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fitspresso

https://www.sightcare-co.com/ - 0 views

www.sightcare-co.com

sight care sightcare group training nearsightedness food for eyesight carey codd vitasight vision how to cure bad eye tips fix improve your red light eyes diet improvement skincare malaysia costos de medicare indonesia singapore eyecare

shared by fitspresso on 27 Sep 23 - No Cached
  • fitspresso on 27 Sep 23
     
    Sight Care | Official Site sightcare-co.com · by Sight Care Sight Care Only $49/Bottle Limited Time Offer! Sight Care Special Deal + Special 67% Discount Save $600 + 180 Days Money Back Guarantee #1.The Sight Care vision supplement is a dietary supplement for helping you improve your vision and brain health. Sight Care eye supplements are formulated to provide a synergistic blend of vitamins, minerals, antioxidants, and other bioactive compounds that are essential for maintaining healthy vision Regular Price: 147/per bottle Only for: $49/per bottle What Is Sight Care? This powerful vision support supplement is made with a unique blend of natural ingredients and plant extracts that work together synergistically to deliver numerous benefits for your brain and eye health. With Sight Care, you can expect to experience increased energy levels, improved eyesight, and an overall revitalized sense of well-being. Taking care of your vision health is not just about seeing clearly; it's also about maintaining your overall brain health. As we age, our vision deteriorates, and our eyes and brain can experience a decline in function, but there are steps you can take to support your visual and cognitive health. Regular eye exams are crucial for detecting and treating vision problems early on, and making healthy choices such as eating a nutritious diet and exercising regularly can also help. However, with busy schedules, it can be difficult to find the time to devote to a healthy lifestyle. This is where the Sight Care supplement comes in. It's designed to support both vision and brain health with its blend of natural ingredients that have been shown to promote healthy vision and cognitive function You must not compromise your eye health for momentary exhilaration. If you are glued to digital screens day and night, you must take measures to prevent eye diseases like age-related macular degeneration. The SightCare vision supplement has been made using 100% natura
spineneuro

Hope in Every Incision: The Promise of Brain Tumor Surgery - 0 views

www.briefingwire.com/...promise-of-brain-tumor-surgery

brain tumor surgery brain tumor surgery survival rate success rate of brain tumor surgery

shared by spineneuro on 04 Jan 24 - No Cached
  • spineneuro on 04 Jan 24
     
    The observed cost of brain tumor surgery is approximately 60% lower than in other developed Western countries. The affordability of brain tumor surgery is significantly lower when compared to developed countries, making India a preferred choice over other Western destinations for brain tumor surgery. The outstanding success rate of brain tumor surgery is attributed to the expertise of top brain tumor surgeons in the country.
spineneuro

Success Rate of Brain Tumor Surgery in India 2021 Doubles Life Expectancy for Brain Cancer - 0 views

www.briefingwire.com/...fe-expectancy-for-brain-cancer

top 10 hospitals for brain tumor surgery in India brain tumor surgery in India top 10 brain tumor surgeons in India best of the top 10 brain tumor surgeons in India brain tumor surgery Brain Tumor Surgery Cost India

shared by spineneuro on 12 Oct 21 - No Cached
  • spineneuro on 12 Oct 21
     
    The Blue 400 is one of many advanced technologies available at the top 10 hospitals for brain tumor surgery in India. "Technology of this type is the future of neurosurgical care. We are thrilled to be one of the first in the region to provide our neurosurgeons with the technology," said the best of the top 10 brain tumor surgeons in India. International Helpline Number : +91-9325887033 Email id: enquiry@spineandneurosurgeryhospitalindia.com
spineneuro

Surgical Solutions on a Budget: Brain Tumor Surgery Cost in India Demystified - 0 views

www.briefingwire.com/...gery-cost-in-india-demystified

brain tumor surgery cost brain tumor surgery brain tumor surgeons brain tumor surgery hospital

shared by spineneuro on 19 Nov 23 - No Cached
  • spineneuro on 19 Nov 23
     
    The brain tumor surgery cost is exceptionally affordable, with a price nearly one-third of that in developed countries like the US and the UK. In addition to the brain tumor surgery cost, the success rate of the procedure performed by the best doctors for brain cancer in India is comparable to some of the best brain tumor surgery hospitals globally.
spineneuro

