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Richard Herron

Braconidae - Wikipedia, the free encyclopedia - 1 views

  • Endoparasitoid species often display elaborate physiological adaptations to enhance larval survival within the host, such as the co-option of endosymbiotic viruses for compromising host immune defenses.
  • he DNA of the wasp actually contains portions that are the templates for the components of the viral particles and they are assembled in an organ in the female's abdomen known as the calyx.
  • Because of this highly modified system of host immunosuppression it is not surprising that there is a high level of parasitoid-host specificity. It is this specificity that makes Braconids a very powerful and important biological control agent.
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    My husband was telling me about this yesterday. He heard about it on reddit but he couldn't remember which kind of bug it was.
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    That's actually where I found it the other night. It was a very interesting read to say the least.
Casey Finnerty

Really? The Claim: Hand Sanitizer Stops Norovirus Spread - NYTimes.com - 0 views

  • Some viruses, like influenza, are coated in lipids, “envelopes” that alcohol can rupture.
    • Casey Finnerty
       
      Which are more resistant to dessication, enveloped or naked viruses?
Richard Herron

Viruses Can Have Immune System, Study Finds | Biology | Sci-News.com - 1 views

  • A new research led by Dr Kimberley Seed from the Tufts University School of Medicine provides the first evidence that bacteriophages – viruses that infect and replicate within bacteria – can acquire a wholly functional and adaptive immune system.
  • The study, published today in the journal Nature, finds that a viral predator of the cholera bacteria can steal the functional immune system of bacteria and use it against its bacterial host.
  • Developing phage therapy is particularly important because some bacteria, called superbugs, are resistant to most or all current antibiotics.
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  • This study focused on a phage that attacks Vibrio cholerae, the bacterium responsible for cholera epidemics in humans.
  • Finding a CRISPR/Cas system in a phage shows that there is gene flow between the phage and bacteria even for something as large and complex as the genes for an adaptive immune system,”
Richard Herron

Child born with HIV cured by US doctors | Society | The Guardian - 0 views

  • Doctors in the US have made medical history by effectively curing a child born with HIV, the first time such a case has been documented.
  • Dr Hannah Gay, who cared for the child at the University of Mississippi medical centre, told the Guardian the case amounted to the first "functional cure" of an HIV-infected child.
  • but it is likely that a tiny amount remains in their body.
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  • ypically, women with HIV are given antiretroviral drugs during pregnancy to minimise the amount of virus in their blood. Their newborns go on courses of drugs too, to reduce their risk of infection further. The strategy can stop around 98% of HIV transmission from mother to child.
    • Richard Herron
       
      I had no idea modern medicine was this effective against transmission from mother to child.
  • "It is far too early for anyone to try stopping effective therapy just to see if the virus comes back," she said.
Casey Finnerty

Baby With H.I.V. Is Reported Cured - NYTimes.com - 1 views

  • If the report is confirmed, the child born in Mississippi would be only the second well-documented case of a cure in the world
  • Typically a newborn with an infected mother would be given one or two drugs as a prophylactic measure. But Dr. Gay said that based on her experience, she almost immediately used a three-drug regimen aimed at treatment, not prophylaxis, not even waiting for the test results confirming infection.
  • Virus levels rapidly declined with treatment and were undetectable by the time the baby was a month old. That remained the case until the baby was 18 months old, after which the mother stopped coming to the hospital and stopped giving the drugs.
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  • Dr. Gay contacted Dr. Katherine Luzuriaga, an immunologist at the University of Massachusetts,
  • Dr. Steven Deeks, professor of medicine at the University of California, San Francisco, said if the reservoir never established itself, then he would not call it a true cure, though this was somewhat a matter of semantics. “Was there enough time for a latent reservoir, the true barrier to cure, to establish itself?” he said.
  • One hypothesis is that the drugs killed off the virus before it could establish a hidden reservoir in the baby.
  • They found tiny amounts of some viral genetic material but no virus able to replicate, even lying dormant in so-called reservoirs in the body.
  • “For pediatrics, this is our Timothy Brown,” said Dr. Deborah Persaud, associate professor at the Johns Hopkins Children’s Center and lead author of the report on the baby. “It’s proof of principle that we can cure H.I.V. infection if we can replicate this case.”
  • Dr. Hannah B. Gay, an associate professor of pediatrics,
  • The results have not yet been published in a peer-reviewed medical journal.
  • The baby, born in rural Mississippi, was treated aggressively with antiretroviral drugs starting around 30 hours after birth, something that is not usually done. If further study shows this works in other babies, it will almost certainly be recommended globally.
  • those reports and this new one could suggest there is something different about babies’ immune systems, said Dr. Joseph McCune of the University of California, San Francisco.
  • the results could lead to a new protocol for quickly testing and treating infants.
Whitney Hopfauf

Doctors warned to be vigilant for warn new deadly virus sweeping the globe from Middle ... - 0 views

  • three confirmed infections in Britain suggests the virus can pass from person to person rather than from animal to humans
  • coronavirus, part of the same family of viruses as the common cold and the deadly outbreak of Severe Acute Respiratory Syndrome
  • 60-year-old man who had recently traveled to Pakistan and Saudi Arabia and developed a respiratory illness on January 24, 2013. Samples from the man showed he was infected with both the new virus and with H1N1
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    While the number of confirmed cases is really low, the unnerving aspect is that 8 of the 14 people infected died. 
Elijah Velasquez

A viral grappling hook: Flu virus attacks like a pirate boarding party - 1 views

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    The flu virus carries about 300 to 400 of these hooks and virologists had known that several are needed to fuse the membranes. 4 hooks has recently been identified as the number of hooks required to pull the two membranes together. Without the attachment of 4 hooks the virus is vulnerable to inhibitors which will prevent fusion.
Whitney Hopfauf

Could new flu spark global flu pandemic? New bird flu strain seen adapting to mammals, ... - 0 views

  • "The human isolates, but not the avian and environmental ones, have a protein mutation that allows for efficient growth in human cells and that also allows them to grow at a temperature that corresponds to the upper respiratory tract of humans, which is lower than you find in birds,
    • Whitney Hopfauf
       
      These are the same researchers who did the infamous bird flu study that was temporarily banned
  • new virus has sickened at least 33 people, killing nine.
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    • Whitney Hopfauf
       
      This is so concerning... and yet it seems that the general population is oblivious to the implications of this virus
  • majority of the viruses in the study -- from both humans and birds -- display mutations in the surface protein hemagglutinin, which the pathogen uses to bind to host cells.
  • The same mutation, Kawaoka notes, lets the avian virus thrive in the cooler temperatures of the human upper respiratory system
  • the new strain could be treated with another clinically relevant antiviral drug, oseltamivir.
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    Genetic sequencing of the current H7N9 outbreak in China has revealed the ability of the virus to adapt to a human host
Casey Finnerty

Hilary Koprowski, Developed Live-Virus Polio Vaccine, Dies at 96 - NYTimes.com - 0 views

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    Fascinating obituary on the scientist who developed the first attenuated virus vaccine for polio. Surprise! It was not Salk nor Sabin.
Casey Finnerty

In Nigeria, Polio Vaccine Workers Are Killed by Gunmen - NYTimes.com - 0 views

  • In a roundabout way, the C.I.A. has been blamed for the Pakistan killings.
  • The killings, with eerie echoes of attacks that killed nine female polio workers in Pakistan in December, represented another serious setback for the global effort to eradicate polio.
  • Since the vaccine ruse in Pakistan, she said, “Frankly, now, I can’t go to them and say, ‘The C.I.A. isn’t involved.’ ”
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