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Nathan Goodyear

Statins use and coronary artery plaque composition: Results from the International Mult... - 0 views

www.ncbi.nlm.nih.gov/...PMC4277888

statin statins plaque CAD coronary artery disease coronary artery calcium cardiovascular disease

shared by Nathan Goodyear on 17 Oct 17 - No Cached
  • Statin use is associated with an increased prevalence and extent of coronary plaques possessing calcium
  • As compared with individuals not taking statins, those taking statins possessed a significantly higher prevalence of obstructive CAD, as well as higher numbers of vessels with obstructive CAD
  • non-calcified plaques (NCP)
  • ...11 more annotations...
  • non-calcified (NCP), mixed (MP), or calcified (CP) plaque
  • statin use was each associated with a significantly higher prevalence of NCP, MP and CP
  • statin use was associated with increased presence of MP [odds ratio (OR) 1.46, 95% confidence interval (CI) 1.27–1.68, p < 0.001] and CP (OR 1.54, 95% CI 1.36–1.74, p < 0.001], but not NCP
  • statin use was associated with increasing numbers of coronary segments possessing MP and CP but not associated with increasing numbers of coronary segments possessing NCP
  • North America, Europe and Asia
  • A total of 6673 individuals (2413 on statin therapy and 4260 not on statin therapy) comprised the study population
  • we identified a strong association of statin use to coronary artery plaque features
  • statin use was associated with a differentially increased prevalence and extent of MP and CP
  • one potential unifying hypothesis is that rather than regression of coronary plaque, statins may contribute to the conversion of coronary plaque constituents, perhaps by conversion of NCP to plaque possessing calcium
  • Coronary computed tomographic angiography (CCTA)
  • Statin use was associated with a higher frequency of severe coronary artery stenoses as well as numbers of coronary vessels with obstructive CAD
  • Nathan Goodyear on 17 Oct 17
     
    Study finds statin therapy associated with increased coronary plaque with calcium.
Nathan Goodyear

Unintended effects of statins from observational studies in the general population: sys... - 0 views

www.ncbi.nlm.nih.gov/...PMC3998050

statin therapy statins myopathy cholesterol side effects diabetes liver liver enzymes

shared by Nathan Goodyear on 19 Mar 15 - No Cached
  • A markedly increased risk of myopathy was observed
  • One cohort study (Women’s Health Initiative) of higher quality and larger sample size found stronger evidence of an increased risk of self-reported T2DM (OR=1.47; 95% CI 1.32 to 1.64) for the groups of women who reported statin use at baseline and three years later
  • Hippisley-Cox et al. found an increased risk of liver enzyme changes
  • ...5 more annotations...
  • weak evidence of an increased risk of type 2 diabetes mellitus (T2DM) was observed
  • Smeeth et al. found an increased risk of incident liver disease in the first year after the index date
  • The cumulative incidence of T2DM after three years of statin treatment was 6.25%, corresponding to an excess risk of 2.25%
  • We found no increased risk of peripheral neuropathy, depression, common eye diseases, renal disorders or arthritis associated with taking statins. Studies of higher quality did not show previously reported protective effects of statins on fractures, venous thrombo-embolism or pneumonia
  • There was evidence of an increase in myopathy, raised liver enzymes and diabetes.
  • Nathan Goodyear on 19 Mar 15
     
    Statin use associated with increased myopathy, liver dysfunction, and type II Diabetes.  The authors conclude that the absolute risk is very low, yet OR was 1.47 for type II Diabetes (translated 47% increased odds of developing Diabetes as a result of statins) and OR of 2.63 in risk of myopathy (translated 163% increased odds of developing myopathy as a result of statins).  Seems the authors "low risk" statement is just applies to those without symptoms/side effects.  Physicians need to do a better job of understanding risks and customizing therapies.
Nathan Goodyear

