Group items tagged tight junctions - Dr. Goodyear

Lipopolysaccharide Causes an Increase in Intestinal Tight Junction Permeabili... - 0 views

www.ncbi.nlm.nih.gov/...PMC3562736

lipopolysaccharide metabolic endotoxemia TLR-4 leaky gut LPS TLR4 lipopolysaccharides

shared by Nathan Goodyear on 24 Jan 22 - No Cached

Nathan Goodyear on 24 Jan 22

LPS increases break in tight junctions, leaky gut, to increase TLR4 expression and signaling.

<div class="cArrow"> </div><div class="cContentInner">LPS increases break in tight junctions, leaky gut, to increase TLR4 expression and signaling.</div>

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Zonulin, regulation of tight junctions, and autoimmune disease - 0 views

www.ncbi.nlm.nih.gov/...PMC3384703

zonulin autoimmune disease tight junctions

shared by Nathan Goodyear on 25 Jan 17 - No Cached

Nathan Goodyear on 25 Jan 17

Zonulin and autoimmune disease

<div class="cArrow"> </div><div class="cContentInner">Zonulin and autoimmune disease</div>

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Mechanism of IL-1β-Induced Increase in Intestinal Epithelial Tight Junction P... - 0 views

www.jimmunol.org/...5653.full

inflammation Gut NF-kappaB intestinal inflammatory conditions

shared by Nathan Goodyear on 22 Mar 11 - No Cached

The IL-1β-induced increase in intestinal epithelial tight junction (TJ) permeability has been postulated to be an important mechanism contributing to intestinal inflammation of Crohn’s disease and other inflammatory conditions of the gut
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the role of myosin L chain kinase (MLCK)
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IL-1β caused a progressive increase in MLCK protein expression.
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...1 more annotation...
The IL-1β-induced increase in MLCK mRNA transcription and subsequent increase in MLCK protein expression and Caco-2 TJ permeability was mediated by activation of NF-κB
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Nathan Goodyear on 22 Mar 11

How systemic inflammation comes from the gut

<div class="cArrow"> </div><div class="cContentInner">How systemic inflammation comes from the gut</div>

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Interleukin-10 mediates the neuroprotection of hyperbaric oxygen therapy against trauma... - 0 views

www.ncbi.nlm.nih.gov/...24291771

hyperbaric hyperbaric therapy brain TBI traumatic brain injury IL-10

shared by Nathan Goodyear on 17 May 17 - No Cached

Nathan Goodyear on 17 May 17

abstract of animal study finds that hyperbaric therapy provides neuroprotection via increase in IL-10; improved blood-brain barrier, improved tight junctions were about of the benefit found.

<div class="cArrow"> </div><div class="cContentInner">abstract of animal study finds that hyperbaric therapy provides neuroprotection via increase in IL-10; improved blood-brain barrier, improved tight junctions were about of the benefit found.</div>

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SARS-CoV-2 Spike Protein Induces Degradation of Junctional Proteins That Maintain Endot... - 0 views

www.ncbi.nlm.nih.gov/...PMC8225996

COVID19 endothelium endothelial dysfunction SARS-CoV-2 spike protein COVID tight junctions COVID-19 spike proteins

shared by Nathan Goodyear on 28 Nov 21 - No Cached

Changes in gut microbiota control metabolic endotoxemia-induced inflammation in high-fa... - 0 views

diabetes.diabetesjournals.org/...db07-1403

gut microbiota flora metabolic endotoxemia inflammation insulin resistance IR obesity diabetes DM

shared by Nathan Goodyear on 18 Jan 12 - No Cached

high-fat feeding strongly increased intestinal permeability and reduced the expression of genes coding for proteins of the tight junctions
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Nathan Goodyear on 18 Jan 12

changes in the gut flora shown to induce metabolic endotoxemia, inflammation, insulin resistance, and obesity. Granted, this study was done in mice.

<div class="cArrow"> </div><div class="cContentInner">changes in the gut flora shown to induce metabolic endotoxemia, inflammation, insulin resistance, and obesity. Granted, this study was done in mice.</div>

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Tight Junctions, Intestinal Permeability, and Autoimmunity Celiac Disease and Type 1 Di... - 0 views

www.ncbi.nlm.nih.gov/...PMC2886850

gut flora microbiota bacteroides bifidobacterium lactobacillus dysbiosis leaky celiac disease diabetes

shared by Nathan Goodyear on 29 Feb 12 - No Cached

Nathan Goodyear on 29 Feb 12

this study from 2009 showed how disrupted/imbalanced gut flora leads to leaky gut. This case, high bacteroides relative to bifidobacterium and lactobacillus resulted in disruption of the zonulin pathway and thus lncreased intestinal permeability.

