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Are statins analogues of vitamin D? Grimes DS. Lancet. 2006 Jul 1;368(9529):83-6. Review. PMID: 16815382 doi:10.1016/S0140-6736(06)68971-X There are many reasons why the dietary-heart-cholesterol hypothesis should be questioned, and why statins might be acting in some other way to reduce the risk of coronary heart disease. Here, I propose that rather than being cholesterol-lowering drugs per se, statins act as vitamin D analogues, and explain why. This proposition is based on published observations that the unexpected and unexplained clinical benefits produced by statins have also been shown to be properties of vitamin D. It seems likely that statins activate vitamin D receptors.

Neotonics Only $49/Bottle Limited Time Offer! Neotonics Special Deal + Special 51% Discount Save $300 + 60 Days Money Back Guarantee Neotonics FDA Five Star Neotonics™ is a dietary supplement specifically designed to provide essential probiotics, which are known to promote youthful, glowing skin while reducing the appearance of wrinkles. Regular Price: $99/per bottle Only for: $49/per bottle Buy Now Support Healthy Eyesight No Matter Your Age 100% NATURAL 100% NATURAL with ingredients sourced from local growers that let plants naturally reach their full maturity and use no chemical treatments 100% EFFECTIVE 100% EFFECTIVE mixing ingredients in the right way and in the right amount to keep their properties intact 100% SAFE 100% SAFE processed under strict sterile standards with regularly disinfected equipment. What Is Neotonics? NeoTonics is an all-natural supplement formulated with strains that promote skin and digestive health. Notably, the combined ingredients are reckoned to foster dermal balance, support digestion, and, thus, ensure a healthy weight. Neotonics Gummies is an all-new supplement created to enhance the health and well-being of your skin. The formula is based on research that suggests gut health plays an important role in maintaining healthy skin. This is why the Neotonics supplement boosts both gut health and skin health by using a combination of amazing nutrients. These transform the gut health and restore its functions effectively. Available as a gummy, Neotonics delivers a blend of crucial probiotics and other complementary ingredients to promote skin health, digestion, weighty loss, and more. Just take one gummy daily to support active effects. The creators of Neotonics developed the gummy based on new scientific discoveries from May 2023. That discovery revealed the root cause of skin cell turnover: an aging gut. Your gut dictates the cellular turnover rate, and gut health can promote skin health. Neotonics is

FitSpresso Only $39/Bottle Limited Time Offer! FitSpresso Special Deal + Special 51% Discount Save $660 + 60 Days Money Back Guarantee FitSpresso Herpesyl Five Star FitSpresso is a supplement made to help people lose weight naturally. This supplement comes in the form of veggie capsules, and it is designed to boost metabolism, promote weight loss, burn fat, slow down weight gain, and destroy fat cells. Regular Price: 149/per bottle Only for: $39/per bottle Buy Now What Is FitSpresso? FitSpresso is promoted as a natural supplement that comes in the form of diet pills, and it can aid in rapid and efficient weight loss, similar to many other supplements. The term "natural supplements refers to a nutritional supplement that is made entirely of natural, chemical-free materials. You can utilize these organic ingredients to aid in natural weight loss. It can speed up your body's metabolism and assist with other crucial processes. All parts of our bodies are impacted by weight increase, and not only do we need to deal with the increased weight, but we also need to deal with the numerous problems and illnesses that come along with it. This refers to the risk of developing chronic cardiac conditions, low blood pressure, and, in some circumstances, problems with blood sugar. However, FitSpresso even with its bright and bold claims, can help you efficiently manage your weight and completely avoid these extra uncomfortable problems. FitSpresso is a supplement that comes in the form of a pill, which makes it tasty, simple to swallow, and handy. According to the manufacturer, these diet tablets are GMO-free and toxic-free, making them edible. This is why we have things such as weight loss supplements. Thanks to modern advancements, we can just take a dietary supplement pill to bring about significant weight loss in a completely healthy and natural manner. Not only this, but dietary supplements can also support healthy blood sugar levels and help with insulin re

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Intoxicants In islam were forbidden in the Qur'an through several separate verses revealed at different times over a period of years. At first, it was forbidden for Muslims to attend to prayers while intoxicated . - See more at: http://www.rehabiti.blogspot.com/2013/06/why-is-alcohol-forbidden-in-islam.html#sthash.4zAMOQ1z.dpuf

ScienceDaily (Aug. 25, 2009) - Low levels of vitamin D are known to nearly double the risk of cardiovascular disease in patients with diabetes, and researchers at Washington University School of Medicine in St. Louis now think they know why. They have found that diabetics deficient in vitamin D can't process cholesterol normally, so it builds up in their blood vessels, increasing the risk of heart attack and stroke. The new research has identified a mechanism linking low vitamin D levels to heart disease risk and may lead to ways to fix the problem, simply by increasing levels of vitamin D.