Top 10 Brain Specialist Doctor in World Perform First-in-India Robot-Assisted Neuro Sur... - 0 views

www.briefingwire.com/...a-robot-assisted-neuro-surgery

Top 10 brain specialist doctors in World brain tumor surgeries Brain Tumor Surgery in India Brain Tumor Surgery

shared by spineneuro on 14 Dec 21 - No Cached
  • spineneuro on 14 Dec 21
     
    Top 10 brain specialist doctors in India conducted the world's first robot-assisted neurosurgery. They are one of the few surgeons within the world to discover a unique interest in complex brain tumor surgeries and have successfully operated on a large number of brain tumor patients. Brain Tumor Surgery in India International Helpline Number : +91-9325887033 Email id: enquiry@spineandneurosurgeryhospitalindia.com
Nathan Goodyear

PLOS ONE: Depletion of Brain Docosahexaenoic Acid Impairs Recovery from Traumatic Brain... - 0 views

journals.plos.org/...article

DHA TBI traumatic brain injury omega 3 brain injury brain omega-3

shared by Nathan Goodyear on 31 Aug 15 - No Cached
  • The polyunsaturated fatty acids linoleic (LA, 18:2n-6) and linolenic acid (LNA, 18:3n-3) are essential fatty acids that cannot be synthesized by the body.
  • LNA serves as the precursor for long chain omega-3 fatty acids such as docosahexaenoic acid (DHA) while LA is converted into long chain omega-6 fatty acids such as arachidonic acid (AA)
  • DHA and AA are abundantly found in the brain, where these are stored mainly in membrane phospholipids
  • ...10 more annotations...
  • DHA has been shown to increase neurite outgrowth and synaptogenesis, and promotes glutamatergic neurotransmission through increase in glutamate receptor subunit expression
  • DHA has been shown to be converted to anti-inflammatory, proresolving and neuroprotective mediators, such as resolvins [7] and protectins
  • AA is converted by cyclooxygenases into 2-series prostaglandins and 4-series leukotrienes, most of which exert pro-inflammatory effects
  • Supplementation of DHA exerts neuroprotective effects and has been reported to afford protection from diffuse axonal injury [11] and mixed brain injury [12] as well
  • severe depletion of membrane DHA in the brain renders mice significantly more susceptible to TBI and impairs recovery following the injury
  • Omega-3 fatty acids may serve as nutraceutical agents and precondition the brain to make it more resilient to injury
  • it can be suggested that enriching DHA in the brain may be prophylactic and protective against brain injury
  • severe DHA deficiency in the brain impairs functional recovery from TBI in terms of vestibulo-motor and cognitive deficits
  • DHA deficiency further elevates TBI-induced production of SBDPs
  • less neurons were found around the injury site of DHA deficient brain after TBI compared to the omega-3 fatty acid adequate group
  • Nathan Goodyear on 31 Aug 15
     
    mouse study finds prolonged recovery in DHA deficient mice compared to controls.
spineneuro

Miracles in the Operating Room: Unveiling the Secrets of Successful Brain Tumor Surgery - 0 views

www.briefingwire.com/...successful-brain-tumor-surgery

Brain tumor surgery brain tumor surgery success rate in India Top hospitals for brain tumors

shared by spineneuro on 22 Jun 23 - No Cached
  • spineneuro on 22 Jun 23
     
    Brain tumor surgery is the most effective and it targets the specific place and the cells, consequently, giving it the highest success rate of brain tumor surgery in India. That is true for people undergoing brain tumor surgery in India, even as in most cases, the patients in the preliminary levels of their cancer get effortlessly cured with high brain tumor surgery success rate in India.
Nathan Goodyear

