Role of Polymorphic Human Cytochrome P450 Enzymes in Estrone Oxidation - 0 views
cebp.aacrjournals.org/...551.long
estrogen metabolism estrogen metabolites cytochrome P450 estrogen estrone hormones detoxification metabolites
shared by Nathan Goodyear on 11 Sep 15
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CYP1A1 and CYP1B1 are not expressed in any significant quantity in the liver. Therefore, they would not be expected to contribute to the overall systemic metabolism of estrone. However, both enzymes have been identified in breast tissue
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CYP1A1 displayed relatively high activity for all three hydroxylations, suggesting that it may play an important role in extrahepatic tissues where it is expressed
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CYP1A1 was more active with regard to 2-hydroxylation and 4-hydroxylation, it also displayed one of the greatest 16α-hydroxylating activities of the CYP enzymes tested.
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CYP1B1 displayed a high affinity for estrone and preferentially catalyzed 4-hydroxylation over 2-hydroxylation
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CYP1B1 was shown to preferentially catalyze 4-hydroxylation, whereas CYP1A1 was shown to preferentially catalyze 2-hydroxylation
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Among the CYP enzymes expressed in the liver, CYP1A2 was the most active with regard to 2-hydroxylation