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Nathan Goodyear

Testosterone Replacement in Hypogonadal Men With Type 2 Diabetes and/or Metabolic Syndrome (the TIMES2 Study) - 0 views

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    Testosterone therapy in men with low Testosterone was found to improve insulin sensitivity, total cholesterol levels, LDL, Lpa, and sexual performance in men with low T, type II diabetes and/or metabolic syndrome.  There is suggestion that muscle composition was improved as well.
Nathan Goodyear

JAMA Network | JAMA | Effects of Testosterone Administration for 3 Years on Subclinical Atherosclerosis Progression in Older Men With Low or Low-Normal Testosterone Levels:  A Randomized Clinical Trial - 0 views

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    new study finds Testosterone therapy does not increase atherosclerosis in older men.  Study also found little improvement in quality of life and sexual function with Testosterone therapy in men with low to low-normal Testosterone.
therapy1on1

How Addiction Counselling Services Can Help to Overcome Addiction? - 0 views

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    Addictions can create from what might be viewed as fairly innocent, or at least common social propensities. Drinking alcohol, gambling, eating, engaging in sexual relations and utilizing the web can all turn from what is viewed as a common activity, to a darker, increasingly destructive compulsion. Addiction treatment, for example, addiction counselling services, is critical for helping individuals perceive the issue and make the steps to recuperation.
trungtamnamkhoa

Phương pháp điều trị xuất tinh sớm hiệu quả nhất - Men's Health Vietnam - 1 views

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    Premature ejaculation is a male sexual disorder characterized by ejaculation that occurs always (or almost always) before or within a minute after putting the penis into the vagina, unable to control ejaculation every time. put penis into vagina. And this condition causes negative consequences for yourself such as depression, frustration, sexual intercourse.
sofiawalker171

Hypnosis For Enhancing Performance | Sports Performance Hypnosis Atwell - 0 views

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    Hypnosis treatment for work life enrichment, anger management, improving sexual difficulties or improving confidence & enhancing performance of Women in Atwell
trungtamnamkhoa

Pharma Injectable Sust 250mg of the faculty Men's Health - 1 views

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    Pharma Sust 250mg injections treat hypogonadism disorders in men, after the illness, impotence due to lack of hormones, menstrual symptoms in men such as reducing sexual pleasure and physiological activities. Side effects: The drug can cause erectile dysfunction, signs of excessive sexual stimulation, reduced sperm count, decreased volume of ejaculation, water & salt retention. In pre-puberty boys: develop sex early, increase the frequency of erectile dysfunction, enlargement of the penis, and early growth of bone heads.
trungtamnamkhoa

Learn The Pathology Of Premature Ejaculation In Young People - Men's Health Viet Nam - 1 views

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    This situation of "not going to the market has run out of money" is also a complaint that most doctors in Nam Khoa listen to from patients. If from the beginning, sexual and sexual attractions were simply a kind of human instinct, through which the race would be passed on to the next generation, today with development. The prosperity of human society, sex is also a joy, a happiness and sometimes also a powerful demonstration of love for couples. Because of that, the strategy of "beating fast and fast" which is an advantage in the past has become a difficult obstacle for the heart of the foolish love. Let's find out how to overcome "the market has not run out of money" by the article Premature ejaculation cause and treatment - Men Health!
Nathan Goodyear

Randomized placebo-controlled trial of testosterone replacement in men with mild Leydig cell insufficiency following cytotoxic chemotherapy. - PubMed - NCBI - 0 views

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    The authors conclusion here is all wrong.  The men with low T had improvement in energy and LDL, but no improvement in mood and sexual function.
Nathan Goodyear

The 20-Year Public Health Impact and Direct Cost of Testosterone Deficiency in U.S. Men - Moskovic - 2012 - The Journal of Sexual Medicine - Wiley Online Library - 0 views

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    This study assumes a 13% low T prevalence.  Probably too low.  This will only grow.  Low T contributes to many disease states in men. This study showed a cost of 190-525$ billion in cost from these disease states over a 20 year time period.
Nathan Goodyear

