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Casey Finnerty

Panel Recommends HPV Vaccine for Boys and Young Men - NYTimes.com - 0 views

  • HPV infection is the most common sexually transmitted disease — between 75 percent and 80 percent of females and males in the United States will be infected at some point in their lives. Most will overcome the infection with no ill effects. But in some people, infections lead to cellular changes that cause warts or cancer, including cervical, vaginal and vulvar cancers in women and anal cancers in men and women. A growing body of evidence suggests that HPV also causes throat cancers in men and women as a result of oral sex. HPV infections cause about 15,000 cancers in women and 7,000 cancers in men each year. And while cervical cancer rates have plunged over the past four decades because of widespread screening, anal cancer rates in men and women have been increasing. Head and neck cancers have also been increasing, with the share associated with HPV infection increasing rapidly — perhaps because oral sex has increased in popularity.
Casey Finnerty

In Nigeria, Polio Vaccine Workers Are Killed by Gunmen - NYTimes.com - 0 views

  • In a roundabout way, the C.I.A. has been blamed for the Pakistan killings.
  • The killings, with eerie echoes of attacks that killed nine female polio workers in Pakistan in December, represented another serious setback for the global effort to eradicate polio.
  • Since the vaccine ruse in Pakistan, she said, “Frankly, now, I can’t go to them and say, ‘The C.I.A. isn’t involved.’ ”
Casey Finnerty

Study Points to New Culprit in Heart Disease - NYTimes.com - 0 views

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    NYTimes report on Nathan's post about carnitine and it's conversion to TMAO by gut bacteria.
Casey Finnerty

Eggs, Too, May Provoke Bacteria to Raise Heart Risk - NYTimes.com - 0 views

  • The lecithin study, published Wednesday in The New England Journal of Medicine, is part of a growing appreciation of the role the body’s bacteria play in health and disease. With heart disease, investigators have long focused on the role of diet and heart disease, but expanding the scrutiny to bacteria adds a new dimension.
  • “Heart disease perhaps involves microbes in our gut,”
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    First carnitine and meat, now lecithin and eggs! Darn it! All things in moderation, I guess.
Casey Finnerty

Baby With H.I.V. Is Reported Cured - NYTimes.com - 1 views

  • If the report is confirmed, the child born in Mississippi would be only the second well-documented case of a cure in the world
  • Typically a newborn with an infected mother would be given one or two drugs as a prophylactic measure. But Dr. Gay said that based on her experience, she almost immediately used a three-drug regimen aimed at treatment, not prophylaxis, not even waiting for the test results confirming infection.
  • Virus levels rapidly declined with treatment and were undetectable by the time the baby was a month old. That remained the case until the baby was 18 months old, after which the mother stopped coming to the hospital and stopped giving the drugs.
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  • Dr. Gay contacted Dr. Katherine Luzuriaga, an immunologist at the University of Massachusetts,
  • Dr. Steven Deeks, professor of medicine at the University of California, San Francisco, said if the reservoir never established itself, then he would not call it a true cure, though this was somewhat a matter of semantics. “Was there enough time for a latent reservoir, the true barrier to cure, to establish itself?” he said.
  • One hypothesis is that the drugs killed off the virus before it could establish a hidden reservoir in the baby.
  • They found tiny amounts of some viral genetic material but no virus able to replicate, even lying dormant in so-called reservoirs in the body.
  • “For pediatrics, this is our Timothy Brown,” said Dr. Deborah Persaud, associate professor at the Johns Hopkins Children’s Center and lead author of the report on the baby. “It’s proof of principle that we can cure H.I.V. infection if we can replicate this case.”
  • Dr. Hannah B. Gay, an associate professor of pediatrics,
  • The results have not yet been published in a peer-reviewed medical journal.
  • The baby, born in rural Mississippi, was treated aggressively with antiretroviral drugs starting around 30 hours after birth, something that is not usually done. If further study shows this works in other babies, it will almost certainly be recommended globally.
  • those reports and this new one could suggest there is something different about babies’ immune systems, said Dr. Joseph McCune of the University of California, San Francisco.
  • the results could lead to a new protocol for quickly testing and treating infants.
Casey Finnerty

