemia and oxidative stress
  • ...30 more annotations...
  • Previous studies showed that GBM survival and tumor growth was correlated with blood glucose levels
  • Evidence indicates that glioma cells cannot effectively use ketone bodies for energy due to defects in the number, structure, and function of their mitochondria
  • The accuracy of the GKI as a predictor for therapeutic efficacy, however, is better when ketone bodies are measured from the blood than when measured from the urine
  • A reduction of glucose-driven lactic acid fermentation would not only increase tumor cell apoptosis, but would also reduce inflammation and edema in the tumor microenvironment thus reducing tumor cell angiogenesis and invasion
  • Besides serving as a metabolic fuel for GBM, glutamine is also an essential metabolite for normal immune cells
  • therapies that inhibit glutamine availability and utilization must be strategically employed to avoid inadvertent impairment of immune cell functions
  • we used the non-toxic green tea extract, EGCG, and chloroquine in an attempt to limit glutamine availability to the tumor cells
  • EGCG is thought to target the glutamate dehydrogenase activity that facilitates glutamine metabolism in GBM cells
  • Chloroquine, on the other hand, will inhibit lysosomal digestion thus restricting fermentable amino acids and carbohydrates from phagocytosed materials in the tumor microenvironment
  • HBOT to increase oxidative stress in the tumor cells
  • As glucose and glutamine fermentation protect tumor cells from oxidative stress, reduced availability of these metabolites under ketosis could enhance the therapeutic action of HBOT, as we recently described
  • Prior to subtotal tumor resection and standard of care (SOC), the patient conducted a 72-h water-only fast
  • Following the fast, the patient initiated a vitamin/mineral-supplemented ketogenic diet (KD) for 21 days that delivered 900 kcal/day
  • KD (increased to 1,500 kcal/day at day 22
  • the patient received metformin (1,000 mg/day), methylfolate (1,000 mg/day), chloroquine phosphate (150 mg/day), epigallocatechin gallate (400 mg/day), and hyperbaric oxygen therapy (HBOT) (60 min/session, 5 sessions/week at 2.5 ATA)
  • Biomarkers showed reduced blood glucose and elevated levels of urinary ketones with evidence of reduced metabolic activity (choline/N-acetylaspartate ratio) and normalized levels of insulin, triglycerides, and vitamin D
  • This is the first report of confirmed GBM treated with a modified SOC together with KMT and HBOT, and other targeted metabolic therapies
  • Glioblastoma multiforme (GBM) is the most common and malignant of the primary adult brain cancers
  • less than 20% of younger adults generally survive beyond 24 months
  • glucose and glutamine are the primary fuels that drive the rapid growth of most tumors including GBM
  • Glucose drives tumor growth through aerobic fermentation (Warburg effect), while glutamine drives tumor growth through glutaminolysis
  • The fermentation waste products of these molecules, i.e., lactic acid and succinic acid, respectively, acidify the tumor microenvironment thus contributing further to tumor progression
  • Glucose and glutamine metabolism is also responsible for the high antioxidant capacity of the tumor cells thus making them resistant to chemo- and radiotherapies
  • The reliance on glucose and glutamine for tumor cell malignancy comes largely from the documented defects in the number, structure, and function of mitochondria and mitochondrial-associated membranes
  • These abnormalities cause the neoplastic GBM cells to rely more heavily on substrate level phosphorylation than on oxidative phosphorylation for energy
  • dexamethasone not only increases blood glucose levels but also increases glutamine levels through its induction of glutamine synthetase activity
    • Nathan Goodyear
      Nathan Goodyear on 21 May 18
       
      use mannitol instead
  • Calorie restriction and restricted KD are anti-angiogenic, anti-inflammatory, anti-invasive, and also kill tumor cells through a proapoptotic mechanism
  • Evidence also shows that therapeutic ketosis can act synergistically with several drugs and procedures to enhance cancer management improving both progression free and overall survival
  • hyperbaric oxygen therapy (HBOT) increases oxidative stress on tumor cells especially when used alongside therapies that reduce blood glucose and raise blood ketones
  • The glutamine dehydrogenase inhibitor, epigallocatechin gallate (EGCG) is also proposed to target glutamine metabolism
  • Nathan Goodyear on 01 Apr 18
     
    Case study of Glioblastoma treated with ketogenic metabolic therapy as an adjuct to modified standard therapy.
spineneuro

Success Rate of Brain Tumor Surgery in India 2021 Doubles Life Expectancy for Brain Cancer - 0 views

www.briefingwire.com/...fe-expectancy-for-brain-cancer

top 10 hospitals for brain tumor surgery in India brain tumor surgery in India top 10 brain tumor surgeons in India best of the top 10 brain tumor surgeons in India brain tumor surgery Brain Tumor Surgery Cost India

shared by spineneuro on 12 Oct 21 - No Cached
  • spineneuro on 12 Oct 21
     
    The Blue 400 is one of many advanced technologies available at the top 10 hospitals for brain tumor surgery in India. "Technology of this type is the future of neurosurgical care. We are thrilled to be one of the first in the region to provide our neurosurgeons with the technology," said the best of the top 10 brain tumor surgeons in India. International Helpline Number : +91-9325887033 Email id: enquiry@spineandneurosurgeryhospitalindia.com
spineneuro

