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Lee Vander Loop

Recombinant Erythropoietin for Neuroprotection in Very Preterm Infants - China Medical ... - 0 views

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    A recent study using high-dose rhEpo (3000 U rhEpo/kg body weight at birth) for neuroprotection in very preterm infants revealed that no signs of adverse effects of early high-dose rhEpo treatment in very preterm infants were identified. Contrary to this, a recent study in PVL of a rat model revealed that using a low dose rhEpo (50-100 U/kg) was effective in the treatment of brain damage induced by hypoxia-ischemia and did not affect normal oligodendrocyte maturity. On this basis, the researchers intent to investigate (1) whether low-dose rhEpo (100 U/kg) or high-dose rhEpo (3,000 U/kg) given to very preterm infants (gestation age < 32 weeks) immediately after birth and subsequently during the first 2 days is safe and possesses neuroprotective properties;(2) whether there are gender differences in response to the hypoxia-ischemic insult and EPO treatment; (3)the pharmacokinetics of low dose and high dose rhEPO.
Lee Vander Loop

Neuroprotection by Magnesium Sulfate Given to Women at Risk of Very Preterm Birth - 0 views

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    Magnesium is neuroprotective in neonatal animal models of acquired hypoxic-ischemic and/or inflammatory cerebral lesions. It is associated with a significant reduction of perinatal death and cerebral palsy in some observational studies.The objective of the study is to assess if prenatal magnesium sulfate given to women at risk of preterm birth before 33 week's gestation is neuroprotective
Lee Vander Loop

Perinatal asphyxia: current status and approaches ... [Neurotox Res. 2010] - PubMed result - 0 views

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    PubMed Abstract: Perinatal asphyxia: current status and approaches towards neuroprotective strategies, with focus on sentinel proteins
Lee Vander Loop

Study of Citicoline for the Treatment of Traumatic Brain Injury (COBRIT) - 0 views

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    Citicoline Brain Injury Treatment (COBRIT) trial of the effects of 90 days of citicoline on functional outcome in patients with complicated mild, moderate and severe traumatic brain injury. Citicoline (also known as CDP-Choline) is a naturally occurring endogenous compound. Citicoline may have neuroprotective effects and may potentiate neuro-recovery which has led to the evaluation of it as treatment for both stroke and TBI in animal models and in human clinical trials.
Lee Vander Loop

Long-term evaluation of granulocyte-colony stimula... [Intensive Care Med. 2010] - PubM... - 0 views

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    Long-term evaluation of granulocyte-colony stimulating factor on hypoxic-ischemic brain damage in infant rats. Hypoxia-ischemia (HI), as a major cause of fetal brain damage, has long-lasting neurological implications. Therefore, therapeutic interventions that attenuate the neuropathological out come of HI while also improving the neurofunctional outcome are of paramount clinical importance. The aim of this study was to investigate the long-term functional and protective actions of granulocyte-colony stimulating factor (G-CSF) treatment in an experimental model of cerebral. RESULTS: Granulocyte-colony stimulation promoted somatic growth and prevented brain atrophy and underdevelopment of the heart in infant rats.
Lee Vander Loop

Neonatal Erythropoietin in Asphyxiated Term Newborns - 1 views

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    Future planned study being conducted by the University of California to determine the safety and pharmacokinetics of moderate to high doses of erythropoietin in newborn infants with birth asphyxia.
Lee Vander Loop

Neuroprotective Effects of Hypothermia Combined With Inhaled Xenon Following Perinatal ... - 0 views

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    Imperial College London sponsored trial in newborn infants with perinatal asphyxial encephalopathy assessing whether a combination of hypothermia and inhaled xenon preserve cerebral metabolism and structure.
Lee Vander Loop

Does Erythropoietin Improve Outcome in Very Preterm Infants? - 0 views

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    PRIMARY OBJECTIVE of study is to determine whether cerebral outcome is improved if infants born between 24 0/7 and 31 6/7 gestational weeks at birth receive erythropoietin in high dose in the first three days after birth. SECONDARY OBJECTIVES To determine whether early administration of EPO alters the incidence of complications typically associated with preterm birth, i.e. mortality, septicaemia, necrotising enterocolitis, bronchopulmonary dysplasia (oxygen dependency at 36 weeks postmenstrual age), retinopathy, intracranial haemorrhage, white matter disease (periventricular leucomalacia), growth failure, cerebral palsy and handicap at 5 years.
Lee Vander Loop

Inflammatory Cytokines Associated With Perinatal Brain Injury - 2 views

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    Completed observational study assessed whether measurements of certain pro-inflammatory and anti-inflammatory cytokines in the blood (either singly or in combination) at birth and/or up to day of life 21 can predict cerebral palsy at 18-22 months corrected age.
Lee Vander Loop

Study of Cerebrolysin for Treatment of Neonatal Hypoxic Ischemic Encephalopathy - 0 views

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    Study is to determine whether nerve growth factor (cerebrolysin®) therapy will improve the psychomotor outcome in infants with moderate and severe hypoxic ischemic encephalopathy.
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