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Nathan Goodyear

Annals of Internal Medicine | Gene-Diet Interactions in Brain Aging and Neurodegenerati... - 0 views

annals.org/article.aspx

diet calorie neurodegenerative disease brain neurology parkinson's disease Alzheimer's disease aging

shared by Nathan Goodyear on 25 Jun 12 - No Cached
  • it appears that dietary restriction promotes neuronal survival, plasticity, and even neurogenesis by inducing a mild cellular stress response that involves activation of genes that encode proteins designed to promote neuronal growth and surviva
  • Studies of animal models of Alzheimer disease and Parkinson disease have shown that, by decreasing homocysteine levels, dietary folic acid can be neuroprotective
  • The current average daily calorie intake of Americans is approximately 2700 for women and more than 3000 for men
  • Nathan Goodyear on 25 Jun 12
     
    what you eat and how many calories you eat effects you brain and your risk of neurodegenerative diseases, such as Parkinson's and Alzheimer's disease.
Nathan Goodyear

The role of long chain fatty acids in regulating food intake and cholecystokinin releas... - 0 views

www.ncbi.nlm.nih.gov/...PMC1727908

LCFA long-chain fatty acids cholecystokinin calorie restriction calorie obesity overweight food intake

shared by Nathan Goodyear on 11 Jun 12 - No Cached
  • Nathan Goodyear on 11 Jun 12
     
    long chain fatty acids (LCFA), associated with decreased calorie intake.  This occurs through up regulation/release of cholecystokinin.
Nathan Goodyear

Thieme E-Journals - Hormone and Metabolic Research / Abstract - 0 views

www.thieme-connect.com/...DOI

very-low-calorie diet calorie restriction nutrition low T low Testosterone male hormones Testosterone men male hormone hormones

shared by Nathan Goodyear on 27 Oct 14 - No Cached
  • Nathan Goodyear on 27 Oct 14
     
    Very low calorie diet over 12 weeks increased endogenous Testosterone levels in men via improved Testicular production and reduced aromatase activity due to decreased adipose tissue.
Nathan Goodyear

Metabolic management of glioblastoma multiforme using standard therapy together with a ... - 0 views

www.ncbi.nlm.nih.gov/...PMC2874558

ketogenic ketogenic diet cancer ketones ketone bodies

shared by Nathan Goodyear on 17 Nov 16 - No Cached
  • Nathan Goodyear on 17 Nov 16
     
    case study highlights the use of a calorie restricted, ketogenic diet to augment glioblastoma multiforme.  In incomplete resection, at 2 months no brain tumor was visualized via PET and MRI.
Nathan Goodyear

PLoS ONE: Metabolic and Behavioral Compensations in Response to Caloric Restriction: Im... - 0 views

www.plosone.org/...journal.pone.0004377

weight weight loss loss overweight obesity

shared by Nathan Goodyear on 11 Jul 11 - Cached
  • Nathan Goodyear on 11 Jul 11
     
    exercise and muscle very important to maintaining weight loss long-term.  Calorie restriction results in muscle mass loss and this will impair the ability to maintain weight loss long term
Nathan Goodyear

Primary care-led weight management for remission of type 2 diabetes (DiRECT): an open-l... - 0 views

www.thelancet.com/...fulltext

obesity type 2 diabetes type II diabetes calorie restriction nutrition weight loss diet

shared by Nathan Goodyear on 11 Dec 17 - No Cached
  • Nathan Goodyear on 11 Dec 17
     
    study finds very low calorie diet reversed diabetes. The greatest weight loss was associated with greatest remission of diabetes at 86% with >15 kg weight loss.
Nathan Goodyear

Akkermansia muciniphila and improved metabolic health during a dietary intervention in ... - 0 views

gut.bmj.com/...gutjnl-2014-308778.abstract

akkermansia muciniphila gut flora gut microbiome gut microbiota metabolism obesity

shared by Nathan Goodyear on 11 Aug 15 - No Cached
  • Nathan Goodyear on 11 Aug 15
     
    akkermansia muciniphila bacteria associated with improved metabolism following calorie restriction in obese adults.  Again, gut flora effects metabolism
Nathan Goodyear

https://www.jstage.jst.go.jp/article/jcbn/58/1/58_15-48/_pdf - 0 views

www.jstage.jst.go.jp/..._pdf

lifestyle Testosterone low T low Testosterone exercise nutrition hormones obesity overweight

shared by Nathan Goodyear on 25 Jan 16 - No Cached
  • Nathan Goodyear on 25 Jan 16
     
    study finds that lifestyle interventions, aerobic exercise and calorie restriction, increased Testosterone levels in men that were overweight or obese.  The men included in this study did not meet most definitions of "low Testosterone".
Nathan Goodyear

A Randomized Pilot Trial of a Moderate Carbohydrate Diet Compared to a Very Low Carbohy... - 0 views

www.ncbi.nlm.nih.gov/...PMC3981696

diabetes ketogenic diet nutrition diet obesity

shared by Nathan Goodyear on 09 Feb 16 - No Cached
  • Nathan Goodyear on 09 Feb 16
     
    low carb ketogenic diet, high in fat worked better in glycemic control versus DA low fat, medium carbohydrate, calorie restricted diet.
Nathan Goodyear

