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Nathan Goodyear

Ascorbic acid suppresses endotoxemia and NF-κB signaling cascade in alcoholic... - 0 views

pubmed.ncbi.nlm.nih.gov/24239723

metabolic endotoxemia NF-kappaB vitamin C inflammation NFKB

shared by Nathan Goodyear on 09 Oct 21 - No Cached
  • Nathan Goodyear on 09 Oct 21
     
    Vitamin C inhibits metabolic endotoxemia NFKB inflammatory signaling.
Nathan Goodyear

Low doses of LPS and minimally oxidized LDL cooperatively activate macrophages via NF-k... - 0 views

www.ncbi.nlm.nih.gov/...PMC2904601

metabolic endotoxemia atherosclerosis CVD cardiovascular disease inflammation

shared by Nathan Goodyear on 14 Jan 13 - No Cached
  • Nathan Goodyear on 14 Jan 13
     
    metabolic endotoxemia shown to play role in atherosclerosis lesion acceleration.  
Nathan Goodyear

THE NEUROPROTECTIVE PROPERTIES OF CALORIE RESTRICTION, THE KETOGENIC DIET, AND KETONE B... - 0 views

www.ncbi.nlm.nih.gov/...PMC2649682

calorie restriction ketogenic diet NF-KappaB BDNF neuroprotection SIRT1 mitochondria glutamate excitotoxicity inflammation antioxidants

shared by Nathan Goodyear on 25 Jun 12 - No Cached
  • Nathan Goodyear on 25 Jun 12
     
    Fantastic read on the biochemical benefits of calorie restriction and a ketogenic diet.
Nathan Goodyear

Molecular inflammation: Underpinnings of aging and age-related diseases 10.1016/j.arr.2... - 0 views

www.sciencedirect.com/...S1568163708000299

inflammation NF-KappaB aging disease ageing

shared by Nathan Goodyear on 23 Jan 12 - No Cached
  • Nathan Goodyear on 23 Jan 12
     
    chronic inflammation appears to be the major player in aging and age-related chronic diseases
Nathan Goodyear

The Potential Utility of Curcumin in the Treatment of HER-2-Overexpressed Breast Cancer... - 0 views

www.ncbi.nlm.nih.gov/...PMC3162976

curcumin HER-2 breast cancer NF-KappaB

shared by Nathan Goodyear on 19 Jan 12 - No Cached
  • Nathan Goodyear on 19 Jan 12
     
    Curcumin downregulates HER-2 oncoprotein in breast cancer in vitro and in vivo.  IN this study, the combination of taxol and curcumin was comparable to that of taxol and perceptin.
Nathan Goodyear

Curcumin Blocks the Activation of Androgen and Interlukin-6 on Prostate-Specific Antige... - 0 views

onlinelibrary.wiley.com/...full

curcumin tumeric prostate cancer PSA

shared by Nathan Goodyear on 25 Sep 13 - No Cached
  • Nathan Goodyear on 25 Sep 13
     
    curcumin reduces the genetic expression of PSA from androgen dependent and androgen independent prostate cancer.
Nathan Goodyear

Toll-like Receptor Status in Obesity and Metabolic Syndrome: A Translational Perspectiv... - 0 views

press.endocrine.org/...jc.2013-3092

toll like receptors toll-like receptors TLRs TLR-4 TLR4 inflammation metabolic syndrome MetS insulin resistance IR Diabetes obesity

shared by Nathan Goodyear on 06 Jan 14 - No Cached
  • Nathan Goodyear on 06 Jan 14
     
    Only the abstract is available publicly.   Toll-like receptors, particularly TLR-4 has been shown to be associated with insulin resistance.  These TLRs have specific pathogen recognition sites.  TLRs are stimulated by fatty acids (FA) and endotoxemia from bacteria.  Thus, dietary intake of high trans fats, inflammation originating from the gut can be the source of insulin receptor dysfunction through TLRs.
Nathan Goodyear

Anti-Inflammatory Effects of Progesterone in Lipopolysaccharide-Stimulated BV-2 Microglia - 0 views

www.ncbi.nlm.nih.gov/...PMC4117574

progesterone inflammation TNF-alpha NF-kappaB hormone hormones LPS microglia

shared by Nathan Goodyear on 29 Aug 14 - No Cached
  • Nathan Goodyear on 29 Aug 14
     