Inflammatory cause of metabolic syndrome via brain stress and NF-κB - 0 views

www.ncbi.nlm.nih.gov/...PMC3314172

metabolic syndrome TLR cytokines hypothalamus brain neurology metabolic syndrome NF-kappaB DIO diet induced obesity over nutrition nutrition inflammation

shared by Nathan Goodyear on 09 Jul 13 - No Cached
  • Mechanistic studies further showed that such metabolic inflammation is related to the induction of various intracellular stresses such as mitochondrial oxidative stress, endoplasmic reticulum (ER) stress, and autophagy defect under prolonged nutritional excess
  • intracellular stress-inflammation process for metabolic syndrome has been established in the central nervous system (CNS) and particularly in the hypothalamus
  • the CNS and the comprised hypothalamus are known to govern various metabolic activities of the body including appetite control, energy expenditure, carbohydrate and lipid metabolism, and blood pressure homeostasis
  • ...56 more annotations...
  • Reactive oxygen species (ROS) refer to a class of radical or non-radical oxygen-containing molecules that have high oxidative reactivity with lipids, proteins, and nucleic acids
  • a large measure of intracellular ROS comes from the leakage of mitochondrial electron transport chain (ETC)
  • Another major source of intracellular ROS is the intentional generation of superoxides by nicotinamide adenine dinucleotide phosphate (NADPH) oxidase
  • there are other ROS-producing enzymes such as cyclooxygenases, lipoxygenases, xanthine oxidase, and cytochrome p450 enzymes, which are involved with specific metabolic processes
  • To counteract the toxic effects of molecular oxidation by ROS, cells are equipped with a battery of antioxidant enzymes such as superoxide dismutases, catalase, peroxiredoxins, sulfiredoxin, and aldehyde dehydrogenases
  • intracellular oxidative stress has been indicated to contribute to metabolic syndrome and related diseases, including T2D [72; 73], CVDs [74-76], neurodegenerative diseases [69; 77-80], and cancers
  • intracellular oxidative stress is highly associated with the development of neurodegenerative diseases [69] and brain aging
  • dietary obesity was found to induce NADPH oxidase-associated oxidative stress in rat brain
  • mitochondrial dysfunction in hypothalamic proopiomelanocortin (POMC) neurons causes central glucose sensing impairment
  • Endoplasmic reticulum (ER) is the cellular organelle responsible for protein synthesis, maturation, and trafficking to secretory pathways
  • unfolded protein response (UPR) machinery
  • ER stress has been associated to obesity, insulin resistance, T2D, CVDs, cancers, and neurodegenerative diseases
  • brain ER stress underlies neurodegenerative diseases
  • under environmental stress such as nutrient deprivation or hypoxia, autophagy is strongly induced to breakdown macromolecules into reusable amino acids and fatty acids for survival
  • intact autophagy function is required for the hypothalamus to properly control metabolic and energy homeostasis, while hypothalamic autophagy defect leads to the development of metabolic syndrome such as obesity and insulin resistance
  • prolonged oxidative stress or ER stress has been shown to impair autophagy function in disease milieu of cancer or aging
  • TLRs are an important class of membrane-bound pattern recognition receptors in classical innate immune defense
  • Most hypothalamic cell types including neurons and glia cells express TLRs
  • overnutrition constitutes an environmental stimulus that can activate TLR pathways to mediate the development of metabolic syndrome related disorders such as obesity, insulin resistance, T2D, and atherosclerotic CVDs
  • Isoforms TLR1, 2, 4, and 6 may be particularly pertinent to pathogenic signaling induced by lipid overnutrition
  • hypothalamic TLR4 and downstream inflammatory signaling are activated in response to central lipid excess via direct intra-brain lipid administration or HFD-feeding
  • overnutrition-induced metabolic derangements such as central leptin resistance, systemic insulin resistance, and weight gain
  • these evidences based on brain TLR signaling further support the notion that CNS is the primary site for overnutrition to cause the development of metabolic syndrome.
  • circulating cytokines can limitedly travel to the hypothalamus through the leaky blood-brain barrier around the mediobasal hypothalamus to activate hypothalamic cytokine receptors
  • significant evidences have been recently documented demonstrating the role of cytokine receptor pathways in the development of metabolic syndrome components
  • entral administration of TNF-α at low doses faithfully replicated the effects of central metabolic inflammation in enhancing eating, decreasing energy expenditure [158;159], and causing obesity-related hypertension
  • Resistin, an adipocyte-derived proinflammatory cytokine, has been found to promote hepatic insulin resistance through its central actions
  • both TLR pathways and cytokine receptor pathways are involved in central inflammatory mechanism of metabolic syndrome and related diseases.
