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Lee Vander Loop

Pharmacokinetics of Immediate-Release vs. Delayed-Release Omeprazole in Gastroparesis - 0 views

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    Completed study comparing the blood drug levels of two prescribed medications, Immediate-release omeprazole 40 mg powder and delayed-release omeprazole 40 mg capsule to determine which drug is better absorbed in patients with a slow stomach emptying (gastroparesis). Delayed-release omeprazole has a protective coating to prevent the drug omeprazole from being neutralized by stomach acid. Immediate-release omeprazole has sodium bicarbonate (antacid) which neutralizes the stomach acid, eliminating the need for a protective coating. Immediate-release omeprazole suspension may have a more rapid pharmacokinetic profile and greater overall drug absorption in gastroparesis.
Lee Vander Loop

Drug Trial for Children with Partial Onset Seizures - DukeHealth.org - 0 views

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    Duke University and Multicenter, Open-label Study to Investigate the Safety, Tolerability and Pharmacokinetics of Lacosamine (LCM) Oral Solution (syrup) as Adjunctive Therapy in Children with Partial Onset Seizures. This study is being done to test the safety of the study drug Lacosamide (LCM) syrup and how the body processes it.
Lee Vander Loop

Efficacy and Safety Study Comparing Lorazepam and Diazepam for Children in the Emergenc... - 0 views

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    Study comparing diazepam, a drug that is labeled by the FDA for this indication, with lorazepam. The study will show whether one drug is more effective and safer than the other.
Lee Vander Loop

Lamotrigine Cognitive Function Study in Adult Untreated Epilepsies - Full Text View - C... - 0 views

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    Korean study comparing the effect of anti-epileptic drugs' (AEDs) long-term treatment on cognitive function. This study is an open-label, randomized, multicenter comparative trial of lamotrigine versus carbamazepine"
Lee Vander Loop

17OHP for Reduction of Neonatal Morbidity Due to Preterm Birth (PTB) in Twin and Triple... - 0 views

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    Hypothesis of study is that among women with twin or triplet pregnancies, weekly injections of 17-alpha-hydroxyprogesterone caproate (17OHP), started before 24 weeks of gestation, will reduce neonatal morbidity by reducing the rate of preterm delivery.This study involves two concurrent double-blinded randomized clinical trials of 17OHP versus placebo. Each trial will test the efficacy and safety of 17OHP in women with a specific risk factor for preterm birth. The two risk factors to be studied are: Twin pregnancy - Triplet pregnancy
Lee Vander Loop

Phase II Randomized Study of Early Surgery Vs Multiple Sequential Antiepileptic Drug Th... - 0 views

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    Completed study that evaluated the efficacy of surgical resection of an identifiable zone of cortical abnormality versus multiple drug therapy in children with infantile spasms refractory to standard therapy: II. Assess how infantile spasms interfere with development and whether this is partially reversible. III. Determine the predictors of good surgical outcome and whether surgery permanently controls seizures and improves development.
Lee Vander Loop

Progesterone for managemnet of preterm premature rupture of the membranes - 0 views

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    Study to determine if the drug 17-hydroxyprogesterone caproate can help reduce the risk of preterm delivery in women with certain risk factors for preterm birth. We hope to learn whether this same medication can be used to prolong pregnancy in a group of patients in whom this medication has not been previously studied. Specifically, we hope to learn whether progesterone supplementation will delay delivery in women with pre-term, premature rupture of membranes (PPROM).
Lee Vander Loop

Pregabalin in Pediatric Patients with Partial Onset Seizures - DukeHealth.org - 0 views

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    Duke University Clinical trial and study to evaluate the safety, tolerability, and pharmacokinetics of the study drug Pregabalin in pediatric patients with partial onset seizures in addition to measuring how much pregabalin is in your child's blood and urine after he/she takes the study drug
Lee Vander Loop

A Pharmacokinetics (Blood Levels), Pharmacodynamics (How the Drug Acts on the Body) and... - 0 views

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    Study is to evaluate the pharmacokinetics (blood levels), pharmacodynamics (how the drug acts on the body), and the safety of rabeprazole sodium for the treatment of gastroesophageal reflux disease (GERD) in new borns and pre-term infants (less than 44 weeks of age).
Lee Vander Loop

