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Megan Goldman

Frontiers | Who possesses drug resistance genes in the aquatic environment?: sulfametho... - 0 views

www.frontiersin.org/...abstract

shared by Megan Goldman on 30 Apr 13 - No Cached
  • Megan Goldman on 30 Apr 13
     
    Frontiers | Who possesses drug resistance genes in the aquatic environment?: sulfamethoxazole (SMX) resistance genes among the bacterial community in water environment of Metro-Manila, Philippines | Frontiers in Antimicrobials, Resistance and Chemotherapy publishes articles on the most outstanding discoveries across the research spectrum of Frontiers | Who possesses drug resistance genes in the aquatic environment?: sulfamethoxazole (SMX) resistance genes among the bacterial community in water environment of Metro-Manila, Philippines | Antimicrobials, Resistance and Chemotherapy.
Tyrell Varner

Bacteria evolve resistance more quickly when stronger antibiotics are used - 1 views

phys.org/...sistance-quickly-stronger.html

resistance antibiotics

shared by Tyrell Varner on 24 Apr 13 - No Cached
  • they found that the rate of evolution of antibiotic resistance speeds up when potent treatments are given because resistant bacterial cells flourish most during the most aggressive therapies.
  • Tyrell Varner on 24 Apr 13
     
    Hmm common sense?
  • Casey Finnerty on 25 Apr 13
     
    Kind of. So if you remove the competition more completely with aggressive antibiotics, the proportion of remaining bacteria that are resistant is higher. Of course, the opposite happens when you treat incompletely with antibiotics (i.e. stop taking them early). In that case our thinking is that the immune system is unlikely to kill all the remaining bacteria, increasing the chance resistant bacteria will survive.
Nate Scheibe

Resistance to last-line antibiotic makes bacteria resistant to immune system - 0 views

www.sciencedaily.com/...130521011230.htm

resistance genes antibiotic bacteria

shared by Nate Scheibe on 21 May 13 - No Cached
  • Nate Scheibe on 21 May 13
     
    An interesting article on cross-resistance.
Casey Finnerty

BBC News - Antibiotic 'apocalypse' warning - 1 views

www.bbc.co.uk/...health-21178718

microbiology antibiotic resistance

shared by Casey Finnerty on 24 Jan 13 - No Cached
  • The rise in drug resistant infections is comparable to the threat of global warming, according to the chief medical officer for England.
  • MRSA rapidly became one of the most feared words in hospitals wards and there are growing reports of resistance in strains of E. coli, tuberculosis and gonorrhoea.
  • Casey Finnerty on 07 Mar 13
     
    Some UK perspective on the antibiotic resistance problem.
Casey Finnerty

A superbug that resisted 26 antibiotics | Minnesota Public Radio News - 0 views

www.mprnews.org/...g-that-resisted-26-antibiotics

antibiotic resistance

shared by Casey Finnerty on 18 Jan 17 - No Cached
  • a woman in Nevada who died of an incurable infection, resistant to all 26 antibiotics available in the U.S. to treat infection.
  • as people cross borders and board airplanes, the bacteria spread in the same way that brought CRE to Reno.
  • all hospitals should double down on preventive efforts, including a travel history.
  • ...2 more annotations...
  • But in this case, there was no effective antibiotic. "And we're going to see more of these, from a drip, drip, drip of cases to a steady drizzle to a rainstorm," predicts Johnson. "It's scary, but it's good to get scared if that motivates action."
  • The action needed is to use antibiotics wisely, in people and in animals, so strains of bacteria don't get a chance to develop resistance, says Johnson. And to continue research into development of new antibiotics.
Nate Scheibe

Carbapenem-resistant Enterobacteriaceae - 1 views

www.cdc.gov/...mm62e0305.pdf

drug resistance carbapenem

shared by Nate Scheibe on 05 Mar 13 - No Cached
  • Nate Scheibe on 05 Mar 13
     
    Here is a new MMWR on carbapenem-resistant Enterobacteriaceae.
Casey Finnerty

'We Have a Limited Window of Opportunity': CDC Warns of Resistance 'Nightmare' | Wired ... - 0 views