Statin use and risk of diabetes mellitus - 0 views

www.ncbi.nlm.nih.gov/...PMC4360430

statin statin therapy diabetes insulin resistance GLUT4 HgbA1c

shared by Nathan Goodyear on 04 Oct 17 - No Cached
  • An increase in new onset diabetes, i.e., 3% in statin arm and 2.4% in placebo arm was reported. This was accompanied by increase in median value of glycated haemoglobin and was one of the earlier studies to report the increase in new onset diabetes in patients on statins
  • Even after adjustment for potential confounders, statin therapy was associated with an increased risk of new-onset diabetes mellitus
  • Authors suggest that statin-induced diabetes mellitus is a medication class effect
  • ...10 more annotations...
  • Another study also reported that as compared to placebo, statin group showed a higher risk of physician reported incident diabetes and it was also observed that risk was higher in women as compared to men
  • Meta-analysis of randomized controlled trials by Sattar et al[25] involving 91140 non-diabetic patients showed that statin therapy was associated with 9% increased risk of incident diabetes
  • A number of studies showed dose dependent association between statin administration and incident diabetes
  • intensive dose of statins was associated with high incidence of new - onset diabetes
  • Treatment with atorvastatin and simvastatin may be associated with an increased risk of new onset diabetes as compared to pravastatin
  • Increased incidence of diabetes was seen with atorvastatin in the Anglo-Scandinavian Cardiac Outcomes Trial
  • Increased insulin resistance secondary to statins was demonstrated in a prospective non randomised study in patients with coronary bypass surgery
  • downregulation of GLUT4
  • Prevention of coronary and stroke events with atorvastatin in hypertensive patients who have average or lower-than-average cholesterol concentrations, in the Anglo-Scandinavian Cardiac Outcomes Trial--Lipid Lowering Arm (ASCOT-LLA): a multicentre randomised controlled trial
  • Prevention of coronary and stroke events with atorvastatin in hypertensive patients who have average or lower-than-average cholesterol concentrations, in the Anglo-Scandinavian Cardiac Outcomes Trial--Lipid Lowering Arm (ASCOT-LLA): a multicentre randomised controlled trial
  • Nathan Goodyear on 04 Oct 17
     
    Great review article of the increased risk of worsening insulin resistance, glycated hemoglobin, and diabetes risk.  Atorvastatin appears to be the worst culprit.  Mechanism partially through a decrease in GLUT4.
Nathan Goodyear

Changes in Ubiquitin Proteasome Pathway Gene Expression in Skeletal Muscle With Exercis... - 0 views

atvb.ahajournals.org/...2560.long

statins statin CoQ10 ubiquinone mitochondria muscle

shared by Nathan Goodyear on 16 Mar 12 - No Cached
  • Nathan Goodyear on 16 Mar 12
     
    statin therapy shown to decrease genetic expression of the ubiquitin proteasome pathway.   Not only do statins damage mitochondria through CoQ10 depletion, but this study shows a new component of the damage statins do: they actually change the human genetic expression.  This should startle you.
Nathan Goodyear

Statin Therapy Worsens Insulin Sensitivity in Women With Polycystic Ovary Syndrome (PCO... - 0 views

jcem.endojournals.org/...jc.2013-2674.abstract

statin insulin sensitivity resistance PCOS diabetes polycystic ovarian syndrome

shared by Nathan Goodyear on 28 Oct 13 - No Cached
  • Nathan Goodyear on 28 Oct 13
     
    statin therapy worsens insulin sensitivity in women with PCOS.  Statin therapy in this study did lower CRP, LDL and triglycerides.  Of note, DHEA decreased. This should be no surprise as statins are HMG-CoA reductase inhibitors which reduces hormone synthesis from cholesterol.
Nathan Goodyear

The effect of ezetimibe-statin combination on steroid hormone produ... - PubMed - NCBI - 0 views

www.ncbi.nlm.nih.gov/...25712655

Testosterone men male hormone hormones statin cholesterol CVD cardiovascular disease

shared by Nathan Goodyear on 02 Mar 15 - No Cached
  • Nathan Goodyear on 02 Mar 15
     