  • In quiescent state, NF-κB resides in the cytoplasm in an inactive form due to inhibitory binding by IκBα protein
  • IKKβ activation via receptor-mediated pathway, leading to IκBα phosphorylation and degradation and subsequent release of NF-κB activity
  • Research in the past decade has found that activation of IKKβ/NF-κB proinflammatory pathway in metabolic tissues is a prominent feature of various metabolic disorders related to overnutrition
  • it happens in metabolic tissues, it is mainly associated with overnutrition-induced metabolic derangements, and most importantly, it is relatively low-grade and chronic
  • this paradigm of IKKβ/NF-κB-mediated metabolic inflammation has been identified in the CNS – particularly the comprised hypothalamus, which primarily accounts for to the development of overnutrition-induced metabolic syndrome and related disorders such as obesity, insulin resistance, T2D, and obesity-related hypertension
  • evidences have pointed to intracellular oxidative stress and mitochondrial dysfunction as upstream events that mediate hypothalamic NF-κB activation in a receptor-independent manner under overnutrition
  • In the context of metabolic syndrome, oxidative stress-related NF-κB activation in metabolic tissues or vascular systems has been implicated in a broad range of metabolic syndrome-related diseases, such as diabetes, atherosclerosis, cardiac infarct, stroke, cancer, and aging
  • intracellular oxidative stress seems to be a likely pathogenic link that bridges overnutrition with NF-κB activation leading to central metabolic dysregulation
  • overnutrition is an environmental inducer for intracellular oxidative stress regardless of tissues involved
  • excessive nutrients, when transported into cells, directly increase mitochondrial oxidative workload, which causes increased production of ROS by mitochondrial ETC
  • oxidative stress has been shown to activate NF-κB pathway in neurons or glial cells in several types of metabolic syndrome-related neural diseases, such as stroke [185], neurodegenerative diseases [186-188], and brain aging
  • central nutrient excess (e.g., glucose or lipids) has been shown to activate NF-κB in the hypothalamus [34-37] to account for overnutrition-induced central metabolic dysregulations
  • overnutrition can present the cell with a metabolic overload that exceeds the physiological adaptive range of UPR, resulting in the development of ER stress and systemic metabolic disorders
  • chronic ER stress in peripheral metabolic tissues such as adipocytes, liver, muscle, and pancreatic cells is a salient feature of overnutrition-related diseases
  • recent literature supports a model that brain ER stress and NF-κB activation reciprocally promote each other in the development of central metabolic dysregulations
  • when intracellular stresses remain unresolved, prolonged autophagy upregulation progresses into autophagy defect
  • autophagy defect can induce NF-κB-mediated inflammation in association with the development of cancer or inflammatory diseases (e.g., Crohn's disease)
  • The connection between autophagy defect and proinflammatory activation of NF-κB pathway can also be inferred in metabolic syndrome, since both autophagy defect [126-133;200] and NF-κB activation [20-33] are implicated in the development of overnutrition-related metabolic diseases
  • Both TLR pathway and cytokine receptor pathways are closely related to IKKβ/NF-κB signaling in the central pathogenesis of metabolic syndrome
  • Overnutrition, especially in the form of HFD feeding, was shown to activate TLR4 signaling and downstream IKKβ/NF-κB pathway
  • TLR4 activation leads to MyD88-dependent NF-κB activation in early phase and MyD88-indepdnent MAPK/JNK pathway in late phase
  • these studies point to NF-κB as an immediate signaling effector for TLR4 activation in central inflammatory response
  • TLR4 activation has been shown to induce intracellular ER stress to indirectly cause metabolic inflammation in the hypothalamus
  • central TLR4-NF-κB pathway may represent one of the early receptor-mediated events in overnutrition-induced central inflammation.
  • cytokines and their receptors are both upstream activating components and downstream transcriptional targets of NF-κB activation
  • central administration of TNF-α at low dose can mimic the effect of obesity-related inflammatory milieu to activate IKKβ/NF-κB proinflammatory pathways, furthering the development of overeating, energy expenditure decrease, and weight gain
  • the physiological effects of IKKβ/NF-κB activation seem to be cell type-dependent, i.e., IKKβ/NF-κB activation in hypothalamic agouti-related protein (AGRP) neurons primarily leads to the development of energy imbalance and obesity [34]; while in hypothalamic POMC neurons, it primarily results in the development of hypertension and glucose intolerance
  • the hypothalamus, is the central regulator of energy and body weight balance [
  • Nathan Goodyear on 09 Jul 13
     
