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Nathan Goodyear

Sex hormone binding globulin, but not testosterone, is associated with the metabolic sy... - 0 views

europepmc.org/...23812344

metabolic syndrome metabolic syndrome MetS PCOS women hormone hormones Testosterone obesity obese insulin resistance SHBG

shared by Nathan Goodyear on 12 Mar 14 - No Cached
  • Nathan Goodyear on 12 Mar 14
     
    This study finds an association between low SHBG and increased metabolic syndrome in obese women with PCOS.  Testosterone was not associated.  Other studies have shown a positive association between Testosterone and MetS in women.  This follows men in that SHBG shows an association with MetS.  Only the abstract is present here, so I can't look at the data presented.
Nathan Goodyear

Low testosterone level predicts prostate cancer in r... [BJU Int. 2012] - PubMed - NCBI - 0 views

www.ncbi.nlm.nih.gov/...22257176

low testosterone prostate cancer SHBG

shared by Nathan Goodyear on 16 Nov 13 - No Cached
  • Nathan Goodyear on 16 Nov 13
     
    study finds high incidence of prostate cancer in those with low Testosterone at the time of biopsy for HGPIN. What is also interesting, is that the authors found a higher SHBG.  It is well known that Estradiol increases SHBG.  It is also well known that Testosterone to Estradiol in the prostate plays a role in prostate cancer.
Nathan Goodyear

Association between endogenous sex steroid hormones and inflammatory biomarkers in US men - 0 views

www.ncbi.nlm.nih.gov/...PMC3812341

low Testosterone Estrogen Estradiol low T Testosterone hormone hormones CRP inflammation SHBG WBC men male

shared by Nathan Goodyear on 28 Apr 15 - No Cached
  • modest statistically significant inverse associations for total and calculated free testosterone, and modest positive associations for total and calculated free estradiol with CRP concentration
  • Estradiol concentrations were also weakly positively associated with WBC count
  • SHBG was weakly inversely associated with WBC
  • ...21 more annotations...
  • An association between testosterone and WBC count was not observed
  • These findings are consistent with the hypothesis that in men higher androgen concentration is anti-inflammatory, and higher estrogen concentration is pro-inflammatory.
  • the probability of elevated CRP concentrations (≥ 3 mg/L) decreased with higher total and calculated free testosterone concentrations, while the probability increased with higher total and calculated free estradiol concentrations
  • there is ample evidence supporting the immunosuppressive effect of androgens
  • The incidence of autoimmune diseases is higher in androgen-deficient men
  • Studies have shown that the induction of hypogonadism in older men is followed by a significant increase in IL-6 concentrations (Khosla et al. 2002), a potent stimulator of inflammation, and that activation of the androgen receptor exerts a direct anti-inflammatory effect
  • It has been suggested that the mechanisms for the immunosuppressive effect of androgens could be either a direct effect on the expression of inflammatory genes (Bellido et al. 1995; Asirvatham et al. 2006), or an indirect effect through inhibition of nuclear factor-kB activation
  • Estradiol is the major biologically active estrogen, and about 80% is formed in adult men from the aromatization of testosterone primarily in the adipose tissue
  • estrogen can stimulate the transcription factor C/EBP-β, which is involved in CRP transcription
  • Most prior cross-sectional studies have observed inverse associations between androgen concentrations and inflammatory biomarkers
  • A recent study in Chinese men showed that lower concentrations of total and calculated free testosterone were associated with higher CRP concentration
  • Data from the Boston Area Community Health Survey also reported inverse associations between testosterone and CRP concentrations
  • Total testosterone was inversely associated with WBC count (Tang et al. 2007; Schneider et al. 2009; Brand et al. 2012), but calculated free testosterone was not associated with WBC
  • The first trial found a decrease in CRP, interleukin-1β (IL-1β), and tumor necrosis factor-α (TNFα) but no changes in IL-6 and IL-10 concentrations between the active treatment and placebo arms
  • the majority of studies in the literature have not observed statistically significant associations between estradiol and inflammatory biomarkers in men, although several of them observed point estimates in the positive direction
  • total testosterone and estradiol compete for binding to SHBG, and seem to have opposite effects on the concentration of inflammatory biomarkers
  • A small randomized controlled trial of estrogen replacement therapy in prostate cancer patients showed an increase in CRP in the active treatment group versus the comparator group
  • Obese men are known to have lower androgen concentrations compared to their normal-weight counterparts
  • The strongest suggestion of an interaction was the inverse association between androstanediol glucuronide and CRP concentrations in obese participants, while the association was positive in the non-obese
  • A recent Chinese cross-sectional study observed stronger inverse associations between total testosterone and CRP concentrations in individuals with a BMI of 27.5 kg/m2 or greater
  • our results suggest that total and calculated free testosterone are modestly inversely associated with CRP concentrations, and that total and calculated free estradiol are modestly positively associated with CRP and WBC
  • Nathan Goodyear on 28 Apr 15
     
