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CDC Center for Disease Control and Prevention - About Cerebral Palsy

Archive from Cerebral Palsy Internation Research Foundation. Results of study conducted to examine the effect of magnesium sulfate on the rate of stillbirth or infant death and rate of moderate or severe cerebral palsy at or after the after of 2 years

Cerebral Palsy at mayoclinic.com - Definition - Symptoms - Risk Factors - Complications - Tests and Diagnosis - Treatments and drugs - Prevention

NIH, and Eunice Kennedy Shriver National Institute of Child Health and Human Development - Review and trial to determine whether magnesium sulfate administered to women at risk of preterm delivery may reduce the risk of cerebral palsy in their children

Definition of Cerebral Palsy at Centers for Disease Control and Prevention CDC - Types of Cerebral Palsy - Description - Symptoms - Developmental Disabilities

Online brochure describing what Cerebral Palsy is, its causes, its treatments, and how it might possibly be prevented.

Article from The New England Journal of Medicne - offering information on a Randomized, Controlled Trial of Magnesium Sulfate for the Prevention of Cerebral Palsy

National Institute of Health NIH, National Library of Medicine PubMed article Abstract: Defining cerebral palsy: pathogenesis, pathophysiology and new intervention. The focus of this paper is to explore antenatal antecedents as etiologies of CP and the impact of obstetric care on the prevention of CP.

The New England Journal of Medicine Abstract: Can We Prevent Cerebral Palsy, Oct 2003

University of California - Irvine conducted successful study involving two compounds developed by UC Irvine and Northwestern University scientists that prevented cerebral palsy in preclinical animal trials, giving hope that a new drug for humans may be on the horizon

PRIMARY OBJECTIVE of study is to determine whether cerebral outcome is improved if infants born between 24 0/7 and 31 6/7 gestational weeks at birth receive erythropoietin in high dose in the first three days after birth. SECONDARY OBJECTIVES To determine whether early administration of EPO alters the incidence of complications typically associated with preterm birth, i.e. mortality, septicaemia, necrotising enterocolitis, bronchopulmonary dysplasia (oxygen dependency at 36 weeks postmenstrual age), retinopathy, intracranial haemorrhage, white matter disease (periventricular leucomalacia), growth failure, cerebral palsy and handicap at 5 years.

Magnesium is neuroprotective in neonatal animal models of acquired hypoxic-ischemic and/or inflammatory cerebral lesions. It is associated with a significant reduction of perinatal death and cerebral palsy in some observational studies.The objective of the study is to assess if prenatal magnesium sulfate given to women at risk of preterm birth before 33 week's gestation is neuroprotective

National Library of Medicine National Institutes of Health PubMed Abstract: Antenatal magnesium sulfate for the prevention of cerebral palsy in preterm infants less than 34 weeks gestation: a systematic reiew and metaanalysis

Study sponsored by Eunice Kennedy Shriver National Institute of Child Health and Human Development NICHD will evaluate the effects of giving magnesium to premature infants.

Magnesium Sulfate Study for the Prevention of Cerebral Palsy

As many more premature infants survive, the numbers of these infants with health problems increases. The rate of cerebral palsy (CP) in extremely premature infants is approximately 20%. Magnesium sulfate, the most commonly used drug in the US to stop premature labor, may prevent CP. This trial tests whether magnesium sulfate given to a woman in labor with a premature fetus (24 to 31 weeks out of 40) will reduce the rate of death or moderate to severe CP in the children at 2 years. The children receive ultrasounds of their brains as infants and attend three follow-up visits over two years to assess their health and development.

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Study will determine whether giving low-dose indomethacin to infants weight 500 to 999 grams (approximately 1 to 2 pounds) at birth improves their survival without cerebral palsy or developmental problems at 18 to 22 months of age.

A Pilot Study to Assess the Efficacy and Effectiveness of High-Frequency Chest Wall Oscillation (HFCWO) in Preventing Pulmonary Exacerbations in Children With Muscle Weakness and Restrictive Lung Disease To further demonstrate that airway clearance provided by Vest therapy reduces the frequency of respiratory exacerbations requiring hospitalization or antibiotic utilization in patients with muscle weakness and restrictive lung disease.

Italian sponsored and NIH PubMed published abstract of study in the role of foetal lactate in the prevention of cerebral palsy during labor