Pilot Study of Bumetanide for Newborn Seizures - 0 views

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    Study to obtain pharmacokinetic and safety data of bumetanide in newborns with refractory seizures. The overall hypothesis is that bumetanide, added to conventional antiepileptic (antiseizure) medications, will be a safe and well tolerated medication, compared with conventional antiepileptic drugs alone.
Lee Vander Loop

Epilepsy Drug Discovery - Carnegie Mellon University - 0 views

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    Preventing Seizure Progression - Carnegie Mellow University researchers have identified a new anticonvulsant compount that has the potential to stop the development of epilepsy. Findings are published in the journal Epilepsia.
Lee Vander Loop

Study to evaluate an investigational, oral medication for epilepsy patients with uncont... - 0 views

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    Mayo study to evaluate a potential new treatment for epilepsy. Researchers want to learn if the investigational drug called perampanel is safe and can help people with partial seizures who are already taking seizure medications and the current seizure medications are not enough to control those seizures. Perampanel is being tested as a possible add-on drug for people with seizures who are taking other seizure medications.
Lee Vander Loop

A Study to Evaluate Safety, Side Effects, Muscle Activity and Speed of Gastric Emptying... - 0 views

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    Completed study on Motilin, a peptide, whose action is controlled by motilin receptors located in the gut. Action of Motilin at motilin receptors increases the gastric emptying rate (rate of emptying of food and fluid from the stomach). Compounds which stimulate motilin receptors therefore provide a potential approach to the treatment of a range of clinical conditions where delayed gastric emptying may contribute to symptoms, such as enteral feeding ntolerance (post-operative or intensive care patients), gastroparesis, diabetic gastroparesis, and functional dyspepsia. This study is the First Time In Human study for the motilin receptor agonist, GSK962040.
Lee Vander Loop

Safety and Quality of Life Study of Dexlansoprazole Modified Release Formulation to Tre... - 0 views

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    The purpose of this study is to determine the long-term safety profile of daily treatment with dexlansoprazole MR in subjects with gastroesophageal reflux disease.
Lee Vander Loop

Measuring Signatures in the Fluid Surrounding the Spinal Cord in Patients Who Have Prob... - 0 views

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    "The purpose of this study is to record signatures from the fluid surrounding the spinal cord from people who have an implanted drug infusion system"
Lee Vander Loop

Reflux Esophagitis Phase III Study (Maintenance Treatment) - 1 views

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    Study to Compare the Efficacy and Safety of Esomeprazole 20 mg Once Daily Oral Administration With Omeprazole 10 mg and Esomeprazole 10 mg Once Daily Oral Administration in Maintenance Treatment in Patients With Healed Reflux Esophagitis
Lee Vander Loop

Erythropoietin for Infants With Brain Injuries Due to Oxygen Deprivation at Birth - 2 views

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    Eunice Kennedy Shriver National Institute of child Health and Human Development (NICHD) Study to evaluate the safety of high-dose Erythropoietin (Epo) in infants who did not get enough oxygen during birth. Erythropoietin is a hormone normally found in the body that may protect brain cells from damage due to lack of oxygen.
Lee Vander Loop

Researchers Identify a Signal for Cell Death during Stroke: National Institute of Neuro... - 0 views

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    NINDS - Researchers Identify a Signal for Cell Death during Stroke - In a new study, researchers have identified a signal that promotes the death of vulnerable brain cells in an animal model of stroke. In the future, drugs designed to inhibit this death signal might help reduce brain damage in stroke patients
Lee Vander Loop

Efficacy, Safety and Tolerability of TRI476 (Oxcarbazepine) in Children With Inadequate... - 0 views

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    Study is designed to provide short term efficacy and safety data of TRI476 in children with inadequately-controlled partial seizures. The purpose of study is to confirm that TRI476 as adjunctive therapy is effective and safe.
Lee Vander Loop

Preventing Epilepsy After Traumatic Brain Injury With Topiramate - University of Pennsy... - 0 views

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    Research/study hypothesis is that topiramate will reduce acute seizures after traumatic brain injury and will help prevent the development of epilepsy after traumatic brain injury.
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