www.wired.com/...cre-cdc

microbiology antibiotic resistance

shared by Casey Finnerty on 07 Mar 13 - No Cached
  • “We have a very serious problem, and we need to sound an alarm.”
  • Healthcare institutions in 42 states have now identified at least one case of CRE. The occurrence of this resistance in the overall family of bacteria has risen at least four-fold over 10 years. In the CDC’s surveillance networks, 4.6 percent of hospitals and 17.8 percent of long-term care facilities diagnosed this bug in the first half of 2012.
  • CRE stands for “carbapenem-resistant Enterobacteriaceae.” Enterobacteriaceae are a family of more than 70 bacteria which share the characteristic of being gut-dwelling (“entero”)
  • ...3 more annotations...
  • the CDC reviewed six steps that they first published last year in a CRE Toolkit and want health care facilities to take:
  • But an important point is that none of this is required, and none of this is funded.
  • There are no reimbursements, under Medicare, for infection-control as a hospital task
  • Casey Finnerty on 07 Mar 13
     
    This article does a good job summarizing this week's announcement by the CDC director on the gravity of the CRE problem.
Elijah Velasquez

Bacterial byproduct offers route to avoiding antibiotic resistance - 0 views

phys.org/...ute-antibiotic-resistance.html

resistance

shared by Elijah Velasquez on 24 Mar 13 - No Cached
  • Elijah Velasquez on 24 Mar 13
     
    Increasing ROS (reactive oxygen species) in bacteria allow current antibiotics to be more potent. This approach weakens the bacteria allowing lower doses of antibiotics to be effective. This is can potentially help reduce the rate of antibiotic resistance. As we continue to develop a greater understanding about disease causing bacteria we can expose numerous ways to weaken the bacteria.
Jenna Veldhuizen

Discovery holds potential in destroying drug-resistant bacteria - 0 views

www.sciencedaily.com/...130507155033.htm

shared by Jenna Veldhuizen on 08 May 13 - No Cached
  • Dr. Montelaro and his colleagues found that a particular sequence of amino acids on the tail end of HIV allow the virus to "punch into" and infect cells. The team manufactured a synthetic and more efficient version of this sequence -- called engineered cationic antimicrobial peptides, or "eCAPs" -- that laboratory tests have shown to rapidly destroy bacteria that are otherwise resistant to most standard antibiotics.
  • Traditional antibiotics typically work by poisoning important metabolic processes after being taken up by the target bacteria, a process that may take hours, or days, to clear a bacterial infection. In contrast, the eCAPs are specifically attracted to the surface of target bacteria where they disrupt the bacterial membrane, causing death within seconds, or minutes.
  • eCAPs work well against biofilms
  • Jenna Veldhuizen on 08 May 13
     
    very interesting...the same mechanism HIV uses to infect cells can be manufactured and used to destroy antibiotic-resistant bacteria
Megan Rasmussen

Protein complex in human breast milk can help reverse antibiotic resistance - 0 views

www.news-medical.net/...rse-antibiotic-resistance.aspx

microbiology resistance antibiotic

shared by Megan Rasmussen on 05 May 13 - No Cached
  • Megan Rasmussen on 05 May 13
     
    This complex was tested and found to make resistant bacteria more susceptible to antibiotics!
Casey Finnerty

Resistance to the Antibiotic of Last Resort Is Silently Spreading - The Atlantic - 0 views

www.theatlantic.com/...512705

antibiotic resistance

shared by Casey Finnerty on 23 Jan 17 - No Cached
  • farmers started using it by the tons in animals, where low doses of antibiotics can promote growth.
  • November 18, 2015, scientists published a report in the British medical journal The Lancet: A single, easily spreadable gene makes the bacteria that carry it resistant to colistin, our antibiotic of last resort.
  • Chinese scientists had found this gene, called mcr-1, in pig farms and on meat in supermarkets.
  • ...1 more annotation...
  • By the time anyone had figured out mcr-1’s existence, it had already spread around the world.  
Casey Finnerty

Scientists may have worked out how to defeat antibiotic-resistant superbugs - 0 views

www.engadget.com/...ientists-uea-superbug-solution

antibiotic resistance

shared by Casey Finnerty on 20 Jun 14 - No Cached
  • It turns out that the reason bugs like Staphylococcus aureus are capable of resisting antibiotics is because they develop a lipid-based outer membrane.
    • Casey Finnerty
      Casey Finnerty on 20 Jun 14
       
