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Nathan Goodyear

Thimerosal and the Occurrence of Autism: Negative Ecological Evidence From Danish Population-Based Data - 0 views

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    Danish study that had data altered prior to publication.  The original data showed decreasing Autism rate in Danish children after removal of thimerosal from their vaccines
Nathan Goodyear

Toll-like Receptor Status in Obesity and Metabolic Syndrome: A Translational Perspective: The Journal of Clinical Endocrinology & Metabolism: Vol 99, No 1 - 0 views

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    Only the abstract is available publicly.   Toll-like receptors, particularly TLR-4 has been shown to be associated with insulin resistance.  These TLRs have specific pathogen recognition sites.  TLRs are stimulated by fatty acids (FA) and endotoxemia from bacteria.  Thus, dietary intake of high trans fats, inflammation originating from the gut can be the source of insulin receptor dysfunction through TLRs.
Nathan Goodyear

https://www.endocrine.org/~/media/endosociety/Files/Publications/Clinical%20Practice%20Guidelines/Evaluation-treatment-of-Adult-Growth-Hormone-Deficiency-Clinical-Practice-Guideline-NonCME.pdf - 0 views

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    Current recommendations on HGH origin, evaluation, and therapy.
Nathan Goodyear

https://www.nature.com/articles/6603740.pdf?origin=ppub - 0 views

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    Zometa (a bisphosophate) plus doxycycline reduce bone metastasis tumor burden on breast cancer model.
Nathan Goodyear

https://www.nature.com/articles/6601943.pdf?origin=ppub - 0 views

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    CD4 tumor infiltrates of the tumor microenvironment is associated with worse overall survival in prostate cancer patients.
Nathan Goodyear

Metabolic endotoxaemia - a potential novel link between ovarian inflammation and impaired progesterone production: Gynecological Endocrinology: Vol 31, No 4 - 0 views

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    Systemic LPS, metabolic endotoxemia, that is the result of inflammation originating out of the gut found to cause luteal phase dysfunction--low progesterone.  Now, we have the gut-hormone connection.
fnfdoc

How Lupus Affects The Health? - 0 views

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    SLE or Lupus is an autoimmune disease that causes inflammation of the organs and swelling of the joints. It has vast effects on the renal, skeletal, gastrointestinal and blood systems. It affects mostly people of Chinese and African origin and presents in a capricious and unpredictable manner.
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    10 May Is Lupus Day We Must Know About Lupus
Nathan Goodyear

https://www.nature.com/articles/2401085.pdf?origin=publication_detail - 0 views

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    IL-2 therapy foud to kill myeloid leukemia cells via NK activation in vitro study.
Nathan Goodyear

http://www.nature.com/ijo/journal/v24/n2s/pdf/0801281a.pdf?origin=publication_detail - 0 views

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    Elevated insulin levels in men is associated with decreased liver production of SHBG and thus reduced SHBG levels.  Obesity is associated with decreased urinary cortisol in this study.  The authors found the low cortisol also contributed to the low SHBG as well. Low SHBG is associated with puberty, obesity, IR, hypothyroidism, and during androgen therapy.  SHBG is increased as a result of aging, short-term fasting, Estrogen, hyperthyroid, and liver disease.
snfilms

Music Videos of Mannat Noor - 0 views

shared by snfilms on 03 Apr 21 - No Cached
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    Did you know Kelmash Devi is the original name of Indian #punjabisinger Mannat Noor? Check out #MannatNoor superhit #musicvideos on #sdtunes http://www.sdtunes.com/.../mannat-noor-huge-hit-music...
snfilms

Music Videos Of The Weeknd - 0 views

shared by snfilms on 15 May 21 - No Cached
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    Did you know the original name of #theweeknd is Abel Makkonen Tesfaye ?. Watch his #musicvideos on #sdtunes http://www.sdtunes.com/.../the-weeknd-huge-hit-music...
snfilms

SN Films Performing Arts - Audition & Admission Open. - 0 views

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    জ্বলছে আগুন, বাইরে ফাগুন । Coming up with original music videos and short films. Subscribe us to stay tuned ( https://bit.ly/3sefG51 ) Contact SN Films Performing Arts (snfpa) at 9051355050 for artists' audition and students' admission.
snfilms

Ooty Pykara Lake Shoot Pic... - 0 views

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    Shooting at Ooty Pykara Lake before lockdown - with Sanjib Nath, Debasmita Chattopadhyay, Taryn Nath, Olina Nath, Debjani Chattopadhyay. https://www.youtube.com/user/SNFilmsVideos Check out our original #movies, #musicVideos, #webSeries and more on website and snfilms youtube channel.
pharmacybiz

