Group items tagged

Premature ovarian failure shown to be autoimmune.  This study from '97 describes the mechanism of the autoimmune ovarian failure.  Now, case studies are emerging of young women developing premature ovarian failure following the HPV vaccine.

nano-Niclosamide more effective than traditional Niclosamide in in vitro and in vivo ovarian cancer.

IV, high dose, vitamin C adjunct therapy shown to aid in the remission in to women with ovarian cancer. These two cases studies do only looked and high dose antioxidant therapy as an adjunct in ovarian cancer and they found good results.

Low estrogen levels in ovarian failure patients found to reduce flares in those with Lupus.  Estrogen can promote inflammation, especially high estrone levels.  It is easy to see how ovarian failure and a drop in estrogen could reduce inflammation and thus autoimmune flares.

Study finds decreased ovarian reserve in women 20-29 with metabolic syndrome compared to controls.  They determined this via ovarian volume measurements as FSH, LH, Estradiol, and Progesterone did not differ.   One item of interest was that women with MetS, had significantly higher Testosterone levels compared to controls.  This association of MetS and elevated Testosterone in women has been shown consistently in the literature.  This should bring great questions to the doping of Testosterone in women today.

Bisphenol A shown to disrupt ovarian estrogen production from exposure in adults.  The point of this that is important is that BPA, a xenoestrogen, can infact disrupt physiologic hormone production in adults, and contribute to ovarian failure.  BPA, itself, is 1,000 fold weaker than E2, yet it disrupts ovarian function.

Studies in breast cancer and prostate cancer have revealed different effects by ER alpha vs ER beta.  It is no surprise that the same effects are found in ovarian cancer.  This study found ER alpha antagonists and ER beta agonists "significantly" suppressed growth in the ovarian cancer cell lines SKOV3 and OV2008.  Also, ER alpha agonist and ER beta antagonist "significantly" increased growth in the same cell lines.  These findings point to in increased proliferation with ER alpha and decreased with ER beta.  This is consistent with breast and prostate cancer also.

Niclosamide, common anti-parasitic medication, inhibits cellular metabolism and increases ROS; both of which provide powerful anti-proliferative, anti-cancer treatment mechanism in TICs. Powerful target therapy for cancer stem cells. Also shown to inhibit Wnt stimulated oncogenes survivin and c-Myc, disrupts Notch signaling, inactivates NF-kappaBeta, and inhibits mTOR-signaling.  This has been found in in vitro and in vivo studies.

Curcumin increases chemosensitization of ovarian cancer.

glutathione levels inversely associated with drug resistance in the treatment of ovarian cancer.

Alpha lipoic acid shown to inhibit ovarian cancer cell growth in culture.

metformin improves survival rate in ovarian cancer

premature ovarian failure shown to be more common post hysterectomy

Ovarian Cancer screening provides no benefit

Ivermectin found to block PAK-1 in ovarian cancer cell lines.

glutathione and ovarian cancer

Glutathione shown to provide longer survival in Ovarian cancer.  They describe glutathione as "novel".  Glutathione, in this study, was used as an adjunct in therapy.

with with ovarian cancer, found to have dysregulated cortisol patterns.  Found to be associated with increased rates of depression. Oh, by the way, this study utilized salivary cortisol.

IV glutathione reduces the toxicity of cisplatin in women treated for ovarian cancer.  Quality of life also improved

statement from KU on their new study on IV vitamin C in stage III and IV ovarian cancer.