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Alison Prodzinski

How Pigs on Antibiotics Are Making Superbugs Stronger | Popular Science - 0 views

www.popsci.com/...-are-making-superbugs-stronger

shared by Alison Prodzinski on 28 Mar 13 - No Cached
  • new research suggests it’s the animals, and the drugs we feed them
  • MRSA started out as a drug-defeatable bug and then transferred into the pig population, where it developed resistance to two common forms of antibiotics
  • “[It’s] like watching the birth of a superbug,”
  • ...1 more annotation...
  • humans have supplied a strong force through the excessive use of antibiotic drugs in farm animal production,
  • Alison Prodzinski on 28 Mar 13
     
    MSRA could be defeated when first discovered. However, it was transferred to the pig population and went crazy after that. Humans over immunize animals and make super-bugs from inappropriate and overuse of antibiotics.  New tests are being done with bacteria being injected into other hosts - which then can be used to kill MRSA. This method could find new and natural antibiotics that could fight various forms of drug-resistant superbugs!
Katelyn Madigan

Tomorrow's life-saving medications may currently be living at the bottom of the sea - 1 views

www.sciencedaily.com/...130129130949.htm

medications sea

shared by Katelyn Madigan on 30 Jan 13 - No Cached
  • new antibiotics to keep these diseases at bay.
  • Bacteria that live in harmony with animals are a promising source. "
  • bacteria carried by cone snails produce a chemical that is neuroactive,
  • ...2 more annotations...
  • chemicals have promise for treatment of pain
  • "Mollusks with external shells, like the cone snail, were previously overlooked in the search for new antibiotics and other medications
  • Katelyn Madigan on 30 Jan 13
     
    Scientists return to previously overlooked sources for new antibiotics and other medications - really portrays the prevalence of antibiotic-resistant microbes.
  • Richard Herron on 01 Feb 13
     
    This is great news not only for what we've overlooked, but future implications that deep-sea life has a lot to offer in antibiotics. Another important factor is that we know more about the surface of the moon then our own oceans, so gives us the opportunity and a reason for categorizing deep-sea life.
Casey Finnerty

A superbug that resisted 26 antibiotics | Minnesota Public Radio News - 0 views

www.mprnews.org/...g-that-resisted-26-antibiotics

antibiotic resistance

shared by Casey Finnerty on 18 Jan 17 - No Cached
  • a woman in Nevada who died of an incurable infection, resistant to all 26 antibiotics available in the U.S. to treat infection.
  • as people cross borders and board airplanes, the bacteria spread in the same way that brought CRE to Reno.
  • all hospitals should double down on preventive efforts, including a travel history.
  • ...2 more annotations...
  • But in this case, there was no effective antibiotic. "And we're going to see more of these, from a drip, drip, drip of cases to a steady drizzle to a rainstorm," predicts Johnson. "It's scary, but it's good to get scared if that motivates action."
  • The action needed is to use antibiotics wisely, in people and in animals, so strains of bacteria don't get a chance to develop resistance, says Johnson. And to continue research into development of new antibiotics.
Casey Finnerty

We Will Miss Antibiotics When They're Gone - The New York Times - 0 views

www.nytimes.com/...d-a-post-antibiotic-world.html

antibiotic resistance

shared by Casey Finnerty on 20 Jan 17 - No Cached
  • more than 23,000 people in the United States are estimated to die every year from resistant bacteria.
  • Yet few new antibiotics are in development. Most large drug companies have fled the field. The reason is simple: To conserve their effectiveness, new antibiotics are put on the shelf to be used only when older antibiotics stop working. That makes perfect sense for public health, but companies can’t make a profit on what they can’t sell.
Elijah Velasquez

Bacterial byproduct offers route to avoiding antibiotic resistance - 0 views

phys.org/...ute-antibiotic-resistance.html

resistance

shared by Elijah Velasquez on 24 Mar 13 - No Cached
  • Elijah Velasquez on 24 Mar 13
     
    Increasing ROS (reactive oxygen species) in bacteria allow current antibiotics to be more potent. This approach weakens the bacteria allowing lower doses of antibiotics to be effective. This is can potentially help reduce the rate of antibiotic resistance. As we continue to develop a greater understanding about disease causing bacteria we can expose numerous ways to weaken the bacteria.
Emma Radzak

Superbugs: Unmasking the Threat - 0 views

web.ebscohost.com/...pdfviewer

shared by Emma Radzak on 18 Apr 13 - No Cached
  • Emma Radzak on 18 Apr 13
     
    More information about superbugs summarizing how they become resistant to antibiotics, the new classes of antibiotics created to combat them, and what we can do to prevent antibiotic resistance. In the article it listed 12 steps to prevent antibiotic resistance, where it stresses the importance of vaccinations, timely diagnosis, limiting the antibiotics being used, and "breaking the chain" (staying at home when your sick, and washing your hands).
Megan Rasmussen

