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Nate Scheibe

Dozens of Okla. dentist's patients positive for hepatitis - CNN.com - 0 views

  • Health officials in Oklahoma are notifying 57 patients who tested positive for hepatitis C and three patients who tested positive for hepatitis B after visiting oral surgeon W. Scott Harrington's office in Tulsa and a city suburb, according to a joint statement issued Wednesday by the Oklahoma State Department of Health and the Tulsa Health Department.
  • Dental patients tested for HIV, hepatitis var currExpandable="expand25"; if(typeof CNN.expandableMap==='object'){CNN.expandableMap.push(currExpandable);} var mObj={}; mObj.type='video'; mObj.contentId=''; mObj.source='us/2013/03/29/sot-nr-colton-scott-hiv-hepatitis-dentist-harrington.cnn'; mObj.videoSource='CNN'; mObj.videoSourceUrl='http://newsroom.blogs.cnn.com/'; mObj.lgImage="http://i2.cdn.turner.com/cnn/dam/assets/130328181821-01-oklahoma-dentist-story-body.png"; mObj.lgImageX=300; mObj.lgImageY=169; mObj.origImageX="214"; mObj.origImageY="120"; mObj.contentType='video'; CNN.expElements.expand25Store=mObj;
  • Dentist's former patient: How could you? "This is a complex investigation," state epidemiologist Kristy Bradley said in the statement. "The next phase will include more in-depth interviews of persons who test positive to determine the likelihood that their exposure is associated with their dental surgical procedure at the Harrington practice. We will certainly continue to keep the public informed as we learn more." Mor
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    A sad follow-up to a story I found earlier in the semester.
Casey Finnerty

Meningitis From Tainted Drugs Puts Patients, Doctors In Quandary : Shots - Health News ... - 0 views

  • 14,000 Americans
  • alert to illness among patients who have received injections of hundreds of other products
  • the number must run into the tens of thousands.
  • ...14 more annotations...
  • it was really a mini-pharmaceutical manufacturer, not the pharmacy it was licensed to be.
  • 1,200 different drugs
  • Apparently, all of this has been caused by contamination of drugs by a black mold called Exserohilum rostratum, which is common in the environment but almost unheard of as a cause of human disease.
  • For instance, on 13 occasions, they said, New England Compounding shipped out vials of drugs in three suspect lots before getting back results of their own tests confirming the drugs were sterile.
  • "indicated a failure ... to sterilize products for even the minimum amount of time necessary to ensure sterility,"
  • The firm's premises were not clean
  • medications were not labeled with individual patients' names
  • he may harbor a fungal infection that could kill him, there's no proof that he does — and there may never be.
  • many anxious patients are undergoing painful spinal taps and some are getting antifungal drugs that can damage the kidneys and liver.
  • The caution is warranted. This type of fungal infection can smolder for weeks and months before exploding into meningitis or causing massive strokes.
  • "It causes a quandary for the infectious disease doc to figure out, well, should this patient receive treatment at all?" O'Connell says. "Should they receive full-boat treatment, which would be an IV? Could they instead just be watched very closely with daily phone calls and visits to the office? We just don't know."
  • "Should we do lumbar punctures on those kinds of people so that we can anticipate those that are going to get symptomatic later and beat the fungus to it?" Schaffner wonders. "That is, initiate treatment much earlier, thus averting tissue damage, particularly those devastating strokes."
  • When to stop is also uncertain.
  • six months, maybe longer.
Casey Finnerty

Fecal Treatment Gains Favor for Some Illnesses - NYTimes.com - 3 views

  • A new study finds that such transplants cured 15 of 16 people who had recurring infections with Clostridium difficile bacteria, whereas antibiotics cured only 3 of 13 and 4 of 13 patients in two comparison groups.
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    I didn't know this was even possible. I wonder how they convinced people to donate. "The donors were tested for an array of diseases to make sure they did not infect the patients." I wonder how extensive that panel was and what they tested for.
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    Isn't this neat? I have met people who are hoping to get this treatment. Re: the screening, I think it is probably just for the absence of pathogens. As the article states, we really don't know what the "good" bacteria are that help these patients.
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    RE: I would hope that they would check for things like HIV and other blood to blood transmitted diseases. If there was a bleed in the GI tract of both the donor and the patient, I could imagine it would be a problem.
Alison Prodzinski

