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Nathan Goodyear

Elevated C-reactive protein and homocysteine value... [Atherosclerosis. 2003] - PubMed ... - 0 views

www.ncbi.nlm.nih.gov/...12535752

hypothyroidism hypothyroid CRP

shared by Nathan Goodyear on 01 Feb 11 - No Cached
  • This is the first paper to show that CRP values increase with progressive thyroid failure and may count as an additional risk factor for the development of coronary heart disease in hypothyroid patient
  • Nathan Goodyear on 01 Feb 11
     
    inflammation, CRP, associated with hypothyroidism
Nathan Goodyear

The development of mitochondrial medicine - 0 views

www.pnas.org/...8731.short

mitochondrial mitochondria disease Parkinson Alzheimer Huntington ALS

shared by Nathan Goodyear on 03 Mar 11 - No Cached
  • n addition to being a primary cause of disease, mitochondrial DNA mutations and impaired oxidation have now been found to occur as secondary phenomena in aging as well as in age-related degenerative diseases such as Parkinson, Alzheimer, and Huntington diseases, amyotrophic lateral sclerosis and cardiomyopathies, atherosclerosis, and diabetes mellitus.
  • Nathan Goodyear on 03 Mar 11
     
    good discussion on primary and secondary mitochondrial diseases.  Aging and age-related disease are the result of secondary mitochondrial dysfunction
Nathan Goodyear

Magnesium metabolism in health and disease. [Dis Mon. 1988] - PubMed result - 0 views

www.ncbi.nlm.nih.gov/...3282851

magnesium disease health

shared by Nathan Goodyear on 21 Mar 11 - No Cached
  • Less than 1% of the total body magnesium is present in blood
  • A large segment of the U.S. population may have an inadequate intake of magnesium and may have a chronic latent magnesium deficiency that has been linked to atherosclerosis, myocardial infarction, hypertension, cancer, kidney stones, premenstrual syndrome, and psychiatric disorders.
  • Nathan Goodyear on 21 Mar 11
     
    Magnesium in health and disease
Nathan Goodyear

Access : Cardiovascular effects of leptin : Nature Reviews Cardiology - 0 views

www.nature.com/...nrcardio.2009.224.html

cardiovascular leptin effects

shared by Nathan Goodyear on 24 May 11 - No Cached
  • obesity and hyperleptinemia have often been associated with hypertension, and regulation of sympathetic tone or direct effects of leptin on contributors such as atherosclerosis, endothelial dysfunction, and thrombosis have been documented
  • Nathan Goodyear on 24 May 11
     
    Leptin and cardiovascular disease
Nathan Goodyear

Aging, telomeres, and atherosclerosis - 0 views

cardiovascres.oxfordjournals.org/...213.full

ageing Telomere length disease cardiovascular

shared by Nathan Goodyear on 19 Jul 11 - No Cached
  • Nathan Goodyear on 19 Jul 11
     
    Clear association of shortened telomere length and cardiovascular disease is seen; but direct cause and effect relationship needs further evaluation
Nathan Goodyear

ScienceDirect - Atherosclerosis : Lipoprotein(a) associated with coronary artery diseas... - 0 views

www.sciencedirect.com/...S0021915000004275

Lp(a) Lipoprotein A CAD cardiovascular disease

shared by Nathan Goodyear on 03 Aug 11 - No Cached
  • elevated Lp(a) was associated with a significantly increased risk of CAD in men and women
  • Nathan Goodyear on 03 Aug 11
     
    elevated Lp(a) associated with a significant increased risk of CAD in both men and women
Nathan Goodyear

The implication of obesity and central fat on markers of chronic inflammation: The ATTI... - 0 views

www.atherosclerosis-journal.com/...abstract

obesity inflammation CRP fibrinogen IL-6

shared by Nathan Goodyear on 14 Aug 11 - No Cached
  • Nathan Goodyear on 14 Aug 11
     
    obesity increases inflammation
Nathan Goodyear

Is the use of cholesterol in mortality risk algorithms in clinical guidelines valid? Te... - 0 views

onlinelibrary.wiley.com/...abstract

cholesterol heart disease risk CVD atherosclerosis hyperlipidemia mortality

shared by Nathan Goodyear on 26 Oct 11 - No Cached
  • Nathan Goodyear on 26 Oct 11
     
    new study of 52,087 shows cholesterol up to 270 actually lowers heart disease mortality
Nathan Goodyear