    Great article chronicles the biochemistry of "over nutrition" and inflammation through NF-kappaB activation and its impact on the brain.
spineneuro

Children With Brain Tumors Will Benefit From Targeted Treatment - 0 views

www.briefingwire.com/...enefit-from-targeted-treatment

top brain tumor surgeons List of top brain tumor surgeons India brain tumor list of top 10 hospitals for brain tumor surgery in India

shared by spineneuro on 23 Apr 22 - No Cached
  • spineneuro on 23 Apr 22
     
    List of top brain tumor surgeons India, accomplished a large-scale examination of 241 infants from around the world identified with glioma brain tumors - working with colleagues at the list of top 10 hospitals for brain tumor surgery India.
spineneuro

Artificial Intelligence Expedites Brain Tumor Diagnosis during Brain Tumor Surgery in W... - 0 views

www.101pressrelease.com/g-brain-tumor-surgery-in-world

brain tumor surgeons in world Top 10 brain tumor surgeons in world best brain tumor surgery in world brain tumor

shared by spineneuro on 31 Jan 22 - No Cached
  • spineneuro on 31 Jan 22
     
    Before the new technology may be elevated to different centers and institutions, "robust testing with more patients and increasing the generation to include rare brain tumors are substantially needed," Top 10 brain tumor surgeons in world said.
wheelchairindia9

Chair For Cerebral Palsy Child - 0 views

www.wheelchairindia.com/...Cerebral-Palsy-Wheelchair

cerebellum and the cortex common causes of brain damage cause like chicken pox or measles neurological problems are properly managed

shared by wheelchairindia9 on 12 May 15 - No Cached
  • wheelchairindia9 on 12 May 15
     
    Cerebral palsy (CP) is a group of conditions caused by medical abnormalities in the development of a fetus or the early life of a child. These lead to damage or delayed development in the brain. The disorder is permanent and, though it does not worsen with age, the level of functionality of a person with cerebral palsy varies widely: in some cases, effects may be very minor, while in others, movement is impaired to the extent that a wheelchair is required. Common complications associated with CP vary by the type of CP disorder but can include vision problems, seizures, learning disabilities, and issues speaking, writing, and performing other tasks. Cerebral palsy causes problems with muscle tone, movement, balance and/or coordination. Symptoms and effects range from mild to severe. In some infants, problems are evident soon after birth. In others, diagnosis comes in later infancy or toddlerhood. Cerebral Palsy Wheelchair Description: The model designed for cerebral palsy child only. Ultra light weight aluminium alloy frame. Seat Width 38 cms (15"). Net Weight: 18.5 kgs. Epoxy powder coated frame. Detachable arm rest & foot rest provided. Elevated and swinging foot rest. Elevated foot rest provided to elevate leg angle. Height adjustable and detachable head rest. Hydraulic reclining high back for a comfortable posture. Hydraulic adjustable seat angle. Detachable back and seat pad. Extra cushion upholstery provided to under arm, head & calg Foldable. Lever and paddle brakes provided. Safety belt provided. Maintenance free rear solid wheels. Cloth look like water proof upholstery. Anti wheels for better safety and stability. Extra cushion upholstery provided to under arm, head & leg Folding action. Lever and paddle brakes provided. Safety belt provided. Maintenance free rear solid wheels. Cerebral Palsy Wheelchair Recline system: Recline system provides kids with the most comfortable resting environment. It also allows stretching abdomin
spineneuro

