another review of the science on curcumin in treatment of disease. Pay careful attention to the pharmacokinetics portion of this article. Notice this is an "alternative Medicine" article, yet it is all science. The use of the word alternative is simply fear mongering.
Isn't it amazing how "alternative" medical therapies are proven time and time again with science?
This study finds modes improvement in blood pressure with probiotics greater than 100 million CFU for more than 8 weeks. The therapy provided a modest decrease in B/P, but a decrease none the less.
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study finds benefit in fasting. Here fasting is defined as < 25% energy requirements. They authors of this study found an increase adiponectin, a decrease in CRP, a decrease in leptin, a reduction in weight, and a reduction in fat free mass. The study alternated with a almost binge type day, but this is unhealthy.
it is clear that serum IGF-1 and or IGFBP-3 can be normal in patients with undisputed GHD
Various investigators have reported normal IGF-1 values in 37–70% of GH deficient adults
The co-administration of arginine and GHRH (the combined test) is a powerful stimulus for GH production and has gained increasing acceptance as a useful method of diagnosing GHD [34]. This test has been advocated as a suitable alternative to ITT
The glucagon stimulation test (GST) is a reliable, safe alternative to the ITT in the diagnosis of GHD
An intravenous infusion of arginine (0.5 g/kg body weight) together with an intravenous bolus of GHRH (1 mcg/kg body weight) is administered [30]. Serum samples for GH are then obtained every 15–30 minutes for two hours.
Obesity, particularly marked obesity, is associated with blunted GH secretion in response to provocative stimuli
It has also been suggested that that even mildly increased BMI (25–30 kg/m2) can result in diminished stimulated GH production in 13% of healthy subjects
Corneli et al. have defined BMI-specific cut-off points for diagnosing adult-onset GHD using GHRH + arginine—11.5 ng/mL for those with BMI < 25 kg/m2, 8.0 ng/mL for BMI 25–30 kg/m2, 4.2 ng/mL for those with BMI > 30 kg/m2
GH levels are higher during the luteal phase in comparison with the follicular phase of the cycle
Oral, in contrast to transdermal oestrogen, lowers IGF-1 levels and is associated with increased GH levels
Adequate pituitary replacement with thyroxine and hydrocortisone are needed for optimal GH production
one cannot rely on a low IGF-1 to diagnose GHD in women taking oral oestrogen preparations.
Numerous GH secretagogues are available with the insulin tolerance test being the gold standard and the glucagon stimulation test or the GHRH + arginine as acceptable alternatives
ain et al. found the GST to be at least as good as the ITT in provoking GH secretion
the GST is safe, with almost no contraindications, it causes nausea and sometimes vomiting in 15–20% of subjects
This article describes how important glutamine is as an alternative energy source in Glioblastoma. Cancer is a substrate-level dependent energy production disease. If one disrupts glycolysis as a source of energy, then many cancers will use glutamine through glutaminolysis. The cancer cells will do this through glutamate dehydrogenase and glutamate production. This will increase alpha-ketoglutarate which will then feed the substrate-level phosphorylation through the TCA cycle. This study mentioned that EGCG is a way to naturally inhibit glutamate dehydrogenase.
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This study shows that DHT is a good alternative androgen to Testosterone. It was shown to have no positive/negative effect on the prostate. The negative of this study was found to be bone loss from supra physiologic DHT. The point there is to keep hormone replacement physiologic, as one should with all BHRT.
Those with Alzheimer's disease have associated dysfunction of glucose metabolism in the brain, particularly in the hippocampus. It has been reported that a ketogenic diet can improve cognitive function in these individuals. In this study, the ketone bodies were initiated through a diet high in medium chain fatty acids. The ketone bodies served as an alternative fuel source for the brain.
Great, great read on how biochemistry effects brain function. Beta-hydroxybutyrate is an alternative fuel source for the brain in times of calorie restriction. This promotes neuroplasticity and neurogenesis without the inflammatory effects of glucose and insulin.
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