Sex hormones and high density lipoproteins i... [Atherosclerosis. 1979] - PubMed - NCBI - 0 views

www.ncbi.nlm.nih.gov/...229880

Testosterone hormone hormones male men HDL cholesterol lipids

shared by Nathan Goodyear on 08 Jan 14 - No Cached
  • Nathan Goodyear on 08 Jan 14
     
    Higher serum testosterone levels associated with higher HDL
Nathan Goodyear

Sex hormone-binding globulin is a major dete... [Atherosclerosis. 2005] - PubMed - NCBI - 0 views

www.ncbi.nlm.nih.gov/...15777555

SHBG HDL triglycerides lipids cardiovascular disease cholesterol

shared by Nathan Goodyear on 08 Jan 14 - No Cached
  • Nathan Goodyear on 08 Jan 14
     
    SHBG positively associated with HDL and negatively associated with triglycerides.
Nathan Goodyear

Testosterone deficiency and cardiovascular mortality Morgentaler A, - Asian J Androl - 0 views

www.ajandrology.com/preprintarticle.asp

testosterone low t low Testosterone CVD cardiovascular mortality therapy

shared by Nathan Goodyear on 01 Dec 14 - No Cached
  • overall mortality and CV mortality were inversely associated with serum T concentrations.
  • men with low serum T, defined as < 8.7 nmol l−1 (250 ng dl−1 ), demonstrated significantly greater all-cause mortality than men with higher serum T (hazard ratio [HR]: 2.24; 95% CI: 1.41-3.57), as well as greater CV mortality
  • lower T levels were significantly associated with the presence of any CV disease
  • ...19 more annotations...
  • more than 30 years of studies suggesting that low levels of T represent an increased risk for CV and overall mortality,
  • lower serum T concentrations also are associated with CV disease, including incident coronary artery disease [17],[18],[19] and atherosclerosis,
  • the actual rate of adverse events was only half as great in the T group (123 events in 1223 men at risk = 10.1%) as in the untreated group (1587 events in 7486 men = 21.2%)
  • The study by Vigen et al. [7] has already undergone two published corrections,
  • 29 medical societies have called for retraction of the article, asserting "gross data mismanagement and contamination," that rendered the study "no longer credible
  • Mortality in T-treated men was reduced by approximately half in treated men compared with untreated men, at 10.3% versus 20.7%, respectively
  • The mortality rate for men who received TTh was 3.4 deaths per 100 person-years, and 5.7 deaths per 100 person-years in untreated men
  • HR of 0.61 (95%CI: 0.42-0.88; P = 0.008), indicating a significant reduction in mortality with TTh
  • men in the highest prognostic MI risk quartile, treatment with TTh was associated with reduced risk
  • tripling in T prescriptions in the US over the last decade
  • a majority of observational studies have found that low endogenous serum T levels are associated with increased mortality.
  • Men who received TTh were able to exercise significantly longer without ischemia compared with men who received placebo
  • In men with congestive heart failure, those who received T demonstrated greater walking distance and other functional endpoints compared with those who received placebo
  • TTh has been shown uniformly and repeatedly to improve several known CV risk factors, including reduced fat mass, body fat percent, and waist circumference, and increased lean mass
  • improved glycemic control
  • reductions in insulin resistance.
  • the evidence strongly points to improved CV status with normal serum T or treatment with TTh in men with TD
  • analysis of health insurance claims data that reported a 36% increased rate of nonfatal MI in the 90d following receipt of a T prescription compared with the 12 prior months.
  • Comparison with men who received a prescription for a phosphodiesterase type 5 inhibitor (PDE5i) revealed no increased rate of MI following the prescription
  • Nathan Goodyear on 01 Dec 14
     
    Great review by Morgentaler of Testosterone and CVD.  He highlights the significant flaws in the JAMA and the NEJM articles of Testosterone therapy risks.  Morgentaler highlights the significant evidence that points to low T and increased risk of CVD. On contention I have, is Morgantaler seems to flip aside the massive uptick of Testosterone use in the US as compared to other countries.  The evidence definitely points to Testosterone therapy as being safe in those with low T, but there is definitely a problem of significant Testosterone doping that is taking place as well.
Nathan Goodyear

http://atvb.ahajournals.org/content/25/5/1038.full.pdf - 0 views

atvb.ahajournals.org/...1038.full.pdf

metabolic syndrome insulin resistance uric acid carotid plaque atherosclerosis

shared by Nathan Goodyear on 24 Aug 14 - No Cached
  • Nathan Goodyear on 24 Aug 14
     
    Increasing uric acid concentrations is found to be associated with insulin resistance and metabolic syndrome in both men and women.  Equally, it is associated with carotid plaque formation.
Nathan Goodyear