DHSC adds Dexcom One transmitter to March 2023 Drug Tariff - 0 views

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    Department of Health of Social Care (DHSC) has confirmed that the Dexcom One Transmitter will be added to Part IXA of the March 2023 Drug Tariff. "Previously, patients were advised to obtain the free-of-charge Dexcom One transmitters directly from the pharmacies, without a prescription, as the original Drug Tariff application for the transmitter was unsuccessful," said the Pharmaceutical Services Negotiating Committee (PSNC) It has raised concerns with DHSC and Dexcom that these distribution arrangements for transmitters are unacceptable because they result in extra unfunded activity for community pharmacies. Both, DHSC and Dexcom acted upon these concerns by agreeing to add the Dexcom One transmitter to the Drug Tariff from March 2023. At the same time, Dexcom One CGM System (containing 1 sensor, 1 sensor applicator, 1 transmitter) will also be added to the March Drug Tariff.
umar111

Body Luxuries Miracle Perfume for Ladies - 0 views

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    Body Luxuries Miracle Perfume for Ladies The Scent That Will Make You Feel Divine. Perfume is an essential part of every woman's beauty regimen. The right scent can lift your mood, boost your confidence, and make you feel divine. But finding the perfect perfume can be a challenge with so many options available in the market. This is where Body Luxuries Miracle Perfume comes in, a fragrance that promises to make you feel like a goddess. What is Body Luxuries Miracle Perfume? Body Luxuries Miracle Perfume is a luxury fragrance designed for women who want to feel confident, alluring, and sophisticated. This fragrance is made from high-quality ingredients, making it long-lasting and ideal for everyday wear. Its unique blend of floral and fruity notes creates a delightful aroma that is sure to turn heads. What makes Body Luxuries Miracle Perfume so special? The scent of Body Luxuries Miracle Perfume is both sensual and captivating. It has a top note of juicy pear and luscious peach that gives it a fruity aroma. The heart notes are a blend of floral scents such as jasmine, lily-of-the-valley, and peony, which give it a feminine touch. The base notes of vanilla, musk, and cedarwood create a warm and inviting aroma, making it perfect for any occasion. The fragrance is long-lasting, so you can wear it all day without having to reapply. This makes it ideal for women who want to smell great throughout the day. Additionally, Body Luxuries Miracle Perfume is affordable, making it accessible to women from all walks of life. How to use Body Luxuries Miracle Perfume To get the best out of Body Luxuries Miracle Perfume, you need to apply it correctly. Start by taking a shower and moisturizing your skin. This will help the fragrance to last longer. Next, spray the perfume onto your pulse points, such as your wrists, neck, and behind the ears. These areas are warmer than other parts of your body, which helps the fragrance to diffuse better. Conclusion Original Body Luxuries Miracle P
umar111

Colour Me Black Perfume - 0 views

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    If you're looking for a new fragrance that can transform your personality, then you must try Colour Me Black perfume. This captivating fragrance has been designed to evoke a sense of sensuality and confidence, and is perfect for those who want to make a bold statement. With its unique blend of exotic and alluring notes, Colour Me Black is a perfume that is sure to turn heads. The Fragrance of Colour me Black Perfume Original Colour Me Black perfume is a seductive fragrance that combines rich and spicy notes to create an alluring aroma. The top notes of this fragrance are made up of bergamot, lavender, and pineapple, which provide a fresh and invigorating scent. The heart notes include jasmine, geranium, and nutmeg, which add a spicy and exotic twist to the fragrance. The base notes of Colour Me Black are made up of cedarwood, musk, and amber, which provide a warm and sensual finish.
Nathan Goodyear

Assessment of Colorectal Cancer Molecular Features along Bowel Subsites Challenges the Conception of Distinct Dichotomy of Proximal vs. Distal Colorectum - PMC - 0 views

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    Clearly different cancer types between distal and proximal colorectal origin-microbiome?
Edgar Anderson

Professional Help In Losing Weight - 1 views

I gained much weight after giving birth and I really wanted to go back to my original weight or at least lost some of it. So I have tried many ways of losing weight but none of them worked to my ad...

started by Edgar Anderson on 18 Dec 12 no follow-up yet
Nathan Goodyear

Beyond the male sex hormone: deciphering the metabolic and vascular actions of testosterone - 0 views

