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Casey Finnerty

Panel Recommends HPV Vaccine for Boys and Young Men - NYTimes.com - 0 views

  • HPV infection is the most common sexually transmitted disease — between 75 percent and 80 percent of females and males in the United States will be infected at some point in their lives. Most will overcome the infection with no ill effects. But in some people, infections lead to cellular changes that cause warts or cancer, including cervical, vaginal and vulvar cancers in women and anal cancers in men and women. A growing body of evidence suggests that HPV also causes throat cancers in men and women as a result of oral sex. HPV infections cause about 15,000 cancers in women and 7,000 cancers in men each year. And while cervical cancer rates have plunged over the past four decades because of widespread screening, anal cancer rates in men and women have been increasing. Head and neck cancers have also been increasing, with the share associated with HPV infection increasing rapidly — perhaps because oral sex has increased in popularity.
Casey Finnerty

Yeast Infection Led to Removal of Transplanted Uterus - The New York Times - 0 views

  • The infection was caused by a fungus, a type of yeast called Candida albicans
  • It is normally found in the vagina, living in balance with bacteria and other microbes. But illness or some medications can disrupt the balance, allowing for a problematic overgrowth of the yeasts.
  • The surgeons said that since yeasts normally inhabit the genital tract, they could have come from either the donor or the recipient.
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  • But in transplant recipients, yeast infections can be hard to control, because the drugs that prevent rejection also prevent the immune system from fighting the infection. If a yeast infection spreads into the bloodstream, it can be extremely difficult to treat, and can be fatal.
  • Doctors rushed Ms. McFarland into surgery and discovered that an infection — they did not know then what kind — had extended into an artery they had connected to provide blood flow to the uterus. It had damaged the vessel and caused clots. The transplant had to be removed immediately. A week later, Ms. McFarland needed another operation, to treat more bleeding.
  • Once the cause of the infection was identified, she was treated with antifungal medicines. With the transplant removed, she was able to stop taking antirejection drugs and give her immune system a chance to recover and help control the infection.
  • She spent about five weeks in the hospital. Dr. Tzakis said she was still taking antifungal medicine, but was well.
  • The goal of the surgery is to make pregnancy and childbirth possible for women who were born without a uterus or lack one because of illness or injury.
  • They said they were considering various options, like using antifungal medicines preventively and washing the tissues of both the donor and recipient to reduce the risk of infection.
  • The only successful uterus transplants have been performed in Sweden, at the University of Gothenburg. Nine women have had the transplants there, and five have given birth.
  • Two of the nine transplants failed during the first year after the surgery and had to be removed
  • the other because of a bacterial infection.
  • Unlike the Cleveland team, doctors in Sweden used live uterus donors rather than cadavers for the transplants.
  • He also said that the Baylor team had adjusted its screening procedures to take into account possible exposure to the Zika virus
Nate Scheibe

Dozens of Okla. dentist's patients positive for hepatitis - CNN.com - 0 views

  • Health officials in Oklahoma are notifying 57 patients who tested positive for hepatitis C and three patients who tested positive for hepatitis B after visiting oral surgeon W. Scott Harrington's office in Tulsa and a city suburb, according to a joint statement issued Wednesday by the Oklahoma State Department of Health and the Tulsa Health Department.
  • Dental patients tested for HIV, hepatitis var currExpandable="expand25"; if(typeof CNN.expandableMap==='object'){CNN.expandableMap.push(currExpandable);} var mObj={}; mObj.type='video'; mObj.contentId=''; mObj.source='us/2013/03/29/sot-nr-colton-scott-hiv-hepatitis-dentist-harrington.cnn'; mObj.videoSource='CNN'; mObj.videoSourceUrl='http://newsroom.blogs.cnn.com/'; mObj.lgImage="http://i2.cdn.turner.com/cnn/dam/assets/130328181821-01-oklahoma-dentist-story-body.png"; mObj.lgImageX=300; mObj.lgImageY=169; mObj.origImageX="214"; mObj.origImageY="120"; mObj.contentType='video'; CNN.expElements.expand25Store=mObj;
  • Dentist's former patient: How could you? "This is a complex investigation," state epidemiologist Kristy Bradley said in the statement. "The next phase will include more in-depth interviews of persons who test positive to determine the likelihood that their exposure is associated with their dental surgical procedure at the Harrington practice. We will certainly continue to keep the public informed as we learn more." Mor
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    A sad follow-up to a story I found earlier in the semester.
Casey Finnerty

