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Matti Narkia

Thromboxane A2 - Wikipedia, the free encyclopedia - 0 views

en.wikipedia.org/...Thromboxane_A2

thromboxane A2 thromboxane_A2 TXA2 info reference wikipedia blood_clots aspirin COX-1 COX unstable omega-6 AA nutrition

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    Thromboxane A2 (TXA2) is a thromboxane. It is generated from prostaglandin H2 by thromboxane-A synthase. It is also a major component of blood clots. Aspirin irreversibly inhibits platelet cyclooxygenase 1 preventing the formation of prostaglandin H2, and therefore thromboxane A2. TXA2 is very unstable in aqueous solution, since it is hydrolyzed within about 30 seconds to the biologically inactive thromboxane B2. Due to its very short half life, TXA2 primarily functions as an autocrine or paracrine mediator in the nearby tissues surrounding its site of production.
Matti Narkia

Thromboxane - Wikipedia, the free encyclopedia - 0 views

en.wikipedia.org/Thromboxane

thromboxane TX info reference wikipedia eicosanoids vasoconstrictor hypertensive agent platelet aggregation platelet_aggregation thrombosis thromboxane_A2 A2 thromboxane_B2 B2 TXA2 TXB2 COX omega-6 AA nutrition

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    Thromboxane is a member of the family of lipids known as eicosanoids. The two major thromboxanes are thromboxane A2 and thromboxane B2. Thromboxane is named for its role in clot formation (thrombosis).
Matti Narkia

Lipid mediators: lipoxin and aspirin-triggered 15-epi-lipoxins. - Bentham Science Publi... - 0 views

www.benthamdirect.org/...content.php

2006 April study review lipxins lipoxin 15-Epi-Lipoxins aspirin-triggered aspirin lipd_mediators ATL inflammation resolution 12-LOX 5-LOX COX-2 LOX metabolism omega-6 AA nutrition medline eicosanoids

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    Lipid mediators: lipoxin and aspirin-triggered 15-epi-lipoxins. Romano M. Inflamm Allergy Drug Targets. 2006 Apr;5(2):81-90. Review. PMID: 16613567
Matti Narkia

Aspirin-triggered lipoxin A4 blocks reactive oxygen species generation in end... - 0 views

www.schattauer.de/index.php

2007 January study research lipoxins lipoxin A4 lipoxin_A4 LXA4 omega-6 AA aspirin-triggered aspirin ATL CVD angiotensin ROS generation ROS_generation novel antioxidative mechanism nutrition medline

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    Aspirin-triggered lipoxin A4 blocks reactive oxygen species generation in endothelial cells: a novel antioxidative mechanism. Nascimento-Silva V, Arruda MA, Barja-Fidalgo C, Fierro IM. Thromb Haemost. 2007 Jan;97(1):88-98. PMID: 17200775 DOI: 10.1160/TH06-06-0315
Matti Narkia

Lipoxin A4 levels in asthma: relation with disease severity and aspirin sensitivity. - ... - 0 views

www3.interscience.wiley.com/...abstract

2007 October study research epidemiolgical humans lipoxins lipoxin A4 lipoxin_A4 LXA4 anti-inflammatory eicosanoid omega-6 AA asthma severity aspirin inflammation low levels low_levels nutrition medline 15-epi-LXA4 AERD

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    Lipoxin A4 levels in asthma: relation with disease severity and aspirin sensitivity. Celik GE, Erkekol FO, Misirligil Z, Melli M. Clin Exp Allergy. 2007 Oct;37(10):1494-501. PMID: 17883729 DOI: 10.1111/j.1365-2222.2007.02806.x
Matti Narkia

Native and aspirin-triggered lipoxins control innate immunity by inducing proteasomal d... - 0 views

jem.rupress.org/...1077

2008 May study research in_vivo lipoxins lipoxin native aspirin-triggered aspirin innate immunity innate_immunity TRAF6 SOCS-2 nutrition medline omega-6 AA anti-inflammatory LXA4 ATL ASA

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    Native and aspirin-triggered lipoxins control innate immunity by inducing proteasomal degradation of TRAF6. Machado FS, Esper L, Dias A, Madan R, Gu Y, Hildeman D, Serhan CN, Karp CL, Aliberti J. J Exp Med. 2008 May 12;205(5):1077-86. Epub 2008 Apr 14. PMID: 18411340 doi:10.1084/jem.20072416
Matti Narkia

Anti-inflammatory actions of lipoxin A4 and aspirin-triggered lipoxin are SOCS-2 depend... - 0 views

www.nature.com/...nm1355.html

2006 March nature study research in_vivo lipoxins lipoxin A4 lipoxin_A4 LXA4 aspirin anti-inflammatory actions SOCS-2 IL-12 dendritic_cells nutrition medline omega-6 AA

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    Anti-inflammatory actions of lipoxin A4 and aspirin-triggered lipoxin are SOCS-2 dependent. Machado FS, Johndrow JE, Esper L, Dias A, Bafica A, Serhan CN, Aliberti J. Nat Med. 2006 Mar;12(3):330-4. Epub 2006 Jan 15. PMID: 16415877 doi:10.1038/nm1355\n
Matti Narkia

