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Nathan Goodyear

Modulators of estrogen receptor inhibit prostate cancer - 0 views

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    Curcumin inhibits prostate cancer growth through signaling with ER-beta receptor. This mimics the 3beta-androstanediol negative feedback loop.
Nathan Goodyear

Amplification and Overexpression of Androgen Receptor Gene in Hormone-Refractory Prosta... - 0 views

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    Androgen resistance drives increase in AR gene activation and expression
Nathan Goodyear

Estrogen-like e - 0 views

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    In vitro study finds that T3 has estrogenic activity. Proposed mechanism is via common ERE binding.
Nathan Goodyear

Medically Induced Euthyroid Hypothyroxinemia May Extend Survival in Compassionate Need ... - 0 views

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    T3 + methimazole inhibits TSH and T4 signaling resulting in increased survival length. This was referred to as an induction of hypothyroxinemia.
Nathan Goodyear

Thyroid hormone signaling in human ovarian surface epithelial cells. - Abstract - Europ... - 0 views

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    T3 stimulation of TR-alpha increases ER-alpha transcription and COX-2
Nathan Goodyear

Contributions of Thyroid Hormone to Cancer Metastasis - 0 views

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    T4 via Integrin αvβ3 binding leads to metastasis.
Nathan Goodyear

Thyroid hormones in diabetes, cancer, and aging - 0 views

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    To be read
Nathan Goodyear

Metabolic syndrome, hyperinsulinemia, and cancer | The American Journal of Clinical Nut... - 0 views

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    Good review of insulin metabolic syndrome, insulin resistance, and cancer.
Nathan Goodyear

Redox regulation in cancer - 0 views

  • Mitochondrial electron-transport chain and other oxidizing agents are the prime pathways that generate excess ROS in vivo
  • Permanent modification of genetic material resulting from the oxidative damage is one of the vital steps involved in mutagenesis that leads to carcinogenesi
  • The most frequent DNA mutations caused during oxidative stress, initiated by ionizing radiation and other environmental carcinogens are 7,8-dihydro-8-oxoguanine (8-Oxo-G) and Thymine Glycol (TG)
  • ...3 more annotations...
  • catalase and SOD, GPx, GST
  • insulin like growth factor I, or fibroblast growth factor 2 generates ROS
  • Depletion of GSH increases the sensitivity of cells to ROS
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    The redox reaction in cancer: great read!
dblendstore

Overview of Pain Management Treatment - DBlend Store - 0 views

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    Chronic pain treatments are as varied as its causes. There are numerous approaches available, ranging from over-the-counter and prescription drugs to mind/body techniques and acupuncture. However, when it comes to treating chronic pain, no single technique can guarantee complete pain relief. A combination of treatment options may provide relief.
Nathan Goodyear

["Low triiodothyronine (T3) syndrome": "thyroxine (T4) euthyroidism" evidence (author's... - 0 views

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    Only abstract available here.
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