Eggs, Too, May Provoke Bacteria to Raise Heart Risk - NYTimes.com - 0 views

  • The lecithin study, published Wednesday in The New England Journal of Medicine, is part of a growing appreciation of the role the body’s bacteria play in health and disease. With heart disease, investigators have long focused on the role of diet and heart disease, but expanding the scrutiny to bacteria adds a new dimension.
  • “Heart disease perhaps involves microbes in our gut,”
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    First carnitine and meat, now lecithin and eggs! Darn it! All things in moderation, I guess.
Casey Finnerty

Rare Fungal Meningitis Outbreak Spreads To Six States : Shots - Health Blog : NPR - 0 views

  • The drug was contaminated with the spores of a common leaf mold — nobody knows how.
  • Five patients have died.
    • Casey Finnerty
       
      As of 2012-10-15, 203 cases, 15 deaths.
  • Compounding pharmacies, which provide up to 10 percent of U.S. pharmaceuticals, are more loosely regulated than traditional drug companies. As is common, NECC is licensed by a state pharmacy board, which doesn't have the staff to conduct regular inspections. The company has been cited for contamination problems in the past, as the Boston Globe reports.
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  • Surprisingly, the FDA says it has no idea how many doses of the tainted medicine have been shipped out.
  • methylprednisolone
  • The incubation period of fungal meningitis may be as long as four weeks.
  • Dr. April Pettit
  • People don't get Apergillus infections unless they have severely compromised immunity.
  • Pettit learned the man had gotten a spinal injection a couple of weeks earlier. She put two and two together and notified state health authorities.
  • There's one lucky aspect of this disaster: Unlike more common forms of meningitis, this type can't be passed from person to person.
Casey Finnerty

Baby With H.I.V. Is Reported Cured - NYTimes.com - 1 views

  • If the report is confirmed, the child born in Mississippi would be only the second well-documented case of a cure in the world
  • Typically a newborn with an infected mother would be given one or two drugs as a prophylactic measure. But Dr. Gay said that based on her experience, she almost immediately used a three-drug regimen aimed at treatment, not prophylaxis, not even waiting for the test results confirming infection.
  • Virus levels rapidly declined with treatment and were undetectable by the time the baby was a month old. That remained the case until the baby was 18 months old, after which the mother stopped coming to the hospital and stopped giving the drugs.
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  • Dr. Gay contacted Dr. Katherine Luzuriaga, an immunologist at the University of Massachusetts,
  • Dr. Steven Deeks, professor of medicine at the University of California, San Francisco, said if the reservoir never established itself, then he would not call it a true cure, though this was somewhat a matter of semantics. “Was there enough time for a latent reservoir, the true barrier to cure, to establish itself?” he said.
  • One hypothesis is that the drugs killed off the virus before it could establish a hidden reservoir in the baby.
  • They found tiny amounts of some viral genetic material but no virus able to replicate, even lying dormant in so-called reservoirs in the body.
  • “For pediatrics, this is our Timothy Brown,” said Dr. Deborah Persaud, associate professor at the Johns Hopkins Children’s Center and lead author of the report on the baby. “It’s proof of principle that we can cure H.I.V. infection if we can replicate this case.”
  • Dr. Hannah B. Gay, an associate professor of pediatrics,
  • The results have not yet been published in a peer-reviewed medical journal.
  • The baby, born in rural Mississippi, was treated aggressively with antiretroviral drugs starting around 30 hours after birth, something that is not usually done. If further study shows this works in other babies, it will almost certainly be recommended globally.
  • those reports and this new one could suggest there is something different about babies’ immune systems, said Dr. Joseph McCune of the University of California, San Francisco.
  • the results could lead to a new protocol for quickly testing and treating infants.
Casey Finnerty

Global Malaria Deaths Hit A New Low : Shots - Health News : NPR - 0 views

  • The death rate from malaria dropped by 45 percent globally between 2000 and 2012, the World Health Organization reported Wednesday. In Africa, the rate fell by almost half.
Casey Finnerty

Probiotic Logic vs. Gut Feelings - NYTimes.com - 1 views

  • Still, he added, taking them doesn’t seem harmful. “It’s a relatively low-cost treatment worth trying if you have a condition like Crohn’s disease,” he said. “But for most conditions, the potential benefit is uncertain.”
  • There is growing evidence for the role of the appendix in restoring a healthful balance of microbes in the body.
  • The challenge in taking probiotics is to get the microbes past the stomach, where most are killed by gastric acid, said Robert Dunn, a biologist at North Carolina State University. Once in the intestines, they must compete effectively with the microbes already present.
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    I always wondered how the probiotics we get from yogurt etc. were supposed to make it past the stomach. If the stomach does indeed neutralize probiotics, does eating yogurt to prevent antibiotic associated diarrhea (for instance) really help?
Casey Finnerty

