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Nathan Goodyear

acute stimulation of aromatization in Leydig cells by human chorionic gonadotropin in v... - 0 views

www.pnas.org/...4460.full.pdf

HCG aromatase aromatization leydig cells human chorionic gonadotropin hormone hormones men male

shared by Nathan Goodyear on 11 Jun 13 - No Cached
  • Nathan Goodyear on 11 Jun 13
     
    Granted, this is a in vitro study, but this study found that HCG stimulated increased leydig cell estrogen production through stimulation of aromatase activity.
Nathan Goodyear

Inhibition of diabetes in NOD mice by human preg... [Hum Immunol. 2001] - PubMed - NCBI - 0 views

www.ncbi.nlm.nih.gov/...11755999

HCG Th1 autoimmune disease autoimmune diabetes

shared by Nathan Goodyear on 15 May 12 - No Cached
  • Nathan Goodyear on 15 May 12
     
    HCG shown to inhibit and decrease activity of Th1 cells.
Nathan Goodyear

Dose-dependent increase in intratest... [J Clin Endocrinol Metab. 2010] - PubMed - NCBI - 0 views

www.ncbi.nlm.nih.gov/...20484472

HCG ITT intratesticular testosterone testosterone

shared by Nathan Goodyear on 15 May 12 - No Cached
  • Nathan Goodyear on 15 May 12
     
    low dose HCG maintains intratesticular testosterone levels.
Nathan Goodyear

Low-Dose Human Chorionic Gonadotropin Maintains Intratesticular Testosterone in Normal ... - 0 views

digital.lib.washington.edu/...JCEM_2005_Low_Dose_Human.pdf

HCG ITT intratesticular testosterone testosterone

shared by Nathan Goodyear on 15 May 12 - No Cached
  • Nathan Goodyear on 15 May 12
     
    low dosage HCG maintains ITT.
Nathan Goodyear

Low-dose human chorionic gonadotropin maintains intratesticular testosterone in normal ... - 0 views

digital.lib.washington.edu/...4415

HCG testosterone ITT intratesticular testosterone

shared by Nathan Goodyear on 15 May 12 - No Cached
  • Nathan Goodyear on 15 May 12
     
    low dose HCG, given every other day, shown to maintain intratesticular testosterone levels (ITT) in this with testosterone induced suppression.  A high ITT:T ratio is needed for appropriate spermatogenesis.
Nathan Goodyear

Serum 17-hydroxyprogesterone strongly correlates with intratesticular testosterone in g... - 0 views

www.ncbi.nlm.nih.gov/...PMC2674872

17-hydroxyprogesterone 17-OH progesterone ITT intratesticular testosterone HCG

shared by Nathan Goodyear on 15 May 12 - No Cached
  • Nathan Goodyear on 15 May 12
     
    as the title states: 17-OH progesterone is an appropriate tool to follow ITT levels in those on HCG therapy.
Nathan Goodyear

Hum Rep - 0 views

m.humrep.oxfordjournals.org/...2294.full

HCG

shared by Nathan Goodyear on 22 Aug 12 - No Cached
  • Nathan Goodyear on 22 Aug 12
     
    IM HCG shown to be more bioavailable than SQ.
Nathan Goodyear

The effect of human chorionic gonadotropin-based h... [Andrology. 2013] - PubMed - NCBI - 0 views

www.ncbi.nlm.nih.gov/...24123916

HCG testosterone azoospermia hormone hormones men

shared by Nathan Goodyear on 21 Oct 13 - No Cached
  • Nathan Goodyear on 21 Oct 13
     
    HCG injections useful in raising intra-testicular testosterone levels and aiding sperm production in those with azoospermia.
Nathan Goodyear

A clinical study of the use of human chorionic gon... [J Fam Pract. 1977] - PubMed result - 0 views

www.ncbi.nlm.nih.gov/...321723

HCG human chorionic gonadotropin weight loss overweight obesity

shared by Nathan Goodyear on 21 Apr 11 - No Cached
  • reatment of obesity with human chorionic gonadotrophin was shown to be of no better value than saline in a double-blind crossover study of weight reduction in obese subjects
  • o significant difference in mood,
  • hunger, or missed injections, and no apparent difference in adherence to diet when the two agents were compare
  • Nathan Goodyear on 21 Apr 11
     
