Diet-induced obesity and low testosterone increase neuroinflammation and impair neural ... - 0 views
-
both obesity and low testosterone are also risk factors for neural dysfunction, including cognitive impairment [58–61] and development of AD
-
Levels of obesity and testosterone are often inversely correlated
-
diet-induced obesity causes significant metabolic disturbances and impairs central and peripheral nervous systems.
- ...23 more annotations...
-
Study points to obesity and low Testosterone contribution of neuroinflammation. No effect of body weight was seen with TRT. This animal model found similar positive effects of TRT in insulin sensitivity. Obesity and low T increase inflammatory cytokine production: this study found an increase in TNF-alpha and IL-1beta and TRT reduced TNF-alpha and IL-1beta to near base-line. Testosterone is neuroprotective and this study reviewed the small volume of evaded that pointed to benefit from estradiol. Testosterone's effect on glial survival was positive but not significant. Obesity and low T were found to be associated with increased macrophage infiltration in the PNS with increased TNF-alpha and IL-1beta. Testosterone therapy improved peripheral neuropathy via its positive effects on nocicieption.