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University of Medicine & Dentistry of New Jersey 2007 Study documents Widespread Repair of Neonatal Brain Injury from Adult Stem Cells - Neuroscientists at UMDNJ-New Jersey Medical School have discovered that the neonatal brain possesses a previously unknown capacity to replace damaged neurons in multiple brain regions. Furthermore, their research reveals that the production of these new neurons lasts for at least five months following injury.Levison's study reveals that in addition to neurons acquiring new or different responsibilities, that another adaptive response, one that has not been suspected, occurs. Their data show that large numbers of new neurons are produced from the brain's resident stem cells during their recovery from injury. These findings suggest that these new neurons are further increasing the infant brain's ability to repair itself after injury.

The Fern Lab - The Fern lab is located in the Department of Neurology at the University of Washington in Seattle. The lab's research focuses on ischemic injury of the brain, in particular the neonatal/developing brain. Ischemia is the term given to a loss of blood supply and can arise due to obstruction of a blood vessel (leading to a stroke), or from factors that are currently not well understood but which produce the brain injury that underlies cerebral palsy.

Trakya University School of Medicine, Turkey study to evaluate the impact of the Neonatal Resuscitation Program (NRP) on morbidity and mortality of newborn infants with perinatal asphyxia. The study concluded that after Neonatal resuscitation (RP) courses, the number of patients with perinatal asphyxia and with no resuscitation and also the duration of hospitalization decreased significantly, whereas the first minute Apgar scores increased significantly.

Neuropathology online - Course material - Asphyxia and hypoxic-ischemic encephalopathy in mature infants

Acute birth asphyxia is a cause of death and neurological injury. At present, there is no proven treatment; however, studies in animals suggest that brain cooling may protect against brain injury. This large multicenter trial will randomize term infants with a history of problems at delivery and signs of depression to total body cooling or standard care.

NICHD, NIH, Sponored and American Academy of Pediatrics, and American College of Obstetricians and Gynecologists co-sponsored study and Report of the Workship on Acute Perinatal Asphyxia in Term Infants.

NCBI NIH PubMed.gov Abstract of Finland study investigating reproductive maternal risk factors of intrapartum fetal asphyxia. The study concluded that the incidence of intrapartum fetal asphyxia was 2.5%. Placental abruption, primiparity, alcohol use during pregnancy, low birth weight, preeclampsia, male fetuses, and small-for-gestational age births were independent risk factors of intrapartum asphyxia, with adjusted relative risks of 3.74, 3.10, 1.75, 1.57, 1.49, 1.48 and 1.33, respectively. Most cases of intrapartum fetal asphyxia occur in low-risk pregnancies and, therefore, risk screening in antenatal care cannot accurately predict which women will eventually need emergency care for fetal asphyxia.

Clinical trial being sponsored by the Eunice Kennedy Shriver National Institute of Child Health and Human Development NICHD to evaluate whether induced whole-body hypothermia initiated between 6-24 hours of age and continued for 96 hours in infants ≥ 36 weeks gestational age with hypoxic-ischemic encephalopathy will reduce the incidence of death or disability at 18-24 months of age.