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Nathan Goodyear

Metabolic and Endocrine Effects of a Polyunsaturated Fatty Acid-Rich Diet in Polycystic... - 0 views

academic.oup.com/...jc.2003-030666

PCOS polycystic ovarian syndrome PUFA fats polyunsaturated fats diet nutrition hormones

shared by Nathan Goodyear on 08 Feb 17 - No Cached
  • Nathan Goodyear on 08 Feb 17
     
    polyunsaturated fats found to improve PCOS
Nathan Goodyear

The polycystic ovary syndrome per se is not associated with increased chronic inflammation - 0 views

www.eje-online.org/...525.short

PCOS BMI fat overweight obese inflammation women CVD polycystic ovarian syndrome

shared by Nathan Goodyear on 10 May 12 - No Cached
  • Nathan Goodyear on 10 May 12
     
    This study finds no association between PCOS and inflammation, when matched with age/BMI controls.  However, inflammation was associated with increased BMI.  Not all women with PCOS are overweight.  But, the majority are and this would contribute to inflammation and thus CVD.
Nathan Goodyear

Altered Cortisol Metabolism in Polycystic Ovary Syndrome: Insulin Enhances 5α... - 0 views

jcem.endojournals.org/...5907.long

PCOS PCO polycystic ovaries insulin IR resistance steroid 5-alpha reductase androgens

shared by Nathan Goodyear on 13 Mar 12 - No Cached
  • Nathan Goodyear on 13 Mar 12
     
    insulin, in women with PCOS, promotes increased 5-alpha reductase activity.  This results in a dysregulated HPA axis, promoting increased cortisol and androgen levels.
Nathan Goodyear

Increased 5α-Reductase Activity and Adrenocortical Drive in Women with Polycy... - 0 views

jcem.endojournals.org/...3558.long

5-alpha reductase activity women PCOS PCO polycystic ovary ovarian syndrome 11-betaHSD

shared by Nathan Goodyear on 13 Mar 12 - No Cached
  • Nathan Goodyear on 13 Mar 12
     
    increased 5-alpha reductase activity found in women with PCOS. Weight showed no variance.  Additionally, no change in 11-betaHSD activity was found.
Nathan Goodyear

Polycystic Ovary Syndrome with Hyperandrogenism Is Characterized by an Increased Risk o... - 0 views

jcem.endojournals.org/...jc.2012-1382.abstract

PCOS NAFLD obesity insulin resistance polycystic ovarian syndrome ovary syndrome non-alcoholic fatty liver

shared by Nathan Goodyear on 30 Jul 12 - No Cached
  • Nathan Goodyear on 30 Jul 12
     
    PCOS with associated hyperandrogenism, is associated with increased risk of NAFLD versus PCOS without hyperandrogenism.
Nathan Goodyear

The effect of oral micronized progesterone on ... [Fertil Steril. 2010] - PubMed - NCBI - 0 views

www.ncbi.nlm.nih.gov/...19409554

progesterone metabolic syndrome PCOS

shared by Nathan Goodyear on 01 Sep 13 - No Cached
  • Nathan Goodyear on 01 Sep 13
     
    The effect of oral micronized progesterone on hormonal and metabolic parameters in anovulatory patients with polycystic ovary syndrome.
Nathan Goodyear

Black women with polycystic ovary syndrome (PCOS) have increased risk for metabolic syn... - 0 views

www.fertstert.org/...abstract

PCOS polycystic ovarian syndrome metabolic syndrome cardiovascular disease CVD women

shared by Nathan Goodyear on 18 Feb 14 - No Cached
  • Nathan Goodyear on 18 Feb 14
     
    The medical field continues to be amazed that people are different. More, that different people groups are different.  This study found that black women with PCOS have an elevated risk of metabolic syndrome when compared to white women with PCOS.  Body weight was a variable that was controlled for.  This was a retrospective study.
Nathan Goodyear