    Study results suggest that higher Testosterone and lower Estrogen levels provide anti-inflammatory effects in men.  The inflammatory biomarker assessed here was CRP.  Low total and calculated free Testosterone was associated with an increase in CRP.  In contrast, total and free Estrogen was associated with an increase in CRP.  Estradiol increased WBC count and SHBG was inversely related to WBC count in this study.
Nathan Goodyear

Re: Plasma Sex Steroid Hormone Levels and Risk of Breast Cancer in Postmenopausal Women... - 0 views

jnci.oxfordjournals.org/...380.full

hormones breast cancer SHBG

shared by Nathan Goodyear on 28 Jan 11 - No Cached
  • Nathan Goodyear on 28 Jan 11
     
    non-SHBG bound serum estradiol, testosterone and DHEA reveal increase breast cancer risk; other studies show saliva testing equal to serum non-bound SHBG hormones
Nathan Goodyear

Lower sex hormone-binding globulin is more strongly associated with metabolic syndrome ... - 0 views

eje-online.org/...785.long

metabolic syndrome SHBG low T Testosterone low T low Testosteorne men male hormone hormones health

shared by Nathan Goodyear on 07 Aug 14 - No Cached
  • Nathan Goodyear on 07 Aug 14
     
    low SHBG found to be more associated with metabolic syndrome in older men than low Testosterone.  The study consisted of 2502 men older than 70.  The authors proposed this occurs through the relationship between SHBG and insulin sensitivity.  I think that is a little too simplistic.
Nathan Goodyear

Associations between Circulating Reproductive Hormones and SHBG and Prevalent and Incid... - 1 views

press.endocrine.org/...jc.2014-2464

metabolic syndrome metabolic syndrome men male hormone hormones health Testosterone DHT SHBG cFT free Testosterone

shared by Nathan Goodyear on 06 Oct 14 - No Cached
  • Nathan Goodyear on 06 Oct 14
     
    The best marker associated with MetS in older men was low SHBG. Low T, DHT, and cFT were found to be more biomarkers of poor health rather than causal.
Nathan Goodyear

Aging, androgens, and the metabolic syndrome in a longitudinal stud... - PubMed - NCBI - 0 views

www.ncbi.nlm.nih.gov/...17595254

metabolic syndrome SHBG Testosterone total Testosterone men male hormone hormones

shared by Nathan Goodyear on 03 Mar 15 - No Cached
  • Nathan Goodyear on 03 Mar 15
     
    In men, 20-94, lower Total Testosterone and SHBG was found to be associated with a higher incidence of metabolic syndrome.  Abstract only.  The greatest association was found with SHBG.
Nathan Goodyear

The Evaluation of Serum Levels of Testosterone in Type 2 Diabetic Men and Its Relation ... - 0 views

www.ncbi.nlm.nih.gov/...PMC4347063

low t low Testosterone total testosterone free testosterone glucose cholesterol LDL HgbA1c SHBG Testosterone men male hormone diabetes

shared by Nathan Goodyear on 10 Mar 15 - No Cached
  • Nathan Goodyear on 10 Mar 15
     
    Small study of 2 men with type II diabetes finds fasting glucose levels negatively correlate with total and free Testosterone levels, HgbA1c negatively correlated with SHBG only, total cholesterol and LDL negatively correlated with SHBG and total testosterone.  The prevalence of type II diabetes was higher with low free Testosterone than total Testosterone, but both were statistically significant.
Nathan Goodyear

http://care.diabetesjournals.org/content/33/7/1618.full.pdf - 0 views

care.diabetesjournals.org/...1618.full.pdf

metabolic syndrome low T Testosterone low T low Testosterone SHBG men male hormone hormones

shared by Nathan Goodyear on 06 Aug 14 - No Cached
  • Nathan Goodyear on 06 Aug 14
     
    Men with low T and low SHBG have a significantly elevated risk of metabolic syndrome.  Other studies have actually shown that low SHBG is more associated and that TT is more than free Testosterone.
Nathan Goodyear

Low Sex-Hormone Binding Globulin is Associated with the Metabolic Syndrome in Postmenop... - 0 views

www.ncbi.nlm.nih.gov/...PMC1633722

metabolic syndrome MetS SHBG post-menopause post menopause menopause Testosterone free androgen index women female hormone hormones

shared by Nathan Goodyear on 05 Aug 14 - No Cached
  • Nathan Goodyear on 05 Aug 14
     
    low SHBG in post-menopausal women correlates with increased risk of metabolic syndrome.  More than that, there is an inverse correlation with SHBG in women and metabolic syndrome components.  Also, Increasing components of MetS was correlated with Testosterone and free androgen index.
Nathan Goodyear

