Salivary progesterone profiles derived from daily sampling of 20 infertile patients not only allowed accurate assessment of ovarian dysfunction but also indicated more effectively than conventional techniques the change in hormonal status following ovulation induction therapy with clomiphene citrate or bromocriptine.
Clomiphene citrate effects on testosterone/estroge... [J Sex Med. 2005] - PubMed - NCBI - 0 views
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small cohort with low serum Total Testosterone improved T:E2 ratio with clomid. Clomid restores the HPA through inhibition of the negative feedback of Estradiol on the Hypothalamus and Pituitary in men. This allows for an increase in gonadotropin production and thus increase in testosterone production. Aromatase inhibition therapy would likely still prove beneficial in this situation.
An integrative analysis reveals coordinated reprogramming of the epigenome and the tran... - 0 views
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contribution to the training response of the epigenome as a mediator between genes and environment
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Differential DNA methylation was predominantly observed in enhancers, gene bodies and intergenic regions and less in CpG islands or promoters
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highly consistent and associated modifications in methylation and expression, concordant with observed health-enhancing phenotypic adaptations, are induced by a physiological stimulus
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Exercise alters gene expression via methylation--the power of epigenetics. Interestingly, the majority of the methylation was outside the CPG island regions. This 3 month study found methylation of 5,000 sites across the genome resulting in altered expression of apps 4,000 genes. The altered muscle changes of the endurance training was linked to DNA methylation changes.
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