Surgical Solutions on a Budget: Brain Tumor Surgery Cost in India Demystified - 0 views

www.briefingwire.com/...gery-cost-in-india-demystified

brain tumor surgery cost brain tumor surgery brain tumor surgeons brain tumor surgery hospital

shared by spineneuro on 19 Nov 23 - No Cached
  • spineneuro on 19 Nov 23
     
    The brain tumor surgery cost is exceptionally affordable, with a price nearly one-third of that in developed countries like the US and the UK. In addition to the brain tumor surgery cost, the success rate of the procedure performed by the best doctors for brain cancer in India is comparable to some of the best brain tumor surgery hospitals globally.
spineneuro

Children With Brain Tumors Will Benefit From Targeted Treatment - 0 views

www.briefingwire.com/...enefit-from-targeted-treatment

top brain tumor surgeons List of top brain tumor surgeons India brain tumor list of top 10 hospitals for brain tumor surgery in India

shared by spineneuro on 23 Apr 22 - No Cached
  • spineneuro on 23 Apr 22
     
    List of top brain tumor surgeons India, accomplished a large-scale examination of 241 infants from around the world identified with glioma brain tumors - working with colleagues at the list of top 10 hospitals for brain tumor surgery India.
spineneuro

Artificial Intelligence Expedites Brain Tumor Diagnosis during Brain Tumor Surgery in W... - 0 views

www.101pressrelease.com/g-brain-tumor-surgery-in-world

brain tumor surgeons in world Top 10 brain tumor surgeons in world best brain tumor surgery in world brain tumor

shared by spineneuro on 31 Jan 22 - No Cached
  • spineneuro on 31 Jan 22
     
    Before the new technology may be elevated to different centers and institutions, "robust testing with more patients and increasing the generation to include rare brain tumors are substantially needed," Top 10 brain tumor surgeons in world said.
spineneuro

Brain Tumor Surgery Statistics in India 2020 of Excellence in Neurosurgery - 101 Press ... - 0 views

www.101pressrelease.com/-of-excellence-in-neurosurgery

Brain Tumor Brain Tumor Surgery in India Brain Tumor Surgery Cost India Brain Tumor Surgery Statistics in India 2020 India's Best Brain Tumor Surgeons Top Hospitals for Brain Tumor India

shared by spineneuro on 25 Oct 21 - No Cached
  • spineneuro on 25 Oct 21
     
    This year, an estimated 24,530 adults (13,840 men and 10,690 women) will be recognized with primary cancerous tumors of the brain and spinal cord. A person's chance of growing this sort of tumor of their lifetime is much less than 1%. For more Info International Helpline Number : +91-9325887033 Email id: enquiry@spineandneurosurgeryhospitalindia.com
spineneuro

Health Articles - Brain Tumor Surgery Cost in India Is As Good As Anywhere Else in the... - 0 views

www.amazines.com/...6262353

Brain Tumor Surgery in India Brain Tumor Surgery Cost India Cost of Brain Tumor Surgery India Top Brain Tumor Surgeons India Best Brain Tumor Surgeons of India List of Top Brain Tumor Surgeons India

shared by spineneuro on 23 Aug 21 - No Cached
  • spineneuro on 23 Aug 21
     
    Brain tumor surgery cost India, it is extraordinarily affordable and when compared to the developed countries comes out to be extraordinarily low cost, which is nearly one third the price in evaluation to US & UK.Top brain tumor surgeon India have gained reputation all across the world, all thanks to the high end specialists giving the best of the healthcare service at affordable cost.Spine and neuro surgery service India is right here that will help you with the high-quality low cost medical neurology procedure. Please Call +91-98604-32255 Email id:- enquiry@spineandneurosurgeryhospitalindia.co
spineneuro

The Cost-Effective Solution: Affordable Brain Tumor Surgery in India - 0 views

www.linkedin.com/...ain-tumor-india-hospital-india

Brain tumor surgery cost Brain tumor surgery affordable brain tumor surgery cost

shared by spineneuro on 24 Apr 23 - No Cached
  • spineneuro on 24 Apr 23
     
    Brain tumor surgery cost, its miles distinctly affordable and when in comparison to the evolved countries comes out to be tremendously low price, which is almost one 1/3 the rate in evaluation to US & UK. Besides the cost, the success rate of the process by a list of top brain tumor surgeons in India is at par globally with some of the brain tumor surgery best hospitals in India.
spineneuro