Both total testosterone and sex hormone-binding globulin are independent risk factors f... - 0 views

onlinelibrary.wiley.com/...abstract

metabolic syndrome men male hormone hormones Total Testosterone free bioavailable SHBG low T low Testosterone

shared by Nathan Goodyear on 06 Aug 14 - No Cached
  • Nathan Goodyear on 06 Aug 14
     
    Study of 2361 Chinese men found that men with MetS had lower TT, bioavailable Testosterone, free Testosterone and SHBG than those men without MetS.  Additionally, Total Testosterone and SHBG were both inversely associated with the risk of MetS.  This inverse association stood for both after adjusting for the other.
Nathan Goodyear

Inhibition of sex hormone-binding globulin production in the human ... - PubMed - NCBI - 0 views

www.ncbi.nlm.nih.gov/...2842359

SHBG insulin Prolactin Testosterone Estradiol E2 T4 hormone hormones

shared by Nathan Goodyear on 28 Oct 14 - No Cached
  • Nathan Goodyear on 28 Oct 14
     
    Insulin and Prolactin inhibit liver SHBG production.  Testosterone, Estradiol and T4 stimulate SHBG in in vitro study.
Nathan Goodyear

Leptin and Androgens in Male Obesity: Evidence for Leptin Contribution to Reduced Andro... - 0 views

press.endocrine.org/...jcem.84.10.6082

obesity leptin low T low Testosterone Testosterone low T leydig cells LH leutenizing hormone men male hormones hormone

shared by Nathan Goodyear on 04 Sep 14 - No Cached
  • in male obesity basal and LH-stimulated androgen levels are reduced and inversely correlated with circulating leptin
  • functional leptin receptors are present in rodent Leydig cells
  • it is conceivable that in males high leptin concentrations may have a direct inhibitory effect(s) on Leydig cell function.
  • ...18 more annotations...
  • insulin is an important inhibitor of the synthesis of SHBG
  • no correlation between leptin and SHBG levels
  • SHBG reduction in obesity is a minor determinant of lowered androgen levels
  • SHBG can explain only up to 3% of the correlation
  • testicular T de novo production is impaired in obese men and that leptin seems to be the best hormonal predictor of this blunted response to LH stimulation
  • The low basal 17-OH-P levels found in massively obese men are consistent with a global impairment of Leydig cell steroidogenic function in this group of subjects.
  • These findings indicate that obese men have a FM-related defect in the enzymatic conversion of 17-OH-P to T, which is revealed by hCG stimulation.
  • Other studies have investigated the adrenal function in male obesity and have shown that basal cortisol and 17-OH-progesterone levels tend to decrease with the increase in the degree of obesity
  • High E2 can inhibit the expression and activity of the 17,20-lyase and may be responsible for this steroidogenic lesion
  • However, stimulated E2 levels were not higher in the obese than in controls, excluding the fact that the lower androgen response was due to an increased aromatization of T to E2 and that estrogens have a major role in the observed defect of 17,20-lyase activity in obese men.
  • the percentage increase in the 17-OH-progesterone to T molar ratio paralleled the increase in leptin levels of obese men
  • Multiple regression analysis indicated that the best hormonal predictor of the obesity-related reduction in T and FT basal levels and androgen changes after hCG stimulation was serum leptin concentration
  • insulin has no negative influences on androgen production in obese men
  • insulin is known to have stimulatory actions on T production that have been demonstrated in obese and normal weight men (57) and in Leydig cells in culture
  • the negative correlation between insulin and basal T can be partly explained by the inhibitory action of insulin on SHBG production
  • hypogonadal men have higher circulating leptin levels compared with hypogonadal patients under effective androgen substitution therapy
  • The impaired androgen response to LH stimulus was due to a defect in the enzymatic conversion of 17-OH-progesterone to T, which was disclosed by a leptin-related increase in 17-OH-progesterone to T ratio
  • Estrogens, which are inhibitory modulators of LH pulsatility and bioactivity
  • Nathan Goodyear on 04 Sep 14
     
    Leptin appears to be a good marker of low Testosterone.  This study proposes that the mechanism of action is potentially 2 fold: first, a decrease in LH release by leptin (kisspeptin?) and 2nd, a directed decrease in Testosterone production by the leydig cells in the testes.
Nathan Goodyear

Low serum sex hormone-binding globulin: marker of inflammation? - PubMed - NCBI - 0 views

www.ncbi.nlm.nih.gov/...22293276

inflammation hsCRP CRP SHBG

shared by Nathan Goodyear on 06 Apr 15 - No Cached
  • Nathan Goodyear on 06 Apr 15
     
    hs-CRP and SHBG inversely related in men and women.  Translated: inflammation is associated with decreased SHBG.
Nathan Goodyear