Health Articles - Brain Tumor Surgery Cost in India Is As Good As Anywhere Else in the... - 0 views

www.amazines.com/...6262353

Brain Tumor Surgery in India Brain Tumor Surgery Cost India Cost of Brain Tumor Surgery India Top Brain Tumor Surgeons India Best Brain Tumor Surgeons of India List of Top Brain Tumor Surgeons India

shared by spineneuro on 23 Aug 21 - No Cached
  • spineneuro on 23 Aug 21
     
    Brain tumor surgery cost India, it is extraordinarily affordable and when compared to the developed countries comes out to be extraordinarily low cost, which is nearly one third the price in evaluation to US & UK.Top brain tumor surgeon India have gained reputation all across the world, all thanks to the high end specialists giving the best of the healthcare service at affordable cost.Spine and neuro surgery service India is right here that will help you with the high-quality low cost medical neurology procedure. Please Call +91-98604-32255 Email id:- enquiry@spineandneurosurgeryhospitalindia.co
spineneuro

The Cost-Effective Solution: Affordable Brain Tumor Surgery in India - 0 views

www.linkedin.com/...ain-tumor-india-hospital-india

Brain tumor surgery cost Brain tumor surgery affordable brain tumor surgery cost

shared by spineneuro on 24 Apr 23 - No Cached
  • spineneuro on 24 Apr 23
     
    Brain tumor surgery cost, its miles distinctly affordable and when in comparison to the evolved countries comes out to be tremendously low price, which is almost one 1/3 the rate in evaluation to US & UK. Besides the cost, the success rate of the process by a list of top brain tumor surgeons in India is at par globally with some of the brain tumor surgery best hospitals in India.
spineneuro

Get New-Age Technology and Expertise At Top Hospitals for Brain Tumor India - Spine and... - 0 views

spineandneurosurgeryhospitalindia.wordpress.com/...ospitals-for-brain-tumor-india

brain tumor surgery top brain tumor hospitals in India Top Brain Tumor Surgeon In India

shared by spineneuro on 08 Jun 22 - No Cached
  • spineneuro on 08 Jun 22
     
    It is been observed that brain tumor surgery in India is around 60% lesser than in other western advanced countries. That is why overseas patients choose India for their brain tumor surgery because of professional surgeons, top brain tumor hospitals in India, and affordable cost.
Nathan Goodyear