Analysis of the vascular responses in a murine model of polycystic ovary syndrome - 0 views

joe.endocrinology-journals.org/...205.abstract

PCOS polycystic ovarian syndrome CVD DHT

shared by Nathan Goodyear on 24 Jul 13 - No Cached
  • Nathan Goodyear on 24 Jul 13
     
    Animal model of PCOS provides insight to changes in vascular response.  In this animal mode, DHT resulted in a decrease in vasorelaxation of arterial endothelium.
Nathan Goodyear

A possible new mechanism in the pathophysiology of polycystic ovary syndrome: The disco... - 0 views

jcem.endojournals.org/...jc.2013-3685.abstract

PCOS telomere telomeres polycystic ovary syndrome

shared by Nathan Goodyear on 09 Dec 13 - No Cached
  • Nathan Goodyear on 09 Dec 13
     
    shorter Telomere length associated with PCOS.
Nathan Goodyear

Hyperhomocysteinaemia is as... [Eur J Obstet Gynecol Reprod Biol. 2013] - PubMed - NCBI - 0 views

www.ncbi.nlm.nih.gov/...24169034

homocysteine women hormone Testosterone hormones PCOS polycystic ovarian syndrome polycystic ovary syndrome

shared by Nathan Goodyear on 12 Dec 13 - No Cached
  • Nathan Goodyear on 12 Dec 13
     
    Women with PCOS will have hyperandrogenism. This study finds an association between this increased androgen levels and hyperhomocysteinemia.
Nathan Goodyear

Statin Therapy Worsens Insulin Sensitivity in Women With Polycystic Ovary Syndrome (PCO... - 0 views

jcem.endojournals.org/...jc.2013-2674.abstract

statin insulin sensitivity resistance PCOS diabetes polycystic ovarian syndrome

shared by Nathan Goodyear on 28 Oct 13 - No Cached
  • Nathan Goodyear on 28 Oct 13
     
    statin therapy worsens insulin sensitivity in women with PCOS.  Statin therapy in this study did lower CRP, LDL and triglycerides.  Of note, DHEA decreased. This should be no surprise as statins are HMG-CoA reductase inhibitors which reduces hormone synthesis from cholesterol.
Nathan Goodyear

Serum Aldosterone Concentration and Cardiovascular Risk in Women with Polycystic Ovaria... - 0 views

jcem.endojournals.org/...4395.full

PCOS aldosterone edema fluid retention polycystic ovarian syndrome cardiovascular

shared by Nathan Goodyear on 20 Oct 11 - No Cached
  • Nathan Goodyear on 20 Oct 11
     
    PCOS associated with elevated aldosterone and thus fluid retention
Nathan Goodyear

Androgen activation by 5α-reductase in patients with PCOS - 0 views

www.endocrine-abstracts.org/...ea0021sig3.1.htm

PCOS 5 alpha reductase polycystic ovarian syndrome polycystic ovary syndrome insulin obesity female hormone hormones

shared by Nathan Goodyear on 10 Sep 14 - No Cached
  • Nathan Goodyear on 10 Sep 14
     
    5alpha-reductase PCOS.  Insulin and obesity are associated with increased 5alpha-reductase activity.
Nathan Goodyear

http://www.ccjm.org/content/70/1/31.full.pdf - 0 views

www.ccjm.org/...31.full.pdf

PCOS polycystic ovarian syndrome polycystic ovary syndrome female hormone hormones

shared by Nathan Goodyear on 10 Sep 14 - No Cached
  • Nathan Goodyear on 10 Sep 14
     
    brief review of PCOS; not so much the treatment, but the discussion of the common biochemical findings.
Nathan Goodyear

Licorice reduces serum testosterone in heal... [Steroids. 2004 Oct-Nov] - PubMed - NCBI - 0 views

www.ncbi.nlm.nih.gov/...15579328

PCOS polycystic ovarian syndrome polycystic ovary syndrome licorice licorice root extract Glycyrrhiza Testosterone women female hormones hormone herbal herbs natural therapy

shared by Nathan Goodyear on 10 Sep 14 - No Cached
  • Nathan Goodyear on 10 Sep 14
     