Is serum sex hormone-binding globulin a dominant risk factor for metabolic syndrome? - ... - 0 views

www.ncbi.nlm.nih.gov/...25851658

SHBG total Testosterone free Testosterone Testosterone metabolic syndrome men male hormone hormones

shared by Nathan Goodyear on 13 Apr 15 - No Cached
  • Nathan Goodyear on 13 Apr 15
     
    Nice study of Chinese men, only abstract available, finds that serum total Testosterone and SHBG were inversely associated with metabolic syndrome in men.  SHBG association was the strongest and TT the weakest.  Free Testosterone had no association in this study.
Nathan Goodyear

The Association of Obesity with Sex Hormone Binding Globulin is Str... - PubMed - NCBI - 0 views

www.ncbi.nlm.nih.gov/...25777143

obesity SHBG hormone Testosterone low T low Testosterone men male hormones

shared by Nathan Goodyear on 24 Mar 15 - No Cached
  • Nathan Goodyear on 24 Mar 15
     
    Obesity is significantly associated with low SHBG.  This stands in contrast to aging association with higher SHBG.  Obesity out weighed the association compared to age.  Calculated free Testosterone did not vary between obese and non-obese men.
Nathan Goodyear

Genetic Determinants of Serum Testosterone Concentrations in Men - 0 views

www.ncbi.nlm.nih.gov/...PMC3188559

epigenetics low Testosterone SNPs Testosterone

shared by Nathan Goodyear on 19 Sep 17 - No Cached
  • mean serum testosterone concentrations were found to be lower in men with GG than in those with TT genotype for rs12150660
  • men with the CT genotype for rs6258 had lower serum testosterone concentrations than those with CC genotype.
  • The two autosomal SNPs identified by GWAS had a significant influence on the risk of having low serum testosterone (serum testosterone <300 ng/dl) in both the discovery and the replication cohorts with a combined odds ratio (OR) per minor allele of 0.72 (95% CI, 0.65 – 0.79) and 2.7 (95% CI, 2.1 – 3.5) for rs12150660 and rs6258, respectively
  • ...3 more annotations...
  • The risk of having low serum testosterone concentrations increased by the number of risk alleles with an OR of 1.62 (95% CI, 1.41 – 1.86) for each risk allele (Figure S4). Low serum testosterone concentrations were 6.5-times more prevalent in men with ≥3 risk alleles (30.1% prevalence of low serum testosterone) compared to men without any risk allele (4.6% prevalence of low serum testosterone;
  • SNP rs5934505 was associated with serum testosterone without SHBG-adjustment (combined p-value of 1.7×10−9) and with free testosterone (combined p-value of 6.7×10−15), but not with SHBG
  • The mean serum testosterone and calculated free testosterone but not SHBG concentrations were lower in men with T genotype than in those with C genotype for rs5934505
  • Nathan Goodyear on 19 Sep 17
     
    Genetic SNP rs5934505 associated with lower total Testosterone and lower calculated free Testosterone.  No effects on SHBG.
Nathan Goodyear

SHBG, Sex Hormones, and Inflammatory Markers in Older Women - 0 views

jcem.endojournals.org/...1053.long

women post-menopausal SHBG inflammation inflammatory cytokines estradiol E2 testosterone hormone hormones menopause

shared by Nathan Goodyear on 05 Dec 12 - No Cached
  • Nathan Goodyear on 05 Dec 12
     
    post menopausal estradiol in women associated with pro-inflammatory state.  SHBG was associated with a decrease in the inflammatory cytokine biomarkers.  Postmenopausal women were found to have an increased Testosterone to estradiol ratio.
Nathan Goodyear

Testosterone, SHBG and risk of type 2 diab... [Eur J Clin Invest. 2012] - PubMed - NCBI - 0 views

www.ncbi.nlm.nih.gov/...21679181

testosterone SHBG hormone hormones

shared by Nathan Goodyear on 11 Jun 13 - No Cached
  • Nathan Goodyear on 11 Jun 13
     
    SHBG levels run higher in women than men.  This study proposes that this is protective.
Nathan Goodyear

Testosterone, SHBG and cardiovascula... [Int J Impot Res. 2010 Mar-Apr] - PubMed - NCBI - 0 views

www.ncbi.nlm.nih.gov/...20090761

Testosterone postmenopausal women hormone hormones SHBG CVD cardiovascular disease risk

shared by Nathan Goodyear on 25 Feb 14 - No Cached
  • Nathan Goodyear on 25 Feb 14
     
    Higher Testosterone and low SHBG  in postmenopausal women is associated with increased CVD risk
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