CORONARY ARTERY CALCIUM SCORE VERSUS A MULTIPLE BIOMARKER APPROACH FOR CORONARY HEART D... - 0 views

www.sciencedirect.com/...S0735109713608128

coronary artery calcium CAD CVD cardiovascular disease heart health risk homocysteine BNP

shared by Nathan Goodyear on 26 Aug 14 - No Cached
  • Nathan Goodyear on 26 Aug 14
     
    Coronary artery calcium is positively associated with CAD risk.  It compares to multiple biomarker assessment, BNP, and homocysteine assessment.
Nathan Goodyear

The Association between Premature Coronary Art... [Arch Iran Med. 2014] - PubMed - NCBI - 0 views

www.ncbi.nlm.nih.gov/...25065277

low T Testosterone low T low Testosterone free Testosterone Total Testosterone CAD coronary artery disease atherosclerosis heart disease men male hormone hormones health

shared by Nathan Goodyear on 30 Jul 14 - No Cached
  • Nathan Goodyear on 30 Jul 14
     
    Low free and Total Testosterone levels found to be associated with premature CAD in men.  Some confounders were present, which they tried to account for--this should leave some healthy questioning of this study results.  That being said, this is not the first time low T has been found to be associated with CAD in men.  This study found a statistical significant association with Free and Total Testosterone levels in young men.  Another point to consider is the Low T a cause or a biomarker and an effect of poor/declining health?  I would so more to the biomarker point.
Nathan Goodyear

International Journal of Impotence Research - Obesity, low testosterone levels and erec... - 0 views

www.nature.com/...ijir200842a.html

low T low Testosterone men male hormone hormones ED erectile dysfunction Testosterone diabetes metabolic syndrome obesity

shared by Nathan Goodyear on 27 Jan 15 - No Cached
  • Studies have shown that ED may be an early biomarker of general endothelial dysfunction, atherosclerosis and CVD
  • testosterone treatment of hypogonadal young and older men improves sexual function, increases lean mass and decreases fat mass
  • In men with low serum testosterone (for example, <8 or 230 nmol l−1) with obesity, metabolic syndrome and diabetes mellitus, treatment with testosterone is warranted
  • ...12 more annotations...
  • In obese middle-aged men, testosterone treatment reduced visceral adipocity, insulin resistance, serum cholesterol and glucose levels
  • testosterone replacement has a favorable impact on body mass, insulin secretion and sensitivity, lipid profile and blood pressure in hypogonadal men with the metabolic syndrome as well as type 2 diabetes mellitus
  • Testosterone significantly inhibits lipoprotein lipase activity, which reduces triglycerides uptake into adipocytes in the abdominal adipose tissue
  • testosterone treatment decreased endogenous inflammatory cytokines (tumor necrosis factor-α and IL-1β) and lipids (total cholesterol) and increased IL-10 in hypogonadal men
  • Testosterone treatment reduced leptin and adiponectin levels in hypogonadal type 2 diabetic men after 3 months of testosterone replacement
  • available data clearly show a relationship between obesity, low testosterone levels and ED
  • Obesity adversely affects endothelial function and lowers serum testosterone levels through the development of insulin resistance and metabolic syndrome
  • Metabolic disturbances as well as production of cytokines and adipokines by inflamed fat cells may be causal factors in the development of ED
  • The onset of ED and the associated risk of CVD may be delayed through lifestyle modifications that affect obesity, such as diet and exercise
  • Very low testosterone levels contribute to the development of ED in obesity, metabolic syndrome and type 2 diabetes mellitus
  • Obesity is associated with low total testosterone levels that can be explained at least partially by lower sex hormone-binding globulin (SHBG) in obese men
  • epidemiological studies have shown a negative correlation between BMI and total testosterone and to a lesser extent with free and bioavailable (biologically active) testosterone levels
  • Nathan Goodyear on 27 Jan 15
     
    Obesity is associated with low Testosterone and ED in men.
Nathan Goodyear

ENDOGENOUS SEX HORMONES, BLOOD PRESSURE CHANGE, AND RISK OF HYPERTENSION IN POSTMENOPAU... - 0 views

www.ncbi.nlm.nih.gov/...PMC3428144

hormone hormones Testosterone Estradiol Estrogen women CVD cardiovascular disease female SHBG hypertension post-menopause blood pressure