    Progesterone and its anti-inflammatory effects.
Nathan Goodyear

Omega-3 Fatty Acids and Inflammatory Processes - 0 views

www.ncbi.nlm.nih.gov/...PMC3257651

fats nutrition diet omega 3 inflammation NF-kappaB TNF-alpha omega-3 fish oil DHA EPA docosahexaenoic acid eicosapentaenoic acid

shared by Nathan Goodyear on 15 Sep 17 - No Cached
  • marine n-3 PUFAs have also been shown to alter the production of inflammatory proteins including chemokines, cytokines, growth factors and matrix proteases
  • Two transcription factors that are likely to play a role in inflammation are nuclear factor κ B (NFκB) and PPAR-γ
  • NFκB is the principal transcription factor involved in upregulation of inflammatory cytokine, adhesion molecule and cyclooxygenase-2 genes
  • ...3 more annotations...
  • PPAR-γ, is believed to act in an anti-inflammatory manner
  • PPAR-γ directly regulates inflammatory gene expression, it also interferes with the activation of NFκB creating an intriguing interaction between these two transcription factors
  • Both NFκB and PPAR-γ may be regulated by n-3 PUFAs.
  • Nathan Goodyear on 15 Sep 17
     
    great review of the anti-inflammatory effects of omega 3 DHA and EPA.  EPA inhibits COX and 5-LOX and their downstream prostaglandin and leukotrienes.  EPA/DHA inhibited endotoxin-stimulated IL-6, IL-8,TNF-alpha, and NFkappaB.
Nathan Goodyear

Drug Screening Identifies Niclosamide as an Inhibitor of Breast Cancer Stem-Like Cells - 0 views

journals.plos.org/...article

Niclosamide cancer cancer stem cells breast cancer

shared by Nathan Goodyear on 21 Mar 18 - No Cached
  • cancer stem cells may also contribute to tumor formation, metastasis, and treatment resistance
  • Studies have shown that some agents (such as metformin) can selectively target cancer stem cells and that dietary polyphenols, curcumin, peperine, and sulforaphane, which are derived from broccoli/broccoli sprouts, are able to target breast cancer stem cells via inhibition of the Wnt signaling, which affects mammosphere size and colony formation
  • niclosamide inhibits tumor growth and reduces tumor weight
  • ...8 more annotations...
  • Niclosamide treatment inhibited the expression of cyclin D1, Hes1, and PTCH by 33%, 57%, and 79%, respectively
  • The mechanism via which niclosamide, a protonophoric anthelmintic drug, induces stem-like-cell-specific toxicity in breast cancer is interesting. It is an old drug that has been used to treat tapeworms in animals
  • Niclosamide is known to uncouple mitochondrial oxidative phosphorylation during tapeworm killing
  • A screening of autophagy modulators revealed that niclosamide is a novel inhibitor of mTORC1 signaling
  • A recent work also demonstrated that niclosamide induces the apoptosis of myelogenous leukemic cells via the inactivation of NF-kappaB and reactive oxygen species generation
  • Niclosamide was also reported to inhibit Wnt signaling [31]–[33] in colon cancer cells
  • Our recent work demonstrated that niclosamide disrupts multiple metabolic pathways in ovarian-cancer-initiating cells
  • The present study showed that niclosamide treatment resulted in the downregulation of target genes involved in the self-renewal of cancer stem-like cells and inhibited breast SPS
  • Nathan Goodyear on 21 Mar 18
     
    Old ant-parasitic, niclosamide, found to down-regulate cancer stem cell activity.
Nathan Goodyear

Curcumin inhibits the growth of liver cancer by impairing myeloid-derived suppressor ce... - 0 views

www.ncbi.nlm.nih.gov/...PMC7905673

NF-kappaB MDSC curcumin TLR4 COX2 COX-2 IL-1 angiogenesis cancer LOX IL-6

shared by Nathan Goodyear on 14 May 21 - No Cached
  • Nathan Goodyear on 14 May 21
     
    Curcumin inhibit MDSC
Nathan Goodyear

Targeted Transdermal Delivery of Curcumin for Breast Cancer Prevention - 0 views

www.ncbi.nlm.nih.gov/...PMC6950673

TNF-alpha curcumin transdermal NF-kappaB breast cancer

shared by Nathan Goodyear on 21 Jan 21 - No Cached
  • Nathan Goodyear on 21 Jan 21
     
    Theoretical analysis of the use of transdermal curcumin to target breast cancer.
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