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The first comprehensive comparative effectiveness clinical trial of three widely used anti-seizure drugs for childhood absence epilepsy - the most common form of epilepsy in kids - has established an evidence-based approach for initial drug therapy. Published March 4 in the New England Journal of Medicine*, data from the double-blind, randomized, comparative clinical trial fill a large information gap in the treatment of childhood absence epilepsy, also known as "petit mal" epilepsy. The research, which identifies important differences between drugs in seizure control and side effects, is expected to impact how physicians select and monitor initial therapy for children with the disorder and ultimately lead to improved outcomes.

Preventing Seizure Progression - Carnegie Mellow University researchers have identified a new anticonvulsant compount that has the potential to stop the development of epilepsy. Findings are published in the journal Epilepsia.

Mayo clinic Epilepsy Treatments and drugs - Ketogenic Diet

Mayo study to look for genes that are the cause of epilepsy and to look for genes that have an impact on the effectiveness of over the counter and prescription medicines used to treat epilepsy.

NINDS Information Sheet on Seizures and Epilepsy: Hope through Research

Research/study hypothesis is that topiramate will reduce acute seizures after traumatic brain injury and will help prevent the development of epilepsy after traumatic brain injury.

PubMed - Abstract - Application of magnetoencephalography (MEG) in epilepsy patients with widespread spike or slow-wave activity

"The purpose of this study is to collect detailed information about the characteristics and genetics of a large number of individuals with epilepsy"

Mayo research study to determine if there are enough patients with hard to treat epilepsy that might qualify for a future study of a medical device that is being developed to treat epilepsy. Participants will not be testing the device during this study. The study doctor will be assessing seizure type(s) and determine how frequently they occur, and to verify if antiseizure medications can be held constant for a period of 12 weeks.

Cincinnati Children's is conducting a research study, sometimes known as a clinical trial or clinical study, to better understand what causes epilepsy and the role our genes play, which treatments will be more effective, and why some families have multiple relatives with seizures

Patients with epilepsy undergoing deep brain stimulation (DBS) have electroencephalograms (EEGs) recorded before and during their stimulation treatment. Subsequently we will be using computer-assisted analysis of the digitally-recorded EEG signals to assess the effects of DBS on the brain-wave frequency content and any abnormal seizure-like patterns that may be present.

WebMD Epilepsy Seizure Types and Symptoms

WebMD Epilepsy Health Center - Seizures - Topic Overview

Mayo study to evaluate a potential new treatment for epilepsy. Researchers want to learn if the investigational drug called perampanel is safe and can help people with partial seizures who are already taking seizure medications and the current seizure medications are not enough to control those seizures. Perampanel is being tested as a possible add-on drug for people with seizures who are taking other seizure medications.

NINDS sponsored study will examine the safety and effectiveness of infusing a chemical called muscimol into the brain to control seizures in patients with intractable epilepsy (frequent seizures that persist despite therapy). Muscimol, which is similar to a naturally occurring brain chemical called GABA, has been shown to reduce seizures in rats.

Safety and Efficacy of Vanquix™ Auto-Injector (Diazepam Injection) for the Management of Selected, Refractory Patients With Epilepsy Who Require Intermittent Medical Intervention to Control Episodes of Acute Repetitive Seizures

Charliet Foundation - Offering Hope through the Ketogenic Diet. Founded in 1994 after twenty month old Charlie Abrahams, having endured multiple daily seizures, and failed every available anti-convulsant drug and one brain surgery, was cured of his epilepsy by the ketogenic diet at Johns Hopkins Hospital. The diet was undertaken despite resistance from the five pediatric neurologists he had seen.

Intraoperative Optical Imaging Mapping of Neocortical Epilepsy in Human

A preeminent non-profit professional association of pediatric neurologists in the United States, Canada, and worldwide devoted to fostering the discipline of child neurology and promoting the optimal care and welfare of children with neurological and neurodevelopmental disorders. These disorders include epilepsy, cerebral palsy, mental retardation, learning disabilities, complex metabolic diseases, nerve and muscle diseases and a host of other highly challenging conditions

NINDS - a Brain-Recording Device that Melts into Place - The technology could pave the way for better devices to monitor and control seizures, and to transmit signals from the brain past damaged parts of the spinal cord. "These implants have the potential to maximize the contact between electrodes and brain tissue, while minimizing damage to the brain. They could provide a platform for a range of devices with applications in epilepsy, spinal cord injuries and other neurological disorders," said Walter Koroshetz, M.D., deputy director of the National Institute of Neurological Disorders and Stroke (NINDS), part of the National Institutes of Health.