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Katelyn Madigan

First documented case of child cured of HIV - 0 views

  • i diagnosed with HIV at birth and immediately put on antiretroviral therapy.
  • brought back into care at 23 months, despite being off treatment for five months, the child was found to have an undetectable viral load
  • d today no signs of HIV infection in the child can be detected by the most sensitive means available.
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  • physician was able to treat his leukemia with a stem-cell transplant from a person who was born with a genetic mutation causing immunity to HIV infection. Following the transplant, Mr. Brown was able to stop HIV treatment without experiencing a return of his HIV disease
  • achieved by antiretroviral therapy alone
Richard Herron

Child born with HIV cured by US doctors | Society | The Guardian - 0 views

  • Doctors in the US have made medical history by effectively curing a child born with HIV, the first time such a case has been documented.
  • Dr Hannah Gay, who cared for the child at the University of Mississippi medical centre, told the Guardian the case amounted to the first "functional cure" of an HIV-infected child.
  • but it is likely that a tiny amount remains in their body.
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  • ypically, women with HIV are given antiretroviral drugs during pregnancy to minimise the amount of virus in their blood. Their newborns go on courses of drugs too, to reduce their risk of infection further. The strategy can stop around 98% of HIV transmission from mother to child.
    • Richard Herron
       
      I had no idea modern medicine was this effective against transmission from mother to child.
  • "It is far too early for anyone to try stopping effective therapy just to see if the virus comes back," she said.
Whitney Hopfauf

First documented case of child cured of HIV - 0 views

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    Exciting when AIDS research takes a step forward. However, is it true that although they cannot detect the virus, it may lie dormant? How sensitive are those tests? There was a case of a man who had HIV and leukemia and so they treated him with a bone marrow transplant from someone who was resistant to HIV. The man was said to be cured but there were later debates on the validity. 
Katelyn Madigan

Nanoparticles loaded with bee venom kill HIV - 0 views

  • ee venom contains a potent toxin called melittin that can poke holes in the protective envelope that surrounds HIV
  • When the nanoparticles come into contact with normal cells, which are much larger in size, the particles simply bounce off
  • an advantage of this approach is that the nanoparticle attacks an essential part of the virus' structure. In contrast, most anti-HIV drugs inhibit the virus's ability to replicate
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  • The nanoparticles could be injected intravenously and, in theory, would be able to clear HIV from the blood stream
Casey Finnerty

Malaria and HIV Spike as Greece Cuts Healthcare Spending - Michael Scaturro - The Atlantic - 0 views

  • "After mosquito spraying programs were cut, we've seen a return of malaria, which the country has kept under control for the past four decades. New HIV infections have jumped more than 200 percent," he noted.
  • "Greece is an example of perhaps the worst case of austerity leading to public health disasters," Mr. Stuckler explained in a telephone interview.
  • HIV spiked because government needle exchange programs ran out of clean syringes for heroin addicts. By Stuckler's estimate, the average Greek junkie requires 200 clean needles in a given year. "But now they're only getting three a year each," Stuckler said.
anonymous

U.S.-backed HIV vaccine fails; study halted - 0 views

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    The tested HIV vaccine was based on the common cold virus, to alert the body's immune system.There are still many HIV vaccine trials being tested, so HIV vaccines are still in the works.
Richard Herron

A mutant Tat protein provides strong pr - PubMed Mobile - 0 views

  • Nullbasic is a mutant form of the HIV-1 Tat protein that was previously shown to strongly inhibit HIV-1 replication in non-hematopoietic cell lines by targeting three steps of HIV-1 replication: reverse transcription, transport of viral mRNA and transactivation of HIV-1 gene expression.
Alison Prodzinski

Brand-New Vaccine Strategy Works Against Herpes, And Potentially HIV | Popular Science - 0 views

  • The Yale team’s “prime and pull” method is focused on exactly that. Working with mice, the researchers found a way to “prime” T cells to fight a certain kind of infection
  • through conventional vaccination that causes a system-wide immune response.
  • The “prime and pull” technique could potentially be used to combat any infectious agent that enters the body through any specific tissue--agents like the human immunodeficiency virus (HIV) that causes AIDS.
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    Manipulating T-Cells to fight certain infections, then pulling them out of the body as to not harm anything - because they can spread nasty diseases in places like the central nervous system.  They are now testing these T-cells against HIV. This could be revolutionary - in that the 'Prime and Pull' method could be used over and over without harming the person.  Just proof of how cool T-cells are!! Both useful and harmful if used inappropriately.
Charles Bach