    Statin and combined Ezetimibe-statin therapy reduce Testosterone levels in men--though combination therapy reduced LH and Testosterone levels less than high dose statin therapy, but it still did reduce Testosterone.  This is so counterproductive and reveals much of the thought behind cholesterol.  Low T in men is associated with all CVD.
Nathan Goodyear

JAMA Network | JAMA Internal Medicine | Statins and Musculoskeletal Conditions, Arthrop... - 0 views

archinte.jamanetwork.com/article.aspx

statin therapy statins medicine

shared by Nathan Goodyear on 11 Jun 13 - No Cached
  • Nathan Goodyear on 11 Jun 13
     
    statin use found to be associated with pain and increased injuries versus those not taking statins.
Nathan Goodyear

JAMA Network | Archives of Internal Medicine | Statin Use and Risk of Diabetes Mellitus... - 0 views

archinte.jamanetwork.com/article.aspx

type II DM Diabetes DM statins statin therapy cholesterol

shared by Nathan Goodyear on 21 Jun 12 - No Cached
  • Nathan Goodyear on 21 Jun 12
     
    women using statin therapy to lower cholesterol have increased type II Diabetes.  Variables were accounted for and this existed across all classes of statins.
Nathan Goodyear

Statin Therapy Worsens Insulin Sensitivity in Women With Polycystic Ovary Syndrome (PCO... - 0 views

jcem.endojournals.org/...4798.abstract

statin statins atorvastatin diabetes women insulin sensitivity resistance PCOS polycystic ovarian syndrome polycystic ovary syndrome

shared by Nathan Goodyear on 11 Dec 13 - No Cached
  • Nathan Goodyear on 11 Dec 13
     
    Statin therapy worsens insulin sensitivity and thus glucose regulation in women with PCOS.  Women with PCOS are at increased risk for type II Diabetes.  Statins interfere with glucose metabolism and thus will increase the effective risk for these women.  This study was a randomized, prospective study.
Nathan Goodyear

Long-Term Statin Use and Risk of Ductal and Lobular Breast Cancer among Women 55 to 74 ... - 0 views

cebp.aacrjournals.org/...1529.abstract

statins statin therapy breast cancer invasive lobular ductal carcinoma women

shared by Nathan Goodyear on 25 Mar 14 - No Cached
  • Nathan Goodyear on 25 Mar 14
     
    Why has this study not received major press?  Study finds that 10+ year users of statin therapies have an 83% increased risk of invasive ductal carcinoma of the breast, a 97% increase in invasive lobular carcinoma of the breast.  In women with elevated cholesterol, the data gets worse.  There is a 204% increased risk of invasive ductal carcinoma of the breast and a 243% increased risk of invasive lobular carcinoma of the breast in women with elevated lipids and on statins 10+ years.  No matter how  you try to slice this data, this is not good news for a large sub set of women.
Nathan Goodyear

Risk of incident diabetes among patients treated with statins: population based study |... - 0 views

www.bmj.com/bmj.f2610

statin statin therapy diabetes

shared by Nathan Goodyear on 04 Oct 17 - No Cached
  • Nathan Goodyear on 04 Oct 17
     
    Higher dosed and higher potency statins are associated with greater risk of new onset diabetes.  Atorvastatin was the worst statin in this regard.
Nathan Goodyear

American College of Cardiology Foundation | Journal of the American College of Cardiolo... - 0 views

content.onlinejacc.org/article.aspx

statin therapy statins CoQ10 mitochondria

shared by Nathan Goodyear on 18 Mar 13 - No Cached
  • Nathan Goodyear on 18 Mar 13
     
    Small study, but well designed study shows that statins inhibit CoQ10 mediated oxidative phosphorylation through decrease in CoQ10.  This points directly at a decrease in mitochondrial function as a result of statin therapy.
Nathan Goodyear