Brain Scans Offer Precise Measurement Of Human Pain | Popular Science - 0 views

  • Further research along these lines could lead to an objective measure of physical pain, though that's still a long ways away.
  • Right now, if a doctor wants to measure or record someone's pain, she'll generally just ask her patient about it, or ask her patient to rate his pain from 1 to 10. That will always be a very important part of diagnosis, Wager says, but having a less subjective measure could nevertheless help. Some people, such as very young, very old or certain disabled people, can't communicate well. Others may underreport their pain—or are less likely to be believed.
  • Using this pain signature, they were then able to evaluate people's pain in response to particular levels of heat with 90 to 100 percent accuracy
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    Pain is exactly that - no matter what kind! Pain from sunburn or pressure initiates the same pain... Researchers will be using this to test how much pain they have. Using the research that they have found, they will be able to deduce how much pain a person is in!!
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    But aren't there different types of pain sensation? Sharp/stabbing vs. dull/pounding, for example? And doesn't the perceived source/location matter?
Tiffany Arcand

Antibody transforms stem cells directly into brain cells - 0 views

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    Scientists have turned stem cells into brain cells using antibodies, which turned out to be simpler than using conventional methods. In the future, this could be a very effective method for treating neurological injuries, and would nearly eliminate any chance for rejection by the patient.
Casey Finnerty

What Happens When Parents Are Rude in the Hospital - The New York Times - 0 views

  • “All the collaborative mechanisms and things that make a team a team, rather than four individuals working separately, were damaged by the exposure to rudeness.”
  • After such a comment, the teams performed significantly worse in the simulated patient emergencies. Their diagnostic skills deteriorated, and so did their technical procedural abilities, from ventilating and resuscitating the artificial babies properly to ordering and giving the right medications. Both doctors and nurses tended to perform worse individually. They also worked less effectively as teams, as far as communicating and helping one another take care of the sick “patient.”
Casey Finnerty

Will polymerase chain reaction (PCR)-based diagnostics improve outcome in septic patien... - 0 views

  • if the primary aim of PCR diagnostics is to decrease inappropriate empirical treatment and improve patient outcome, detection should focus on those pathogens or resistance determinants that are not covered by guideline-recommended treatment regimens and that have been identified as the major cause of inappropriate treatment according to current studies
Nate Scheibe

CDC: Man died of rabies from kidney transplant - CNN.com - 0 views

  • Doctors knew the donor had encephalitis, an inflammation of the brain, when they harvested the organs. However, they didn't know rabies was the cause.
  • In this most recent case, the donor was experiencing "changes in mental status" before he died, according to Dr. Matthew Kuehnert, director of the CDC's Office of Blood, Organ, and Other Tissue Safety. He said doctors in Florida tested the donor for various causes of encephalitis, including West Nile Virus and herpes, but did not test for rabies.
  • Hospitals do test for other causes of encephalitis, and if no cause is found, the organs are donated.
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    The part that is most concerning is that the doctors knew the patient had encephalitis (granted not all causes of encephalitis are infectious in nature) and decided to donate the organs anyway.
Whitney Hopfauf

Kala-azar treatment failing in Nepal - 2 views

  • When Miltefosine was first introduced as part of a regional campaign in the Indian subcontinent for kala-azar elimination a decade ago, the drug proved to be very effective
  • so far no Miltefosine-resistant parasites were detected in patients
  • super-parasites
Elijah Velasquez

Thermo Fisher Scientific launches Brilliance GBS Agar - 1 views

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    The Brilliance GBS Agar is used for the testing of Group B streptococci (GBS) during pregnancy. The new agar is designed to reduce the number of test steps for clinical technicians, give more reliable results, and enable faster patient treatment by featuring proprietary Inhibigen™ technology. In trials, up to 99% of the negatives show no growth, greatly simplifying interpretation. And because the product requires only a single inoculation, it is also ideal for those laboratories who are already automating their test procedures. Screening for GBS can now be as simple as screening for MRSA".
Nate Scheibe

Scores of Tulsa dental patients tested for hepatitis, HIV exposure - CNN.com - 0 views

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    A sad reminder of why we use proper sterilization techniques.
Tyrell Varner

Avian virus may be harmful to cancer cells - 0 views

  • We modified the virus so that it replicates only in the presence of an active prostate-specific antigen and, therefore, is highly specific to prostate cancer. We also tested its efficacy in a tumor model in vitro," Subbiah said. "The recombinant virus efficiently and specifically killed prostate cancer cells, while sparing normal human cells in the laboratory, but it would take time for this to move from the discovery phase to a treatment for prostate cancer patients."
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    They are looking for commercial entities that are interested in licensing the technology for human clinical trials and treatment. In addition, the researchers have also received a National Institutes of Health exploratory grant to develop the cell type-specific disease virus for several other types of cancer cells, including breast, pancreas, brain, prostate, and multiple myeloma. Although, it will work most effectively in prostate cancer.
Casey Finnerty