Why is it that vitamin D deficiency can manifest in so many different ways in different people? One big reason is something called vitamin D receptor (VDR) genotypes, the variation in the receptor for vitamin D. Why is it that the dose of vitamin D necessary to reach a specific level differs so widely from one person to the next? VDR genotype, again. Variation in blood levels of 25-hydroxy vitamin D from a specific dose of vitamin D can vary three-fold, as shown by a University of Toronto study. In other words, a dose of 4000 units per day may yield a 25-hydroxy vitamin D blood level of 30 ng/ml in Mary, 60 ng/ml in Paul, and 90 ng/ml in Pete--same dose, different blood levels

Improved cholecalciferol nutrition in rats is noncalcemic, suppresses parathyroid hormone and increases responsiveness to 1, 25-dihydroxycholecalciferol. Vieth R, Milojevic S, Peltekova V. J Nutr. 2000 Mar;130(3):578-84. PMID: 10702588 We conclude suppression of 1,25(OH)(2)D and PTH, and higher renal VDR mRNA and 24-hydroxylase did not involve higher free 1,25(OH)(2)D concentration or a first pass effect at the gut. Thus, 25(OH)D or a metabolite other than 1,25(OH)(2)D is a physiological, transcriptionally and biochemically active, noncalcemic vitamin D metabolite. When viewed from a perspective that starts with higher vitamin D nutrition, the results indicate that low vitamin D nutrition may bring about a form of resistance to 1,25(OH)2D. This situation would explain why, in humans, nutritional rickets and osteomalacia are commonly associated with normal or increased levels of 1,25(OH)2D (Chesney et al. 1981Citation , Eastwood et al. 1979Citation , Garabedian et al. 1983Citation ,Rasmussen et al. 1980Citation )-these are not like the low hormone levels associated with any other endocrine-deficiency disorder. A connection between lower vitamin D nutrition and vitamin D resistance helps to explain why the supposedly inactive compound 25(OH)D is more relevant in diagnosing nutritional rickets than is the active hormone 1,25(OH)2D. If the features of improved vitamin D nutrition shown here were demonstrated for any newly synthesized compound, the compound would be classified as a noncalcemic 1,25(OH)2D analogue (Brown et al. 1989Citation , Finch et al. 1999Citation , Goff et al. 1993Citation , Koshizuka et al. 1999Citation ). Thus, we contend that 25(OH)D or a metabolite of it other than 1,25(OH)2D exists as a physiological and biologically-active noncalcemic vitamin D metabolite whose effects require further examination, particularly in relationship to studies involving the synthetic analogs of 1,25(OH)2D.

"So why is Dr Vieth so frustrated? You might think he'd have cause for celebration. But for him and other vitamin D researchers around the world, the good news comes with a bitter aftertaste. They believe they can prove vitamin D could help millions live longer and be healthier and yet they have not been able to convince their own governments. In the US and Canada, official vitamin D policy is set by the Institute of Medicine. And in the opinion of Vieth, the current recommendations - 200 International Units per day for people under 50, 400 for people aged 51-70, and 600 for those 71 and older - are outrageously low. Bruce Hollis, professor of paediatrics at the Medical University of South Carolina, calls 400 IU a day "a joke". That's because the best research suggests that to achieve the higher vitamin D blood levels associated with disease prevention, most adults in the US would need to take 1,000-2,000 IU a day: five to 10 times more than the current official recommendation for adult In 1999, Reinhold Vieth (pictured right) published a review of vitamin D research in response to the IOM conclusions. In it, he argued that there was no evidence that amounts lower than 20,000 IU a day could be toxic. "Throughout my preparation of this review, I was amazed at the lack of evidence supporting statements about the toxicity of moderate doses of vitamin D," Vieth wrote. Studies have since shown 10,000 IU a day of vitamin D to be safe. While any substance will become toxic in excess, vitamin D researchers today accept that the current vitamin D recommendations could be more than quadrupled with no fear of toxicity.!