Get New-Age Technology and Expertise At Top Hospitals for Brain Tumor India - Spine and... - 0 views

spineandneurosurgeryhospitalindia.wordpress.com/...ospitals-for-brain-tumor-india

brain tumor surgery top brain tumor hospitals in India Top Brain Tumor Surgeon In India

shared by spineneuro on 08 Jun 22 - No Cached
  • spineneuro on 08 Jun 22
     
    It is been observed that brain tumor surgery in India is around 60% lesser than in other western advanced countries. That is why overseas patients choose India for their brain tumor surgery because of professional surgeons, top brain tumor hospitals in India, and affordable cost.
spineneuro

Top 10 Brain Specialist Doctor in World Perform First-in-India Robot-Assisted Neuro Sur... - 0 views

www.briefingwire.com/...a-robot-assisted-neuro-surgery

Top 10 brain specialist doctors in World brain tumor surgeries Brain Tumor Surgery in India Brain Tumor Surgery

shared by spineneuro on 14 Dec 21 - No Cached
  • spineneuro on 14 Dec 21
     
    Top 10 brain specialist doctors in India conducted the world's first robot-assisted neurosurgery. They are one of the few surgeons within the world to discover a unique interest in complex brain tumor surgeries and have successfully operated on a large number of brain tumor patients. Brain Tumor Surgery in India International Helpline Number : +91-9325887033 Email id: enquiry@spineandneurosurgeryhospitalindia.com
spineneuro

Get the Most Reliable Care With Brain Tumor Surgery In India - 0 views

www.briefingwire.com/...h-brain-tumor-surgery-in-india

brain tumor brain tumor surgery Brain tumor surgery cost Brain tumor surgeon

shared by spineneuro on 07 Nov 22 - No Cached
  • spineneuro on 07 Nov 22
     
    A brain tumor is known as an unusual mass of cells in the brain that have no reason. In general, tumors arise while cells divide and grow excessively within the body.
spineneuro

Never Give Up Hope With Top 5 Brain Tumor Surgeons in World - Spine and Neuro Hospital ... - 0 views

spineandneurosurgeryhospitalindia.wordpress.com/...-brain-tumor-surgeons-in-world

brain tumor brain surgery brain tumor removal surgery cost brain tumor surgeons tumor

shared by spineneuro on 15 Feb 22 - No Cached
  • spineneuro on 15 Feb 22
     
    It is been observed that affordable brain tumor removal surgery cost in India is around 60% lesser than other western advanced countries. Brain tumor removal surgery cost in India is extraordinarily affordable and when compared to the developed countries comes out to be extraordinarily low cost, which is nearly one-third of cost in evaluation to US & UK. Call us at +91-98604-32255 or Mail us at: enquiry@spineandneurosurgeryhospitalindia.com
spineneuro

Get Superior Brain Tumor Surgery in India on Behance - 0 views

www.behance.net/...r-Brain-Tumor-Surgery-in-India

Brain Tumor Surgery brain tumor surgery success rate in India common symptoms For Brain Tumor Surgery brain tumor surgery cost in rupees

shared by spineneuro on 16 Mar 22 - No Cached
  • spineneuro on 16 Mar 22
     
    That is true for people undergoing brain tumor surgery in India, even as in most cases, the patients in the preliminary levels in their cancer get effortlessly cured with high brain tumor surgery success rate in India. Although success rates offered are more than 98%, patients are usually satisfied with the surgical result. Send Your Medical Report by Email at: enquiry@spineandneurosurgeryhospitalindia.com or you can Talk with our Expert in Call just dial +91-9325887033
spineneuro

Affordable Cost of Brain Tumor Surgery India Will Increase Your Life Span - 0 views

www.briefingwire.com/...a-will-increase-your-life-span

brain tumor surgery low cost of brain tumor surgery India's best brain tumor surgeons

shared by spineneuro on 28 Aug 22 - No Cached
  • spineneuro on 28 Aug 22
     
    India is well known globally for the low cost of brain tumor surgery India. India sees limitless patients coming from all parts of the world to get treated for brain tumors in the excellent way possible.
spineneuro

Brain Tumor Surgery Success Rate In India Offering With Hope - 0 views

www.briefingwire.com/...te-in-india-offering-with-hope

Brain Tumor Surgery Brain tumor surgery success rate in India brain tumor surgery cost in rupees

shared by spineneuro on 18 Sep 22 - No Cached
  • spineneuro on 18 Sep 22
     
    Brain tumor surgery success rate in India is the most effective and it targets the specific place and the cells, consequently, giving it the highest brain tumor surgery success rate in India.
spineneuro

Get the Best Price for Brain Tumor Surgery India With New-Age Technology and ... - 0 views

spineandneurosurgeryhospitalindia.wordpress.com/...hnology-and-expertise%ef%bf%bc

brain tumor brain tumor surgery Best price for brain tumor surgery in India Brain tumor surgery cost

shared by spineneuro on 03 May 22 - No Cached
  • spineneuro on 03 May 22
     
    As an example, a brain tumor surgical procedure approximately charges only USD 6,000-12000 in India in comparison to the international cost of USD 60,000 (nearly 70-80% much less).
1 - 20 of 99 Next › Last »
Showing 20▼ items per page