Metabolic management of brain cancer - 0 views

www.sciencedirect.com/...S0005272810006857

brain cancer

shared by Nathan Goodyear on 17 Jun 13 - No Cached
  • Glutamine is a major metabolic fuel for both brain tumor cells and tumor-associated macrophages (TAMs)
  • the malignant phenotype of brain tumor cells that survive radiotherapy is often greater than that of the cells from the original tumor.
  • Conventional chemotherapy has faired little better than radiation therapy for the long-term management of malignant brain cancer
  • ...37 more annotations...
  • most conventional radiation and brain cancer chemotherapies can enhance glioma energy metabolism and invasive properties, which would contribute to tumor recurrence and reduced patient survival [34].
  • We contend that all cancer regardless of tissue or cellular origin is a disease of abnormal energy metabolism
  • complex disease phenotypes can be managed through self-organizing networks that display system wide dynamics involving oxidative and non-oxidative (substrate level) phosphorylation
  • As long as brain tumors are provided a physiological environment conducive for their energy needs they will survive; when this environment is restricted or abruptly changed they will either grow slower, growth arrest, or perish [8] and [19]
  • New information also suggests that ketones are toxic to some human tumor cells and that ketones and ketogenic diets might restrict availability of glutamine to tumor cells [68], [69] and [70].
  • The success in dealing with environmental stress and disease is therefore dependent on the integrated action of all cells in the organism
  • Tumor cells survive in hypoxic environments not because they have inherited genes making them more fit or adaptable than normal cells, but because they have damaged mitochondria and have thus acquired the ability to derive energy largely through substrate level phosphorylation
  • Cancer cells survive and multiply only in physiological environments that provide fuels (mostly glucose and glutamine) subserving their requirement for substrate level phosphorylation
  • Integrity of the inner mitochondrial membrane is necessary for ketone body metabolism since β-hydroxybutyrate dehydrogenase, which catalyzes the first step in the metabolism of β-OHB to acetoacetate, interacts with cardiolipin and other phospholipids in the inner membrane
  • the mitochondria of many gliomas and most tumors for that matter are dysfunctional
  • Cardiolipin is essential for efficient oxidative energy production and mitochondrial function
  • Any genetic or environmental alteration in the content or composition of cardiolipin will compromise energy production through oxidative phosphorylation
  • The Crabtree effect involves the inhibition of respiration by high levels of glucose
  • the Warburg effect involves elevated glycolysis from impaired oxidative phosphorylation
  • the Crabtree effect can be reversible, the Warburg effect is largely irreversible because its origin is with permanently damaged mitochondria
  • The continued production of lactic acid in the presence of oxygen is the metabolic hallmark of most cancers and is referred to as aerobic glycolysis or the Warburg effect
  • We recently described how the retrograde signaling system could induce changes in oncogenes and tumor suppressor genes to facilitate tumor cell survival following mitochondrial damage [48].
  • In addition to glycolysis, glutamine can also increase ATP production under hypoxic conditions through substrate level phosphorylation in the TCA cycle after its metabolism to α-ketoglutarate
  • mitochondrial lipid abnormalities, which alter electron transport activities, can account in large part for the Warburg effect
  • targeting both glucose and glutamine metabolism could be effective for managing most cancers including brain cancer
  • The bulk of experimental evidence indicates that mitochondria are dysfunctional in tumors and incapable of generating sufficient ATP through oxidative phosphorylation
  • Cardiolipin defects in tumor cells are also associated with reduced activities of several enzymes of the mitochondrial electron transport chain making it unlikely that tumor cells with cardiolipin abnormalities can generate adequate energy through oxidative phosphorylation
  • The Crabtree effect involves the inhibition of respiration by high levels of glucose
  • Warburg effect involves elevated glycolysis from impaired oxidative phosphorylation
  • TCA cycle substrate level phosphorylation could therefore become another source of ATP production in tumor cells with impairments in oxidative phosphorylation
  • Caloric restriction, which lowers glucose and elevates ketone bodies [63] and [64], improves mitochondrial respiratory function and glutathione redox state in normal cells
  • DR naturally inhibits glycolysis and tumor growth by lowering circulating glucose levels, while at the same time, enhancing the health and vitality of normal cells and tissues through ketone body metabolism
  • DR is anti-angiogenic
  • DR also reduces angiogenesis in prostate and breast cancer
  • We suggest that apoptosis resistance arises largely from enhanced substrate level phosphorylation of tumor cells and to the genes associated with elevated glycolysis and glutaminolysis, e.g., c-Myc, Hif-1a, etc, which inhibit apoptosis
  • Modern medicine has not looked favorably on diet therapies for managing complex diseases especially when well-established procedures for acceptable clinical practice are available, regardless of how ineffective these procedures might be in managing the disease
  • More than 60 years of clinical research indicates that such approaches are largely ineffective in extending survival or improving quality of life
  • The process is rooted in the well-established scientific principle that tumor cells are largely dependent on substrate level phosphorylation for their survival and growth
  • Glucose and glutamine drive substrate level phosphorylation
  • targeting the glycolytically active tumor cells that produce pro-cachexia molecules, restricted diet therapies can potentially reduce tumor cachexia
  • It is important to recognize, however, that “more is not better” with respect to the ketogenic diet
  • Blood glucose ranges between 3.0 and 3.5 mM (55–65 mg/dl) and β-OHB ranges between 4 and 7 mM should be effective for tumor management
  • Nathan Goodyear on 17 Jun 13
     