    Licorice root extract, also known as glycyrrhizic acid, found to quickly reduce endogenous Testosterone production in women.  The proposed mechanism is via inhibition of 17-hydroxysteroid dehydrogenase and 17-20 Lyase.  This is a good adjuvant in the treatment of PCOS.
Nathan Goodyear

Focus on metabolic and nutritional corre... [Arch Gynecol Obstet. 2014] - PubMed - NCBI - 0 views

www.ncbi.nlm.nih.gov/...25200687

PCOS polycystic ovarian syndrome polycystic ovary syndrome nutrition diet lifestyle women female hormone hormones

shared by Nathan Goodyear on 12 Sep 14 - No Cached
  • Nathan Goodyear on 12 Sep 14
     
    Dietary lifestyle changes still prove to be the most effective treatment strategy for women with PCOS.
Nathan Goodyear

Androgens and polycystic ovary syndrome. - PubMed - NCBI - 0 views

www.ncbi.nlm.nih.gov/...19390322

PCOS polycystic ovarian syndrome Testosterone androgens women female hormone hormones

shared by Nathan Goodyear on 10 Mar 15 - No Cached
  • Nathan Goodyear on 10 Mar 15
     
    Only abstract available here. Exact complexity of the signaling involved in PCOS is yet to be determined, but increased androgens in women is proving to be a strong link between PCOS and metabolic dysfunction.
Nathan Goodyear

Spectrum of metabolic dysfunction in relationship with hyperandrogenemia in obese adole... - 0 views

eje-online.org/...1093.long

PCOS polycystic ovarian syndrome CRP inflammation insulin insulin resistance women female hormone hormones androgens Testosterone hyperandrogenism

shared by Nathan Goodyear on 10 Mar 15 - No Cached
  • subjects with hyperandrogenemic phenotypes displayed the greatest degree of hyperinsulinemia, β-cell function, and chronic inflammation
  • The rise in serum androgens is accompanied by excess insulin secretion, suggesting that insulin directly stimulates ovarian androgen production
  • The degree of hyperinsulinemia does not seem to be directly correlated with the development of HS
  • ...7 more annotations...
  • higher androgen and insulin levels stimulate hair growth
  • genetic and epigenetic changes may be involved in the pathogenesis of PCOS
  • HA has been identified as an important risk factor for MS and dyslipidemias in premenopausal women and adolescents
  • In our study, HA was found to be an independent risk factor for MS as previously reported by Coviello et al.
  • obesity and HA, and not insulin resistance, are the major determinants of chronic inflammation and risk of atherosclerosis in adolescents with PCOS
  • use of an inflammation marker may help identify high-risk females with PCOS
  • hyperandrogenemic PCOS phenotypes have greatest degree of hyperinsulinemia, insulin resistance, and inflammation
  • Nathan Goodyear on 10 Mar 15
     
    Elevated androgens are associated increasing insulin, insulin resistance, and inflammation (as measured by CRP).
Nathan Goodyear

Serum Leptin Level in Women with Polycystic Ovary Syndrome: Correlation with Adiposity,... - 0 views

www.ncbi.nlm.nih.gov/...PMC3728861

women female hormone hormones PCOS polycystic ovarian syndrome leptin Testosterone

shared by Nathan Goodyear on 27 Oct 14 - No Cached
  • Nathan Goodyear on 27 Oct 14
     
    Increasing leptin levels in women with/without PCOS correlate positively with serum Testosterone levels.
Nathan Goodyear

Epigenetic and Transcriptional Alterations in Human Adipose Tissue of Polycystic Ovary ... - 0 views

www.nature.com/...srep22883

epigenetics PCOS polycystic ovarian syndrome

shared by Nathan Goodyear on 20 Sep 17 - No Cached
  • Nathan Goodyear on 20 Sep 17
     
    Study finds statistically increased methylation of many genes in women with PCOS: it is called epigenetics.
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