Chemistry and Structural Biology of Androgen Receptor - 0 views

  • Healthy adult men typically produce approximately 3–10 mg of testosterone per day
  • circulating levels ranging from 300 to 700 ng/dL in eugonadal men
  • endogenous testosterone secretion is pulsatile and diurnal
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  • highest concentration occurring at about 8:00 a.m. and the lowest at about 8:00 p.m.
  • Average serum concentrations and diurnal variation in testosterone diminish as men age
  • 40% is sequestered with high affinity to sex hormone-binding globulin (SHBG)
  • almost 60% is bound with low affinity to albumin
  • 2% as free, unbound hormone
  • 5α-DHT has even greater binding affinity to sex hormone-binding globulin than does testosterone
  • 5α-DHT is only about 5% as abundant in the blood as testosterone and is largely derived from peripheral metabolism of testosterone
  • Both 5α-reduction and aromatization are irreversible processes
  • Approximately 90% of an oral dose of testosterone is metabolized before it reaches the systemic circulation
  • there are three modes of action of testosterone. It may directly act through AR in target tissues where 5α-reductase is not expressed, be converted to 5α-DHT (5–10%) by 5α-reductase before binding to AR, or be aromatized to estrogen (0.2%) and act through the estrogen receptor
  • 5α-DHT is a more potent AR ligand than testosterone
  • has 2–10-fold higher potency than testosterone in androgen-responsive tissues
  • estrogen plays a major role in regulating metabolic process,74,75 mood and cognition,76 cardiovascular disease,77,78 sexual function including libido,79 and bone turnover in men
  • Free testosterone is considered the most “biologically active” form
  • testosterone is the major androgen that acts in the “DHT-independent” tissues, such as skeletal muscle, where 5α-reductase is not expressed or is expressed at a very low level
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    good review of androgens and AR.
Nathan Goodyear

Effect of aqueous extract of Bulbine natalensis (Baker) stem on the sexual behaviour of male rats - Yakubu - 2008 - International Journal of Andrology - Wiley Online Library - 0 views

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    Bulbine natalensis (Baker) stem found to be useful in libido/ED at doses of 25-50 mg/kg in animal studies.
Nathan Goodyear

Effect of Tongkat Ali on stress hormones and psychological mood state in moderately stressed subjects - 0 views

  • At the age of 60, testosterone levels are typically only 40-50% of youthful levels and may be lower
  • Eurycoma contains a group of small peptides referred to as “eurypeptides” that are known to have effects in improving energy status and sex drive in studies of rodents
  • The effects of tongkat ali in restoring normal testosterone levels appears to be less due to actually “stimulating” testosterone synthesis, but rather by increasing the release rate of “free” testosterone from its binding hormone, sex-hormone-binding-globulin (SHBG)
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  • The current study found that daily supplementation with tongkat ali root extract (200 mg/day) improves stress hormone profile (lower cortisol; higher testosterone) and certain mood state parameters (lower tension, anger, and confusion)
  • tongkat ali supplementation (100 mg/day) improved lean body mass, 1-RM strength, and arm circumference to a significantly greater degree compared to a placebo group.
  • In a recent 12-week trial [46] of Eurycoma longifolia supplementation (300 mg/day), men (30–55 years of age) showed significant improved compared to placebo in the Physical Functioning domain of the SF-36 quality of life survey
  • sexual libido was increased by 11%
  • In men with low testosterone levels (average age 51 years), one month of daily supplementation with tongkat ali extract (200 mg/day) resulted in a significant improvement in serum testosterone levels and quality-of-life parameters
  • rise in cortisol and drop in testosterone is an early signal of “overtraining”
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    Tongkat Ali, commonly known as long jack, is found to reduce stress and increase Testosterone.  Stress is one of the common causes of low T in men.  It appears that long Jack functions as an adaptogen.
Nathan Goodyear

Kisspeptin modulates sexual and emotional brain processing in humans - 0 views

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    Men, get to know Kisspeptin. Your Testosterone will thank you.
Nathan Goodyear

Effects of Smoking on Plasma Testosterone Level and Erectile Function in Rats - Park - 2011 - The Journal of Sexual Medicine - Wiley Online Library - 0 views

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    smoking reduces serum testosterone in rats.  The real question is what does it do to the salivary levels (tissue) and the metabolism of testosterone.
Nathan Goodyear

Dehydroepiandrosterone (DHEA)-A Precursor Steroid or an Active Hormone in Human Physiology (CME) - Traish - 2011 - The Journal of Sexual Medicine - Wiley Online Library - 0 views