<div class="cArrow"> </div><div class="cContentInner">this study from 2009 showed how disrupted/imbalanced gut flora leads to leaky gut. This case, high bacteroides relative to bifidobacterium and lactobacillus resulted in disruption of the zonulin pathway and thus lncreased intestinal permeability.</div>

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IN THIS ISSUE - The Journal of Immunology - 0 views

www.jimmunol.org/...5155.short

Immune system thymus immunity

shared by Nathan Goodyear on 22 Mar 11 - No Cached

t has been suggested that increased permeability of intestinal epithelial tight junctions (TJ) in these diseases is mediated by proinflammatory cytokines including IL-1β,
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Al-Sadi et al. (p. 5653 ) hypothesized that myosin light chain kinase (MLCK), which is known to be important for intestinal TJ permeability, could mediate IL-1β-induced disruption of the epithelial barrier
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Nathan Goodyear on 22 Mar 11

Heavy article on immune system activation

<div class="cArrow"> </div><div class="cContentInner"> Heavy article on immune system activation</div>

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Nutrients | Free Full-Text | Effect of Probiotics on Metabolic Outcomes in Pregnant Wom... - 0 views

www.mdpi.com/...htm

probiotics alternative medicine natural medicine natural therapies diabetes gestational diabetes

shared by Nathan Goodyear on 15 May 17 - No Cached

The gut microbial composition is altered during pregnancy
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probiotic supplements may contribute to the maintenance of bacterial diversity and glucose homeostasis in individuals with metabolic disturbances
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Assessment of four randomized controlled trials in this review involving 288 pregnant women with GDM found that a 6–8 week probiotic intervention did not improve FBG or LDL-cholesterol levels
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probiotic supplementation in women with GDM was associated with significant reductions in insulin resistance
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One proposed method is by the production of short chain fatty acids (SCFAs), generated as a by-product of bacterial fermentation of dietary fibers. SCFAs act as an energy source for intestinal cells and have been found to regulate the production of hormones effecting energy intake and expenditure such as leptin and grehlin
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Another hypothesized mechanism of SCFA action includes reducing gastrointestinal permeability by upregulating transcription of tight junction proteins, enhancing production of Glucagon-like peptide-2 (GLP-2) which promotes crypt cell proliferation, and reducing inflammation in colonic epithelial cells by increasing PPAR-gamma activation
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Maintenance of the integrity of the gut barrier minimizes the concentration of lipopolysaccharide (LPS) in circulation
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LPS is a structural component of gram negative bacterial cell walls, which induces an immune-cell response upon absorption into the human bloodstream, stimulating proinflammatory cytokine production and the onset of insulin resistance and hyperglycemia
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Nathan Goodyear on 15 May 17

Review (4 studies) found that 6-8 weeks of probiotic therapy of pregnant women with gestational diabetes improved insulin resistance.

<div class="cArrow"> </div><div class="cContentInner">Review (4 studies) found that 6-8 weeks of probiotic therapy of pregnant women with gestational diabetes improved insulin resistance.</div>

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Open TeleShop on 17 May 17

Hey Dear Check Out Our Online Shopping store in all Over Pakistan.As Seen as On Tv Products Like as Health Beauty,Fitness,Homeware,Kitchenware,And Other Electronic Products in Pakistan Check Out Now| www.openTeleshop.Com

<div class="cArrow"> </div><div class="cContentInner">Hey Dear Check Out Our Online Shopping store in all Over Pakistan.As Seen as On Tv Products Like as Health Beauty,Fitness,Homeware,Kitchenware,And Other Electronic Products in Pakistan Check Out Now| <a href="http://www.openTeleshop.Com" rel="nofollow" target="_blank">www.openTeleshop.Com</a></div>

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ARTICLES | Physiological Reviews - 0 views

physrev.physiology.org/...151

zonulin gut tight junctions autoimmune disease

shared by Nathan Goodyear on 07 Jun 17 - No Cached

Nathan Goodyear on 07 Jun 17

good review on zonulin, leaky gut, and disease.

<div class="cArrow"> </div><div class="cContentInner">good review on zonulin, leaky gut, and disease.</div>

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