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Lee Vander Loop

Erythropoietin for Infants With Brain Injuries Due to Oxygen Deprivation at Birth - 2 views

clinicaltrials.gov/...NCT00491413

clinical trial clinical trials drug study biologic effect of Epo in asphyxia erythropoietin study research asphyxia hypoxemia erythropoiesis pharmacokinetics Erythropoietin study at NICHD birth injury risks

shared by Lee Vander Loop on 19 May 10 - Cached
  • Lee Vander Loop on 19 May 10
     
    Eunice Kennedy Shriver National Institute of child Health and Human Development (NICHD) Study to evaluate the safety of high-dose Erythropoietin (Epo) in infants who did not get enough oxygen during birth. Erythropoietin is a hormone normally found in the body that may protect brain cells from damage due to lack of oxygen.
Lee Vander Loop

Does Erythropoietin Improve Outcome in Very Preterm Infants? - 0 views

clinicaltrials.gov/...NCT00413946

clinical trial clinical trials neuroprotection erythropoietin

shared by Lee Vander Loop on 11 May 10 - Cached
  • Lee Vander Loop on 11 May 10
     
    PRIMARY OBJECTIVE of study is to determine whether cerebral outcome is improved if infants born between 24 0/7 and 31 6/7 gestational weeks at birth receive erythropoietin in high dose in the first three days after birth. SECONDARY OBJECTIVES To determine whether early administration of EPO alters the incidence of complications typically associated with preterm birth, i.e. mortality, septicaemia, necrotising enterocolitis, bronchopulmonary dysplasia (oxygen dependency at 36 weeks postmenstrual age), retinopathy, intracranial haemorrhage, white matter disease (periventricular leucomalacia), growth failure, cerebral palsy and handicap at 5 years.
Lee Vander Loop

Neonatal Erythropoietin in Asphyxiated Term Newborns - 1 views

clinicaltrials.gov/...NCT00719407

birth asphyxia birth asphyxia intervention neonatal encephalopathy hypoxic-ischemic encephalopathy clinical trial clinical trials erythropoietin neuroprotection research University of California

shared by Lee Vander Loop on 10 May 10 - Cached
  • Lee Vander Loop on 10 May 10
     
    Future planned study being conducted by the University of California to determine the safety and pharmacokinetics of moderate to high doses of erythropoietin in newborn infants with birth asphyxia.
Lee Vander Loop

Recombinant Erythropoietin for Neuroprotection in Very Preterm Infants - China Medical ... - 0 views

clinicaltrials.gov/...NCT00910234

clinical trial clinical trials research study erythropoietin neuroprotection

shared by Lee Vander Loop on 27 May 10 - Cached
  • Lee Vander Loop on 27 May 10
     
    A recent study using high-dose rhEpo (3000 U rhEpo/kg body weight at birth) for neuroprotection in very preterm infants revealed that no signs of adverse effects of early high-dose rhEpo treatment in very preterm infants were identified. Contrary to this, a recent study in PVL of a rat model revealed that using a low dose rhEpo (50-100 U/kg) was effective in the treatment of brain damage induced by hypoxia-ischemia and did not affect normal oligodendrocyte maturity. On this basis, the researchers intent to investigate (1) whether low-dose rhEpo (100 U/kg) or high-dose rhEpo (3,000 U/kg) given to very preterm infants (gestation age < 32 weeks) immediately after birth and subsequently during the first 2 days is safe and possesses neuroprotective properties;(2) whether there are gender differences in response to the hypoxia-ischemic insult and EPO treatment; (3)the pharmacokinetics of low dose and high dose rhEPO.
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