Genetic Determinants of Serum Testosterone Concentrations in Men - 0 views
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mean serum testosterone concentrations were found to be lower in men with GG than in those with TT genotype for rs12150660
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men with the CT genotype for rs6258 had lower serum testosterone concentrations than those with CC genotype.
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The two autosomal SNPs identified by GWAS had a significant influence on the risk of having low serum testosterone (serum testosterone <300 ng/dl) in both the discovery and the replication cohorts with a combined odds ratio (OR) per minor allele of 0.72 (95% CI, 0.65 – 0.79) and 2.7 (95% CI, 2.1 – 3.5) for rs12150660 and rs6258, respectively
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