shared by Nathan Goodyear on 02 Feb 15 - No Cached
  • Among postmenopausal women, serum T was elevated in hypertensive participants [9, 11, 12], and total T, free T, and DHEA were positively correlated with SBP
  • T and DHEA were attenuated by adjustment for BMI, reflecting either a confounding or a mediating effect of obesity
  • SHBG concentration was inversely associated with risk of hypertension and longitudinal rise of BP over time
  • ...8 more annotations...
  • SHBG has been postulated as a marker for insulin resistance
  • In vitro studies showed that insulin inhibits SHBG production from hepatoma cells
  • In intervention studies, successful weight loss and weight maintenance increased SHBG in men with obesity
  • E2 may also induce insulin resistance and thereafter tend to raise BP.
  • strong association between E2 and measures of insulin resistance in postmenopausal women, independent of adiposity
  • In postmenopausal women that received hormone replacement therapy, estrogen therapy increased mononuclear cell secretion of tumor necrosis factor alpha (TNF-α)
  • estrone levels were positively associated with inflammatory markers in postmenopausal women
  • higher baseline concentrations of endogenous E2, total and bioavailable T, and DHEA and lower concentration of SHBG were associated with a higher incidence of hypertension and a greater increase in BP during follow-up
  • Nathan Goodyear on 02 Feb 15
     
    Data from MESA study finds that increasing endogenous Estradiol, Total and free Testosterone, DHEA, and lower SHBG were associated with hypertension in postmenopausal women.
Nathan Goodyear

Spectrum of metabolic dysfunction in relationship with hyperandrogenemia in obese adole... - 0 views

eje-online.org/...1093.long

PCOS polycystic ovarian syndrome CRP inflammation insulin insulin resistance women female hormone hormones androgens Testosterone hyperandrogenism

shared by Nathan Goodyear on 10 Mar 15 - No Cached
  • subjects with hyperandrogenemic phenotypes displayed the greatest degree of hyperinsulinemia, β-cell function, and chronic inflammation
  • The rise in serum androgens is accompanied by excess insulin secretion, suggesting that insulin directly stimulates ovarian androgen production
  • The degree of hyperinsulinemia does not seem to be directly correlated with the development of HS
  • ...7 more annotations...
  • higher androgen and insulin levels stimulate hair growth
  • genetic and epigenetic changes may be involved in the pathogenesis of PCOS
  • HA has been identified as an important risk factor for MS and dyslipidemias in premenopausal women and adolescents
  • In our study, HA was found to be an independent risk factor for MS as previously reported by Coviello et al.
  • obesity and HA, and not insulin resistance, are the major determinants of chronic inflammation and risk of atherosclerosis in adolescents with PCOS
  • use of an inflammation marker may help identify high-risk females with PCOS
  • hyperandrogenemic PCOS phenotypes have greatest degree of hyperinsulinemia, insulin resistance, and inflammation
  • Nathan Goodyear on 10 Mar 15
     
    Elevated androgens are associated increasing insulin, insulin resistance, and inflammation (as measured by CRP).
Nathan Goodyear

Low Testosterone Concentration and Atherosclerotic Disease Markers in Male Patients Wit... - 0 views

press.endocrine.org/...jc.2014-2585

low T low Testosterone low T Testosterone carotid intima-media thickness IMT intima-medial thickness atherosclerosis hsCRP free Testosterone endothelial dysfunction men male hormones hormone cardiovascular disease CVD

shared by Nathan Goodyear on 21 Oct 14 - No Cached
  • Nathan Goodyear on 21 Oct 14
     
    Study of men < 70 finds that low Total Testosterone and Free Testosterone is associated with increased Carotid Intima-media thickness (CIMT), increased endothelial dysfunction.  Atherosclerotic plaque and hsCRP were also found to correlate but were adjusted out when age, DM, HgbA1c, lipids, and BMI were excluded.
Nathan Goodyear

JAMA Network | JAMA Internal Medicine | Lipoprotein-Associated Phospholipase A2, High-S... - 0 views

archinte.jamanetwork.com/article.aspx

LP-PLA2 lipoprotein-associated phospholipase A2 stroke CVD hsCRP

shared by Nathan Goodyear on 15 Apr 15 - No Cached
  • Nathan Goodyear on 15 Apr 15
     
    increased LP-PLA2 and hsCRP are associated with increased risk of ischemic stroke.
Nathan Goodyear

Interpretation of the Coronary Artery Calcium Score in Combination with Conventional Ca... - 0 views

www.ncbi.nlm.nih.gov/...PMC3840900

calcium score coronary calcium score CVD heart health heart cardiovascular disease

shared by Nathan Goodyear on 05 Oct 17 - No Cached
  • Nathan Goodyear on 05 Oct 17
     
    A more recent article on the interpretation of the coronary calcium score.  Score alone must be taken in context with the individual.
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