The glucose ketone index calculator: a simple tool to monitor therapeutic efficacy for ... - 0 views

nutritionandmetabolism.biomedcentral.com/...s12986-015-0009-2

cancer GKI glucose ketone index ketogenic diet nutrition

shared by Nathan Goodyear on 02 Apr 18 - No Cached
  • The ‘Glucose Ketone Index’ (GKI) was created to track the zone of metabolic management for brain tumor management
  • The GKI is a biomarker that refers to the molar ratio of circulating glucose over β-OHB, which is the major circulating ketone body.
  • We present evidence showing that the GKI can predict success for brain cancer management in humans and mice using metabolic therapies that lower blood glucose and elevate blood ketone levels
  • ...14 more annotations...
  • The GKI can be useful in determining the success of dietary therapies that shift glucose- and lactate-based metabolism to ketone-based metabolism
  • Alzheimer’s disease, Parkinson’s disease, traumatic brain injury, chronic inflammatory disease, and epilepsy
  • The zone of metabolic management is likely entered with GKI values between 1 and 2 for humans
  • Optimal management is predicted for values approaching 1.0, and blood glucose and ketone values should be measured 2–3 hours postprandial, twice a day if possible
    • Nathan Goodyear
      Nathan Goodyear on 09 May 18
       
      check GKI 2-3 hr postprandial twice daily
  • Preclinical studies have demonstrated a clear linkage between GKI and therapeutic efficacy
  • the Warburg effect (aerobic fermentation of glucose) is a common metabolic malady expressed in nearly all neoplastic cells of these and other malignant tumors
  • Aerobic fermentation (Warburg effect) is necessary to compensate for the insufficiency of mitochondrial oxidative phosphorylation in the cells of most tumors
  • Normal brain cells gradually transition from the metabolism of glucose to the metabolism of ketone bodies (primarily β-hydroxybutyrate and acetoacetate) for energy when circulating glucose levels become limiting
  • Ketone bodies bypass the glycolytic pathway in the cytoplasm and are metabolized directly to acetyl CoA in the mitochondria
  • Tumor cells are less capable than normal cells in metabolizing ketone bodies for energy due to their mitochondrial defects
  • daily activities and emotional stress can cause blood glucose levels to vary making it difficult for some people to enter the predicted zone of metabolic management
  • a clear association of the GKI to the therapeutic action of calorie restriction against distal invasion, proliferation, and angiogenesis in the VM-M3 model of glioblastoma
  • The results suggest that GKI levels that approach 1.0 are therapeutic for managing brain tumor growth
  • Therapeutic efficacy of the KD or calorie restriction is greater with lower GKI values than with higher values
  • Nathan Goodyear on 02 Apr 18
     
    The glucose ketone index shown to predict dietary metabolic success. In humans with brain cancer-- the target is 1.  The glucose and ketone (betahydroxybutyrate) should be measured 2-3 hours postprandial twice daily.
Nathan Goodyear

Synergistic effect of fasting-mimicking diet and vitamin C against KRAS mutated cancers - 0 views

www.ncbi.nlm.nih.gov/...PMC7214421

plant-based diet fasting vitamin C nutrition

shared by Nathan Goodyear on 19 May 20 - No Cached
  • Nathan Goodyear on 19 May 20
     
    vitamin C + calorie-restricted plant-based diet found to inhibit KRAS colorectal cancer cell growth in mouse model.
Nathan Goodyear

FDA says HCG weight-loss products are illegal - - CNN.com Blogs - 0 views

thechart.blogs.cnn.com/...-weight-loss-drugs-are-illegal

FDA HCG natural calorie-restriction

shared by Nathan Goodyear on 10 Dec 11 - No Cached
  • Nathan Goodyear on 10 Dec 11
     
    I agree with the fact that studies have not shown HCG helps with weight loss in addition to the 500 cal diet. We have many studies in diigo supporting this.  However, the FDA is stepping out of its authorized scope.  
Nathan Goodyear

http://care.diabetesjournals.org/content/early/2013/02/07/dc12-1912.full.pdf - 0 views

care.diabetesjournals.org/...dc12-1912.full.pdf

protein carbohydrates macronutrients insulin resistance obesity obese inflammation inflammatory cytokines premenopause women

shared by Nathan Goodyear on 17 Mar 14 - No Cached
  • Nathan Goodyear on 17 Mar 14
     
    Study finds that higher protein to carbohydrate intake has a positive effect on inflammatory cytokines, oxidative stress, improves insulin sensitivity and improves Beta cell function in premenopausal, non diabetic obese women.
Nathan Goodyear

Arch Intern Med -- Abstract: Human Chorionic Gonadotropin (HCG) Treatment of Obesity, F... - 0 views

archinte.ama-assn.org/...151

HCG weight loss obesity

shared by Nathan Goodyear on 21 Apr 11 - No Cached
  • hese results indicate that HCG has no effects on chemical and hormonal parameters measured and offers no advantage over calorie restriction in promoting weight loss.
  • Nathan Goodyear on 21 Apr 11
     
    HCG injections appear to have no effect on weight loss over those following 500 cal diets
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