Reassessing Flu Shots as the Season Draws Near - NYTimes.com - 0 views

  • “It does not protect as promoted. It’s all a sales job: it’s all public relations.”
  • “I say, ‘Use this vaccine,’ ” he said. “The safety profile is actually quite good. But we have oversold it. Use it — but just know it’s not going to work nearly as well as everyone says.”
  • “Does it work as well as the measles vaccine? No, and it’s not likely to. But the vaccine works,” Dr. Joseph Bresee, chief of epidemiology and prevention in the C.D.C.’s influenza division, said. And research is advancing to improve the effectiveness of the vaccine.
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  • “Not having evidence doesn’t prove it doesn’t work; we just don’t know,” said Dr. Roger Thomas, a Cochrane Collaboration coordinator for the University of Calgary in Alberta, who was an author of both of the reviews. “The intelligent decision would be to have large, publicly funded independent trials.”
  • Another option for those who want to reduce their risk of influenza and flulike infections may be simply this: Wash your hands more often. There is good evidence this works.
Casey Finnerty

What Happens When Parents Are Rude in the Hospital - The New York Times - 0 views

  • “All the collaborative mechanisms and things that make a team a team, rather than four individuals working separately, were damaged by the exposure to rudeness.”
  • After such a comment, the teams performed significantly worse in the simulated patient emergencies. Their diagnostic skills deteriorated, and so did their technical procedural abilities, from ventilating and resuscitating the artificial babies properly to ordering and giving the right medications. Both doctors and nurses tended to perform worse individually. They also worked less effectively as teams, as far as communicating and helping one another take care of the sick “patient.”
Casey Finnerty

Rights Advocates Suing U.N. Over the Spread of Cholera in Haiti - NYTimes.com - 0 views

  • Cholera has killed more than 8,300 Haitians and sickened more than 650,000 in the earthquake-ravaged country, the poorest in the Western Hemisphere, since it first reappeared in October 2010.
  • Forensic studies, including one ordered by the United Nations, have identified the culprit bacteria as an Asian strain imported to Haiti by Nepalese members of the United Nations peacekeeping force, known as the United Nations Stabilization Mission in Haiti, which was first authorized in 2004 and maintains about 8,700 soldiers and police officers there, drawn from more than three dozen member states. The forensic studies have also linked the spread of the cholera to a flawed sanitation system at the Nepalese peacekeeper base, which contaminated a tributary that feeds Haiti’s largest river, used by Haitians for drinking and bathing.
Casey Finnerty

Probiotic Logic vs. Gut Feelings - NYTimes.com - 1 views

  • Still, he added, taking them doesn’t seem harmful. “It’s a relatively low-cost treatment worth trying if you have a condition like Crohn’s disease,” he said. “But for most conditions, the potential benefit is uncertain.”
  • There is growing evidence for the role of the appendix in restoring a healthful balance of microbes in the body.
  • The challenge in taking probiotics is to get the microbes past the stomach, where most are killed by gastric acid, said Robert Dunn, a biologist at North Carolina State University. Once in the intestines, they must compete effectively with the microbes already present.
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    I always wondered how the probiotics we get from yogurt etc. were supposed to make it past the stomach. If the stomach does indeed neutralize probiotics, does eating yogurt to prevent antibiotic associated diarrhea (for instance) really help?
Casey Finnerty

Yeast Infection Led to Removal of Transplanted Uterus - The New York Times - 0 views