    HCG appears to be placebo effect
Nathan Goodyear

Chorionic Gonadotropin and Obesity? - 0 views

www.ajcn.org/...681.full.pdf+html

obesity chorionic gonadotropin human HCG weight loss overweight

shared by Nathan Goodyear on 21 Apr 11 - No Cached
  • Nathan Goodyear on 21 Apr 11
     
    early letter casting doubt on HCG for weight loss
Nathan Goodyear

Phase I Study of Human Chorionic Gonadotropin Given Subcutaneously to Patients With Acq... - 0 views

jnci.oxfordjournals.org/...1797.short

HCG human chorionic gonadotopin

shared by Nathan Goodyear on 21 Apr 11 - No Cached
  • The most common side effects were weight gain
  • Nathan Goodyear on 21 Apr 11
     
    HCG in AIDS patients actually causes weight gain as a side effect; not weight loss
Nathan Goodyear

STIMULATION TESTS OF PITUITARY-LEYDIG CELL FUNCTION IN NORMAL MALE SUBJECTS AND HYPOGON... - 0 views

onlinelibrary.wiley.com/...abstract

HCG clomid stimulating test hypogonadism

shared by Nathan Goodyear on 28 Apr 11 - No Cached
  • Nathan Goodyear on 28 Apr 11
     
    HCG and clomid stimulation tests helpful in differentiating male hypogonadism
Nathan Goodyear

ScienceDirect - Journal of Diabetes and its Complications : Starvation diet and very-lo... - 0 views

www.sciencedirect.com/...1056872794000778

very-low-calorie diets VLC starvation HCG diet insulin resistance weight gain

shared by Nathan Goodyear on 09 Jul 11 - No Cached
  • The metabolic situation in extremely low-calorie diets may be comparable to that in starvation
  • increased insulin resistance in states of starvation and anorexia nervosa, with a concomitant role in stress hormones.
  • Nathan Goodyear on 09 Jul 11
     
    very-low-calorie diets, like found in the HCG diet, results in insulin resistance in many individuals, results in muscle mass loss, and results in many negative effects, including weight gain.
Nathan Goodyear

Human chorionic gonadotrophin treatment prior to microdissection testicular sperm extra... - 0 views

humrep.oxfordjournals.org/...331.long

HcG low T Testosterone low t low Testosterone spermatogenesis azoospermia men male hormone hormones

shared by Nathan Goodyear on 03 Aug 14 - No Cached
  • Nathan Goodyear on 03 Aug 14
     
    HCG used to stimulated endogenous Testosterone production and treat azoospermia.  The treatment protocol called for 5,000 IU 3 x weekly.  Even elevated LH/FSH levels decreased as endogenous Testosterone levels increased.
Nathan Goodyear

The reversibility of anabolic steroid-induced azoospe... [J Urol. 1995] - PubMed - NCBI - 0 views

www.ncbi.nlm.nih.gov/...7714991

HCG human chorionic gonadotropin low T low Testosterone infertility azoospermia men male hormone hormones

shared by Nathan Goodyear on 03 Aug 14 - No Cached
  • Nathan Goodyear on 03 Aug 14
     
    Case study of 1 of a man with remote history of anabolic steroid use and current azoospermia.  HCG therapy for 3 months led to resolution of infertility.
Nathan Goodyear

Concomitant intramuscular human chorionic gonadotropi... [J Urol. 2013] - PubMed - NCBI - 0 views

www.ncbi.nlm.nih.gov/...23260550

HCG low t low testosterone low t Testosterone men male hormone hormones human chorionic gonadotropin hypogonadism replacement

shared by Nathan Goodyear on 03 Aug 14 - No Cached
  • Nathan Goodyear on 03 Aug 14
     
    I can't say I agree with the premise of the study design.  In this study, HCG at 500 IU every other day was used to aid Testosterone therapy.  
Nathan Goodyear

Leptin inhibits testosterone secretion from adult rat testis in vitro. - PubMed - NCBI - 0 views

www.ncbi.nlm.nih.gov/...10320818

leptin Testosterone LH FSH

shared by Nathan Goodyear on 17 Jun 15 - No Cached
  • Nathan Goodyear on 17 Jun 15
     
    high leptin levels found to inhibit pituitary LH/FSH release.  Of note, high leptin levels inhibited leydig cell production of Testosterone following hCG stimulation.  This is a rat in vitro study.
Nathan Goodyear

