Group items tagged

PubMed Study Abstract: Ten indicators available during the first two hours of life, such as clinical criteria of neonatal distress and postnatal arterial blood gases, were compared with the neonatal neurological course in sixty full term newborns with significant birth asphyxia in order to test their value for the diagnosis and the short-term prognosis of severe birth asphyxia. Birth asphyxia was defined as severe when it was followed by symptoms of moderate or severe post-asphyxial encephalopathy.

NCBI NIH PubMed.gov Abstract of Finland study investigating reproductive maternal risk factors of intrapartum fetal asphyxia. The study concluded that the incidence of intrapartum fetal asphyxia was 2.5%. Placental abruption, primiparity, alcohol use during pregnancy, low birth weight, preeclampsia, male fetuses, and small-for-gestational age births were independent risk factors of intrapartum asphyxia, with adjusted relative risks of 3.74, 3.10, 1.75, 1.57, 1.49, 1.48 and 1.33, respectively. Most cases of intrapartum fetal asphyxia occur in low-risk pregnancies and, therefore, risk screening in antenatal care cannot accurately predict which women will eventually need emergency care for fetal asphyxia.

PubMed abstract: Neonatal depression and birth asphyxia in the low birthweight neonate. In 392 low birthweight neonates, acidosis as evident from umbilical artery pH 7.1 or less was strongly associated with Apgar score 6 or lower at 1 minute. However, most cases that were depressed (Apgar score 6 or lower at 1 minute) were not acidotic. Neonatal depression was most strongly and directly correlated with gestational age. Neonatal depression and birth asphyxia are distinct entiti

NIH PUbMed Abstract of Russian study documenting the Physical and neurological state of the newborn afer perinatal asphyxia.This paper is presented as modern conceptions about asphyxia origin, risk factors, neurological and systemic complications for child nervous system and organism.

PubMed Abstract - Early diagnosis of perinatal asphyxia by nucleated red blood cell count: a case-control study

PubMed Abstract: Perinatal asphyxia: current status and approaches towards neuroprotective strategies, with focus on sentinel proteins

Psychiatric Times Article - Neurological Complications of Perinatal Asphyxia

Wiley Interscience - Study - Assessing the contribution of birth asphyxia to cerebral palsy in term singletons

NICHD, NIH, Sponored and American Academy of Pediatrics, and American College of Obstetricians and Gynecologists co-sponsored study and Report of the Workship on Acute Perinatal Asphyxia in Term Infants.

Neuropathology online - Course material - Asphyxia and hypoxic-ischemic encephalopathy in mature infants

Future planned study being conducted by the University of California to determine the safety and pharmacokinetics of moderate to high doses of erythropoietin in newborn infants with birth asphyxia.

Acute birth asphyxia is a cause of death and neurological injury. At present, there is no proven treatment; however, studies in animals suggest that brain cooling may protect against brain injury. This large multicenter trial will randomize term infants with a history of problems at delivery and signs of depression to total body cooling or standard care.

NIH PubMed Central Archives of Disease in Childhood - Umbilical venous blood ph: a useful aid in the diagnosis of asphyxia at birth. Umbilical venous blood, and umbilical arterial blood pH, PO2, PCO2, and base excess were determined in 453 term infants at birth. The results indicate that umbilical venous blood pH, and umbilical arterial blood pH are significantly related to each another.

Eunice Kennedy Shriver National Institute of child Health and Human Development (NICHD) Study to evaluate the safety of high-dose Erythropoietin (Epo) in infants who did not get enough oxygen during birth. Erythropoietin is a hormone normally found in the body that may protect brain cells from damage due to lack of oxygen.

2007 Icelandic study to assess the incidence, obstetric risk factors and the squela of severe asphyxia at Landspitali university hospital.

Study sponsored by Imperial College London - Hypothesis: Study aims to determine whether whole body cooling to 33-34°C is a safe treatment that improves survival, without severe neurological or neurodevelopmental impairments at 18 months, of term infants suffering perinatal asphyxial encephalopathy

Italian sponsored and NIH PubMed published abstract of study in the role of foetal lactate in the prevention of cerebral palsy during labor

PEDIATRICS Journal Abstract of study to determine whether serial head circumference measurements and decreased rate of head growth in asphyxiated full-term newborns during the first few months of life may predict the development of eventual microcephaly.

Study is to determine whether nerve growth factor (cerebrolysin®) therapy will improve the psychomotor outcome in infants with moderate and severe hypoxic ischemic encephalopathy.

Completed Zhengzhou University study to investigate whether systemic hypothermia induced up to 10 hrs after birth would improve the neurodevelopmental outcome at 18 months in infants with moderate or severe HIE.