    Dr Seyfriend presents his metabolic approach to the treatment of brain cancer.
Nathan Goodyear

Low-dose penicillin in early life induces long-term changes in murine gut microbiota, b... - 0 views

www.nature.com/...ncomms15062

brain brain health probiotics antibiotics gut-brain gut bacteria gut flora gut health gut microbiome gut microbiota gut

shared by Nathan Goodyear on 26 Oct 17 - No Cached
  • Nathan Goodyear on 26 Oct 17
     
    Gut bacteria brain connection: animal study finds antibiotics early in life alter gut flora which effects young brain and alters behavior; probiotics with Lactobacillus rhamnosus JB-1 appears to blunt the altered Gut bacteria brain connection.
spineneuro

Brain Tumor Surgery Statistics in India 2020 of Excellence in Neurosurgery - 101 Press ... - 0 views

www.101pressrelease.com/-of-excellence-in-neurosurgery

Brain Tumor Brain Tumor Surgery in India Brain Tumor Surgery Cost India Brain Tumor Surgery Statistics in India 2020 India's Best Brain Tumor Surgeons Top Hospitals for Brain Tumor India

shared by spineneuro on 25 Oct 21 - No Cached
  • spineneuro on 25 Oct 21
     
    This year, an estimated 24,530 adults (13,840 men and 10,690 women) will be recognized with primary cancerous tumors of the brain and spinal cord. A person's chance of growing this sort of tumor of their lifetime is much less than 1%. For more Info International Helpline Number : +91-9325887033 Email id: enquiry@spineandneurosurgeryhospitalindia.com
spineneuro

Get the Most Reliable Care With Brain Tumor Surgery In India - 0 views

www.briefingwire.com/...h-brain-tumor-surgery-in-india

brain tumor brain tumor surgery Brain tumor surgery cost Brain tumor surgeon

shared by spineneuro on 07 Nov 22 - No Cached
  • spineneuro on 07 Nov 22
     
    A brain tumor is known as an unusual mass of cells in the brain that have no reason. In general, tumors arise while cells divide and grow excessively within the body.
spineneuro

Never Give Up Hope With Top 5 Brain Tumor Surgeons in World - Spine and Neuro Hospital ... - 0 views

spineandneurosurgeryhospitalindia.wordpress.com/...-brain-tumor-surgeons-in-world

brain tumor brain surgery brain tumor removal surgery cost brain tumor surgeons tumor

shared by spineneuro on 15 Feb 22 - No Cached
  • spineneuro on 15 Feb 22
     
    It is been observed that affordable brain tumor removal surgery cost in India is around 60% lesser than other western advanced countries. Brain tumor removal surgery cost in India is extraordinarily affordable and when compared to the developed countries comes out to be extraordinarily low cost, which is nearly one-third of cost in evaluation to US & UK. Call us at +91-98604-32255 or Mail us at: enquiry@spineandneurosurgeryhospitalindia.com
spineneuro

Get Superior Brain Tumor Surgery in India on Behance - 0 views

www.behance.net/...r-Brain-Tumor-Surgery-in-India

Brain Tumor Surgery brain tumor surgery success rate in India common symptoms For Brain Tumor Surgery brain tumor surgery cost in rupees

shared by spineneuro on 16 Mar 22 - No Cached
  • spineneuro on 16 Mar 22
     
    That is true for people undergoing brain tumor surgery in India, even as in most cases, the patients in the preliminary levels in their cancer get effortlessly cured with high brain tumor surgery success rate in India. Although success rates offered are more than 98%, patients are usually satisfied with the surgical result. Send Your Medical Report by Email at: enquiry@spineandneurosurgeryhospitalindia.com or you can Talk with our Expert in Call just dial +91-9325887033
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