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Computer Science Tuesday, April 25, 2023 Computer hardware Computer hardware is the physical components that make up a computer system. It includes everything from the central processing unit (CPU) to the monitor, keyboard, and mouse. Understanding the different types of hardware and how they work together is essential for anyone who works with computers. In this article, we will explore the various components of computer hardware, including internal and external components, and the peripherals that connect to them. We will also discuss the importance of hardware maintenance, the latest advancements in computer technology, and factors to consider when choosing the right hardware for your needs. Whether you are a computer technician, a gamer, or simply someone who uses a computer for everyday tasks, this article will help you better understand the world of computer hardware. Introduction to Computer Hardware Computer hardware refers to the physical components that make up a computer system. It includes everything from the processor and memory to input/output devices such as the keyboard and monitor. In this article, we will explore the different types of computer hardware and their functions. What is Computer Hardware Computer hardware refers to the physical components of a computer system. It includes all the components that can be touched, seen, and used to interact with a computer, such as the monitor, keyboard, and mouse. Hardware is different from computer software, which refers to the programs and applications that run on a computer system. History of Computer Hardware The history of computer hardware dates back to the 1820s when Charles Babbage, an English mathematician, and inventor, designed the first analytical engine, which was considered to be the first mechanical computer. With time, more complex electronic computers were developed, including the first Intel microprocessor in 1971. Since then, computer hardware has continued to evolve, becoming

Nearly 9,000 pharmacy contractors benefitted from earlier advance payment in January, Pharmaceutical Services Negotiating Committee (PSNC) said in an update. Contractors who declared their December FP34C submission figures (for the dispensed prescriptions) through the Manage Your Service (MYS) portal by January 6, would have received earlier advance payments on January 12. Meanwhile, all contractors who made submissions after January 6 or used the FP34C paper document, will receive payments as per the normal payment schedule i.e. on February 1, 2022. PSNC encouraged contractors to submit their monthly declaration through the MYS portal by the 5th of the month to avail early payments.

Study finds a reduction in SuperOxide Dismutase and Glutathione Perioxidase in advancing breast cancer.  Cancer is a high oxidative stress disease that results in inflammation, mitochondrial dysfunction and proliferation.  Adenosine Deaminase (ADA) is proposed to be another biomarker to assess tumor stage.  

diabetes associated with increased advanced glycation end products (AGE) in elderly population.  This increase in AGE associated with cognitive decline as evaluated by MMSE.

AGE's, advanced glycation end products, play a role in development/progression of neurodegenerative diseases such as Alzheimer's, Parkinson's...

Small phase II pilot sutyd of advanced ovarian cancer, foud low dose IL-2 at 3 million IU/day X 6 days for 4 weeks preceded by 40 mg melatonin provides some benefit in advanced disease following at least 3 failed polychemotherapy regimens.  

Epilepsy surgeons in India may have specialized training and a track record of successful surgeries and positive patient outcomes. Epilepsy surgeons in India often engage in ongoing research and stay updated on the latest advancements in the field. This commitment to innovation allows patients to benefit from cutting-edge surgical techniques and treatment modalities.

NAC shown to improve secondary measures of cognitive function in small study in those with Alzheimer's disease. NAC proves to be a reliable means to reduce free radical induced advanced glycation end productions and resultant inflammation. Also was shown to be well tolerated.

This study finds that AGE, advanced glycation end products, play a significant role in free radical generation and neurodegenerative disease. Quote: "... pharmacologoical approaches which break the vicious cycle of oxidative stress and neurodegeneration offer new opportunities for the treatment of AD. These approaches include AGE- inhibitors, antioxidants, and anti-inflammatory substances which prevent radical production." They focus on the pharmacological, how about the natural first?

BCAA useful in advanced liver cirrhosis.

good review of BCAA and liver disease: both mechanisms and therapy.

Advanced Neurology & Superspeciality Hospital is an exclusive neurosciences superspeciality hospital of Jaipur,Rajasthan,commonly known by the name of THE BRAIN TOWER. Dr.Sunit shah, man behind brain tower provides treatment of Neurology,physiotherapy,paralysis & Neurosurgery

Hyperthermic therapy augments chemotherapy for some with advanced sarcomas.  Systemic temperature at 37.4 C in this study.

Head to head study of IL-2 + melatonin versus chemotherapy in advanced pancreatic cancer found slightly better outcomes in the immunotherapy arm versus standard chemotherapy.  This difference was statistically significant.

Abstract only here.  Immunotherapy of IL-2 + melatonin provided lack of progression of 67% of patients included with a average duration of 21+ months in patients with untreatable advanced hematologic cancer.  Again, no toxicities.  Interesting, the survival time was similar to the previously reported survival times with the highly toxic high dose IL-2 therapy.

Dated a few years, but good review of systemic treatments for advanced salivary gland cancers...treatment success is limited with systemic therapy and is usually left for recurrence.

Hyperthermia + chemotherapy found to be effective in advanced ovarian cancer, including improvement in pain control.

low vitamin D and PTH in black and white elderly associated with increased mortality; however, the black elderly have lower vitamin D levels in comparison to their white counterparts.  How does this play a in increased advanced disease?  I believe quite a bit.

Interesting cohort of Danish and Finnish men.  What is interesting is that in both groups, men born earlier in the 20th century were found to have higher testosterone levels.  As the year of birth advanced, there were declines in Testosterone, LH, and higher SHBG.

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