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NINDS - a Brain-Recording Device that Melts into Place - The technology could pave the way for better devices to monitor and control seizures, and to transmit signals from the brain past damaged parts of the spinal cord. "These implants have the potential to maximize the contact between electrodes and brain tissue, while minimizing damage to the brain. They could provide a platform for a range of devices with applications in epilepsy, spinal cord injuries and other neurological disorders," said Walter Koroshetz, M.D., deputy director of the National Institute of Neurological Disorders and Stroke (NINDS), part of the National Institutes of Health.

University of Medicine & Dentistry of New Jersey 2007 Study documents Widespread Repair of Neonatal Brain Injury from Adult Stem Cells - Neuroscientists at UMDNJ-New Jersey Medical School have discovered that the neonatal brain possesses a previously unknown capacity to replace damaged neurons in multiple brain regions. Furthermore, their research reveals that the production of these new neurons lasts for at least five months following injury.Levison's study reveals that in addition to neurons acquiring new or different responsibilities, that another adaptive response, one that has not been suspected, occurs. Their data show that large numbers of new neurons are produced from the brain's resident stem cells during their recovery from injury. These findings suggest that these new neurons are further increasing the infant brain's ability to repair itself after injury.

Long-term evaluation of granulocyte-colony stimulating factor on hypoxic-ischemic brain damage in infant rats. Hypoxia-ischemia (HI), as a major cause of fetal brain damage, has long-lasting neurological implications. Therefore, therapeutic interventions that attenuate the neuropathological out come of HI while also improving the neurofunctional outcome are of paramount clinical importance. The aim of this study was to investigate the long-term functional and protective actions of granulocyte-colony stimulating factor (G-CSF) treatment in an experimental model of cerebral. RESULTS: Granulocyte-colony stimulation promoted somatic growth and prevented brain atrophy and underdevelopment of the heart in infant rats.

NICHD - National Institute of Health - Eunice Kennedy Shriver National Institute of Child Health & Human Development - Story of Discovery - Research to Prevent Brain Damage in Newborns

PubMed Study Abstract: Vasoparalysis associated with brain damage in asphyxiated term infants - Dept of Neonatalogy, Rigshospitalet, Copenhagaon, Denmark, 1990

Centers for Disease Control and Prevention CDC 0 Jaundice / Kernicterus - Did you know that jaundice can sometimes lead to brain damage in newborns? - Prevention - Treatment - coping - Free Materials - Frequently Asked Questions and more.

PubMed Abstract of hypothesis article reviewing the Mechanisms of Secondary Brain Injury

NINDS - Researchers Identify a Signal for Cell Death during Stroke - In a new study, researchers have identified a signal that promotes the death of vulnerable brain cells in an animal model of stroke. In the future, drugs designed to inhibit this death signal might help reduce brain damage in stroke patients

Preventable Infant Brain Damage on the Rise - The threat of kernicterus is returning - 2003 article

National, non-profit organization whose mission is to accelerate the development of brain repair therapies and cures by supporting cutting-edge collaborative research on brain damage due to childhood illness, injury, or any other cause. Provides information and resources for families and health care providers."

NIH, NCBI PubMed article abstract: Significance of intrapartum asphyxia for the onset of fetal brain damage

Completed study sponsored by NINDS designed to use positron emission tomography to measure brain energy use. Positron Emission Tomography (PET) is a technique used to investigate the functional activity of the brain. The PET technique allows doctors to study the normal processes of the brain (central nervous system) of normal individuals and patients with neurologic illnesses without physical / structural damage to the brain.

NIH Medline Plus - Low Umbilical Cord pH Tied to Death, Brain Damage

In large, multicenter clinical studies, a therapy has been shown to significantly lower the risk of lung and brain damage in some very low birthweight premature infants. Results from two randomized clinical trials demonstrate that when given within the first few weeks of life, inhaled nitric oxide helps prevent chronic lung disease in some low birthweight premature infants. In addition, when used within 48 hours after birth, treatment appears to protect some premature newborns from brain injury.

Harvard Medical School Publication - Public Release date: 25 Jan 1999

Neuropathology online - Course material - Asphyxia and hypoxic-ischemic encephalopathy in mature infants

Eunice Kennedy Shriver National Institute of child Health and Human Development (NICHD) Study to evaluate the safety of high-dose Erythropoietin (Epo) in infants who did not get enough oxygen during birth. Erythropoietin is a hormone normally found in the body that may protect brain cells from damage due to lack of oxygen.

NIH PUbMed Abstract of Russian study documenting the Physical and neurological state of the newborn afer perinatal asphyxia.This paper is presented as modern conceptions about asphyxia origin, risk factors, neurological and systemic complications for child nervous system and organism.

Completed research study of head cooling to determine whether cooling babies' heads can reduce or prevent brain damage that may have resulted from temporarily reduced oxygen supply to the brain

A recent study using high-dose rhEpo (3000 U rhEpo/kg body weight at birth) for neuroprotection in very preterm infants revealed that no signs of adverse effects of early high-dose rhEpo treatment in very preterm infants were identified. Contrary to this, a recent study in PVL of a rat model revealed that using a low dose rhEpo (50-100 U/kg) was effective in the treatment of brain damage induced by hypoxia-ischemia and did not affect normal oligodendrocyte maturity. On this basis, the researchers intent to investigate (1) whether low-dose rhEpo (100 U/kg) or high-dose rhEpo (3,000 U/kg) given to very preterm infants (gestation age < 32 weeks) immediately after birth and subsequently during the first 2 days is safe and possesses neuroprotective properties;(2) whether there are gender differences in response to the hypoxia-ischemic insult and EPO treatment; (3)the pharmacokinetics of low dose and high dose rhEPO.