Construction and Evaluation of a Novel Recombinant T Cell Epitope-Based Vaccine against... - 0 views

  • No approved human vaccine exists against San Joaquin Valley fever or, for that matter, against any other fungal disease (7).
  • Retrospective evidence from patient studies suggests that people who contract an acute pulmonary or disseminated Coccidioides infection and recover develop lifelong cell-mediated immunity against recurrent coccidioidomycosis.
  • Based on this observation, together with results of protection studies with experimental animals, it has been proposed that generation of a vaccine against this respiratory mycosis is feasible.
Megan Goldman

Researchers Identify Genetic Profile That Predicts Cancer Survival After Chemotherapy ... - 0 views

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    Researchers have identified a biomarker, an eight gene "signature" (a group of genes in a cell whose combined expression is uniquely characteristic of a medical condition), that predicts how long cancer patients might survive without relapse after undergoing chemotherapy. They found that this eight gene signature show a strong correlation to an elevated response to five chemotherapy agents, and showed a lower risk of recurrence and longer relapse-free survival.
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    Curious if this eight gene signature is a result of the genetics of our cell (and resultant interactions) or if it entirely up to the cancerous agent? In simpler terms, are we genetically prone to this eight gene signature or is it luck that our cancer results in this eight gene signature?
Casey Finnerty

AAP 2011: Discussing America's Anti-vaccine Movement - 0 views

  • In response to Pushpendra jain's comments... I am no longer amazed of anything in pediatrics. In 15 years of primary care suburban practice I have learned the following: I am an antibiotic nazi especially if i do not treat by telephone request, my medical expertise is compromised by my financial gains or relationships with pharmaceutical companies, my patients' parents do more "research" than I do--AKA reading a google searched internet account, I should be available at their whim and see them at a time convenient to their kid's soccer schedule as a walk-in service, and parents that think nothing of texting while driving their kids to said soccer game think that a 1 in 10,000-100,000 risk of a vaccination obviates its well documented scientific benefits. We are in a cycle where people no longer believe in science, but they'll be back when we see resurgences of diseases i haven't seen since medical school.
  • Dr. Segedy, I can assure you that your sentiments were shared by a majority of the attendees at the AAP conference. It seems as though we have gotten to a point where the element of surprise no longer exists; health care providers (for the most part) are numb to the fact that studies with ulterior motives (ie, Wakefield & vaccines/autism) and "celebrities" seem to have more of an impact on health care decisions than physicians who have dedicated their entire lives studying medicine. And when it comes to self diagnosing via Dr. Google, Offit specifically mentioned that a website like the "National Vaccine Information Center" (NCVIC.org) comes up on the first page of Google for a search for "vaccines" and yet the information on the website is extremely misleading and, in some cases, downright wrong. But that doesn't stop people from treating it as credible; after all, it's on the Internet so it must be true!
Casey Finnerty

Molecule in meat may increase heart disease risk | Genes & Cells | Science News - 3 views

  • Hazen’s group also found that blood levels of TMAO and L-carnitine could predict heart disease risk, which they learned by collecting blood samples from 2,595 patients and tracking their health for three years.
    • Casey Finnerty
       
      That is a fairly large sample size and long term study.
  • Molecules proposed as biomarkers for heart disease often look promising in initial studies but fizzle out clinically. “We’ve been down this road so many times before.”
    • Casey Finnerty
       
      Very true.
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    This is an interesting story on how the microbiota of our gut may play an indirect role in cardiovascular disease.
Amy Jorgenson

Signal transducer and activator of transcription 1 (STAT1) gain-of-function mutations a... - 0 views

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    This paper does an excellent job researching the correlation of the methylation of the STAT-1 gene and genetic mutations in coccidiodiomycosis and histoplasmosis. The paper shows evidence of the methylation of the STAT-1 by the PIAS1 protein. This gene mutation immunologically challenges the IFN-γ and alters the body's defense mechanisms. Excellent paper on a very scary disease. Hopeful for a vaccine!!! 
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    This article was used as a resource for our presentation. This is the article where we obtained the information regarding the patient case studies.
Nate Scheibe

Tigecycline Versus Levofloxacin in Hospitalized Patients With Community-Acquired Pneumo... - 0 views

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    Reference for presentation.
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