  • The infection was caused by a fungus, a type of yeast called Candida albicans
  • It is normally found in the vagina, living in balance with bacteria and other microbes. But illness or some medications can disrupt the balance, allowing for a problematic overgrowth of the yeasts.
  • The surgeons said that since yeasts normally inhabit the genital tract, they could have come from either the donor or the recipient.
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  • But in transplant recipients, yeast infections can be hard to control, because the drugs that prevent rejection also prevent the immune system from fighting the infection. If a yeast infection spreads into the bloodstream, it can be extremely difficult to treat, and can be fatal.
  • Doctors rushed Ms. McFarland into surgery and discovered that an infection — they did not know then what kind — had extended into an artery they had connected to provide blood flow to the uterus. It had damaged the vessel and caused clots. The transplant had to be removed immediately. A week later, Ms. McFarland needed another operation, to treat more bleeding.
  • Once the cause of the infection was identified, she was treated with antifungal medicines. With the transplant removed, she was able to stop taking antirejection drugs and give her immune system a chance to recover and help control the infection.
  • She spent about five weeks in the hospital. Dr. Tzakis said she was still taking antifungal medicine, but was well.
  • The goal of the surgery is to make pregnancy and childbirth possible for women who were born without a uterus or lack one because of illness or injury.
  • They said they were considering various options, like using antifungal medicines preventively and washing the tissues of both the donor and recipient to reduce the risk of infection.
  • The only successful uterus transplants have been performed in Sweden, at the University of Gothenburg. Nine women have had the transplants there, and five have given birth.
  • Two of the nine transplants failed during the first year after the surgery and had to be removed
  • the other because of a bacterial infection.
  • Unlike the Cleveland team, doctors in Sweden used live uterus donors rather than cadavers for the transplants.
  • He also said that the Baylor team had adjusted its screening procedures to take into account possible exposure to the Zika virus
Casey Finnerty

For DTaP Vaccine, Thigh May Be Better Injection Site Than Arm - NYTimes.com - 0 views

  • researchers found that children between the ages of 1 and 3 who were given the DTaP vaccine in their thigh instead of in their upper arm were around half as likely to have a local reaction
    • Casey Finnerty
       
      Simple but effective.
Casey Finnerty

Really? The Claim: Hand Sanitizer Stops Norovirus Spread - NYTimes.com - 0 views

  • Some viruses, like influenza, are coated in lipids, “envelopes” that alcohol can rupture.
    • Casey Finnerty
       
      Which are more resistant to dessication, enveloped or naked viruses?
Casey Finnerty

Fecal Treatment Gains Favor for Some Illnesses - NYTimes.com - 3 views

  • A new study finds that such transplants cured 15 of 16 people who had recurring infections with Clostridium difficile bacteria, whereas antibiotics cured only 3 of 13 and 4 of 13 patients in two comparison groups.
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    I didn't know this was even possible. I wonder how they convinced people to donate. "The donors were tested for an array of diseases to make sure they did not infect the patients." I wonder how extensive that panel was and what they tested for.
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    Isn't this neat? I have met people who are hoping to get this treatment. Re: the screening, I think it is probably just for the absence of pathogens. As the article states, we really don't know what the "good" bacteria are that help these patients.
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    RE: I would hope that they would check for things like HIV and other blood to blood transmitted diseases. If there was a bleed in the GI tract of both the donor and the patient, I could imagine it would be a problem.
Casey Finnerty

A DNA Lesson, From the Expert's Pen - NYTimes.com - 1 views

  • The final piece in solving the puzzle of DNA was achieved on the morning of Feb. 28, 60 years ago this week, when Dr. Watson saw how the bases of DNA paired up.
Alison Prodzinski

Bathing, but Not Alone - NYTimes.com - 0 views

  • Another paradox of city life: it seems it is healthier to inhale the subway’s air than the shower’s mist.
  • the deluge of bacteria that hit your face and flow deep into your lungs in the morning shower
  • Running the water for 30 seconds before stepping in would mean fewer bacteria in one’s face
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  • Aside from the thought of being sprayed in the face by a bacterial cocktail every morning, the shower bacteria present no serious danger
  • the subway air is remarkably fresh and like outdoor air
  • Another paradox of city life: it seems it is healthier to inhale the subway’s air than the shower’s mist.
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    Bacteria are everywhere - including the shower!! There are 15 different kinds of bacteria that live in the shower -- they get into your lungs via inhalation and your skin. These bacteria are not all bad though - only Mycobacterium avium - it can cause chest complaints and issues. Research on the shower and bacteria was then compared to a New York City subway - in which the subway was healthier then the shower! WOW!! However, hope is not lost - researchers said to run the shower for 30 seconds and most bacteria will be gone!!
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