Infections With 'Nightmare Bacteria' Are On The Rise In U.S. Hospitals : Shots - Health... - 1 views

  • carbapenem-resistant Enterobacteriaceae, or CRE
  • "They're basically a triple threat."
  • they are resistant to virtually all antibiotics
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  • Infectious disease specialist Dr. Brad Spellberg, of the Los Angeles Biomedical Research Institute at the Harbor-UCLA Medical Center, likens the situation to the Titanic's ill-fated voyage. "We're not talking about an iceberg that's down the line," he says. "The ship has hit the iceberg. We're taking on water. We already have people dying. Not only of CRE, but of untreatable CRE."
  • "If CRE spreads out of hospitals and into communities, that's when the ship is totally underwater and we all drown," Spellberg says.
Casey Finnerty

Malaria and HIV Spike as Greece Cuts Healthcare Spending - Michael Scaturro - The Atlantic - 0 views

  • "After mosquito spraying programs were cut, we've seen a return of malaria, which the country has kept under control for the past four decades. New HIV infections have jumped more than 200 percent," he noted.
  • "Greece is an example of perhaps the worst case of austerity leading to public health disasters," Mr. Stuckler explained in a telephone interview.
  • HIV spiked because government needle exchange programs ran out of clean syringes for heroin addicts. By Stuckler's estimate, the average Greek junkie requires 200 clean needles in a given year. "But now they're only getting three a year each," Stuckler said.
Nate Scheibe

Caltech Wins Toilet Challenge | Caltech - 0 views

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    "According to the World Health Organization, 2.5 billion people around the globe are without access to sanitary toilets, which results in the spread of deadly diseases. Every year, 1.5 million people-mostly those under the age of five-die from diarrhea."
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    This is the infrastructure side of many of the microbes (and more importantly the diseases associated with them) we learned about.
Casey Finnerty

In Nigeria, Polio Vaccine Workers Are Killed by Gunmen - NYTimes.com - 0 views

  • In a roundabout way, the C.I.A. has been blamed for the Pakistan killings.
  • The killings, with eerie echoes of attacks that killed nine female polio workers in Pakistan in December, represented another serious setback for the global effort to eradicate polio.
  • Since the vaccine ruse in Pakistan, she said, “Frankly, now, I can’t go to them and say, ‘The C.I.A. isn’t involved.’ ”
Casey Finnerty

AAP 2011: Discussing America's Anti-vaccine Movement - 0 views

  • In response to Pushpendra jain's comments... I am no longer amazed of anything in pediatrics. In 15 years of primary care suburban practice I have learned the following: I am an antibiotic nazi especially if i do not treat by telephone request, my medical expertise is compromised by my financial gains or relationships with pharmaceutical companies, my patients' parents do more "research" than I do--AKA reading a google searched internet account, I should be available at their whim and see them at a time convenient to their kid's soccer schedule as a walk-in service, and parents that think nothing of texting while driving their kids to said soccer game think that a 1 in 10,000-100,000 risk of a vaccination obviates its well documented scientific benefits. We are in a cycle where people no longer believe in science, but they'll be back when we see resurgences of diseases i haven't seen since medical school.
  • Dr. Segedy, I can assure you that your sentiments were shared by a majority of the attendees at the AAP conference. It seems as though we have gotten to a point where the element of surprise no longer exists; health care providers (for the most part) are numb to the fact that studies with ulterior motives (ie, Wakefield & vaccines/autism) and "celebrities" seem to have more of an impact on health care decisions than physicians who have dedicated their entire lives studying medicine. And when it comes to self diagnosing via Dr. Google, Offit specifically mentioned that a website like the "National Vaccine Information Center" (NCVIC.org) comes up on the first page of Google for a search for "vaccines" and yet the information on the website is extremely misleading and, in some cases, downright wrong. But that doesn't stop people from treating it as credible; after all, it's on the Internet so it must be true!
anonymous

Study Ties Autism Risk to Creases in Placenta - 0 views

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    Autism is trying to be linked to the number of inclusions within the placenta. The placenta were studied after the baby was born and the inclusions were counted. This could lead to more studies comparing the placenta to diseases, which would find the purpose of the placenta.
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