Lipoxin - Wikipedia, the free encyclopedia - 0 views

en.wikipedia.org/Lipoxin

lipoxin lipoxins info reference wikipedia eicosanoids inflammation resolution omega-6 arachidonic_acid AA lipoxin_A4 LXA4 lipoxin_B4 LXB4 NF-KappaB anti-inflammatory mediators lipid_mediators nutrition A4 B4

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  • Matti Narkia on 06 Aug 09
     
    Lipoxins are a series of anti-inflammatory mediators. Lipoxins are short lived endogenously produced nonclassic eicosanoids whose appearance in inflammation signals the resolution of inflammation. They are abbreviated as LX, an acronym for lipoxygenase (LO) interaction products. At present two lipoxins have been identified; lipoxin A4 (LXA4) and lipoxin B4 (LXB4)
Matti Narkia

Eicosapentaenoic acid is anti-inflammatory in preventing choroidal neovascularization i... - 0 views

www.iovs.org/...4328

2007 September study research in_vivo animal_study omega-3 EPA choroidal neovascularization CNV age-related_macular_degeneration AMD blindness nutrition medline VEGF IL-6 ICAM-1 MPC-1 eyes

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    Eicosapentaenoic acid is anti-inflammatory in preventing choroidal neovascularization in mice. Koto T, Nagai N, Mochimaru H, Kurihara T, Izumi-Nagai K, Satofuka S, Shinoda H, Noda K, Ozawa Y, Inoue M, Tsubota K, Oike Y, Ishida S. Invest Ophthalmol Vis Sci. 2007 Sep;48(9):4328-34. PMID: 17724224 DOI:  10.1167/iovs.06-1148
Matti Narkia

Docosahexaenoic acid induces an anti-inflammatory profile in lipopolysaccharide-stimula... - 0 views

www.jnutbio.com/...abstract

2007 April study research in_vitro omega-3 DHA EPA macrophages cytokines NF-KappaB TNF-alpha IL-6 IL-1beta nutrition medline mRNA expression anti-inflammatory

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    Docosahexaenoic acid induces an anti-inflammatory profile in lipopolysaccharide-stimulated human THP-1 macrophages more effectively than eicosapentaenoic acid. Weldon SM, Mullen AC, Loscher CE, Hurley LA, Roche HM. J Nutr Biochem. 2007 Apr;18(4):250-8. Epub 2006 Jun 16. PMID: 16781858 doi:10.1016/j.jnutbio.2006.04.003
Matti Narkia

Differential immunomodulation with long-chain n-3 PUFA in health and chronic disease - ... - 0 views

journals.cambridge.org/...displayFulltext

2007 May study review humans immunomodulation omega-3 DHA EPA fish_oil immune system function immunity nutrition medline immune_function cell-mediated cell-mediated_immunity T-cells Th1 natural_killer_cells NK_cells cytokines

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    Differential immunomodulation with long-chain n-3 PUFA in health and chronic disease. Sijben JW, Calder PC. Proc Nutr Soc. 2007 May;66(2):237-59. Review. PMID: 17466105 doi:10.1017/S0029665107005472
Matti Narkia

Impact of fish oil enriched total parenteral nutrition on DNA synthesis, cytokine relea... - 0 views

journals.cambridge.org/...displayFulltext

2002 January bjn study research clinical_trial rct humans elderly older old fish_oil omega-3 parenteral nutrition TPN medline immune system function immunity IFN-gamma TNF-alpha IL-2 postoperative fish oil

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    Impact of fish oil enriched total parenteral nutrition on DNA synthesis, cytokine release and receptor expression by lymphocytes in the postoperative period. Schauder P, Röhn U, Schäfer G, Korff G, Schenk HD. Br J Nutr. 2002 Jan;87 Suppl 1:S103-10. PMID: 11895146 doi:10.1079/BJN2001463
Matti Narkia

Phospholipase A(2) activation as a therapeutic approach for cognitive enhancement in ea... - 0 views

www.springerlink.com/...fulltext.html

2009 January study research review phospholipase_A2 PLA2 activation learning memory cognitive_training cognition therapeutic Alzheimer's_disease Alzheimer's mild cognitive_impairment brain medline iPLA2 omega-6 AA ARA AD nutrition

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    Phospholipase A(2) activation as a therapeutic approach for cognitive enhancement in early-stage Alzheimer disease. Schaeffer EL, Forlenza OV, Gattaz WF. Psychopharmacology (Berl). 2009 Jan;202(1-3):37-51. Epub 2008 Oct 14. PMID: 18853146 DOI: 10.1007/s00213-008-1351-0
Matti Narkia

Phospholipase A(2) activation as a therapeutic approach for cognitive enhancement in ea... - 0 views

www.springerlink.com/...ph7h8j02207366m5

2009 January study research review phospholipase_A2 PLA2 activation learning memory cognitive_training cognition therapeutic Alzheimer's_disease Alzheimer's mild cognitive_impairment brain medline iPLA2 omega-6 AA ARA AD nutrition

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  • Matti Narkia on 06 Aug 09
     
    Phospholipase A(2) activation as a therapeutic approach for cognitive enhancement in early-stage Alzheimer disease. Schaeffer EL, Forlenza OV, Gattaz WF. Psychopharmacology (Berl). 2009 Jan;202(1-3):37-51. Epub 2008 Oct 14. PMID: 18853146 DOI: 10.1007/s00213-008-1351-0
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