Scientists Use Nature Against Nature to Develop an Antibiotic With Reduced Resistance - 0 views

www.sciencedaily.com/...130410201828.htm

microbiology resistance antibiotic

shared by Megan Rasmussen on 14 Apr 13 - No Cached
  • Megan Rasmussen on 14 Apr 13
     
    Researchers have applied knowledge about bacteria phages in order to develop a new antibiotic. They studied the enzyme 2-epimerase, which controls the formation Bacillus anthracis cell wall. Researchers used an inhibitory molecule that would bind to the allosteric site* site of this enzyme. They tested this antibiotic called Epimerox in mice infected with Ballcillus anthracis and found that it protected the mice from anthrax. It also showed that the bacteria did not develop a resistance to this inhibitory molecule. Although this is just a start, it could change so much in the quest for effective antibiotics!
Tyrell Varner

Bacteria evolve resistance more quickly when stronger antibiotics are used - 1 views

phys.org/...sistance-quickly-stronger.html

resistance antibiotics

shared by Tyrell Varner on 24 Apr 13 - No Cached
  • they found that the rate of evolution of antibiotic resistance speeds up when potent treatments are given because resistant bacterial cells flourish most during the most aggressive therapies.
  • Tyrell Varner on 24 Apr 13
     
    Hmm common sense?
  • Casey Finnerty on 25 Apr 13
     
    Kind of. So if you remove the competition more completely with aggressive antibiotics, the proportion of remaining bacteria that are resistant is higher. Of course, the opposite happens when you treat incompletely with antibiotics (i.e. stop taking them early). In that case our thinking is that the immune system is unlikely to kill all the remaining bacteria, increasing the chance resistant bacteria will survive.
Casey Finnerty

A Science Project With Legs - NYTimes.com - 0 views

well.blogs.nytimes.com/...a-science-project-with-legs

microbiology chicken antibiotic resistance

shared by Casey Finnerty on 10 Nov 13 - No Cached
  • Almost twice as many of the kosher chicken samples tested positive for antibiotic-resistant E. coli as did the those from conventionally raised birds. And even the samples from organically raised chickens and those raised without antibiotics did not significantly differ from the conventional ones.
  • Casey Finnerty on 10 Nov 13
     
    High school student tested chicken from conventional, organic, and kosher producers for antibiotic resistant E. coli. Surprising results
Tyrell Varner

CDC warning of superbug 'nightmare' - Canon City Daily Record - 0 views

www.canoncitydailyrecord.com/...cdc-warning-superbug-nightmare

cdc superbug CRE

shared by Tyrell Varner on 12 Mar 13 - No Cached
    • Tyrell Varner
      Tyrell Varner on 12 Mar 13
       
      This is pretty much exactly what we covered in lecture. I just wonder how far/severe the outcome will be until harsh regulation takes place?
  • Overuse and improper use of antibiotics over the years, both in the medical community and the livestock industry, has led to an increase in the number of bacteria that are drug-resistant.
  • At least 80 percent of antibiotics used annually in the U.S. are used routinely in livestock to promote growth.
  • ...2 more annotations...
  • Food and Drug Administration
  • banned only one type of antibiotic in livestock and urged the industry to voluntarily limit antibiotic use to promote growth.
Tyrell Varner

Research harnesses solar-powered proteins to filter harmful antibiotics from water - 0 views

www.sciencedaily.com/...130419121112.htm

filter antibiotics

shared by Tyrell Varner on 22 Apr 13 - No Cached
  • Tyrell Varner on 22 Apr 13
     
    A new filter made of two bacterial proteins was able to absorb 64% of antibiotics in surface water compared to about 40% absorbed by the currently used filtering technology made of activated carbon. The captured antibiotics can also be harvested from the proteins.
Jeremiah Williamson

Cold Plasma Kills Bacteria Better Than Antibiotics : Discovery News - 0 views

news.discovery.com/...ia-better-than-antibiotics.htm

shared by Jeremiah Williamson on 26 Apr 13 - No Cached
  • Jeremiah Williamson on 26 Apr 13
     
    If we could somehow find a way to work in on humans this could be huge. Many burn victims and other people with wound infections could be save from deadly bacteria, and without some of the harmful side effects of antibiotics.
Jenna Veldhuizen

