Dr. Goodyear

Overeating, which is a classical American diet, was found to increase weight, fat mass and fasting insulin.  In contrast, SHBG, Testosterone and DHT were decreased.  Enzymes responsible for androgen production i.e.3-beta-hydroxysteroid dehydrogenase and 17-beta-hydroxysteroiddehydrogenase, were decreased in muscles of those in this study.  These changes were more pronounced in those with a family h/o of diabetes.

Since when did one medium of evaluation become the only standard.  Since serum T has been the historical standard, that is the only window of evaluation??  This study points to higher free Testosterone levels in saliva versus serum. Has anyone ever thought that we are merely looking through different windows of the same process.  Each window here, serum and saliva, are merely giving us different information on hormones.  That doesn't make one right or wrong, it just requires interpretation.  Science is about being objective! Saliva is the best means to evaluate intracellular hormone levels.  These levels should be different than serum.  Why should anyone think that the total levels would correlate with that delivered to a cell.  Think.

Relora found to reduce cortisol in short study.

good, albeit brief, review of albumin and globulin serum values and their indication.

New study finds autism is mix of genetic and environmental factors.

SEARCH study finds significantly increased rates of type I and type II diabetes in children from 2000 to 2009.

Study worries over the risks of supplements and prescription drugs.  The author should worry more over the lack of knowledge by physicians of the health benefits of supplements.  Instead of focusing on the prescriptions themselves, how about focusing on the supplements to reduce the need for the prescriptions.  This authors focus is all wrong.   Obviously, the patient needs to be forthcoming with his/her physician about all supplements that they are on.  

Very well done article that discusses the relationship between mitochondria and endocrine disorders.  Mitochondrial disorders cannot just include inherited mitochondriopathies, but acquired mitochondriopathies as well.

Not a new finding, but study finds that 60% of PCOS women have elevated androgens, male hormones.  The study also found increased LH, increased FSH, decreased SHBG, increased free androgen index, and increased fasting glucose levels.

Interesting concept on Androgen deprivation therapy.  ADT has significant negative metabolic effects in men.  Here Intermittent ADT is evaluated and found to be questionable in its outcome.

validation of saliva testing in animals.  The point is saliva testing for Testosterone is valid.

study finds Testosterone improves cognitive function in postmenopausal women.  Was this due to aromatase activity and conversant to Estradiol?  Testing was limited in follow up.

Review article that looked at "natural" therapies for cancer therapy.  I have to read this--unread at this point.

Older review of literature on Maitake mushrooms and cancer.

mushrooms and cancer

Iron therapy may benefit some with MS.  

Best olive oils in the world.

Sex hormones in head and neck cancer.  The jury is still out and probably follows other hormone sensitive cancers.  

list of articles that looks at Mercury and MS.  

Good review of the toxic effects of Hg on the CNS and cardiovascular system.