      S. aureus is Gram+, it does not possess an outer membrane!
    • Casey Finnerty
      Casey Finnerty on 20 Jun 14
       
      Also, not all antibiotic resistance results from having an outer membrane.
Casey Finnerty

A Science Project With Legs - NYTimes.com - 0 views

well.blogs.nytimes.com/...a-science-project-with-legs

microbiology chicken antibiotic resistance

shared by Casey Finnerty on 10 Nov 13 - No Cached
  • Almost twice as many of the kosher chicken samples tested positive for antibiotic-resistant E. coli as did the those from conventionally raised birds. And even the samples from organically raised chickens and those raised without antibiotics did not significantly differ from the conventional ones.
  • Casey Finnerty on 10 Nov 13
     
    High school student tested chicken from conventional, organic, and kosher producers for antibiotic resistant E. coli. Surprising results
Casey Finnerty

Infections With 'Nightmare Bacteria' Are On The Rise In U.S. Hospitals : Shots - Health... - 1 views

www.npr.org/...e-on-the-rise-in-u-s-hospitals

microbiology antibiotic resistance CRE

shared by Casey Finnerty on 05 Mar 13 - No Cached
  • carbapenem-resistant Enterobacteriaceae, or CRE
  • "They're basically a triple threat."
  • they are resistant to virtually all antibiotics
  • ...2 more annotations...
  • Infectious disease specialist Dr. Brad Spellberg, of the Los Angeles Biomedical Research Institute at the Harbor-UCLA Medical Center, likens the situation to the Titanic's ill-fated voyage. "We're not talking about an iceberg that's down the line," he says. "The ship has hit the iceberg. We're taking on water. We already have people dying. Not only of CRE, but of untreatable CRE."
  • "If CRE spreads out of hospitals and into communities, that's when the ship is totally underwater and we all drown," Spellberg says.
Alison Prodzinski

How Pigs on Antibiotics Are Making Superbugs Stronger | Popular Science - 0 views

www.popsci.com/...-are-making-superbugs-stronger

shared by Alison Prodzinski on 28 Mar 13 - No Cached
  • new research suggests it’s the animals, and the drugs we feed them
  • MRSA started out as a drug-defeatable bug and then transferred into the pig population, where it developed resistance to two common forms of antibiotics
  • “[It’s] like watching the birth of a superbug,”
  • ...1 more annotation...
  • humans have supplied a strong force through the excessive use of antibiotic drugs in farm animal production,
  • Alison Prodzinski on 28 Mar 13
     
    MSRA could be defeated when first discovered. However, it was transferred to the pig population and went crazy after that. Humans over immunize animals and make super-bugs from inappropriate and overuse of antibiotics.  New tests are being done with bacteria being injected into other hosts - which then can be used to kill MRSA. This method could find new and natural antibiotics that could fight various forms of drug-resistant superbugs!
Emma Radzak

Superbugs: Unmasking the Threat - 0 views

web.ebscohost.com/...pdfviewer

shared by Emma Radzak on 18 Apr 13 - No Cached
  • Emma Radzak on 18 Apr 13
     
    More information about superbugs summarizing how they become resistant to antibiotics, the new classes of antibiotics created to combat them, and what we can do to prevent antibiotic resistance. In the article it listed 12 steps to prevent antibiotic resistance, where it stresses the importance of vaccinations, timely diagnosis, limiting the antibiotics being used, and "breaking the chain" (staying at home when your sick, and washing your hands).
Megan Rasmussen

Scientists Use Nature Against Nature to Develop an Antibiotic With Reduced Resistance - 0 views

www.sciencedaily.com/...130410201828.htm

microbiology resistance antibiotic

shared by Megan Rasmussen on 14 Apr 13 - No Cached
  • Megan Rasmussen on 14 Apr 13
     
    Researchers have applied knowledge about bacteria phages in order to develop a new antibiotic. They studied the enzyme 2-epimerase, which controls the formation Bacillus anthracis cell wall. Researchers used an inhibitory molecule that would bind to the allosteric site* site of this enzyme. They tested this antibiotic called Epimerox in mice infected with Ballcillus anthracis and found that it protected the mice from anthrax. It also showed that the bacteria did not develop a resistance to this inhibitory molecule. Although this is just a start, it could change so much in the quest for effective antibiotics!
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