Why circumcision lowers risk of HIV - 0 views

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    Study shows how important studying the micro biome is. The bacteria on the penis can impact the likelihood HIV will be transmitted and one will be infected.
Jenna Veldhuizen

Discovery holds potential in destroying drug-resistant bacteria - 0 views

  • Dr. Montelaro and his colleagues found that a particular sequence of amino acids on the tail end of HIV allow the virus to "punch into" and infect cells. The team manufactured a synthetic and more efficient version of this sequence -- called engineered cationic antimicrobial peptides, or "eCAPs" -- that laboratory tests have shown to rapidly destroy bacteria that are otherwise resistant to most standard antibiotics.
  • Traditional antibiotics typically work by poisoning important metabolic processes after being taken up by the target bacteria, a process that may take hours, or days, to clear a bacterial infection. In contrast, the eCAPs are specifically attracted to the surface of target bacteria where they disrupt the bacterial membrane, causing death within seconds, or minutes.
  • eCAPs work well against biofilms
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    very interesting...the same mechanism HIV uses to infect cells can be manufactured and used to destroy antibiotic-resistant bacteria
Casey Finnerty

Baby With H.I.V. Is Reported Cured - NYTimes.com - 1 views

  • If the report is confirmed, the child born in Mississippi would be only the second well-documented case of a cure in the world
  • Typically a newborn with an infected mother would be given one or two drugs as a prophylactic measure. But Dr. Gay said that based on her experience, she almost immediately used a three-drug regimen aimed at treatment, not prophylaxis, not even waiting for the test results confirming infection.
  • Virus levels rapidly declined with treatment and were undetectable by the time the baby was a month old. That remained the case until the baby was 18 months old, after which the mother stopped coming to the hospital and stopped giving the drugs.
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  • Dr. Gay contacted Dr. Katherine Luzuriaga, an immunologist at the University of Massachusetts,
  • Dr. Steven Deeks, professor of medicine at the University of California, San Francisco, said if the reservoir never established itself, then he would not call it a true cure, though this was somewhat a matter of semantics. “Was there enough time for a latent reservoir, the true barrier to cure, to establish itself?” he said.
  • One hypothesis is that the drugs killed off the virus before it could establish a hidden reservoir in the baby.
  • They found tiny amounts of some viral genetic material but no virus able to replicate, even lying dormant in so-called reservoirs in the body.
  • “For pediatrics, this is our Timothy Brown,” said Dr. Deborah Persaud, associate professor at the Johns Hopkins Children’s Center and lead author of the report on the baby. “It’s proof of principle that we can cure H.I.V. infection if we can replicate this case.”
  • Dr. Hannah B. Gay, an associate professor of pediatrics,
  • The results have not yet been published in a peer-reviewed medical journal.
  • The baby, born in rural Mississippi, was treated aggressively with antiretroviral drugs starting around 30 hours after birth, something that is not usually done. If further study shows this works in other babies, it will almost certainly be recommended globally.
  • those reports and this new one could suggest there is something different about babies’ immune systems, said Dr. Joseph McCune of the University of California, San Francisco.
  • the results could lead to a new protocol for quickly testing and treating infants.
Nate Scheibe

Scores of Tulsa dental patients tested for hepatitis, HIV exposure - CNN.com - 0 views

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    A sad reminder of why we use proper sterilization techniques.
Nate Scheibe