Discovery holds potential in destroying drug-resistant bacteria - 0 views

www.sciencedaily.com/...130507155033.htm

shared by Jenna Veldhuizen on 08 May 13 - No Cached
  • Dr. Montelaro and his colleagues found that a particular sequence of amino acids on the tail end of HIV allow the virus to "punch into" and infect cells. The team manufactured a synthetic and more efficient version of this sequence -- called engineered cationic antimicrobial peptides, or "eCAPs" -- that laboratory tests have shown to rapidly destroy bacteria that are otherwise resistant to most standard antibiotics.
  • Traditional antibiotics typically work by poisoning important metabolic processes after being taken up by the target bacteria, a process that may take hours, or days, to clear a bacterial infection. In contrast, the eCAPs are specifically attracted to the surface of target bacteria where they disrupt the bacterial membrane, causing death within seconds, or minutes.
  • eCAPs work well against biofilms
  • Jenna Veldhuizen on 08 May 13
     
    very interesting...the same mechanism HIV uses to infect cells can be manufactured and used to destroy antibiotic-resistant bacteria
Megan Rasmussen

Protein complex in human breast milk can help reverse antibiotic resistance - 0 views

www.news-medical.net/...rse-antibiotic-resistance.aspx

microbiology resistance antibiotic

shared by Megan Rasmussen on 05 May 13 - No Cached
  • Megan Rasmussen on 05 May 13
     
    This complex was tested and found to make resistant bacteria more susceptible to antibiotics!
Casey Finnerty

BBC News - Antibiotic 'apocalypse' warning - 1 views

www.bbc.co.uk/...health-21178718

microbiology antibiotic resistance

shared by Casey Finnerty on 24 Jan 13 - No Cached
  • The rise in drug resistant infections is comparable to the threat of global warming, according to the chief medical officer for England.
  • MRSA rapidly became one of the most feared words in hospitals wards and there are growing reports of resistance in strains of E. coli, tuberculosis and gonorrhoea.
  • Casey Finnerty on 07 Mar 13
     
    Some UK perspective on the antibiotic resistance problem.
Casey Finnerty

Resistance to the Antibiotic of Last Resort Is Silently Spreading - The Atlantic - 0 views

www.theatlantic.com/...512705

antibiotic resistance

shared by Casey Finnerty on 23 Jan 17 - No Cached
  • farmers started using it by the tons in animals, where low doses of antibiotics can promote growth.
  • November 18, 2015, scientists published a report in the British medical journal The Lancet: A single, easily spreadable gene makes the bacteria that carry it resistant to colistin, our antibiotic of last resort.
  • Chinese scientists had found this gene, called mcr-1, in pig farms and on meat in supermarkets.
  • ...1 more annotation...
  • By the time anyone had figured out mcr-1’s existence, it had already spread around the world.  
Casey Finnerty

H. Boyd Woodruff, Microbiologist Who Paved Way for Antibiotics, Dies at 99 - The New Yo... - 0 views

www.nytimes.com/...ad-antibiotics-researcher.html

antibiotics microbiology

shared by Casey Finnerty on 04 Feb 17 - No Cached
  • In high school, he considered becoming an architect but, he later recalled, decided he wanted to be a chemist after taking an experimental course that encouraged “unexpected smells and disruptions of nearby classes,” he wrote in the Annual Review of Microbiology in 1981.
  • During that suit, Dr. Waksman said that in isolating streptothricin, Dr. Woodruff had contributed “as much as 20 times” more than Dr. Schatz to the later discovery of streptomycin,
  • “The studies of Albert Schatz in his discovery of streptomycin,” he said, “were dependent on the initial antibiotic demonstration by Boyd Woodruff that one could isolate soil microorganisms, culture them and recover inhibitory compounds from them.”
Casey Finnerty

CDC Threat Report: 'We Will Soon Be in a Post-Antibiotic Era' - Wired Science - 0 views

www.wired.com/...cdc-amr-rpt1

microbiology antibiotic resistance

shared by Casey Finnerty on 17 Sep 13 - No Cached
  • And it calls for action in four areas: gathering better data; preventing infections, through vaccination, better protective behavior in hospitals, and better food handling; improving the way in which antibiotics are used, by not using them inappropriately in health care or agriculture; and developing not just new categories of antibiotics but better diagnostic tests so that resistant organisms can be identified and dealt with sooner, before they spread.
  • “My biggest frustration is the pace of change,” he told me. “Hospitals are making progress, but it’s single digits in terms of the number of hospitals that are being very proactive.
Casey Finnerty

Scientists may have worked out how to defeat antibiotic-resistant superbugs - 0 views

www.engadget.com/...ientists-uea-superbug-solution

antibiotic resistance

shared by Casey Finnerty on 20 Jun 14 - No Cached
  • It turns out that the reason bugs like Staphylococcus aureus are capable of resisting antibiotics is because they develop a lipid-based outer membrane.
    • Casey Finnerty
      Casey Finnerty on 20 Jun 14
       
      S. aureus is Gram+, it does not possess an outer membrane!
    • Casey Finnerty
      Casey Finnerty on 20 Jun 14
       
      Also, not all antibiotic resistance results from having an outer membrane.
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