  • androgen deprivation therapy results in unfavorable changes in body composition, insulin resistance, and dyslipidemia and predisposes men to develop atherosclerosis and an increased risk of cardiovascular mortality
  • The hypogonadal–obesity cycle hypothesis was originally proposed by Cohen in 1999 to explain the relationship between low testosterone levels and metabolic disease. It was based on the finding that obesity impairs testosterone levels by increasing the aromatization of testosterone to estradiol, while low testosterone levels promote increased fat deposition
  • adipocytokines contribute to low testosterone levels as well as to the processes underlying metabolic syndromes and type 2 diabetes
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  • hypogonadal–obesity–adipocytokine hypothesis
  • The presence of estradiol and the adipocytokines TNF-α, IL6, and leptin (as a result of leptin resistance in obesity) inhibits the hypothalamic–pituitary–testicular axis response to decreasing androgen levels
  • An increasing number of studies have illustrated the potential for applying metabolomics to the field of androgen research
  • As early as the 1940s, the therapeutic use of testosterone was reported to improve angina pectoris in men with coronary artery disease
  • most of the epidemiological studies reported increased cardiovascular risk and mortality in men with low testosterone levels
  • long-term testosterone replacement appears to be a safe and effective means of treating hypogonadal elderly men
  • a recent interventional trial showed that testosterone treatment was associated with decreased mortality when compared with no testosterone treatment in an observational cohort of men with low testosterone levels
  • a number of short-term studies conducted support the notion that testosterone therapy reduces the cardiovascular risk
  • The majority of animal studies support the hypothesis that the actions of testosterone on vascular relaxation are both endothelium-dependent and -independent vasodilatory effects
  • Endothelial-dependent actions of testosterone increase the expression or activity of endothelial nitric oxide synthase and enhance nitric oxide production, which in turn activates cyclic guanosine monophosphate to induce vasorelaxation in smooth muscle cells
  • Endothelial-independent mechanisms of testosterone are believed to occur primarily via inhibition of voltage-operated Ca2+ channels and/or activation of K+ channels in smooth muscle cells
  • Testosterone may also inhibit intracellular Ca2+ influx via store-operated Ca2+ channels by blocking the response to prostaglandin F2α
  • testosterone has demonstrated anti-inflammatory effects to protect against atherogenesis in animal studies
  • both genomic AR activation to modulate gene transcription and non-genomic activation to modulate the rapid intracellular signaling pathways of ion channels may mediate testosterone effects on vascular function and inflammation.
  • Butenandt & Ruzicka first showed how testosterone is synthesized and responsible for masculine characteristics in the early 1930s
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    Awesome review on the current understanding of Testosterone and Diabetes, metabolic syndrome, and CVD.  This article even goes into the literature on androgen receptors.
Nathan Goodyear

Minireview: Inflammation and Obesity Pathogenesis: The Hypothalamus Heats Up - 0 views

  • Leptin, secreted by adipocytes in proportion to body fat mass
  • The saturated fatty acid palmitate (16:0) induces NF-κB signaling through a TLR4-dependent mechanism
  • 18:0 (stearic) and longer saturated fatty acids as well as linolenic acid (18:3) increased proinflammatory cytokines, ER stress markers, and TLR4 activation
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  • (SOCS)-3. A member of a protein family originally characterized as negative feedback regulators of inflammation (13, 37), SOCS3 inhibits insulin and leptin signaling
  • IKKβ signaling in discrete neuronal subsets appears to be required for both hypothalamic inflammation and excess weight gain to occur during HF feeding
  • the paradoxical observation that hyperphagia and weight gain occur when hypothalamic inflammation is induced by HF feeding, yet when it occurs in response to systemic or local inflammatory processes (e.g. administration of endotoxin), anorexia and weight loss are the rule
  • , serves as a circulating signal of energy stores in part by providing feedback inhibition of hypothalamic orexigenic pathways [e.g. neurons that express neuropeptide Y and agouti-related peptide (AgRP)]
  • and stimulating anorexigenic neurons
  • signals from Toll-like receptors (TLRs), evolutionarily conserved pattern recognition molecules critical for detecting pathogens, amplified through signaling intermediates such as MyD88 activate the inhibitor of κB-kinase-β (IKKβ)/nuclear factor-κB (NF-κB), c-Jun N-terminal kinase (Jnk) and other intracellular inflammatory signals in response to stimulation by circulating saturated fatty acids
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    great read on the current understanding of how obesity and resultant inflammation disrupts hypothalamic function.
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