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Pub Med Article Abstract presents a short clinical review of metabolic diseases associated with metabolic acidosis in the newborn and discusses appropriate investigations and differential diagnoses. It is important to remember the possibility of metabolic diseases as the cause of metabolic acidosis in the newborn period.

PubMed Article - Metabolic acidosis in newborn infants

1992 Study to determine if there was a significant association between an intrapartum amniotic fluid index (AFI) < or = 5.0 cm and neonatal acidosis (umbilical arterial pH < 7.20 or metabolic acidosis [umbilical arterial pH < 7.20 and base deficit > 10 mEq/L]).

PubMed abstract: Neonatal depression and birth asphyxia in the low birthweight neonate. In 392 low birthweight neonates, acidosis as evident from umbilical artery pH 7.1 or less was strongly associated with Apgar score 6 or lower at 1 minute. However, most cases that were depressed (Apgar score 6 or lower at 1 minute) were not acidotic. Neonatal depression was most strongly and directly correlated with gestational age. Neonatal depression and birth asphyxia are distinct entiti

PubMed Abstract of study to assess the relationship between intrapartum maternal fever and neonatal acidosis as risk factors for neonatal encephalopathy

NIH, NCBI PubMed article abstract: Significance of intrapartum asphyxia for the onset of fetal brain damage

National Institute of Health NIH, National Library of Medicine PubMed article Abstract: Defining cerebral palsy: pathogenesis, pathophysiology and new intervention. The focus of this paper is to explore antenatal antecedents as etiologies of CP and the impact of obstetric care on the prevention of CP.

University of Weatern Ontario, Canada study to estimate to what extent computerized fetal heart rate (FHR) parameters are affected by labor and to estimate the relationship between FHR parameters and the degree of fetal metabolic acidosis in laboring patients at term. Study concluded that in term pregnant women with reassuring FHR tracing, labor causes an increase in both short- and long-term FHR variation, which was abolished in the presence of nonreassuring FHR tracing. Computer-derived FHR parameters studied during the last hour of labor were not correlated with the degree of metabolic acidosis as measured in the umbilical artery at birth.

Psychiatric Times Article - Neurological Complications of Perinatal Asphyxia