Dozens of Okla. dentist's patients positive for hepatitis - CNN.com - 0 views

  • Health officials in Oklahoma are notifying 57 patients who tested positive for hepatitis C and three patients who tested positive for hepatitis B after visiting oral surgeon W. Scott Harrington's office in Tulsa and a city suburb, according to a joint statement issued Wednesday by the Oklahoma State Department of Health and the Tulsa Health Department.
  • Dental patients tested for HIV, hepatitis var currExpandable="expand25"; if(typeof CNN.expandableMap==='object'){CNN.expandableMap.push(currExpandable);} var mObj={}; mObj.type='video'; mObj.contentId=''; mObj.source='us/2013/03/29/sot-nr-colton-scott-hiv-hepatitis-dentist-harrington.cnn'; mObj.videoSource='CNN'; mObj.videoSourceUrl='http://newsroom.blogs.cnn.com/'; mObj.lgImage="http://i2.cdn.turner.com/cnn/dam/assets/130328181821-01-oklahoma-dentist-story-body.png"; mObj.lgImageX=300; mObj.lgImageY=169; mObj.origImageX="214"; mObj.origImageY="120"; mObj.contentType='video'; CNN.expElements.expand25Store=mObj;
  • Dentist's former patient: How could you? "This is a complex investigation," state epidemiologist Kristy Bradley said in the statement. "The next phase will include more in-depth interviews of persons who test positive to determine the likelihood that their exposure is associated with their dental surgical procedure at the Harrington practice. We will certainly continue to keep the public informed as we learn more." Mor
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    A sad follow-up to a story I found earlier in the semester.
anonymous

Circumcision changes penis biology | Body & Brain | Science News - 0 views

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    The study didn't completely answer the question that circumcised men are less likely to contract HIV, but the coauthors suggest that the abundance of bacteria and unknown anaerobic bacteria can contribute to inflammation, which can contribute to infection of HIV within the foreskin.
Nellie Bogunovic

New Tool for Identifying Powerful HIV Antibodies - 0 views

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    This would give them a better idea on how to design the HIV vaccine
Tiffany Arcand

Scientists Find Bacteria Where It Isn't Supposed to Be: The Brain - The Daily Beast - 0 views

  • The researchers found these bacterial molecules in brain samples from people with HIV, as well as people with no known infectious disease but who had undergone brain surgery
    • Tiffany Arcand
       
      So in immunocompromised individuals, as well as those whose brains have been exposed to the operating room - which as we learned in class, can still house bacteria despite all precautions taken.
    • Tiffany Arcand
       
      Sneaky, sneaky viruses!
  • If living bacteria help to maintain brain health in some way, disruptions to them, for example from antibiotics, could contribute to disease
    • Tiffany Arcand
       
      It will be interesting to see what they discover as they research this more. My guess it that the bacteria in the brain are both beneficial and harmful.
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  • Dyes injected into the brain, meanwhile, tended not to appear in the body
    • Tiffany Arcand
       
      Wouldn't a shot into the brain kill you, or at least be very painful?
  • Last fall, for instance, researchers found male genetic material in the brains of women (who almost certainly were not born with it). Perhaps during pregnancy, the scientists suggested, cells from male fetuses had crossed the placenta and entered the women’s bodie
  • Scientists have discovered, for instance, that HIV hides inside white blood cells that enter the brain in order to look for pathogens; they call this the Trojan horse strategy
  • a mind-bending concept
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    Bacteria Can Bypass Blood-Brain Barrier? It's a surprise to researchers who believed the brain-blood barrier created an impenetrable fortress. How are molecules from dirt getting into white matter-and what are they doing up there? 
Casey Finnerty

How Much Is a Drug-Resistance Death Worth? Less Than $600 | Wired Science | Wired.com - 0 views

  • For every death from AIDS, the US federal research establishment awards approximately $69,000 in grant funds. And for every death from MRSA, it awards $570.
  • MRSA, let’s remember, kills an estimated 19,000 Americans a year: more than HIV, and more than pneumococcal disease, meningococcal disease, H. influenzae and group A Streptococcus combined. 
  • because HIV has been a research priority for most of the 30 years of its existence, research has brought forth thousands of  antiviral compounds and drug combinations for treatment.
Casey Finnerty

Fecal Treatment Gains Favor for Some Illnesses - NYTimes.com - 3 views

  • A new study finds that such transplants cured 15 of 16 people who had recurring infections with Clostridium difficile bacteria, whereas antibiotics cured only 3 of 13 and 4 of 13 patients in two comparison groups.
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    I didn't know this was even possible. I wonder how they convinced people to donate. "The donors were tested for an array of diseases to make sure they did not infect the patients." I wonder how extensive that panel was and what they tested for.
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    Isn't this neat? I have met people who are hoping to get this treatment. Re: the screening, I think it is probably just for the absence of pathogens. As the article states, we really don't know what the "good" bacteria are that help these patients.
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    RE: I would hope that they would check for things like HIV and other blood to blood transmitted diseases. If there was a bleed in the GI tract of both the donor and the patient, I could imagine it would be a problem.
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