Use of statins is associated with lower serum total and non-SHBG-bound testosterone lev... - 0 views

www.ncbi.nlm.nih.gov/...26034077

Statin statin therapy statins Testosterone low T low Testosterone free Testosterone HMG-CoQ reductase inhibitors

shared by Nathan Goodyear on 03 Jun 15 - No Cached
  • Nathan Goodyear on 03 Jun 15
     
    Statin use associated with lower total Testosterone and "non-SHBG bound Testosterone" (i.e. free testosterone) in men.  The higher the dose, the lower the trend in Testosterone.  The study found decreased testosterone could occur as soon as 1 month.
Nathan Goodyear

The Effect of Simvastatin on Plasma Steroid Hormone Levels in Metformin-Treated Women w... - 0 views

www.ncbi.nlm.nih.gov/...26824284

statins statin therapy Testosterone androgens DHEA hormones women CAH

shared by Nathan Goodyear on 02 Feb 16 - No Cached
  • Nathan Goodyear on 02 Feb 16
     
    Statins are known to reduce Testosterone in men; new study finds statins reduce all androgens in women.
Nathan Goodyear

http://www.drperlmutter.com/wp-content/uploads/2015/12/Pandit_et_al-Acta_Neurologica_Sc... - 0 views

www.drperlmutter.com/...a_Neurologica_Scandinavica.pdf

statin statin therapy statins brain side effects brain health brain hemorrhage hemorrhage

shared by Nathan Goodyear on 19 Jan 17 - No Cached
  • Nathan Goodyear on 19 Jan 17
     
    study finds significant increase in risk of intracerebral (brain) hemorrhage with high dose statin therapy.  The "high dose" seems to be a fairly regular dose by the patients that walk through my office doors.  This is a meta-analysis
Nathan Goodyear

Statin-Associated Myopathy with Normal Creatine Kinase Levels - 0 views

www.annals.org/...581.full.pdf+html

statins statin muscle cells mitochondria CoQ10 energy myopathy necrosis

shared by Nathan Goodyear on 28 Apr 12 - No Cached
  • Nathan Goodyear on 28 Apr 12
     
    Statins shown to damage the cells ability to make energy and resultant muscle damage occurs.
Nathan Goodyear

Statin-associated muscle-related adverse eff... [Pharmacotherapy. 2010] - PubMed - NCBI - 0 views

www.ncbi.nlm.nih.gov/...20500044

statin statins muscle damage CoQ10

shared by Nathan Goodyear on 16 Mar 12 - No Cached
  • Nathan Goodyear on 16 Mar 12
     
    study showing statin associated muscle damage and the associated symptoms
Nathan Goodyear

Arch Intern Med -- Abstract: Statin Use and Risk of Diabetes Mellitus in Postmenopausal... - 0 views

archinte.ama-assn.org/...archinternmed.2011.625

statin drugs statins diabetes type II DM postmenopausal women health

shared by Nathan Goodyear on 10 Jan 12 - No Cached
  • Nathan Goodyear on 10 Jan 12
     
    New study reveals that statin drug of any kind increases the risk of type II diabetes by 48% in postmenopausal women
Nathan Goodyear

Arch Intern Med -- Abstract: Statin Use and Risk of Diabetes Mellitus in Postmenopausal... - 0 views

archinte.ama-assn.org/...144

Statin statins type II 2 diabetes DM postmenopausal women

shared by Nathan Goodyear on 28 Feb 12 - No Cached
  • Nathan Goodyear on 28 Feb 12
     
    Statin drugs shown to increase risk of Diabetes in postmenopausal women
Nathan Goodyear

The effect of statins on testosterone in men and wom... [BMC Med. 2013] - PubMed - NCBI - 0 views

www.ncbi.nlm.nih.gov/...23448151

statin therapy statins testosterone hormone hormones

shared by Nathan Goodyear on 27 Sep 13 - No Cached
  • Nathan Goodyear on 27 Sep 13
     
    meta-analysis finds that statins lower Testosterone levels.
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