You may be asking yourself why a dermatologist-reviewed site from the American Academy of Dermatology (Academy) still says that diet does not cause acne. After all, haven't research studies found that certain foods cause acne? If you have acne, you may even have noticed that when you eat certain foods you break out. With all this evidence, why does the Academy still say that food does not cause acne

"The results of the uniquely-constructed ERA JUMP Study were just released, a fascinating study of the relationship of omega-3 fatty acids to coronary and carotid plaque. The study adds insight into why the Japanese experience only one third of the heart attacks of Americans, and why Japan occupies the bottom of the list for least heart attacks among all developed countries. The Electron-Beam Tomography, Risk Factor Assessment Among Japanese and U.S. Men in the Post-World War II Birth Cohort Study (ERA JUMP), a collaborative U.S.-Japanese effort, compared three groups of men: -- 281 Japanese men living in Japan -- 306 non-Japanese men living in the U.S. (Pittsburgh, Pennsylvania) -- 303 Japanese Americans (having both parents Japanese without "ethnic admixture") living in Hawaii. The last group represents a group that is genetically similar to the group in Japan, but exposed to an American diet and lifestyle. Three main measures were compared: -- Blood levels of omega-3 fatty acids, EPA and DHA) -- Carotid intimal-medial thickness (CIMT, the thickness of the carotid artery lining that can serve as an index of body-wide atherosclerosis) -- Coronary calcium (heart scan) scores."

It's difficult for most people to maintain a healthy, balanced diet while living their busy schedules, which is certainly why supplements and vitamins have become increasingly popular over the past few years. And one such product that is really beginning to catch on is green lipped mussel supplements, and when you look at all the related benefits, it's easy to understand why.

Mangoes may very well be the king of all fruits. They Prevents Cancer, alkalize the body, aid in weight loss, regulate diabetes, help digestion, clean your skin, and make the perfect snack. and many reasons why you should be Drinking a mango juice every day. They are Many reasons of mango juice 1. Prevents Cancer Antioxidants like quercetin, isoquercitrin, astragalin, fisetin, gallic acid and methylgallat present in mango protect the body against colon, breast, leukemia and prostate cancers. 2. Helps in Lowering Cholesterol Mango has high level of vitamin C, pectin and fibres that help to lower serum cholesterol levels. Fresh mango is a rich source of potassium, which is an important component of cell and body fluids that helps to control heart rate and blood pressure. 3. Mangoes Nourishes Skin Mango is beneficial for skin health. It is a source of antioxidants which delays the onset of skin aging and pigmentation. Vitamin-C in mango helps in curing pimples and acne. It can be directly applied on the skin as it smoothens it and acts as a natural moisturizer. Antioxidants are responsible to protect against harmful free radicals which can cause skin cancer. Vitamin-A and beta carotene helps in rejuvenating the skin and brings glow to the skin. 4. Alkalizes the body According to natural health, mango juice is rich in tartaric acid, malic acid and traces of citric acid that primarily help in maintaining the alkali reserve of the body. 5. Weight loss Mango has a lot of vitamins and nutrients that help the body feel fuller. Also, the fibrous fruit boosts the digestive function of the body by burning additional calories, helping in weight loss. 6. Regulates diabetes Mango Juice Not only the fruit Juice but the leaves of mangoes are healthy too. For people suffering from diabetes, just boil 5-6 mango leaves in a vessel, soak it through night and drink the filtered decoction in the morning. This is helps in regulating your insulin levels. 7. Ap

What causes nausea and how can you avoid/treat it at home? You feel nauseous when your stomach either stops contracting or... Ever wonder why you feel so uneasy while driving across a rough, bumpy road? How does nervousness lead to nausea? Patients with nausea make up 6.7% of all cases treated...

Today was an exceptionally bright day. At least the morning. The rest of the day was marred by Kate throwing up on me nonstop. She felt a strong sensation of nausea and dizziness. But why does she eat at that weird Mexican place when she knows it makes her stomach sick? Every time she goes there, she feels a gut-wrenching, stomach-turning urge to release all that her belly holds. I mean, the stomach is an elastic bag made of muscular walls containing acid. We read that in science once. But why does Kate's stomach hold a serious grudge against Mexican food?

Vitamins and supplements are actually beneficial for your hair, skin and nails. Here we have investigated to find how to they work and why you should consider these vitamin supplements.

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Avocados are an amazing superfood with a rich flavor and an impressive list of health benefits. Here's why they are so healthy and some seriously good reasons to get more of them into your diet.

There are many great reasons why protein shakes, as part of a balanced and healthy diet, can be very beneficial to the body, especially when it comes to gaining muscle mass. It's all about drinking the right type of shake at the right time. However there's a lot of unhelpful advice floating around the Internet these days.