ScienceDirect - Journal of Steroid Biochemistry : Saliva testosterone time-course respo... - 0 views

www.sciencedirect.com/science

saliva salivary testosterone hormone hormones testing

shared by Nathan Goodyear on 18 Jan 11 - No Cached
  • Thus it was suggested to collect saliva instead of plasma for the evaluation of testicular secretion of testosterone after hCG administration
  • Nathan Goodyear on 18 Jan 11
     
    salivary testosterone testing validated
Nathan Goodyear

Exogenous testosterone: a preventable cause of male infertility - Crosnoe - Translation... - 0 views

www.amepc.org/...3145

low T Testosterone low T low Testosterone hormone hormones fertility infertility hypogonadism Hypogonadotropic hog human chorionic gonadotropin clomid

shared by Nathan Goodyear on 03 Aug 14 - No Cached
  • Nathan Goodyear on 03 Aug 14
     
    very nice case review and discussion of the treatment of low T and low sperm count in men desiring preservation of fertility.  Clomid and HCG are viable options to increase endogenous Testosterone production, though both work via different mechanisms.
Nathan Goodyear

Leptin and Androgens in Male Obesity: Evidence for Leptin Contribution to Reduced Andro... - 0 views

press.endocrine.org/...jcem.84.10.6082

obesity leptin low T low Testosterone Testosterone low T leydig cells LH leutenizing hormone men male hormones hormone

shared by Nathan Goodyear on 04 Sep 14 - No Cached
  • in male obesity basal and LH-stimulated androgen levels are reduced and inversely correlated with circulating leptin
  • functional leptin receptors are present in rodent Leydig cells
  • it is conceivable that in males high leptin concentrations may have a direct inhibitory effect(s) on Leydig cell function.
  • ...18 more annotations...
  • insulin is an important inhibitor of the synthesis of SHBG
  • no correlation between leptin and SHBG levels
  • SHBG reduction in obesity is a minor determinant of lowered androgen levels
  • SHBG can explain only up to 3% of the correlation
  • testicular T de novo production is impaired in obese men and that leptin seems to be the best hormonal predictor of this blunted response to LH stimulation
  • The low basal 17-OH-P levels found in massively obese men are consistent with a global impairment of Leydig cell steroidogenic function in this group of subjects.
  • These findings indicate that obese men have a FM-related defect in the enzymatic conversion of 17-OH-P to T, which is revealed by hCG stimulation.
  • Other studies have investigated the adrenal function in male obesity and have shown that basal cortisol and 17-OH-progesterone levels tend to decrease with the increase in the degree of obesity
  • High E2 can inhibit the expression and activity of the 17,20-lyase and may be responsible for this steroidogenic lesion
  • However, stimulated E2 levels were not higher in the obese than in controls, excluding the fact that the lower androgen response was due to an increased aromatization of T to E2 and that estrogens have a major role in the observed defect of 17,20-lyase activity in obese men.
  • the percentage increase in the 17-OH-progesterone to T molar ratio paralleled the increase in leptin levels of obese men
  • Multiple regression analysis indicated that the best hormonal predictor of the obesity-related reduction in T and FT basal levels and androgen changes after hCG stimulation was serum leptin concentration
  • insulin has no negative influences on androgen production in obese men
  • insulin is known to have stimulatory actions on T production that have been demonstrated in obese and normal weight men (57) and in Leydig cells in culture
  • the negative correlation between insulin and basal T can be partly explained by the inhibitory action of insulin on SHBG production
  • hypogonadal men have higher circulating leptin levels compared with hypogonadal patients under effective androgen substitution therapy
  • The impaired androgen response to LH stimulus was due to a defect in the enzymatic conversion of 17-OH-progesterone to T, which was disclosed by a leptin-related increase in 17-OH-progesterone to T ratio
  • Estrogens, which are inhibitory modulators of LH pulsatility and bioactivity
  • Nathan Goodyear on 04 Sep 14
     
    Leptin appears to be a good marker of low Testosterone.  This study proposes that the mechanism of action is potentially 2 fold: first, a decrease in LH release by leptin (kisspeptin?) and 2nd, a directed decrease in Testosterone production by the leydig cells in the testes.
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