  • no significant adverse or negative side effects of DHEA were reported in clinical studies of men and women.
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    review of the clinical studies of DHEA and DHEA-S find no negative side-effects: only positive effects.  Overdosage of DHEA, which is common in women, obviously can result in side effects, though.
Nathan Goodyear

Concerns About Serum Androgens Monitoring During Testosterone Replacement Treatments in Hypogonadal Male Athletes: A Pilot Study - Di Luigi - 2012 - The Journal of Sexual Medicine - Wiley Online Library - 0 views

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    total testosterone serum levels are inadequate to monitor men on testosterone therapy in athletes and non-athletes.
Nathan Goodyear

Is erectile dysfunction a low-grade systemic inflammatory condition? - 0 views

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    ED is the result of low-grade, chronic inflammation.
Nathan Goodyear

Testosterone Replacement Therapy Improves Metabolic Parameters in Hypogonadal Men with Type 2 Diabetes but Not in Men with Coexisting Depression: The BLAST Study - Hackett - 2013 - The Journal of Sexual Medicine - Wiley Online Library - 0 views

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    Testosterone therapy lowered HgbA1c in poorly controlled Diabetics.  These patients were followed out to 52 weeks.  Testosterone therapy, as is lifestyle change, a long term strategy of Diabetes control.  Studies in controlled Diabetics have not shown a reduction in HgbA1c consistently.  Total cholesterol and waist circumference were also reduced.
Nathan Goodyear

Hormonal Modulation in Aging Patients with Erectile Dysfunction and Metabolic Syndrome - 0 views

  • Hypogonadism and MetS are strongly associated [12, 13, 16], having even been demonstrated that with the increasing number of MetS parameters there is a proportional raise in the incidence of hypogonadism
  • increasing number of MetS components is inversely associated with T levels
  • the presence of MetS did not prove to be a significant determinant of hypogonadism, as it did not lead to a decline in T levels, in MetS patients with already established hypogonadism, the increasing number of MetS features was associated with further decline in T
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  • In the setting of MetS, hypertriglyceridemia and increased WC have been reported as the most important determinants of hypogonadism
  • recent literature consistently associates obesity not only with higher risk of hypogonadism [4, 6, 27] but also with lower T levels
  • Visceral adiposity has been particularly related with reduction of T and SHBG levels (independent of other metabolic disorders)
  • WC was one of the MetS parameters with the greatest influence in T levels decrease, presenting itself as a strong risk factor for hypogonadism development
  • MetS-related T decline was not accompanied by an increase in pituitary LH levels, suggesting impairment in gonadotropin secretion
  • The molecules behind this smoothing compensatory effect of GnRH/LH are still unknown, but estrogens and insulin, as well as leptin, TNF-α, and other adipokines, were proposed candidates
  • fat stores undertake an increase aromatization of androgens, therefore raising estrogen levels [9, 15], which in turn decrease LH secretion
  • our data contradicts the concept that estradiol exerts a negative feedback on hypothalamic GnRH secretion
  • taking into account that high estradiol levels have already been described as the only abnormality in a subset of patients with ED, the hypothesis that the later might not only be caused by androgen deficiency is becoming increasingly evident
  • it has been reported that the chronic exposure to phosphodiesterase type 5 inhibitors (PDE5i), widely used for the treatment of ED, may influence serum estradiol levels
  • thyroid disorders (specially hyperthyroidism) have been related to ED and hypogonadism, and so must be considered in a sexual-dysfunction setting
  • It is clear from the current literature that collecting a more thorough hormonal panel might be a wise approach to further uncover hormonal relations
    • Nathan Goodyear
       
      outstanding point.  This hits to the point that Low T is the effect not the cause.
  • We concluded that in ED patients with hypogonadism and MetS, the attenuated response of HPG axis (normal or low LH levels) might not always be due to an underlying adiposity-dependent estrogen-raising effect.
  • our findings indicate that ED, aging, and estradiol might have a stronger connection than what is currently described in the literature.
  • this study underlines the importance of the collection of a full hormonal panel in ED men
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    low T strongly associated with metabolic syndrome in men.
Nathan Goodyear

Dramatic improvement in sexual function induced by... [J Sex Med. 2012] - PubMed - NCBI - 0 views

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    limited study as it is a case study of 1.  However, there was improvement with libido, erection, and orgasm in this case study of 1 with intranasal oxytocin.
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